HK43284A - Local anesthetic mixture for topical application, and process for its preparation - Google Patents

Local anesthetic mixture for topical application, and process for its preparation

Info

Publication number
HK43284A
HK43284A HK432/84A HK43284A HK43284A HK 43284 A HK43284 A HK 43284A HK 432/84 A HK432/84 A HK 432/84A HK 43284 A HK43284 A HK 43284A HK 43284 A HK43284 A HK 43284A
Authority
HK
Hong Kong
Prior art keywords
local anesthetic
base
weight ratio
melting point
process according
Prior art date
Application number
HK432/84A
Other languages
German (de)
English (en)
Inventor
Berndt Fredrik Julius Broberg
Hans Christer Arvid Evers
Original Assignee
Astra Lakemedel Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Lakemedel Aktiebolag filed Critical Astra Lakemedel Aktiebolag
Publication of HK43284A publication Critical patent/HK43284A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Claims (15)

1. Préparation à action anesthésique locale pour une application topique ou parentérale, caractérisée en ce qu'elle comprend comme constituant actif un premier agent à action anesthésique locale sous la forme de sa base et ayant comme tel un point de fusion de 30 à 50°C et un second agent à action anesthésique locale sous la forme de sa base et ayant comme tel un point de fusion supérieur à 30°C, de préférence supérieur à 40°C, lesquels agents lorsqu'ils sont mélangés et chauffés ensemble forment une huile homogène qui a un point de fusion inférieur à 40°C, de préférence inférieur à 25°C.
2. Procédé pour l'obtention de préparations à action anesthésique locale selon la revendication 1, caractérisé en ce qu'un premier agent à action anesthésique locale sous la forme de sa base et ayant comme tel un point de fusion de 30 à 50°C est mélangé avec un second agent à action anesthésique locale, différent du premier, sous forme de sa base, et ayant comme tel un point de fusion supérieur à 30°C, de préférence supérieur à 40°C.
3. Procédé selon la revendication 2, caractérisé en ce quë le premier agent à action anesthésique locale est la prilocaïne ou la tétracaïne sous la forme de leur base et le second agent à action anesthésique locale est la benzocaïne, la lidocaïne, la bupivacaïne, la mépivacaïne, l'étidocaïne ou la tétracaïne sous forme de leur base.
4. Procédé selon l'une des revendications 2 ou 3, caractérisé en ce que la prilocaïne et la benzocaïne sont mélangées ensemble dans un rapport pondéral de 63:37 à 96:4.
5. Procédé selon la revendication 4, caractérisé en ce que le rapport pondéral est compris entre 65:35 et 80:20, et est de préférence de 70:30.
6. Procédé selon l'une des revendications 2 ou 3, caractérisé en ce que la prilocaïne et la lidocaïne sont mélangées ensemble dans un rapport pondéral de 42:58 à 80:20.
7. Procédé selon la revendication 6, caractérisé en ce que le rapport pondéral est compris entre 47:53 et 62:38, et est de préférence de 55:45.
8. Procédé selon l'une des revendications 2 ou 3, caractérisé en ce que la prilocaïne et l'étido- caïne sont mélangées ensemble dans un rapport pondéral de 55:45 à 95:5.
9. Procédé selon la revendication 8, caractérisé en ce que le rapport pondéral est compris entre 60:40 et 80:20, et est de préférence de 70:30.
10. Procédé selon l'une des revendications 2 ou 3, caractérisé en ce que la prilocaïne et la mépivacaïne sont mélangées ensemble dans un rapport pondéral de 80:20 à 97:3.
11. Procédé selon la revendication 10, caractérisé en ce que le rapport pondéral est compris entre 85:15 et 90:10 et est de préférence de 87:13.
12. Procédé selon l'une des revendications 2 ou 3, caractérisé en ce que la prilocaïne et la bupivacaïne sont mélangées ensemble dans un rapport pondéral de 72:28 à 97:3.
13. Procédé selon la revendication 12, caractérisé en ce que le rapport pondéral est compris entre 78:22 et 88:12, et est de préférence de 85:15.
14. Procédé selon l'une des revendications 2 ou 3, caractérisé en ce que la tétracaïne et la lidocaïne sont mélangées ensemble dans un rapport pondéral de 40:60 à 70:30.
15. Procédé selon la revendication 14, caractérisé en ce que le rapport pondéral est compris entre 45:55 et 55:45, et est de préférence de 50:50.
HK432/84A 1977-12-01 1984-05-17 Local anesthetic mixture for topical application, and process for its preparation HK43284A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7713618A SE7713618L (sv) 1977-12-01 1977-12-01 Lokalanestetisk blandning

Publications (1)

Publication Number Publication Date
HK43284A true HK43284A (en) 1984-05-25

Family

ID=20333074

Family Applications (1)

Application Number Title Priority Date Filing Date
HK432/84A HK43284A (en) 1977-12-01 1984-05-17 Local anesthetic mixture for topical application, and process for its preparation

Country Status (19)

Country Link
US (2) US4529601A (fr)
EP (1) EP0002425B1 (fr)
JP (1) JPS54101414A (fr)
AR (1) AR218948A1 (fr)
AT (1) AT364451B (fr)
AU (1) AU525417B2 (fr)
CA (1) CA1118350A (fr)
DE (1) DE2861326D1 (fr)
DK (1) DK154187C (fr)
FI (1) FI68173C (fr)
HK (1) HK43284A (fr)
IE (1) IE47682B1 (fr)
LU (1) LU88309I2 (fr)
MY (1) MY8500061A (fr)
NL (1) NL930051I2 (fr)
NO (1) NO149913C (fr)
NZ (1) NZ189026A (fr)
SE (1) SE7713618L (fr)
SG (1) SG8484G (fr)

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SG8484G (en) 1985-02-08
NL930051I1 (nl) 1993-09-01
IE782350L (en) 1979-06-01
NO149913B (no) 1984-04-09
CA1118350A (fr) 1982-02-16
AR218948A1 (es) 1980-07-15
DK154187C (da) 1989-03-13
DK154187B (da) 1988-10-24
FI68173B (fi) 1985-04-30
NZ189026A (en) 1984-07-06
FI68173C (fi) 1985-08-12
US4562060A (en) 1985-12-31
FI783668A7 (fi) 1979-06-02
IE47682B1 (en) 1984-05-30
JPS54101414A (en) 1979-08-10
EP0002425A1 (fr) 1979-06-13
ATA859578A (de) 1981-03-15
EP0002425B1 (fr) 1981-11-11
AU4196078A (en) 1979-06-07
JPS625133B2 (fr) 1987-02-03
NL930051I2 (nl) 1994-01-17
SE7713618L (sv) 1979-06-02
US4529601A (en) 1985-07-16
DE2861326D1 (en) 1982-01-14
MY8500061A (en) 1985-12-31
DK538978A (da) 1979-06-02
NO149913C (no) 1984-07-18
LU88309I2 (fr) 1994-05-04
NO783950L (no) 1979-06-05
AT364451B (de) 1981-10-27
AU525417B2 (en) 1982-11-04

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