HK55896A - Pharmaceutical composition comprising 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) in treating patients infected with retrovirus - Google Patents

Pharmaceutical composition comprising 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) in treating patients infected with retrovirus Download PDF

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Publication number
HK55896A
HK55896A HK55896A HK55896A HK55896A HK 55896 A HK55896 A HK 55896A HK 55896 A HK55896 A HK 55896A HK 55896 A HK55896 A HK 55896A HK 55896 A HK55896 A HK 55896A
Authority
HK
Hong Kong
Prior art keywords
retrovirus
ene
deoxythymidin
composition according
didehydrothymidine
Prior art date
Application number
HK55896A
Other languages
English (en)
French (fr)
Inventor
Lin Tai-Shun
William H. Prusoff
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25478432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK55896(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yale University filed Critical Yale University
Publication of HK55896A publication Critical patent/HK55896A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Claims (8)

  1. Pharmazeutische Zubereitung zur Behandlung von Warmblütlern, die mit einem Retrovirus infiziert sind, enthaltend als aktiven Bestandteil eine anti-retroviral wirksame Menge von 3'-Deoxythymidin-2'-en, entweder allein oder in Gemisch mit den üblichen Zusätzen, z.B. festen, flüssigen oder verflüssigten gasförmigen Verdünnungsmitteln.
  2. Zubereitung nach Anspruch 1, worin das Retrovirus Moloney-Maus-Leukämie-Virus darstellt.
  3. Zubereitung nach Anspruch 1, worin das Retrovirus HTLV III/LAV darstellt.
  4. Zubereitung nach einem der Ansprüche 1 bis 3, enthaltend 0,5 bis 90 % des aktiven Bestandteils.
  5. Zubereitung nach einem der Ansprüche 1 bis 4 in Form einer sterilen, physiologisch isotonischen wäßrigen Lösung.
  6. Zubereitung nach Anspruch 5, enthaltend 5 bis 90 % des aktiven Bestandteils.
  7. Zubereitung nach einem der Ansprüche 1 bis 6 in Form einer Dosiseinheit, z.B. in Form einer Tablette, Pille, eines Dragées, einer Kapsel, Kaplette, Ampulle oder eines Suppositoriums.
  8. Verwendung von 3'-Deoxythymidin-2'-en oder einer pharmazeutischen Zubereitung nach einem der Ansprüche 1 bis 7 zur Herstellung eines Medikaments für die Behandlung von Warmblütlern, die mit einem Retrovirus infiziert sind.
HK55896A 1986-12-17 1996-03-28 Pharmaceutical composition comprising 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) in treating patients infected with retrovirus HK55896A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/942,666 US4978655A (en) 1986-12-17 1986-12-17 Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses

Publications (1)

Publication Number Publication Date
HK55896A true HK55896A (en) 1996-04-03

Family

ID=25478432

Family Applications (1)

Application Number Title Priority Date Filing Date
HK55896A HK55896A (en) 1986-12-17 1996-03-28 Pharmaceutical composition comprising 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) in treating patients infected with retrovirus

Country Status (22)

Country Link
US (1) US4978655A (de)
EP (1) EP0273277B1 (de)
JP (1) JPH07116041B2 (de)
KR (1) KR960000433B1 (de)
AT (1) ATE77554T1 (de)
AU (1) AU593405B2 (de)
CA (1) CA1293447C (de)
DE (1) DE3780016T2 (de)
DK (1) DK174627B1 (de)
EG (1) EG19157A (de)
ES (1) ES2038650T3 (de)
FI (1) FI875544A7 (de)
GR (1) GR3005691T3 (de)
HK (1) HK55896A (de)
IE (1) IE60866B1 (de)
IL (1) IL84790A (de)
LU (1) LU88822I2 (de)
NL (1) NL960024I2 (de)
NZ (1) NZ222935A (de)
PH (1) PH26380A (de)
PT (1) PT86346B (de)
ZA (1) ZA877171B (de)

Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
US5175292A (en) * 1988-01-20 1992-12-29 Regents Of The University Of Minnesota Intermediates for the preparation of dideoxycarbocyclic nucleosides
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
FI95269C (fi) * 1989-05-15 1996-01-10 Squibb Bristol Myers Co 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
US6207650B1 (en) 1989-05-15 2001-03-27 Bristol-Myers Squibb Company Antiviral, highly water soluble, stable, crystalline salts of 2′, 3′-dideoxyinosine, 2′, 3′-dideoxy-2′, 3′-didehydrothymidine and 2′, 3′-dideoxy-2′-fluoroinosine
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US5840711A (en) * 1995-06-21 1998-11-24 University Of Kentucky Research Foundation Compositions containing lithium inorganic salts and anti-viral drugs and method of treating viral infections such as acquired immunodeficiency syndrome
CA2189097A1 (en) 1995-11-15 1997-05-16 Pin-Fang Lin Composition and method of treating retroviral infection
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
WO2000016625A1 (en) * 1998-09-23 2000-03-30 University Of Kentucky Research Foundation Antiviral drug compositions containing lithium inorganic salts
CN1187052C (zh) 2000-03-30 2005-02-02 布里斯托尔-迈尔斯斯奎布公司 含有司他夫定(stavudine)的持续释放微球
EP2316468A1 (de) 2002-02-22 2011-05-04 Shire LLC Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
EA012844B1 (ru) 2003-02-19 2009-12-30 Йельский Университет Аналоги противовирусных нуклеозидов и способы лечения вирусных инфекций, в частности вич-инфекций
US20040200730A1 (en) * 2003-04-14 2004-10-14 Kyo Jibiki Hydrometallurgical copper recovery process
ME03423B (de) 2004-07-27 2020-01-20 Gilead Sciences Inc Phosphonat Analoga von HIV Inhibitor Verbindungen
BRPI0617074A2 (pt) * 2005-08-31 2011-07-12 Cipla Ltd composição farmacêutica, uso de lamivudina, nevirapina e stavudina, uso de stavudina, lamivudina e nevirapina, método para tratar uma infecção viral em um humano, método para preparar uma composição farmacêutica, método para preparar uma forma de dosagem unitária farmacêutica bicamadas e método para preparar uma forma de dosagem unitária farmacêutica tri-camadas
ES2467108T3 (es) 2008-12-09 2014-06-11 Gilead Sciences, Inc. Moduladores de receptores tipo toll
US20110223131A1 (en) 2010-02-24 2011-09-15 Gilead Sciences, Inc. Antiviral compounds
WO2016001907A1 (en) 2014-07-02 2016-01-07 Prendergast Patrick T Mogroside iv and mogroside v as agonist/stimulator/un-blocking agent for toll-like receptor 4 and adjuvant for use in human/animal vaccine and to stimulate immunity against disease agents.
PT3166607T (pt) 2014-07-11 2022-12-07 Gilead Sciences Inc Moduladores de receptores de tipo toll para o tratamento do vih
HK1257270A1 (zh) 2015-09-15 2019-10-18 Gilead Sciences, Inc. 用於治疗hiv的toll样受体(tlr)调节剂

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
JPS5943550B2 (ja) * 1975-08-29 1984-10-23 田辺製薬株式会社 不飽和ヌクレオシドの製法
DE3515870A1 (de) * 1985-05-03 1986-11-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 5-fluortoluol-2,4-disulfochlorid
US4710492A (en) * 1986-06-23 1987-12-01 Yale University 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses
NL8700089A (nl) * 1987-01-15 1988-08-01 Stichting Rega V Z W Therapeutische toepassing van dideoxythymidine en dideoxythymidineen.
DE3806633A1 (de) * 1987-09-01 1989-03-09 Bayer Ag Antivirales mittel
JP2648329B2 (ja) * 1987-09-18 1997-08-27 エフ・ホフマン−ラ ロシュ アーゲー エイズの予防または治療用医薬組成物
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
JPH0227782A (ja) * 1988-07-15 1990-01-30 Hikari Gijutsu Kenkyu Kaihatsu Kk 半導体発光素子
JPH0438727A (ja) * 1990-06-04 1992-02-07 Sharp Corp 光学式ピックアップ装置の対物レンズ塵埃付着防止機構

Also Published As

Publication number Publication date
IL84790A0 (en) 1988-05-31
EP0273277A3 (en) 1989-09-13
KR960000433B1 (ko) 1996-01-06
FI875544A0 (fi) 1987-12-16
FI875544L (fi) 1988-06-18
FI875544A7 (fi) 1988-06-18
DK557087A (da) 1988-06-18
LU88822I2 (fr) 1997-01-06
EP0273277A2 (de) 1988-07-06
PT86346A (en) 1988-01-01
NL960024I1 (nl) 1996-12-02
JPH07116041B2 (ja) 1995-12-13
EG19157A (en) 1994-09-29
ES2038650T3 (es) 1993-08-01
IE60866B1 (en) 1994-08-24
DK557087D0 (da) 1987-10-23
DK174627B1 (da) 2003-07-28
PH26380A (en) 1992-06-01
ATE77554T1 (de) 1992-07-15
AU8090087A (en) 1988-06-23
JPS63215632A (ja) 1988-09-08
ZA877171B (en) 1988-03-24
PT86346B (pt) 1990-11-07
NZ222935A (en) 1990-09-26
NL960024I2 (nl) 1997-06-02
IE873245L (en) 1988-06-17
EP0273277B1 (de) 1992-06-24
GR3005691T3 (de) 1993-06-07
US4978655A (en) 1990-12-18
DE3780016T2 (de) 1992-12-24
IL84790A (en) 1993-03-15
AU593405B2 (en) 1990-02-08
KR880007079A (ko) 1988-08-26
CA1293447C (en) 1991-12-24
DE3780016D1 (de) 1992-07-30

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Effective date: 20071210