ES2155948T3 - 20-oxopregna-derivados 17-cadena lateral alquinilica de la vitamina d, metodos para su produccion y composiciones farmaceuticas de los mismos. - Google Patents

20-oxopregna-derivados 17-cadena lateral alquinilica de la vitamina d, metodos para su produccion y composiciones farmaceuticas de los mismos.

Info

Publication number
ES2155948T3
ES2155948T3 ES96943236T ES96943236T ES2155948T3 ES 2155948 T3 ES2155948 T3 ES 2155948T3 ES 96943236 T ES96943236 T ES 96943236T ES 96943236 T ES96943236 T ES 96943236T ES 2155948 T3 ES2155948 T3 ES 2155948T3
Authority
ES
Spain
Prior art keywords
alquinilica
oxopregna
derivados
vitamin
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96943236T
Other languages
English (en)
Inventor
Robert Henry Hesse
Maurice Murdoch Pechet
Sundara Katugam Srinivas Setty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Medicine and Chemistry Inc
Original Assignee
Research Institute for Medicine and Chemistry Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Institute for Medicine and Chemistry Inc filed Critical Research Institute for Medicine and Chemistry Inc
Application granted granted Critical
Publication of ES2155948T3 publication Critical patent/ES2155948T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

DERIVADOS 1 - HIDROXI - PREGNACALCIFEROL DE FORMULA (I), Y SUS CORRESPONDIENTES ISOMEROS 5,6 TRANS, EN DONDE R 1 ES HIDROXILO O ALCOXI INFERIOR Y R 2 ES ALQUINILO INFERIOR OPCIONALMENTE HIDROXILADO O ALCOXILADO (CON ALCOXI INFERIOR), O R 1 ES C(R A )(R B )CH 3 , EN DONDE R A ES ALQUINILO INFERIOR OPCIONALMENTE HIDROXILADO O ALCOXILADO (CON ALCOXI INFERIOR), Y R B ES HIDROXILO O ALCOXI INFERIOR, O R A Y R B JUNTOS REPRESENTAN UN GRUPO OXO, Y R 2 ES HIDROGENO, HIDROXILO O ALCOXI INFERIOR, Y R 3 Y R 4 REPRESENTAN ATOMOS DE HIDROGENO; TIENEN ACTIVIDAD ANTIPROGESTERONA Y PUEDEN SER UTILES COMO AGENTES ANTINEOPLASICOS, ANTIFERTILIDAD, ANTIPROLIFERATIVOS, INMUNOSUPRESORES Y/O ANTIINFLAMATORIOS.
ES96943236T 1995-12-21 1996-12-23 20-oxopregna-derivados 17-cadena lateral alquinilica de la vitamina d, metodos para su produccion y composiciones farmaceuticas de los mismos. Expired - Lifetime ES2155948T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9526208.5A GB9526208D0 (en) 1995-12-21 1995-12-21 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2155948T3 true ES2155948T3 (es) 2001-06-01

Family

ID=10785847

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96943236T Expired - Lifetime ES2155948T3 (es) 1995-12-21 1996-12-23 20-oxopregna-derivados 17-cadena lateral alquinilica de la vitamina d, metodos para su produccion y composiciones farmaceuticas de los mismos.

Country Status (21)

Country Link
US (2) US6372926B2 (es)
EP (1) EP0874815B1 (es)
JP (1) JP2000503636A (es)
KR (1) KR19990076664A (es)
CN (1) CN1086694C (es)
AT (1) ATE200663T1 (es)
AU (1) AU710680B2 (es)
CA (1) CA2241011A1 (es)
CZ (1) CZ290930B6 (es)
DE (1) DE69612568T2 (es)
DK (1) DK0874815T3 (es)
ES (1) ES2155948T3 (es)
GB (1) GB9526208D0 (es)
GR (1) GR3036132T3 (es)
HU (1) HUP9903786A3 (es)
IL (1) IL125027A0 (es)
NO (1) NO982816L (es)
NZ (1) NZ324775A (es)
PT (1) PT874815E (es)
WO (1) WO1997023453A1 (es)
ZA (1) ZA9610874B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003087048A2 (en) * 2002-04-11 2003-10-23 Instytut Farmaceutyczny Preparation of 24 alkyl analogs of cholecalciferol and non-racemic compounds
US7253293B2 (en) * 2004-01-06 2007-08-07 Andrzej Slominski Enzymatic method to produce 7-dehydropregnenolone, vitamin D3-like compounds and derivatives thereof
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
AU2006226297A1 (en) * 2005-03-23 2006-09-28 Bioxell Spa Use of vitamin D compounds to treat endometriosis
TW200714580A (en) * 2005-10-14 2007-04-16 Formosa Lab Inc Process for preparing vitamin D analogs
SG173119A1 (en) * 2009-01-27 2011-08-29 Berg Biosystems Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
MX366076B (es) 2009-08-14 2019-06-27 Berg Llc Vitamina d3 y analogos de la misma para tratar alopecia.
JP5563324B2 (ja) * 2010-02-03 2014-07-30 フォーモサ・ラボラトリーズ・インコーポレーテッド マキサカルシトール中間体およびその製造方法
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6034543B2 (ja) * 1977-07-01 1985-08-09 中外製薬株式会社 ビタミンｄ誘導体
GB9214202D0 (en) 1992-07-03 1992-08-12 Leo Pharm Prod Ltd Chemical compounds
GB9220439D0 (en) * 1992-09-28 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
US5397776A (en) * 1993-08-20 1995-03-14 Wisconsin Alumni Research Foundation Vitamin D compounds with anti-progesterone activity

Also Published As

Publication number Publication date
EP0874815B1 (en) 2001-04-18
ZA9610874B (en) 1997-06-18
US20020188142A1 (en) 2002-12-12
NO982816D0 (no) 1998-06-18
AU1202597A (en) 1997-07-17
IL125027A0 (en) 1999-01-26
EP0874815A1 (en) 1998-11-04
CN1209120A (zh) 1999-02-24
CZ290930B6 (cs) 2002-11-13
ATE200663T1 (de) 2001-05-15
CZ194798A3 (cs) 1998-11-11
KR19990076664A (ko) 1999-10-15
GB9526208D0 (en) 1996-02-21
HUP9903786A3 (en) 2000-09-28
US20020010163A1 (en) 2002-01-24
DK0874815T3 (da) 2002-03-04
NZ324775A (en) 1999-02-25
AU710680B2 (en) 1999-09-30
DE69612568T2 (de) 2001-09-06
CA2241011A1 (en) 1997-07-03
CN1086694C (zh) 2002-06-26
PT874815E (pt) 2001-07-31
GR3036132T3 (en) 2001-09-28
US6372926B2 (en) 2002-04-16
WO1997023453A1 (en) 1997-07-03
HUP9903786A2 (hu) 2000-03-28
NO982816L (no) 1998-08-21
DE69612568D1 (de) 2001-05-23
JP2000503636A (ja) 2000-03-28

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