GR861625B - Optically active pyridobenzoxazines derivatives and intermediate compounds thereof - Google Patents

Optically active pyridobenzoxazines derivatives and intermediate compounds thereof

Info

Publication number: GR861625B
Authority: GR; Greece
Prior art keywords: optically active; derivatives; pyridobenzoxazines; intermediate compounds; preparing
Prior art date: 1985-06-20

Application number

GR861625A

Other languages

English (en)

Inventor

Hayakawa Isao

Atarashi Shohgo

Yuokohama Shuichi

Imamura Masazumi

Sakano Kartsuichi

Higashihashi Nobuyuki

Ohshima Masayuki

Original Assignee

Daiichi Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-20

Filing date

1986-06-20

Publication date

1986-10-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27281433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR861625(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-10-11 Priority claimed from JP60226499A external-priority patent/JPH0720946B2/ja

1986-06-20 Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co

1986-10-21 Publication of GR861625B publication Critical patent/GR861625B/el

Links

QDEJGQKJMKXYLM-UHFFFAOYSA-N 2h-pyrido[2,3-h][1,2]benzoxazine Chemical class C1=CC2=NC=CC=C2C2=C1C=CNO2 QDEJGQKJMKXYLM-UHFFFAOYSA-N 0.000 title abstract 5
150000001875 compounds Chemical class 0.000 title abstract 2
GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 abstract 1
230000000845 anti-microbial effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229960001699 ofloxacin Drugs 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

GR861625A 1985-06-20 1986-06-20 Optically active pyridobenzoxazines derivatives and intermediate compounds thereof GR861625B (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP13471285		1985-06-20
JP60226499A JPH0720946B2 (ja)	1985-10-11	1985-10-11	光学活性３−メチルベンゾオキサジン誘導体およびその製法
JP1649686		1986-01-28

Publications (1)

Publication Number	Publication Date
GR861625B true GR861625B (en)	1986-10-21

Family

ID=27281433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR861625A GR861625B (en)	1985-06-20	1986-06-20	Optically active pyridobenzoxazines derivatives and intermediate compounds thereof

Country Status (16)

Country	Link
US (3)	US5053407A (el)
EP (1)	EP0206283B1 (el)
KR (2)	KR920010048B1 (el)
AT (1)	ATE85057T1 (el)
BG (1)	BG60527B2 (el)
CA (1)	CA1304080C (el)
DE (2)	DE19875012I2 (el)
DK (1)	DK170473B1 (el)
ES (1)	ES8801251A1 (el)
FI (1)	FI90241C (el)
GR (1)	GR861625B (el)
HK (1)	HK91793A (el)
IE (1)	IE59463B1 (el)
NL (1)	NL980016I2 (el)
NO (1)	NO166131C (el)
YU (3)	YU44918B (el)

Families Citing this family (58)

