HK90894A - Tetrapyrrole compounds and process for the production of same and a pharmaceutical composition containing same - Google Patents

Tetrapyrrole compounds and process for the production of same and a pharmaceutical composition containing same Download PDF

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Publication number
HK90894A
HK90894A HK90894A HK90894A HK90894A HK 90894 A HK90894 A HK 90894A HK 90894 A HK90894 A HK 90894A HK 90894 A HK90894 A HK 90894A HK 90894 A HK90894 A HK 90894A
Authority
HK
Hong Kong
Prior art keywords
mono
tetrapyrrole
compounds
chlorin
tumor
Prior art date
Application number
HK90894A
Other languages
English (en)
French (fr)
Inventor
Jerry C. Bommer
Bruce F. Burnham
Original Assignee
Nippon Petrochemicals Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/631,925 external-priority patent/US4675338A/en
Application filed by Nippon Petrochemicals Company, Limited filed Critical Nippon Petrochemicals Company, Limited
Publication of HK90894A publication Critical patent/HK90894A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polyamides (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (14)

  1. Verfahren zur Herstellung eines fluoreszierenden Mono-, Di- oder Polyamids einer Aminodicarbonsäure und eines Tetrapyrrols der Struktur: wobei Z der Aminosäurerest ist, und X den Rest eines Tetrapyrrols der Formel: darstellt, wobei X = H, Vinyl, Ethyl, Acetyl oder Formyl;
    Y =   Methyl oder Formyl;
    M =   Methyl; und
    E =   Ethyl
    ist, und "n" eine Zahl von 1 bis 3 einschließlich ist, das das Kontaktieren des Tetrapyrrols mit einer Aminodicarbonsäure in einem geeigneten Lösungsmittel und gegebenenfalls das Umwandeln des Produkts in ein Salz davon umfaßt.
  2. Verfahren nach Anspruch 1, wobei die Aminosäure eine Alphaaminosäure ist.
  3. Verfahren nach Anspruch 1, wobei das Produkt ein Mono- oder Diamid ist.
  4. Verfahren nach Anspruch 3, wobei das Produkt Mono- oder Di-L-Aspartylchlorin e₆ ist.
  5. Verfahren nach Anspruch 3, wobei das Produkt Mono- oder oder Di-L-Glutamylchlorin e₆ ist.
  6. Verfahren nach Anspruch 3, wobei das Produkt Mono- oder Di-L-Aspartylbacteriochlorin e₆ ist.
  7. Verfahren nach Anspruch 3, wobei das Produkt Mono- oder Di-L-Glutamylbacteriochlorin e₆ ist.
  8. Verfahren nach Anspruch 3, wobei das Produkt Mono- oder Di-L-Aspartylrhodin g₇ ist.
  9. Verfahren nach Anspruch 3, wobei das Produkt Mono- oder Di-L-Glutamylrhodin g₇ ist.
  10. Verfahren nach Anspruch 3, wobei das Produkt Mono- oder Di-L-Glutamylmesochlorin e₆ ist.
  11. Verfahren nach Anspruch 3, wobei das Produkt Mono- oder Di-L-Aspartylmesochlorin e₆ ist.
  12. Verwendung einer Verbindung, hergestellt gemäß dem Verfahren der Ansprüche 1 bis 11, zur Herstellung einer pharamzeutischen Zusammensetzung zum Nachweis und Behandlung von Tumoren und Krebsgeweben im menschlichen oder tierischen Körper.
HK90894A 1984-07-18 1994-09-01 Tetrapyrrole compounds and process for the production of same and a pharmaceutical composition containing same HK90894A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/631,925 US4675338A (en) 1984-07-18 1984-07-18 Tetrapyrrole therapeutic agents
US06/728,784 US4693885A (en) 1984-07-18 1985-04-30 Tetrapyrrole therapeutic agents

Publications (1)

Publication Number Publication Date
HK90894A true HK90894A (en) 1994-09-09

Family

ID=27091504

Family Applications (1)

Application Number Title Priority Date Filing Date
HK90894A HK90894A (en) 1984-07-18 1994-09-01 Tetrapyrrole compounds and process for the production of same and a pharmaceutical composition containing same

Country Status (9)

Country Link
US (1) US4693885A (de)
EP (1) EP0168831B1 (de)
AT (1) ATE67505T1 (de)
AU (1) AU592058B2 (de)
CA (1) CA1264740A (de)
DE (1) DE3584120D1 (de)
DK (1) DK167769B1 (de)
HK (1) HK90894A (de)
NO (1) NO169291C (de)

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Also Published As

Publication number Publication date
AU4515985A (en) 1986-01-23
DK167769B1 (da) 1993-12-13
ATE67505T1 (de) 1991-10-15
AU592058B2 (en) 1990-01-04
NO852872L (no) 1986-01-20
EP0168831A3 (en) 1988-05-04
EP0168831B1 (de) 1991-09-18
CA1264740C (en) 1990-01-23
DE3584120D1 (de) 1991-10-24
NO169291C (no) 1992-06-03
DK326885D0 (da) 1985-07-18
DK326885A (da) 1986-01-19
NO169291B (no) 1992-02-24
EP0168831A2 (de) 1986-01-22
US4693885A (en) 1987-09-15
CA1264740A (en) 1990-01-23

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