GR3036445T3 - Novel 4-(3-benzofuranyl)piperidinyl and 4-(3-benzothienyl)piperidinyl derivatives and pharmaceutical compositions containing them. - Google Patents

Novel 4-(3-benzofuranyl)piperidinyl and 4-(3-benzothienyl)piperidinyl derivatives and pharmaceutical compositions containing them.

Info

Publication number: GR3036445T3
Authority: GR; Greece
Prior art keywords: piperidinyl; hydrogen; pharmaceutical compositions; chr4; novel
Prior art date: 1992-07-13

Application number

GR20010401295T

Other languages

English (en)

Inventor

Jan Vandenberk

Ludo Edmond Josephine Kennis

Heertum Albertus Henricus Van

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-13

Filing date

2001-08-27

Publication date

2001-11-30

2001-08-27 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2001-11-30 Publication of GR3036445T3 publication Critical patent/GR3036445T3/el

Links

-1 4-(3-benzofuranyl)piperidinyl Chemical class 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000001257 hydrogen Substances 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
101100097467 Arabidopsis thaliana SYD gene Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
101100495925 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr3 gene Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000005059 halophenyl group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

GR20010401295T 1992-07-13 2001-08-27 Novel 4-(3-benzofuranyl)piperidinyl and 4-(3-benzothienyl)piperidinyl derivatives and pharmaceutical compositions containing them. GR3036445T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US91239692A	1992-07-13	1992-07-13
PCT/EP1993/001776 WO1994001437A1 (en)	1992-07-13	1993-07-06	Novel 4-(3-benzofuranyl)piperidinyl and 4-(3-benzothienyl)piperidinyl derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number	Publication Date
GR3036445T3 true GR3036445T3 (en)	2001-11-30

Family

ID=25431850

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR20010401295T GR3036445T3 (en)	1992-07-13	2001-08-27	Novel 4-(3-benzofuranyl)piperidinyl and 4-(3-benzothienyl)piperidinyl derivatives and pharmaceutical compositions containing them.

Country Status (18)

Country	Link
US (1)	US6348457B1 (el)
EP (1)	EP0672043B1 (el)
JP (1)	JPH07508741A (el)
KR (1)	KR100251892B1 (el)
AT (1)	ATE201684T1 (el)
AU (1)	AU669196B2 (el)
CA (1)	CA2137673C (el)
DE (1)	DE69330283T2 (el)
DK (1)	DK0672043T3 (el)
ES (1)	ES2159526T3 (el)
FI (1)	FI109536B (el)
GR (1)	GR3036445T3 (el)
IL (1)	IL106311A0 (el)
MX (1)	MX9304190A (el)
NZ (1)	NZ254113A (el)
PT (1)	PT672043E (el)
WO (1)	WO1994001437A1 (el)
ZA (1)	ZA935017B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996016968A1 (en) *	1994-11-25	1996-06-06	Meiji Seika Kabushiki Kaisha	Bicyclic thiazole compound
ES2097093B1 (es) *	1995-05-26	1998-01-16	Ferrer Int	Nuevos compuestos derivados de 5h-tiazolo (3,2-a) pirimidin-5-ona.
GB9513467D0 (en) *	1995-07-01	1995-09-06	Knoll Ag	Therapeutic agents
CN1166665C (zh) *	1998-03-19	2004-09-15	日本农药株式会社	芳基哌啶衍生物及其用途
US6258819B1 (en)	1999-08-05	2001-07-10	Syntex (U.S.A.) Llc	Substituted 2(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)-4(3H)-azaquinazolinones
US6806275B2 (en)	2000-09-13	2004-10-19	Nihon Nohyaku Co., Ltd.	Arylpiperidine derivatives and use thereof
US6924653B2 (en)	2002-08-26	2005-08-02	Micron Technology, Inc.	Selectively configurable microelectronic probes
US6939877B2 (en) *	2002-09-12	2005-09-06	Wyeth	Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
US6919334B2 (en)	2002-09-12	2005-07-19	Wyeth	Antidepressant azaheterocyclymethyl derivatives of 4,5-dihydroimidazo[1,4,5-de][1,4]benzoxazine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4342870A (en) *	1980-03-28	1982-08-03	Janssen Pharmaceutica N.V.	Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
US4443451A (en)	1981-07-15	1984-04-17	Janssen Pharmaceutica N.V.	Bicyclic pyrimidin-5-one derivatives
US4804663A (en) *	1985-03-27	1989-02-14	Janssen Pharmaceutica N.V.	3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
DE3900541A1 (de) *	1989-01-06	1990-07-19	Schering Ag	Substituierte alkene, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
US5140029A (en)	1989-01-09	1992-08-18	Janssen Pharmaceutica N.V.	2-aminopyrimidinone derivatives
GB8900382D0 (en) *	1989-01-09	1989-03-08	Janssen Pharmaceutica Nv	2-aminopyrimidinone derivatives
GB9008850D0 (en) *	1990-04-19	1990-06-13	Janssen Pharmaceutica Nv	Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones

