HRP20000377A2 - Novel urethanes derived from azacycloalkanes,their thio and dithio analogues, their salts, pharmaceutical preparations containing the indicated compounds and their use and preparation processes - Google Patents

Novel urethanes derived from azacycloalkanes,their thio and dithio analogues, their salts, pharmaceutical preparations containing the indicated compounds and their use and preparation processes Download PDF

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Publication number
HRP20000377A2
HRP20000377A2 HR20000377A HRP20000377A HRP20000377A2 HR P20000377 A2 HRP20000377 A2 HR P20000377A2 HR 20000377 A HR20000377 A HR 20000377A HR P20000377 A HRP20000377 A HR P20000377A HR P20000377 A2 HRP20000377 A2 HR P20000377A2
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HR
Croatia
Prior art keywords
denotes
group
atom
general formula
compounds
Prior art date
Application number
HR20000377A
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English (en)
Croatian (hr)
Inventor
Roland Maier
Peter Mueller
Gebhard Schilcher
Gebhard Adelgoss
Rudolf Hurnaus
Michael Mark
Bernhard Eisele
Original Assignee
Boehringer Ingelheim Pharma
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Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of HRP20000377A2 publication Critical patent/HRP20000377A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Birds (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR20000377A 1997-12-10 1998-12-08 Novel urethanes derived from azacycloalkanes,their thio and dithio analogues, their salts, pharmaceutical preparations containing the indicated compounds and their use and preparation processes HRP20000377A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19754796A DE19754796A1 (de) 1997-12-10 1997-12-10 Neue, von Azacycloalkanen abgeleitete Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
PCT/EP1998/007965 WO1999029669A1 (fr) 1997-12-10 1998-12-08 Urethanes derives d'azacycloalcanes, leurs analogues thio et dithio, leur production et leur utilisation comme inhibiteurs de la 2,3-epoxysqualene-lanosterol-cyclase

Publications (1)

Publication Number Publication Date
HRP20000377A2 true HRP20000377A2 (en) 2000-12-31

Family

ID=7851381

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000377A HRP20000377A2 (en) 1997-12-10 1998-12-08 Novel urethanes derived from azacycloalkanes,their thio and dithio analogues, their salts, pharmaceutical preparations containing the indicated compounds and their use and preparation processes

Country Status (27)

Country Link
EP (1) EP1060162B1 (fr)
JP (1) JP3418688B2 (fr)
KR (1) KR20010032977A (fr)
CN (1) CN1281434A (fr)
AR (1) AR017827A1 (fr)
AT (1) ATE234816T1 (fr)
AU (1) AU1759499A (fr)
BG (1) BG104500A (fr)
BR (1) BR9813495A (fr)
CA (1) CA2309388A1 (fr)
CO (1) CO5370694A1 (fr)
DE (2) DE19754796A1 (fr)
DK (1) DK1060162T3 (fr)
EA (1) EA200000631A1 (fr)
EE (1) EE200000342A (fr)
ES (1) ES2190130T3 (fr)
HR (1) HRP20000377A2 (fr)
HU (1) HUP0100335A3 (fr)
IL (1) IL135738A0 (fr)
NO (1) NO20002967L (fr)
PL (1) PL341060A1 (fr)
PT (1) PT1060162E (fr)
SK (1) SK8612000A3 (fr)
TR (1) TR200001635T2 (fr)
WO (1) WO1999029669A1 (fr)
YU (1) YU35600A (fr)
ZA (1) ZA9811262B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055495A1 (fr) * 2001-01-15 2002-07-18 Glaxo Group Limited Derives aryle de piperidine comme inducteurs de l'expression du recepteur ldl
WO2002055497A1 (fr) * 2001-01-15 2002-07-18 Glaxo Group Limited Derives d'arylepiperidine utilises comme inducteurs d'expression de ldl
JP2004520347A (ja) * 2001-01-15 2004-07-08 グラクソ　グループ　リミテッド Ｌｄｌ−受容体発現のインデューサーとしてのアリールピペリジンおよびピペラジン誘導体
DE10132686A1 (de) * 2001-07-05 2003-01-16 Boehringer Ingelheim Pharma Heteroarylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
JP4664634B2 (ja) * 2003-09-05 2011-04-06 富山化学工業株式会社 新規なベンズアミジン誘導体またはその塩

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04312572A (ja) * 1991-04-12 1992-11-04 Takeda Chem Ind Ltd 環状アミン化合物
DE4407138A1 (de) 1994-03-04 1995-09-07 Thomae Gmbh Dr K Aryliden-1-azacycloalkane und Arylalkyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
DE4407136A1 (de) 1994-03-04 1995-09-07 Thomae Gmbh Dr K Aroyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
AR017827A1 (es) 2001-10-24
ATE234816T1 (de) 2003-04-15
WO1999029669A1 (fr) 1999-06-17
CN1281434A (zh) 2001-01-24
BG104500A (bg) 2001-03-30
BR9813495A (pt) 2000-10-10
ZA9811262B (en) 2000-06-09
DE59807591D1 (de) 2003-04-24
JP3418688B2 (ja) 2003-06-23
HUP0100335A3 (en) 2001-11-28
CO5370694A1 (es) 2004-02-27
PL341060A1 (en) 2001-03-26
TR200001635T2 (tr) 2000-11-21
PT1060162E (pt) 2003-08-29
AU1759499A (en) 1999-06-28
SK8612000A3 (en) 2000-11-07
NO20002967D0 (no) 2000-06-09
EP1060162B1 (fr) 2003-03-19
EP1060162A1 (fr) 2000-12-20
DE19754796A1 (de) 1999-06-17
NO20002967L (no) 2000-08-09
IL135738A0 (en) 2001-05-20
EE200000342A (et) 2001-08-15
DK1060162T3 (da) 2003-07-14
HUP0100335A2 (hu) 2001-07-30
JP2001525397A (ja) 2001-12-11
YU35600A (sh) 2002-09-19
CA2309388A1 (fr) 1999-06-17
EA200000631A1 (ru) 2000-12-25
KR20010032977A (ko) 2001-04-25
ES2190130T3 (es) 2003-07-16

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