ATE85057T1 - Optisch aktive pyridobenzoxazinderivate. - Google Patents

Optisch aktive pyridobenzoxazinderivate.

Info

Publication number: ATE85057T1
Authority: AT; Austria
Prior art keywords: optically active; preparing; active pyridobenzoxazine; derivatives; pyridobenzoxazine
Prior art date: 1985-06-20

Application number

AT86108442T

Other languages

English (en)

Inventor

Isao Hayakawa

Shohgo Atarashi

Shuichi Yokohama

Masazumi Imamura

Katsuichi Sakano

Nobuyuki Higashihashi

Masayuki Ohshima

Original Assignee

Daiichi Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-20

Filing date

1986-06-20

Publication date

1993-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27281433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE85057(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-10-11 Priority claimed from JP60226499A external-priority patent/JPH0720946B2/ja

1986-06-20 Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co

1993-02-15 Application granted granted Critical

1993-02-15 Publication of ATE85057T1 publication Critical patent/ATE85057T1/de

Links

QDEJGQKJMKXYLM-UHFFFAOYSA-N 2h-pyrido[2,3-h][1,2]benzoxazine Chemical class C1=CC2=NC=CC=C2C2=C1C=CNO2 QDEJGQKJMKXYLM-UHFFFAOYSA-N 0.000 title abstract 5
GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 abstract 1
230000000845 anti-microbial effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229960001699 ofloxacin Drugs 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT86108442T 1985-06-20 1986-06-20 Optisch aktive pyridobenzoxazinderivate. ATE85057T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP13471285		1985-06-20
JP60226499A JPH0720946B2 (ja)	1985-10-11	1985-10-11	光学活性３−メチルベンゾオキサジン誘導体およびその製法
JP1649686		1986-01-28
EP86108442A EP0206283B1 (de)	1985-06-20	1986-06-20	Optisch aktive Pyridobenzoxazinderivate

Publications (1)

Publication Number	Publication Date
ATE85057T1 true ATE85057T1 (de)	1993-02-15

Family

ID=27281433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86108442T ATE85057T1 (de)	1985-06-20	1986-06-20	Optisch aktive pyridobenzoxazinderivate.

Country Status (16)

Country	Link
US (3)	US5053407A (de)
EP (1)	EP0206283B1 (de)
KR (2)	KR920010048B1 (de)
AT (1)	ATE85057T1 (de)
BG (1)	BG60527B2 (de)
CA (1)	CA1304080C (de)
DE (2)	DE3687599T2 (de)
DK (1)	DK170473B1 (de)
ES (1)	ES8801251A1 (de)
FI (1)	FI90241C (de)
GR (1)	GR861625B (de)
HK (1)	HK91793A (de)
IE (1)	IE59463B1 (de)
NL (1)	NL980016I2 (de)
NO (1)	NO166131C (de)
YU (3)	YU44918B (de)

Families Citing this family (58)