1993
- 1993-07-06 DE DE69330283T patent/DE69330283T2/de not_active Expired - Fee Related
- 1993-07-06 DK DK93915840T patent/DK0672043T3/da active
- 1993-07-06 WO PCT/EP1993/001776 patent/WO1994001437A1/en not_active Ceased
- 1993-07-06 ES ES93915840T patent/ES2159526T3/es not_active Expired - Lifetime
- 1993-07-06 AU AU45659/93A patent/AU669196B2/en not_active Ceased
- 1993-07-06 EP EP93915840A patent/EP0672043B1/en not_active Expired - Lifetime
- 1993-07-06 KR KR1019950700087A patent/KR100251892B1/ko not_active Expired - Fee Related
- 1993-07-06 PT PT93915840T patent/PT672043E/pt unknown
- 1993-07-06 JP JP6502963A patent/JPH07508741A/ja active Pending
- 1993-07-06 AT AT93915840T patent/ATE201684T1/de not_active IP Right Cessation
- 1993-07-06 CA CA002137673A patent/CA2137673C/en not_active Expired - Fee Related
- 1993-07-06 NZ NZ254113A patent/NZ254113A/en not_active IP Right Cessation
- 1993-07-12 MX MX9304190A patent/MX9304190A/es not_active IP Right Cessation
- 1993-07-12 IL IL106311A patent/IL106311A0/xx not_active IP Right Cessation
- 1993-07-12 ZA ZA935017A patent/ZA935017B/xx unknown
1995
- 1995-01-05 US US08/362,529 patent/US6348457B1/en not_active Expired - Fee Related
- 1995-01-12 FI FI950138A patent/FI109536B/fi active
2001
- 2001-08-27 GR GR20010401295T patent/GR3036445T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2137673A1 (en)	1994-01-20
ZA935017B (en)	1995-01-12
EP0672043A1 (en)	1995-09-20
AU669196B2 (en)	1996-05-30
FI109536B (fi)	2002-08-30
PT672043E (pt)	2001-11-30
ES2159526T3 (es)	2001-10-16
JPH07508741A (ja)	1995-09-28
US6348457B1 (en)	2002-02-19
NZ254113A (en)	1995-08-28
KR100251892B1 (ko)	2000-09-01
ATE201684T1 (de)	2001-06-15
EP0672043B1 (en)	2001-05-30
DK0672043T3 (da)	2001-08-27
DE69330283D1 (de)	2001-07-05
IL106311A0 (en)	1993-11-15
AU4565993A (en)	1994-01-31
CA2137673C (en)	2005-09-06
FI950138L (fi)	1995-01-12
WO1994001437A1 (en)	1994-01-20
DE69330283T2 (de)	2002-01-10
MX9304190A (es)	1994-02-28
FI950138A0 (fi)	1995-01-12

Legal Events

Date	Code	Title	Description
2009-02-04	ML	Lapse due to non-payment of fees

Publication	Publication Date	Title
NO944911L (no)	1995-06-22	Ikke-peptid-takykininreseptorantagonister
BG104372A (en)	2000-12-29	(benzodioxan, benzofuran or benzopyran) derivatives possessing fundus relaxing properties
NL300298I2 (nl)	2008-03-03	Nieuwe 3-piperidinyl-1,2-benzisoxazolen
DE60305514D1 (de)	2006-06-29	Neue verwendung von benzothiazolderivaten
ATE59644T1 (de)	1991-01-15	5,6-dihydro-2-(substituiertes phenyl)-1,2,4triazin-3,5(2h,4h)-dione.
NO944930L (no)	1995-06-22	Hemming av dysfunksjonell uterin blödning
GR3036445T3 (en)	2001-11-30	Novel 4-(3-benzofuranyl)piperidinyl and 4-(3-benzothienyl)piperidinyl derivatives and pharmaceutical compositions containing them.
DK0866791T3 (da)	2002-04-22	Diaminopyrimidiner, farmaceutiske præparater indeholdende disse og deres anvendelse som antibakterielle midler
NO882641D0 (no)	1988-06-15	Nye n-(4-piperidinyl)bisyklisk kondensert 2-imidazilaminderivater.
NO972887L (no)	1997-08-20	Piperidineddiksyrederivater anvendelige som fibrinogen-antagonistmiddel
IL117980A0 (en)	1996-08-04	Triazolone derivatives their preparation and pharmaceutical compositions containing them
EP1142883A4 (en)	2002-08-21	HETEROCYCLIC COMPOUNDS AND MEDICINAL COMPOSITIONS THAT CONTAIN THEM
BG106156A (en)	2002-05-31	Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
SE8603589D0 (sv)	1986-08-26	Metylendioxifenantren- och stilbenderivat
NO992316L (no)	1999-07-12	Benzensulfonamidderivater og legemidler inneholdende disse
AU583429B2 (en)	1989-04-27	Novel ``, ``-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, N-oxides
NO973470L (no)	1997-07-28	Fremgangsmåte for minsking av serumkalsiumnivåer