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FI94339C (fi)	1989-07-21	1995-08-25	Warner Lambert Co	Menetelmä farmaseuttisesti käyttökelpoisen /R-(R,R)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
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TW208013B (el) *	1990-03-01	1993-06-21	Daiichi Co Ltd
FI96313C (fi) *	1990-11-28	1996-06-10	Daiichi Seiyaku Co	Menetelmä terapeuttisesti käyttökelpoisten ja optisesti aktiivisten 10-(3-amino-4,4-dialkyyli-1-pyrrolidinyyli)-9-fluori-2,3-dihydro-3(S)-metyyli-7-okso-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihappojen valmistamiseksi
AU674542B2 (en) *	1992-10-07	1997-01-02	Derivados Del Etilo, S.A.	Process for obtaining benzoxazines useful for the synthesis of ofloxacin, levofloxacin and derivatives thereof
ES2055656B1 (es) *	1992-10-07	1995-11-16	Etilo Derivados	Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.
US5532239A (en) *	1993-08-02	1996-07-02	Assistance Publique - Hopitaux De Paris	Therapeutic application of fluoroquinolone derivatives
ZA946853B (en) *	1993-09-10	1995-04-24	Daiichi Seiyaku Co	Crystals of antimicrobial compound.
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US5997893A (en) *	1998-01-20	1999-12-07	Ethicon, Inc.	Alcohol based anti-microbial compositions with cosmetic appearance
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KR100309871B1 (ko)	1999-02-24	2001-10-29	윤종용	(-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
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KR100617952B1 (ko) *	1999-03-04	2006-08-30	보령제약 주식회사	광학활성 피리도 벤즈옥사진 유도체의 제조방법
CA2380359C (en) *	1999-09-08	2011-11-29	Daiichi Pharmaceutical Co., Ltd.	Process for producing benzoxazine derivative and production intermediate thereof
KR20010103346A (ko) *	2000-05-09	2001-11-23	이후근	패각 입자와 접착제 그리고 물감을 혼합하여 그림 밑칠용재료를 제조하는 방법
ES2256331T3 (es)	2000-12-21	2006-07-16	PHARMACIA & UPJOHN COMPANY LLC	Derivados de quinolina antimicrobianos y uso de los mismos para tratar infecciones bacterianas.
US7217560B2 (en)	2001-03-07	2007-05-15	Daiichi Pharmaceutical Co., Ltd.	Process for preparation of optically active propoxyaniline derivatives
JP4031992B2 (ja)	2001-04-27	2008-01-09	リサーチインスティチュートオブインダストリアルサイエンスアンドテクノロジー	優れた熱間加工性を持つ高マンガン二相ステンレス鋼及びその製造方法
US7425628B2 (en) *	2001-10-03	2008-09-16	Teva Pharmaceutical Industries Ltd.	Methods for the purification of levofloxacin
WO2003028664A2 (en)	2001-10-03	2003-04-10	Teva Pharmaceutical Industries Ltd.	Preparation of levofloxacin and forms thereof
KR100440192B1 (ko) *	2001-11-22	2004-07-12	이수화학 주식회사	광학 활성 퀴놀론카르복실산 유도체의 제조방법
AU2002365416A1 (en) *	2001-11-29	2003-06-10	Teva Pharmaceutical Industries Ltd.	Methods for the purification of levofloxacin
US20040052843A1 (en) *	2001-12-24	2004-03-18	Lerner E. Itzhak	Controlled release dosage forms
CA2470495A1 (en) *	2001-12-24	2003-07-17	Teva Pharmaceutical Industries Ltd.	Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
EP2316468A1 (en)	2002-02-22	2011-05-04	Shire LLC	Delivery system and methods for protecting and administering dextroamphetamine
AU2003262704A1 (en) *	2002-08-14	2004-08-30	Teva Pharmaceutical Industries Ltd.	Synthesis of gatifloxacin
US20040152701A1 (en) *	2002-12-02	2004-08-05	Dr. Reddy's Laboratories Limited	Novel anhydrous crystalline form of Levofloxacin and process for preparation there of
FR2859471B1 (fr)	2003-09-09	2006-02-03	Solvay	Procede pour la fabrication d'un compose enantiopur
KR20080004460A (ko)	2005-02-07	2008-01-09	미츠비시 웰파마 가부시키가이샤	광학 활성인 테트라히드로나프탈렌 유도체
US7838532B2 (en) *	2005-05-18	2010-11-23	Mpex Pharmaceuticals, Inc.	Aerosolized fluoroquinolones and uses thereof
US8546423B2 (en)	2005-05-18	2013-10-01	Mpex Pharmaceuticals, Inc.	Aerosolized fluoroquinolones and uses thereof
CA2642754A1 (en) *	2006-02-13	2007-08-23	Trustees Of Boston University	Compositions and methods for antibiotic potentiation and drug discovery
US7973022B2 (en)	2006-02-17	2011-07-05	Idexx Laboratories, Inc.	Fluoroquinolone carboxylic acid salt compositions
US20070197548A1 (en)	2006-02-17	2007-08-23	Murthy Yerramilli V S	Fluoroquinolone compositions
US20100234348A1 (en) *	2006-08-04	2010-09-16	Trustees Of Boston University	Compositions and methods for potentiating antibiotic activity
EP1939206A1 (en) *	2006-12-22	2008-07-02	Farmaprojects, S.A.	Process for the preparation of an antibacterial quinolone compound
WO2008077643A1 (en) *	2006-12-22	2008-07-03	Farmaprojects, S.A.	Process for the preparation of an antibacterial quinolone compound
US7964723B2 (en)	2008-08-02	2011-06-21	Apeloa-Kangyu	And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
EP2346509B1 (en)	2008-10-07	2020-05-13	Horizon Orphan LLC	Inhalation of levofloxacin for reducing lung inflammation
JP2012505223A (ja)	2008-10-07	2012-03-01	エムペックス・ファーマシューティカルズ・インコーポレーテッド	薬物動態の改善のためのエアゾールフルオロキノロン配合物
EA201101564A1 (ru)	2009-05-15	2012-07-30	Редкс Фарма Лимитед	Редокс производные лекарственных средств
RU2563809C2 (ru)	2009-09-04	2015-09-20	Мпекс Фармасьютикалс, Инк.	Применение левофлоксацина в форме аэрозоля для лечения муковисцидоза
CN101659669B (zh) *	2009-09-04	2011-07-20	诚达药业股份有限公司	左旋氧氟沙星的制备方法
CN102775424A (zh) *	2012-07-09	2012-11-14	浙江司太立制药股份有限公司	一种左氧氟沙星杂质的制备方法
CA2904387C (en)	2013-03-15	2021-12-07	Melinta Therapeutics, Inc.	Methods of treating infections in overweight and obese patients using antibiotics
HRP20241165T1 (hr) *	2014-05-09	2024-11-22	Tecnimede Sociedade Tecnico-Medicinal S.A.	Mandelatne soli enantiomera pirlindola za upotrebu u medicini
CN105037388A (zh) *	2015-08-28	2015-11-11	安徽环球药业股份有限公司	一种安妥沙星的制备方法
CN105367585B (zh) *	2015-12-02	2017-11-17	山东齐都药业有限公司	左氧氟沙星杂质的制备方法
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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5746986A (en) *	1980-09-02	1982-03-17	Dai Ichi Seiyaku Co Ltd	Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS5852290A (ja) *	1981-09-21	1983-03-28	Dai Ichi Seiyaku Co Ltd	ピリドベンゾオキサジンカルボン酸誘導体
DE3543513A1 (de) *	1985-12-10	1987-06-11	Bayer Ag	Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln

