HK50996A - Treatment of gastrointestinal disorders using 5-ht3 antagonists - Google Patents

Treatment of gastrointestinal disorders using 5-ht3 antagonists Download PDF

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Publication number
HK50996A
HK50996A HK50996A HK50996A HK50996A HK 50996 A HK50996 A HK 50996A HK 50996 A HK50996 A HK 50996A HK 50996 A HK50996 A HK 50996A HK 50996 A HK50996 A HK 50996A
Authority
HK
Hong Kong
Prior art keywords
use according
diarrhea
methyl
carboxylic acid
indol
Prior art date
Application number
HK50996A
Other languages
German (de)
English (en)
Inventor
Buchheit Karl-Heinz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19843446484 external-priority patent/DE3446484A1/de
Priority claimed from DE19853531281 external-priority patent/DE3531281A1/de
Priority claimed from DE19853531282 external-priority patent/DE3531282A1/de
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK50996A publication Critical patent/HK50996A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (18)

1. L'utilisation d'un composé de formule dans laquelle le groupe -CO-Y-D est situé à l'une des positions 3, 4 ou 5 du système bicyclique,
Z signifie -NR3-, ou -S-,
R1 et R2 , indépendamment, signifient l'hydrogène, un halogène ou un groupe alkyle en C1-C4 ou alcoxy en Ci -C4 , R1 étant en position 4 ou 5,
R3 signifie l'hydrogène ou un groupe alkyle en C1-C4,
Y signifie -O- ou -NH-, et
D signifie un groupe de formule VI
dans laquelle n signifie 2, 3 ou 4, et
R8 signifie l'hydrogène ou un groupe alkyle en C1-C4 ou benzyle, ou un sel d'addition d'acide ou un sel d'ammonium quaternaire pharmaceutiquement acceptables de ce composé, pour la préparation de médicaments appropriés pour le traitement des troubles gastro-intestinaux provoqués par la sérotonine.
2. L'utilisation selon la revendication 1, caractérisée en ce que le composé utilisé est l'ester endo-8-méthyl-8-aza-bicyclo[3,2,1 ]oct-3-ylique de l'acide indole-3-yl-carboxylique.
3. L'utilisation des composés selon la revendication 1 pour la préparation d'un médicament approprié pour le traitement des troubles gastro-intestinaux choisis parmi la gastrite, l'ulcère gastro-duodénal, la dyskinésie biliaire, le côlon irritable, l'appendicite, le syndrome des intestins irritables, la maladie de Crohn, la colite ulcéreuse, le syndrome carcinoïde et les diarrhées d'origines diverses, par exemple la diarrhée secrétoire, la diarrhée provoquée par des bactéries, la diarrhée du choléra, la diarrhée du voyageur, la diarrhée psychogène ou les troubles de la motilité oesophagienne, l'achalasie, la hernie hiatale, l'insuffisance du cardia , le reflux gastro-oesophagien et gastro-duodénal, l'hypotonie stomacale, l'hypertrophie du pylore, l'iléus paralytique et la maladie de Hirschsprung.
4. L'utilisation selon la revendication 3, caractérisée en ce que le composé utilisé est l'ester endo-8-méthyl-8-aza-bicyclo[3,2,1 ]oct-3-ylique de l'acide indole-3-yl-carboxylique.
5. L'utilisation selon la revendication 3, caractérisée en ce que le trouble gastro-intestinal est le trouble du reflux gastro-oesophagien.
6. L'utilisation selon la revendication 5, caractérisée en ce que le composé utilisé est l'ester endo-8-méthyl-8-aza-bicyclo[3,2,1 ]oct-3-ylique de l'acide indole-3-yl-carboxylique.
7. L'utilisation selon la revendication 3, caractérisée en ce que le trouble gastro-intestinal est le côlon irritable.
8. L'utilisation selon la revendication 7, caractérisée en ce que le composé utilisé est l'ester endo-8-méthyl-8-aza-bicyclo[3,2,1 ]oct-3-ylique de l'acide indole-3-yl-carboxylique.
9. L'utilisation selon la revendication 7, caractérisée en ce que le trouble gastro-intestinal est le syndrome des intestins irritables.
10. L'utilisation selon la revendication 9, caractérisée en ce que le composé utilisé est l'ester endo-8-méthyl-8-aza-bicyclo[3,2,1 ]oct-3-ylique de l'acide indole-3-yl-carboxylique.
11. L'utilisation selon la revendication 3, caractérisé en ce que le trouble gastro-intestinal est la diarrhée.
12. L'utilisation selon la revendication 11, caractérisée en ce que le composé utilisé est l'ester endo-8-méthyl-8-aza-bicyclo[3,2,1 ]oct-3-ylique de l'acide indole-3-yl-carboxylique.
13. L'utilisation selon la revendication 11, caractérisée en ce que le trouble gastro-intestinal est la diarrhée secrétoire.
14. L'utilisation selon la revendication 13, caractérisée en ce que le composé utilisé est l'ester endo-8-méthyl-8-aza-bicyclo[3,2,1 ]oct-3-ylique de l'acide indole-3-yl-carboxylique.
15. L'utilisation selon la revendication 11, caractérisée en ce que le trouble gastro-intestinal est la diarrhée du voyageur.
16. L'utilisation selon la revendication 15, caractérisée en ce que le composé utilisé est l'ester endo-8-méthyl-8-aza-bicyclo[3,2,1]oct-3-ylique de l'acide indole-3-yl-carboxylique.
17. L'utilisation selon la revendication 11, caractérisée en ce que le trouble gastro-intestinal est la diarrhée provoquée par des bactéries.
18. L'utilisation selon la revendication 17, caractérisée en ce que le composé utilisé est l'ester endo-8-méthyl-8-aza-bicyclo[3,2,1]oct-3-ylique de l'acide indole-3-yl-carboxylique.
HK50996A 1984-12-20 1996-03-21 Treatment of gastrointestinal disorders using 5-ht3 antagonists HK50996A (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DE19843446484 DE3446484A1 (de) 1984-12-20 1984-12-20 Therapeutische verwendung von benzoesaeurepiperidylestern oder -amiden
CH141485 1985-04-02
CH266785 1985-06-24
CH313085 1985-07-19
CH312985 1985-07-19
CH338385 1985-08-07
CH338285 1985-08-07
DE19853531281 DE3531281A1 (de) 1985-09-02 1985-09-02 Therap. verwendung von mono- oder dicarbocyclischen oder heterocyclischen carbonsaeure- oder sulfonsaeure-estern oder -amiden
DE19853531282 DE3531282A1 (de) 1985-09-02 1985-09-02 Therap. verwendung von mono- oder dicarbocyclischen oder heterocyclischen carbonsaeure- oder sulfonsaeure-estern oder -amiden