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FI94339C (fi)	1989-07-21	1995-08-25	Warner Lambert Co	Menetelmä farmaseuttisesti käyttökelpoisen /R-(R,R)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
FR2655545B1 (fr) *	1989-12-11	1994-06-10	Rhone Poulenc Sante	Nouvelle application therapeutique des derives des fluoroquinolones.
TW208013B (de) *	1990-03-01	1993-06-21	Daiichi Co Ltd
NO179912C (no) *	1990-11-28	1997-01-08	Daiichi Seiyaku Co	Analogifremgangsmåte for fremstilling av et terapeutisk virksomt optisk aktivt pyridobenzoksazinderivat
ES2055656B1 (es) *	1992-10-07	1995-11-16	Etilo Derivados	Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.
JPH07501835A (ja) *	1992-10-07	1995-02-23	デリバドス・デル・エチロ・ソシエダッド・アノニマ	オフロキサジン，レボフロキサジン及び誘導体の合成に使用されるベンゾキサジンの製造法
US5532239A (en) *	1993-08-02	1996-07-02	Assistance Publique - Hopitaux De Paris	Therapeutic application of fluoroquinolone derivatives
ZA946853B (en) *	1993-09-10	1995-04-24	Daiichi Seiyaku Co	Crystals of antimicrobial compound.
US5686095A (en) *	1995-10-23	1997-11-11	Price, Jr.; Francis W.	Method of treating canker sores
PL189872B1 (pl)	1996-07-24	2005-10-31	Warner Lambert Co	Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu
US6022551A (en) *	1998-01-20	2000-02-08	Ethicon, Inc.	Antimicrobial composition
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US5972358A (en) *	1998-01-20	1999-10-26	Ethicon, Inc.	Low tack lotion, gels and creams
KR100309871B1 (ko)	1999-02-24	2001-10-29	윤종용	(-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
US6326391B1 (en)	1998-12-04	2001-12-04	Influx, Inc.	Inhibitors of multidrug transporters
KR100617952B1 (ko) *	1999-03-04	2006-08-30	보령제약 주식회사	광학활성 피리도 벤즈옥사진 유도체의 제조방법
AU6873700A (en) *	1999-09-08	2001-04-10	Daiichi Pharmaceutical Co., Ltd.	Process for the preparation of benzoxazine derivatives and intermediates therefor
KR20010103346A (ko) *	2000-05-09	2001-11-23	이후근	패각 입자와 접착제 그리고 물감을 혼합하여 그림 밑칠용재료를 제조하는 방법
US6689769B2 (en)	2000-12-21	2004-02-10	Pharmacia & Upjohn Company	Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
KR100868619B1 (ko)	2001-03-07	2008-11-13	다이이찌 세이야꾸 가부시기가이샤	광학활성인 프로폭시아닐린 유도체의 제조방법
CN1201028C (zh)	2001-04-27	2005-05-11	浦项产业科学研究院	具有优越热加工性能的高锰二联不锈钢及其制造方法
US7425628B2 (en) *	2001-10-03	2008-09-16	Teva Pharmaceutical Industries Ltd.	Methods for the purification of levofloxacin
US7629458B2 (en)	2001-10-03	2009-12-08	Teva Pharmaceutical Industries Ltd.	Preparation of levofloxacin and hemihydrate thereof
KR100440192B1 (ko) *	2001-11-22	2004-07-12	이수화학 주식회사	광학 활성 퀴놀론카르복실산 유도체의 제조방법
AU2002365416A1 (en) *	2001-11-29	2003-06-10	Teva Pharmaceutical Industries Ltd.	Methods for the purification of levofloxacin
US20040052843A1 (en) *	2001-12-24	2004-03-18	Lerner E. Itzhak	Controlled release dosage forms
KR100897837B1 (ko) *	2001-12-24	2009-05-15	테바 파마슈티컬 인더스트리즈 리미티드	분말 또는 과립 물질의 압착된 환상체 내에 싸인 활성성분의 코어 정제를 갖는 제형과, 이의 제조 방법 및 툴링
EP2316468A1 (de)	2002-02-22	2011-05-04	Shire LLC	Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
WO2004069825A1 (en) *	2002-08-14	2004-08-19	Teva Pharmaceutical Industries Ltd.	Synthesis of gatifloxacin
US20040152701A1 (en) *	2002-12-02	2004-08-05	Dr. Reddy's Laboratories Limited	Novel anhydrous crystalline form of Levofloxacin and process for preparation there of
FR2859471B1 (fr)	2003-09-09	2006-02-03	Solvay	Procede pour la fabrication d'un compose enantiopur
TW200643019A (en)	2005-02-07	2006-12-16	Mitsubishi Pharma Corp	Optically active tetrahydronaphthalene derivative
US8546423B2 (en)	2005-05-18	2013-10-01	Mpex Pharmaceuticals, Inc.	Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) *	2005-05-18	2010-11-23	Mpex Pharmaceuticals, Inc.	Aerosolized fluoroquinolones and uses thereof
US20090264342A1 (en) *	2006-02-13	2009-10-22	Trustees Of Boston University	Compositions and methods for antibiotic potentiation and drug discovery
US20070197548A1 (en)	2006-02-17	2007-08-23	Murthy Yerramilli V S	Fluoroquinolone compositions
US7973022B2 (en)	2006-02-17	2011-07-05	Idexx Laboratories, Inc.	Fluoroquinolone carboxylic acid salt compositions
US20100234348A1 (en) *	2006-08-04	2010-09-16	Trustees Of Boston University	Compositions and methods for potentiating antibiotic activity
US20100029938A1 (en) *	2006-12-22	2010-02-04	Farmaprojects, S. A.	Process for the preparation of an antibacterial quinolone compound
EP1939206A1 (de) *	2006-12-22	2008-07-02	Farmaprojects, S.A.	Herstellungsverfahren für eine antibakterielle Quinolonverbindung
US7964723B2 (en)	2008-08-02	2011-06-21	Apeloa-Kangyu	And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
KR101959873B1 (ko)	2008-10-07	2019-03-19	랩터 파마슈티컬스 인코포레이티드	약동학 개선을 위한 에어로졸 플루오로퀴놀론 제형
CA2739893C (en)	2008-10-07	2016-10-04	Mpex Pharmaceuticals, Inc.	Inhalation of levofloxacin for reducing lung inflammation
NZ610978A (en)	2009-05-15	2014-11-28	Redx Pharma Ltd	Redox drug derivatives
CN101659669B (zh) *	2009-09-04	2011-07-20	诚达药业股份有限公司	左旋氧氟沙星的制备方法
WO2011029059A1 (en)	2009-09-04	2011-03-10	Mpex Pharmaceuticals, Inc.	Use of aerosolized levofloxacin for treating cystic fibrosis
CN102775424A (zh) *	2012-07-09	2012-11-14	浙江司太立制药股份有限公司	一种左氧氟沙星杂质的制备方法
KR102237887B1 (ko)	2013-03-15	2021-04-07	멜린타 서브시디어리 코프.	항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법
SMT202400359T1 (it) *	2014-05-09	2024-11-15	Tecnimede Sociedade Tecnico Medicinal S	Sali mandelati degli enantiomeri del pirlindolo per l'uso in medicina
CN105037388A (zh) *	2015-08-28	2015-11-11	安徽环球药业股份有限公司	一种安妥沙星的制备方法
CN105367585B (zh) *	2015-12-02	2017-11-17	山东齐都药业有限公司	左氧氟沙星杂质的制备方法
US20230233572A1 (en)	2020-06-11	2023-07-27	Sentiss Pharma Private Limited	Ophthalmic compositions comprising a combination of fluoroquinolone antibacterial agent and an anti-inflammatory agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5746986A (en) *	1980-09-02	1982-03-17	Dai Ichi Seiyaku Co Ltd	Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS5852290A (ja) *	1981-09-21	1983-03-28	Dai Ichi Seiyaku Co Ltd	ピリドベンゾオキサジンカルボン酸誘導体
DE3543513A1 (de) *	1985-12-10	1987-06-11	Bayer Ag	Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln

1986
- 1986-06-18 DK DK285086A patent/DK170473B1/da active Protection Beyond IP Right Term
- 1986-06-18 NO NO862426A patent/NO166131C/no not_active IP Right Cessation
- 1986-06-19 CA CA000512000A patent/CA1304080C/en not_active Expired - Lifetime
- 1986-06-19 ES ES556292A patent/ES8801251A1/es not_active Expired
- 1986-06-19 YU YU1073/86A patent/YU44918B/xx unknown
- 1986-06-19 FI FI862643A patent/FI90241C/fi not_active IP Right Cessation
- 1986-06-19 IE IE163186A patent/IE59463B1/en not_active IP Right Cessation
- 1986-06-20 KR KR1019860004934A patent/KR920010048B1/ko not_active Expired
- 1986-06-20 AT AT86108442T patent/ATE85057T1/de active
- 1986-06-20 EP EP86108442A patent/EP0206283B1/de not_active Expired - Lifetime
- 1986-06-20 DE DE8686108442T patent/DE3687599T2/de not_active Expired - Lifetime
- 1986-06-20 GR GR861625A patent/GR861625B/el unknown
- 1986-06-20 DE DE19863687599 patent/DE19875012I2/de active Active
- 1986-06-20 US US06/876,623 patent/US5053407A/en not_active Expired - Lifetime
1988
- 1988-10-05 YU YU1867/88A patent/YU45512B/xx unknown
1989
- 1989-03-23 US US07/327,653 patent/US4985557A/en not_active Expired - Lifetime
- 1989-10-30 YU YU2098/89A patent/YU45524B/xx unknown
1990
- 1990-10-31 KR KR1019900017517A patent/KR940003757B1/ko not_active Expired - Lifetime
1991
- 1991-08-28 US US07/754,198 patent/US5142046A/en not_active Expired - Lifetime
1993
- 1993-09-02 HK HK917/93A patent/HK91793A/en not_active IP Right Cessation
1994
- 1994-02-22 BG BG098511A patent/BG60527B2/bg unknown
1998
- 1998-04-22 NL NL980016C patent/NL980016I2/nl unknown

