ATE85057T1 - Optisch aktive pyridobenzoxazinderivate. - Google Patents

Optisch aktive pyridobenzoxazinderivate.

Info

Publication number: ATE85057T1
Authority: AT; Austria
Prior art keywords: optically active; preparing; active pyridobenzoxazine; derivatives; pyridobenzoxazine
Prior art date: 1985-06-20

Application number

AT86108442T

Other languages

English (en)

Inventor

Isao Hayakawa

Shohgo Atarashi

Shuichi Yokohama

Masazumi Imamura

Katsuichi Sakano

Nobuyuki Higashihashi

Masayuki Ohshima

Original Assignee

Daiichi Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-20

Filing date

1986-06-20

Publication date

1993-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27281433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE85057(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-10-11 Priority claimed from JP60226499A external-priority patent/JPH0720946B2/ja

1986-06-20 Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co

1993-02-15 Application granted granted Critical

1993-02-15 Publication of ATE85057T1 publication Critical patent/ATE85057T1/de

Links

QDEJGQKJMKXYLM-UHFFFAOYSA-N 2h-pyrido[2,3-h][1,2]benzoxazine Chemical class C1=CC2=NC=CC=C2C2=C1C=CNO2 QDEJGQKJMKXYLM-UHFFFAOYSA-N 0.000 title abstract 5
GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 abstract 1
230000000845 anti-microbial effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229960001699 ofloxacin Drugs 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT86108442T 1985-06-20 1986-06-20 Optisch aktive pyridobenzoxazinderivate. ATE85057T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP13471285		1985-06-20
JP60226499A JPH0720946B2 (ja)	1985-10-11	1985-10-11	光学活性３−メチルベンゾオキサジン誘導体およびその製法
JP1649686		1986-01-28
EP86108442A EP0206283B1 (de)	1985-06-20	1986-06-20	Optisch aktive Pyridobenzoxazinderivate

Publications (1)

Publication Number	Publication Date
ATE85057T1 true ATE85057T1 (de)	1993-02-15

Family

ID=27281433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86108442T ATE85057T1 (de)	1985-06-20	1986-06-20	Optisch aktive pyridobenzoxazinderivate.

Country Status (16)