Publications (1)

Publication Number Publication Date
HK50996A true HK50996A (en) 1996-03-29

Family

ID=27575765

Family Applications (1)

Application Number Title Priority Date Filing Date
HK50996A HK50996A (en) 1984-12-20 1996-03-21 Treatment of gastrointestinal disorders using 5-ht3 antagonists

Country Status (10)

Country Link
EP (1) EP0189002B1 (fr)
JP (2) JPS61152628A (fr)
AT (1) ATE86110T1 (fr)
AU (1) AU595172B2 (fr)
CY (1) CY1908A (fr)
DE (1) DE3587151T2 (fr)
DK (1) DK174146B1 (fr)
HK (1) HK50996A (fr)
LU (1) LU88345I2 (fr)
PH (1) PH24193A (fr)

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Also Published As

Publication number Publication date
PH24193A (en) 1990-04-10
EP0189002A3 (en) 1990-01-31
JPH0588207B2 (fr) 1993-12-21
AU5139685A (en) 1986-07-31
JPH02237920A (ja) 1990-09-20
DK591385D0 (da) 1985-12-18
ATE86110T1 (de) 1993-03-15
EP0189002A2 (fr) 1986-07-30
DK591385A (da) 1986-06-21
LU88345I2 (fr) 1994-05-04
DE3587151D1 (de) 1993-04-08
DK174146B1 (da) 2002-07-22
EP0189002B1 (fr) 1993-03-03
CY1908A (en) 1985-12-13
DE3587151T2 (de) 1993-07-15
AU595172B2 (en) 1990-03-29
JPS61152628A (ja) 1986-07-11

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