1986
- 1986-06-18 NO NO862426A patent/NO166131C/no not_active IP Right Cessation
- 1986-06-18 DK DK285086A patent/DK170473B1/da active Protection Beyond IP Right Term
- 1986-06-19 ES ES556292A patent/ES8801251A1/es not_active Expired
- 1986-06-19 YU YU1073/86A patent/YU44918B/xx unknown
- 1986-06-19 FI FI862643A patent/FI90241C/fi not_active IP Right Cessation
- 1986-06-19 IE IE163186A patent/IE59463B1/en not_active IP Right Cessation
- 1986-06-19 CA CA000512000A patent/CA1304080C/en not_active Expired - Lifetime
- 1986-06-20 DE DE19863687599 patent/DE19875012I2/de active Active
- 1986-06-20 AT AT86108442T patent/ATE85057T1/de active
- 1986-06-20 DE DE8686108442T patent/DE3687599T2/de not_active Expired - Lifetime
- 1986-06-20 US US06/876,623 patent/US5053407A/en not_active Expired - Lifetime
- 1986-06-20 KR KR1019860004934A patent/KR920010048B1/ko not_active Expired
- 1986-06-20 EP EP86108442A patent/EP0206283B1/en not_active Expired - Lifetime
- 1986-06-20 GR GR861625A patent/GR861625B/el unknown
1988
- 1988-10-05 YU YU1867/88A patent/YU45512B/xx unknown
1989
- 1989-03-23 US US07/327,653 patent/US4985557A/en not_active Expired - Lifetime
- 1989-10-30 YU YU2098/89A patent/YU45524B/xx unknown
1990
- 1990-10-31 KR KR1019900017517A patent/KR940003757B1/ko not_active Expired - Lifetime
1991
- 1991-08-28 US US07/754,198 patent/US5142046A/en not_active Expired - Lifetime
1993
- 1993-09-02 HK HK917/93A patent/HK91793A/en not_active IP Right Cessation
1994
- 1994-02-22 BG BG098511A patent/BG60527B2/bg unknown
1998
- 1998-04-22 NL NL980016C patent/NL980016I2/nl unknown