Also Published As

Publication number	Publication date
EP0206283A2 (de)	1986-12-30
YU45512B (en)	1992-05-28
HK91793A (en)	1993-09-10
YU186788A (en)	1989-04-30
US5053407A (en)	1991-10-01
NL980016I2 (nl)	1998-08-03
FI862643A0 (fi)	1986-06-19
CA1304080C (en)	1992-06-23
KR940003757B1 (ko)	1994-04-30
DE19875012I2 (de)	2006-06-29
NO166131C (no)	1991-06-05
DE3687599T2 (de)	1993-05-19
IE861631L (en)	1986-12-20
DK170473B1 (da)	1995-09-11
FI90241B (fi)	1993-09-30
FI90241C (fi)	1994-01-10
YU45524B (en)	1992-05-28
KR920009279A (ko)	1992-05-28
DE3687599D1 (de)	1993-03-11
BG60527B2 (bg)	1995-07-28
DK285086A (da)	1986-12-21
EP0206283B1 (de)	1993-01-27
ES556292A0 (es)	1988-01-01
GR861625B (en)	1986-10-21
NL980016I1 (nl)	1998-07-01
US5142046A (en)	1992-08-25
FI862643A7 (fi)	1986-12-21
EP0206283A3 (en)	1988-08-10
NO862426D0 (no)	1986-06-18
NO862426L (no)	1986-12-22
KR920010048B1 (ko)	1992-11-13
NO166131B (no)	1991-02-25
YU44918B (en)	1991-04-30
YU107386A (en)	1988-02-29
ES8801251A1 (es)	1988-01-01
KR870000340A (ko)	1987-02-17
IE59463B1 (en)	1994-02-23
YU209889A (en)	1990-04-30
DK285086D0 (da)	1986-06-18
US4985557A (en)	1991-01-15

Publication	Publication Date	Title
ATE85057T1 (de)	1993-02-15	Optisch aktive pyridobenzoxazinderivate.
DE3585980D1 (de)	1992-06-11	Hydrazinderivate und ihre verwendung.
YU175791A (sh)	1994-01-20	Heterociklični derivati monocikličnih beta laktam antibiotika
AU6307586A (en)	1987-03-26	Quinoline derivatives
AU578489B2 (en)	1988-10-27	Proline derivatives
MX9204642A (es)	1993-12-01	1,4-dihidropiridinas con actividad paf-antagonista
ATE70841T1 (de)	1992-01-15	2-(1-oxo-1-imino-1-thiacycloalkyl)-thiopenemderivate.
ES2052812T3 (es)	1994-07-16	Un procedimiento para la preparacion de derivados de pirrolizina.
SU731725A1 (ru)	2006-12-27	Производные дифенилилхинолина, обладающие противомикробной активностью
SU1610823A1 (ru)	2000-05-10	S-трет-бутилтиуронийбромид, обладающий антиишемической активностью
SU1455633A1 (ru)	1999-05-27	О,о-диизопропил-о-[1, 1-диметил-2-пропилтио-2-(о-о-диизопропилфосфорил)- имино]-этилфосфат, обладающий бактерицидной активностью
SU1351063A1 (ru)	2006-12-20	Производные 2-тиазолзамещенного 5-нитрофурана, проявляющие антистафилококковую активность
SU1455632A1 (ru)	1999-05-27	О,о-диэтил-n-(1-пропилтио-2-гидрокси-2-метилпропилиден)-амидотиофосфат, обладающий бактерицидной активностью
ES2039270T3 (es)	1993-09-16	Derivados de gamma-l-glutamil-4-nitroanilida y procedimiento para determinar actividad de gamma-gtp utilizandolos.
SU1160709A1 (ru)	2002-08-27	Гидрохлорид 6-метил-1-оксо-1,2,3,4-тетрагидроиндоло/2,3-с/-хинолина, обладающий транквилизирующей активностью
SU1573830A1 (ru)	1999-08-10	Фосфорилированные оксиэтиловые эфиры 2,4-дихлорфеноксиуксусной кислоты, обладающие гербицидной активностью
SU1202241A1 (ru)	2000-07-10	Натриевая соль 5-n-хлорбензилидентиазолидиндиона-2,4, обладающая противогрибковой активностью
SU1573800A1 (ru)	1999-08-10	Производные о-аминобензойной кислоты, обладающие фунгицидными свойствами
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