Country	Link
US (3)	US5053407A (de)
EP (1)	EP0206283B1 (de)
KR (2)	KR920010048B1 (de)
AT (1)	ATE85057T1 (de)
BG (1)	BG60527B2 (de)
CA (1)	CA1304080C (de)
DE (2)	DE19875012I2 (de)
DK (1)	DK170473B1 (de)
ES (1)	ES8801251A1 (de)
FI (1)	FI90241C (de)
GR (1)	GR861625B (de)
HK (1)	HK91793A (de)
IE (1)	IE59463B1 (de)
NL (1)	NL980016I2 (de)
NO (1)	NO166131C (de)
YU (3)	YU44918B (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
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ATE110061T1 (de) *	1986-12-25	1994-09-15	Daiichi Seiyaku Co	Optisch aktive 2,3-dihydrobenzoxazinderivate und verfahren zu deren herstellung.
IE75342B1 (en) *	1987-12-25	1997-08-27	Daiichi Seiyaku Co	Propoxybenzene derivatives and process for preparing the same
US5175160A (en) *	1988-08-09	1992-12-29	Daiichi Pharmaceutical Co., Ltd.	Antimicrobial agent for animals
MY104139A (en) *	1988-08-09	1994-02-28	Daiichi Seiyaku Co	Antimicrobial agent for animals
AU4376589A (en) *	1988-11-07	1990-05-10	Gist-Brocades N.V.	Optically active benzoxazines and benzothiazines
FI94339C (fi)	1989-07-21	1995-08-25	Warner Lambert Co	Menetelmä farmaseuttisesti käyttökelpoisen /R-(R,R)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
FR2655545B1 (fr) *	1989-12-11	1994-06-10	Rhone Poulenc Sante	Nouvelle application therapeutique des derives des fluoroquinolones.
TW208013B (de) *	1990-03-01	1993-06-21	Daiichi Co Ltd
FI96313C (fi) *	1990-11-28	1996-06-10	Daiichi Seiyaku Co	Menetelmä terapeuttisesti käyttökelpoisten ja optisesti aktiivisten 10-(3-amino-4,4-dialkyyli-1-pyrrolidinyyli)-9-fluori-2,3-dihydro-3(S)-metyyli-7-okso-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihappojen valmistamiseksi
ES2055656B1 (es) *	1992-10-07	1995-11-16	Etilo Derivados	Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.
EP0619311A1 (de) *	1992-10-07	1994-10-12	Derivados Del Etilo, S.A.	Verfahren zur herstellung von benzoxazine verwendbar zur herstellung von ofloxacin, levofloxacin und derivate
US5532239A (en) *	1993-08-02	1996-07-02	Assistance Publique - Hopitaux De Paris	Therapeutic application of fluoroquinolone derivatives
ZA946853B (en) *	1993-09-10	1995-04-24	Daiichi Seiyaku Co	Crystals of antimicrobial compound.
US5686095A (en) *	1995-10-23	1997-11-11	Price, Jr.; Francis W.	Method of treating canker sores
KR100491282B1 (ko)	1996-07-24	2005-05-24	워너-램버트 캄파니 엘엘씨	통증 치료용 이소부틸가바 및 그의 유도체
US6022551A (en) *	1998-01-20	2000-02-08	Ethicon, Inc.	Antimicrobial composition
US6248343B1 (en)	1998-01-20	2001-06-19	Ethicon, Inc.	Therapeutic antimicrobial compositions
US5997893A (en) *	1998-01-20	1999-12-07	Ethicon, Inc.	Alcohol based anti-microbial compositions with cosmetic appearance
US5972358A (en) *	1998-01-20	1999-10-26	Ethicon, Inc.	Low tack lotion, gels and creams
KR100309871B1 (ko)	1999-02-24	2001-10-29	윤종용	(-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
AU757777B2 (en)	1998-12-04	2003-03-06	Influx, Inc.	Inhibitors of multidrug transporters
KR100617952B1 (ko) *	1999-03-04	2006-08-30	보령제약 주식회사	광학활성 피리도 벤즈옥사진 유도체의 제조방법
US6872823B1 (en) *	1999-09-08	2005-03-29	Daiichi Pharmaceutical Co., Ltd.	Process for producing benzoxazine derivative and production intermediate thereof
KR20010103346A (ko) *	2000-05-09	2001-11-23	이후근	패각 입자와 접착제 그리고 물감을 혼합하여 그림 밑칠용재료를 제조하는 방법
ATE319710T1 (de)	2000-12-21	2006-03-15	Pharmacia & Upjohn Co Llc	Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen
WO2002070726A1 (en) *	2001-03-07	2002-09-12	Daiichi Pharmaceutical Co., Ltd.	Process for preparation of optically active propoxyaniline derivatives
KR100444248B1 (ko)	2001-04-27	2004-08-16	한국산업기술평가원	열간가공성이 우수한 고망간 듀플렉스 스텐레스강과 그제조방법
US7425628B2 (en) *	2001-10-03	2008-09-16	Teva Pharmaceutical Industries Ltd.	Methods for the purification of levofloxacin
ES2272781T5 (es) *	2001-10-03	2010-04-06	Teva Pharmaceutical Industries Ltd.	Preparacion de levofloxacino hemihidratado.
KR100440192B1 (ko) *	2001-11-22	2004-07-12	이수화학 주식회사	광학 활성 퀴놀론카르복실산 유도체의 제조방법
AU2002365416A1 (en) *	2001-11-29	2003-06-10	Teva Pharmaceutical Industries Ltd.	Methods for the purification of levofloxacin
US20040052843A1 (en) *	2001-12-24	2004-03-18	Lerner E. Itzhak	Controlled release dosage forms
NZ552514A (en) *	2001-12-24	2008-08-29	Teva Pharma	Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
IL163666A0 (en)	2002-02-22	2005-12-18	New River Pharmaceuticals Inc	Active agent delivery systems and methods for protecting and administering active agents
PL375437A1 (en) *	2002-08-14	2005-11-28	Teva Pharmaceutical Industries Ltd.	Synthesis of gatifloxacin
US20040152701A1 (en) *	2002-12-02	2004-08-05	Dr. Reddy's Laboratories Limited	Novel anhydrous crystalline form of Levofloxacin and process for preparation there of
FR2859471B1 (fr)	2003-09-09	2006-02-03	Solvay	Procede pour la fabrication d'un compose enantiopur
CA2596993A1 (en)	2005-02-07	2006-08-10	Mitsubishi Pharma Corporation	Optically active tetrahydronaphthalene derivative
US8524735B2 (en)	2005-05-18	2013-09-03	Mpex Pharmaceuticals, Inc.	Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) *	2005-05-18	2010-11-23	Mpex Pharmaceuticals, Inc.	Aerosolized fluoroquinolones and uses thereof
WO2007095187A2 (en) *	2006-02-13	2007-08-23	Trustees Of Boston University	Compositions and methods for antibiotic potentiation and drug discovery
US20070197548A1 (en)	2006-02-17	2007-08-23	Murthy Yerramilli V S	Fluoroquinolone compositions
US7973022B2 (en)	2006-02-17	2011-07-05	Idexx Laboratories, Inc.	Fluoroquinolone carboxylic acid salt compositions
WO2008019292A2 (en) *	2006-08-04	2008-02-14	Trustees Of Boston University	Compositions and methods for potentiating antibiotic activity
WO2008077643A1 (en) *	2006-12-22	2008-07-03	Farmaprojects, S.A.	Process for the preparation of an antibacterial quinolone compound
EP1939206A1 (de) *	2006-12-22	2008-07-02	Farmaprojects, S.A.	Herstellungsverfahren für eine antibakterielle Quinolonverbindung
US7964723B2 (en)	2008-08-02	2011-06-21	Apeloa-Kangyu	And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
CA2739897C (en)	2008-10-07	2017-10-03	Mpex Pharmaceuticals, Inc.	Aerosol fluoroquinolone formulations for improved pharmacokinetics
CA2739893C (en)	2008-10-07	2016-10-04	Mpex Pharmaceuticals, Inc.	Inhalation of levofloxacin for reducing lung inflammation
NZ610978A (en)	2009-05-15	2014-11-28	Redx Pharma Ltd	Redox drug derivatives
CN101659669B (zh) *	2009-09-04	2011-07-20	诚达药业股份有限公司	左旋氧氟沙星的制备方法
SI2473170T1 (sl)	2009-09-04	2019-10-30	Horizon Orphan Llc	Uporaba aerosoliziranega levofloksacina za zdravljenje cistične fibroze
CN102775424A (zh) *	2012-07-09	2012-11-14	浙江司太立制药股份有限公司	一种左氧氟沙星杂质的制备方法
EP2969004B1 (de)	2013-03-15	2026-02-25	Melinta Subsidiary Corp.	Delafloxacin zur verwending in der behandlung von infektionen bei adipösen patienten
UA118587C2 (uk) *	2014-05-09	2019-02-11	Текнімеді Сос'Єдаді Текніку-Медісінал С.А.	Фармацевтично прийнятні солі енантіомерів пірліндолу для застосування в медицині
CN105037388A (zh) *	2015-08-28	2015-11-11	安徽环球药业股份有限公司	一种安妥沙星的制备方法
CN105367585B (zh) *	2015-12-02	2017-11-17	山东齐都药业有限公司	左氧氟沙星杂质的制备方法
WO2021250482A1 (en)	2020-06-11	2021-12-16	Sentiss Pharma Private Limited	Ophthalmic compositions comprising a combination of fluoroquinolone antibacterial agent and an anti-inflammatory agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5746986A (en) *	1980-09-02	1982-03-17	Dai Ichi Seiyaku Co Ltd	Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS5852290A (ja) *	1981-09-21	1983-03-28	Dai Ichi Seiyaku Co Ltd	ピリドベンゾオキサジンカルボン酸誘導体
DE3543513A1 (de) *	1985-12-10	1987-06-11	Bayer Ag	Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln

1986
- 1986-06-18 DK DK285086A patent/DK170473B1/da active Protection Beyond IP Right Term
- 1986-06-18 NO NO862426A patent/NO166131C/no not_active IP Right Cessation
- 1986-06-19 CA CA000512000A patent/CA1304080C/en not_active Expired - Lifetime
- 1986-06-19 YU YU1073/86A patent/YU44918B/xx unknown
- 1986-06-19 IE IE163186A patent/IE59463B1/en not_active IP Right Cessation
- 1986-06-19 ES ES556292A patent/ES8801251A1/es not_active Expired
- 1986-06-19 FI FI862643A patent/FI90241C/fi not_active IP Right Cessation
- 1986-06-20 DE DE19863687599 patent/DE19875012I2/de active Active
- 1986-06-20 DE DE8686108442T patent/DE3687599T2/de not_active Expired - Lifetime
- 1986-06-20 US US06/876,623 patent/US5053407A/en not_active Expired - Lifetime
- 1986-06-20 EP EP86108442A patent/EP0206283B1/de not_active Expired - Lifetime
- 1986-06-20 KR KR1019860004934A patent/KR920010048B1/ko not_active Expired
- 1986-06-20 GR GR861625A patent/GR861625B/el unknown
- 1986-06-20 AT AT86108442T patent/ATE85057T1/de active
1988
- 1988-10-05 YU YU1867/88A patent/YU45512B/xx unknown
1989
- 1989-03-23 US US07/327,653 patent/US4985557A/en not_active Expired - Lifetime
- 1989-10-30 YU YU2098/89A patent/YU45524B/xx unknown
1990
- 1990-10-31 KR KR1019900017517A patent/KR940003757B1/ko not_active Expired - Lifetime
1991
- 1991-08-28 US US07/754,198 patent/US5142046A/en not_active Expired - Lifetime
1993
- 1993-09-02 HK HK917/93A patent/HK91793A/en not_active IP Right Cessation
1994
- 1994-02-22 BG BG098511A patent/BG60527B2/bg unknown
1998
- 1998-04-22 NL NL980016C patent/NL980016I2/nl unknown