Also Published As

Publication number	Publication date
ES8801251A1 (es)	1988-01-01
NL980016I1 (nl)	1998-07-01
YU45512B (en)	1992-05-28
FI862643A7 (fi)	1986-12-21
US4985557A (en)	1991-01-15
US5142046A (en)	1992-08-25
FI90241C (fi)	1994-01-10
KR920010048B1 (ko)	1992-11-13
NO166131B (no)	1991-02-25
ES556292A0 (es)	1988-01-01
KR940003757B1 (ko)	1994-04-30
FI90241B (fi)	1993-09-30
IE861631L (en)	1986-12-20
NO862426D0 (no)	1986-06-18
NO862426L (no)	1986-12-22
EP0206283A3 (en)	1988-08-10
BG60527B2 (bg)	1995-07-28
DE3687599T2 (de)	1993-05-19
HK91793A (en)	1993-09-10
DK285086D0 (da)	1986-06-18
EP0206283B1 (en)	1993-01-27
KR870000340A (ko)	1987-02-17
KR920009279A (ko)	1992-05-28
YU45524B (en)	1992-05-28
DE19875012I2 (de)	2006-06-29
YU209889A (en)	1990-04-30
NL980016I2 (nl)	1998-08-03
CA1304080C (en)	1992-06-23
DE3687599D1 (de)	1993-03-11
EP0206283A2 (en)	1986-12-30
YU44918B (en)	1991-04-30
ATE85057T1 (de)	1993-02-15
YU186788A (en)	1989-04-30
IE59463B1 (en)	1994-02-23
DK285086A (da)	1986-12-21
FI862643A0 (fi)	1986-06-19
DK170473B1 (da)	1995-09-11
US5053407A (en)	1991-10-01
NO166131C (no)	1991-06-05
YU107386A (en)	1988-02-29

Publication	Publication Date	Title
GR861625B (en)	1986-10-21	Optically active pyridobenzoxazines derivatives and intermediate compounds thereof
HUT64310A (en)	1993-12-28	Compositions containing substituted aryl-halogenalkyl-pyrazol derivatives having herbicidal activity and process for producing said compounds
YU175791A (sh)	1994-01-20	Heterociklični derivati monocikličnih beta laktam antibiotika
YU54189A (en)	1990-12-31	Process for obtaining cephem derivatives and midproducts for the same
IE780922L (en)	1978-11-11	1,3,5-s-HEXAHYDROSUBSTITUTED TRIAZINES
AU575342B2 (en)	1988-07-28	Gamma - butyrolactone derivatives
AU571206B2 (en)	1988-04-14	6-hydroxyalkyl-penem derivatives
AU578489B2 (en)	1988-10-27	Proline derivatives
MY106512A (en)	1995-06-30	Process for the preparation of 6-(substitutedaminopro- pionyl)-derivatives of fokskolin.
PT85645A (en)	1987-10-01	2-(1-oxo-1-imino-1-thiacylcloalkyl)-thiopenem derivatives
DE3461806D1 (en)	1987-02-05	2-desoxyoxanosine, a process for the preparation thereof and its use as a medicament
ES2052812T3 (es)	1994-07-16	Un procedimiento para la preparacion de derivados de pirrolizina.
ES8304989A1 (es)	1983-03-16	Mejoras introducidas en un procedimiento para la preparacion hidroximidatos y tiolhidroximidatos heterobiciclicos y de- rivados ester carbomatos de los mismos.
DE3560948D1 (en)	1987-12-17	A n-(6-substituted pyridine-2-carbonyl)-3-substituted histidine derivative, a method of preparing the same and its use as an anti-tumor agent
SU1455633A1 (ru)	1999-05-27	О,о-диизопропил-о-[1, 1-диметил-2-пропилтио-2-(о-о-диизопропилфосфорил)- имино]-этилфосфат, обладающий бактерицидной активностью
SU1573830A1 (ru)	1999-08-10	Фосфорилированные оксиэтиловые эфиры 2,4-дихлорфеноксиуксусной кислоты, обладающие гербицидной активностью
UA11675A1 (uk)	1996-12-25	1-БЕtА-ОКСИЕТИЛАМІHО-3-КЕТО-5,5-ДИМЕТИЛЦИКЛОГЕКСЕH -1, ЯКИЙ МАЄ АHАЛЬГЕТИЧHУ АКТИВHІСТЬ