HK90894A - Tetrapyrrole compounds and process for the production of same and a pharmaceutical composition containing same - Google Patents

Tetrapyrrole compounds and process for the production of same and a pharmaceutical composition containing same Download PDF

Info

Publication number
HK90894A
HK90894A HK90894A HK90894A HK90894A HK 90894 A HK90894 A HK 90894A HK 90894 A HK90894 A HK 90894A HK 90894 A HK90894 A HK 90894A HK 90894 A HK90894 A HK 90894A
Authority
HK
Hong Kong
Prior art keywords
mono
tetrapyrrole
compounds
chlorin
tumor
Prior art date
Application number
HK90894A
Other languages
German (de)
English (en)
Inventor
Jerry C. Bommer
Bruce F. Burnham
Original Assignee
Nippon Petrochemicals Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/631,925 external-priority patent/US4675338A/en
Application filed by Nippon Petrochemicals Company, Limited filed Critical Nippon Petrochemicals Company, Limited
Publication of HK90894A publication Critical patent/HK90894A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyamides (AREA)

Claims (14)

  1. Procédé de préparation d'un mono-, di- ou polyamide fluorescent d'un acide amino dicarboxylique et d'un tétrapyrrole, ayant la structure : dans laquelle :
    - Z est le reste d'acide aminé ; et
    - X est le reste d'un tétrapyrrole de formule : dans laquelle :
    - X = H, vinyle, éthyle, acétyle ou formyle ;
    - Y = méthyle ou formyle ;
    - M = méthyle ; et
    - E = éthyle ; et
    - "n" est un entier de 1 à 3 inclus,
    qui comprend la mise en contact du tétrapyrrole avec un acide amino dicarboxylique, dans un solvant approprié, et la conversion facultative du produit en un sel de celui-ci.
  2. Procédé selon la revendication 1, dans lequel l'acide aminé est un alpha amino acide.
  3. Procédé selon la revendication 1, dans lequel le produit est un mono- ou diamide.
  4. Procédé selon la revendication 3, dans lequel le produit est la mono- ou di-L-aspartyl chlorine e₆.
  5. Procédé selon la revendication 3, dans lequel le produit est la mono- ou di-L-glutamyl chlorine e₆.
  6. Procédé selon la revendication 3, dans lequel le produit est la mono- ou di-L-aspartyl bactériochlorine e₆.
  7. Procédé selon la revendication 3, dans lequel le produit est la mono- ou di-L-glutamyl bactériochlorine e₆.
  8. Procédé selon la revendication 3, dans lequel le produit est la mono- ou di-L-aspartyl rhodine g₇.
  9. Procédé selon la revendication 3, dans lequel le produit est la mono- ou di-L-glutamyl rhodine g₇.
  10. Procédé selon la revendication 3, dans lequel le produit est la mono- ou di-L-glutamyl mésochlorine e₆.
  11. Procédé selon la revendication 3, dans lequel le produit est la mono- ou di-L-aspartyl mésochlorine e₆.
  12. Utilisation d'un composé préparé selon le procédé des revendications 1 à 11, pour la préparation d'une composition pharmaceutique pour la détection et le traitement de tumeurs et de tissus cancéreux dans le corps humain ou animal.
HK90894A 1984-07-18 1994-09-01 Tetrapyrrole compounds and process for the production of same and a pharmaceutical composition containing same HK90894A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/631,925 US4675338A (en) 1984-07-18 1984-07-18 Tetrapyrrole therapeutic agents
US06/728,784 US4693885A (en) 1984-07-18 1985-04-30 Tetrapyrrole therapeutic agents

Publications (1)

Publication Number Publication Date
HK90894A true HK90894A (en) 1994-09-09

Family

ID=27091504

Family Applications (1)

Application Number Title Priority Date Filing Date
HK90894A HK90894A (en) 1984-07-18 1994-09-01 Tetrapyrrole compounds and process for the production of same and a pharmaceutical composition containing same

Country Status (9)

Country Link
US (1) US4693885A (fr)
EP (1) EP0168831B1 (fr)
AT (1) ATE67505T1 (fr)
AU (1) AU592058B2 (fr)
CA (1) CA1264740C (fr)
DE (1) DE3584120D1 (fr)
DK (1) DK167769B1 (fr)
HK (1) HK90894A (fr)
NO (1) NO169291C (fr)

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Also Published As

Publication number Publication date
AU4515985A (en) 1986-01-23
ATE67505T1 (de) 1991-10-15
DK326885D0 (da) 1985-07-18
EP0168831A3 (en) 1988-05-04
NO852872L (no) 1986-01-20
DK326885A (da) 1986-01-19
EP0168831B1 (fr) 1991-09-18
NO169291B (no) 1992-02-24
CA1264740A (fr) 1990-01-23
US4693885A (en) 1987-09-15
DE3584120D1 (de) 1991-10-24
EP0168831A2 (fr) 1986-01-22
CA1264740C (fr) 1990-01-23
NO169291C (no) 1992-06-03
AU592058B2 (en) 1990-01-04
DK167769B1 (da) 1993-12-13

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Effective date: 20050717