Also Published As

Publication number	Publication date
DK285086D0 (da)	1986-06-18
US5053407A (en)	1991-10-01
EP0206283A3 (en)	1988-08-10
EP0206283A2 (de)	1986-12-30
IE861631L (en)	1986-12-20
YU44918B (en)	1991-04-30
NL980016I1 (nl)	1998-07-01
NO166131B (no)	1991-02-25
YU45524B (en)	1992-05-28
KR920010048B1 (ko)	1992-11-13
CA1304080C (en)	1992-06-23
YU209889A (en)	1990-04-30
DE3687599T2 (de)	1993-05-19
KR920009279A (ko)	1992-05-28
YU45512B (en)	1992-05-28
YU107386A (en)	1988-02-29
US4985557A (en)	1991-01-15
DK285086A (da)	1986-12-21
HK91793A (en)	1993-09-10
KR870000340A (ko)	1987-02-17
EP0206283B1 (de)	1993-01-27
YU186788A (en)	1989-04-30
ES556292A0 (es)	1988-01-01
KR940003757B1 (ko)	1994-04-30
DK170473B1 (da)	1995-09-11
FI90241B (fi)	1993-09-30
NL980016I2 (nl)	1998-08-03
NO862426D0 (no)	1986-06-18
NO862426L (no)	1986-12-22
IE59463B1 (en)	1994-02-23
ES8801251A1 (es)	1988-01-01
FI862643A0 (fi)	1986-06-19
FI90241C (fi)	1994-01-10
BG60527B2 (bg)	1995-07-28
DE19875012I2 (de)	2006-06-29
GR861625B (en)	1986-10-21
NO166131C (no)	1991-06-05
FI862643A7 (fi)	1986-12-21
DE3687599D1 (de)	1993-03-11
US5142046A (en)	1992-08-25

Publication	Publication Date	Title
ATE85057T1 (de)	1993-02-15	Optisch aktive pyridobenzoxazinderivate.
DE3585980D1 (de)	1992-06-11	Hydrazinderivate und ihre verwendung.
YU175791A (sh)	1994-01-20	Heterociklični derivati monocikličnih beta laktam antibiotika
AU6307586A (en)	1987-03-26	Quinoline derivatives
AU578489B2 (en)	1988-10-27	Proline derivatives
MX9204642A (es)	1993-12-01	1,4-dihidropiridinas con actividad paf-antagonista
ATE70841T1 (de)	1992-01-15	2-(1-oxo-1-imino-1-thiacycloalkyl)-thiopenemderivate.
ES2052812T3 (es)	1994-07-16	Un procedimiento para la preparacion de derivados de pirrolizina.
SU731725A1 (ru)	2006-12-27	Производные дифенилилхинолина, обладающие противомикробной активностью
SU1610823A1 (ru)	2000-05-10	S-трет-бутилтиуронийбромид, обладающий антиишемической активностью
SU1455633A1 (ru)	1999-05-27	О,о-диизопропил-о-[1, 1-диметил-2-пропилтио-2-(о-о-диизопропилфосфорил)- имино]-этилфосфат, обладающий бактерицидной активностью
SU1351063A1 (ru)	2006-12-20	Производные 2-тиазолзамещенного 5-нитрофурана, проявляющие антистафилококковую активность
SU1455632A1 (ru)	1999-05-27	О,о-диэтил-n-(1-пропилтио-2-гидрокси-2-метилпропилиден)-амидотиофосфат, обладающий бактерицидной активностью
ES2039270T3 (es)	1993-09-16	Derivados de gamma-l-glutamil-4-nitroanilida y procedimiento para determinar actividad de gamma-gtp utilizandolos.
SU1160709A1 (ru)	2002-08-27	Гидрохлорид 6-метил-1-оксо-1,2,3,4-тетрагидроиндоло/2,3-с/-хинолина, обладающий транквилизирующей активностью
SU1573830A1 (ru)	1999-08-10	Фосфорилированные оксиэтиловые эфиры 2,4-дихлорфеноксиуксусной кислоты, обладающие гербицидной активностью
SU1202241A1 (ru)	2000-07-10	Натриевая соль 5-n-хлорбензилидентиазолидиндиона-2,4, обладающая противогрибковой активностью
SU1573800A1 (ru)	1999-08-10	Производные о-аминобензойной кислоты, обладающие фунгицидными свойствами
SU997416A1 (ru)	2006-12-27	Диметил-5-нитрофурфурилсульфоний бромид, обладающий антимикробной активностью
SU1374724A1 (ru)	2005-02-20	1-фосфонометил-2-иминоимидазолидин-4-он, обладающий гербицидной активностью
SU803375A1 (ru)	2000-06-10	Производные 5-м-нитробензилиденселеназолидиндиона-2,4, обладающие психотропной активностью