HRP20000739A2 - sPLA<->2<P> INHIBITOR COMPOUNDS FOR TREATMENT OF DISEASE - Google Patents
sPLA<->2<P> INHIBITOR COMPOUNDS FOR TREATMENT OF DISEASE Download PDFInfo
- Publication number
- HRP20000739A2 HRP20000739A2 HR20000739A HRP20000739A HRP20000739A2 HR P20000739 A2 HRP20000739 A2 HR P20000739A2 HR 20000739 A HR20000739 A HR 20000739A HR P20000739 A HRP20000739 A HR P20000739A HR P20000739 A2 HRP20000739 A2 HR P20000739A2
- Authority
- HR
- Croatia
- Prior art keywords
- amino
- oxy
- indol
- dioxoethyl
- group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8387498P | 1998-05-01 | 1998-05-01 | |
| PCT/US1999/008654 WO1999057100A1 (en) | 1998-05-01 | 1999-04-20 | Spla2 inhibitor compounds for treatment of disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20000739A2 true HRP20000739A2 (en) | 2001-10-31 |
Family
ID=22181224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20000739A HRP20000739A2 (en) | 1998-05-01 | 1999-04-20 | sPLA<->2<P> INHIBITOR COMPOUNDS FOR TREATMENT OF DISEASE |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6340699B1 (cs) |
| EP (1) | EP1084108A4 (cs) |
| JP (1) | JP2002513783A (cs) |
| KR (1) | KR20010043190A (cs) |
| CN (1) | CN1299348A (cs) |
| AU (1) | AU3656299A (cs) |
| BR (1) | BR9910095A (cs) |
| CA (1) | CA2330856A1 (cs) |
| CZ (1) | CZ20004052A3 (cs) |
| EA (1) | EA200001140A1 (cs) |
| HR (1) | HRP20000739A2 (cs) |
| HU (1) | HUP0102243A2 (cs) |
| ID (1) | ID27153A (cs) |
| IL (1) | IL139019A0 (cs) |
| NO (1) | NO20005479L (cs) |
| PL (1) | PL343708A1 (cs) |
| SK (1) | SK16342000A3 (cs) |
| TR (1) | TR200003194T2 (cs) |
| WO (1) | WO1999057100A1 (cs) |
| ZA (1) | ZA200005563B (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
| WO2001055108A2 (en) * | 2000-01-25 | 2001-08-02 | Eli Lilly And Company | Use of spl a2 inhibitors for the treatment of inflammation |
| JPWO2002000621A1 (ja) | 2000-06-29 | 2004-04-22 | 塩野義製薬株式会社 | Ｘ型ｓＰＬＡ２阻害作用を有する化合物 |
| AU2002224531B2 (en) * | 2000-07-24 | 2005-08-25 | Dow Global Technologies Inc. | Thermoplastic superabsorbent polymer blend compositions and their preparation |
| CA2627353A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Indole compounds having c4-acidic substituents and use thereof as phospholipase-a2 inhibitors |
| CN101983188A (zh) * | 2008-04-01 | 2011-03-02 | 安斯泰来制药有限公司 | 吲哚啉酮化合物 |
| NZ720946A (en) | 2009-04-29 | 2017-09-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| US9290752B2 (en) | 2013-03-13 | 2016-03-22 | Sunny Delight Beverages Co. | Process for enhancing the amylase inhibitory efficacy from phaseolus vulgaris extracts |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356919A (en) | 1991-05-30 | 1994-10-18 | G. D. Searle & Co. | Leukotriene B4 synthesis inhibitors |
| DE4218096A1 (de) | 1992-06-02 | 1993-12-09 | Boehringer Mannheim Gmbh | Spiro-oxetane, Verfahren zu ihrer Herstellung und Arzneimittel |
| DE4323409A1 (de) | 1993-07-13 | 1995-01-19 | Boehringer Mannheim Gmbh | Verwendung von Cumarinen und Carbostyrilen als PLA¶2¶-Inhibitoren, neue Cumarine und Carbostyrile, Verfahren zu ihrer Herstellung und Arzneimittel |
| JP3109974B2 (ja) * | 1994-04-01 | 2000-11-20 | イーライ・リリー・アンド・カンパニー | １Ｈ−インドール−３−グリオキシルアミドｓＰＬＡ２阻害剤 |
| WO1995033462A1 (en) * | 1994-06-02 | 1995-12-14 | Smithkline Beecham Corporation | Anti-inflammatory compounds |
| NZ298145A (en) | 1994-12-29 | 1998-08-26 | Yamanouchi Pharma Co Ltd | Monoclonal antibodies having inhibitory effect on type ii phospholipase a2, proteins forming part thereof, cells producing them, dna encoding them, recombinant vector comprising the dna and medicament |
| KR20000049210A (ko) | 1996-10-30 | 2000-07-25 | 피터 지. 스트링거 | 치환된 트리시클릭류 |
| PL343007A1 (en) * | 1998-02-25 | 2001-07-30 | Genetics Inst | Inhibitors of phospholipase enzymes |
-
1999
- 1999-04-20 TR TR2000/03194T patent/TR200003194T2/xx unknown
- 1999-04-20 PL PL99343708A patent/PL343708A1/xx unknown
- 1999-04-20 KR KR1020007012113A patent/KR20010043190A/ko not_active Withdrawn
- 1999-04-20 EA EA200001140A patent/EA200001140A1/ru unknown
- 1999-04-20 ID IDW20002214A patent/ID27153A/id unknown
- 1999-04-20 CN CN99805675A patent/CN1299348A/zh active Pending
- 1999-04-20 JP JP2000547070A patent/JP2002513783A/ja not_active Withdrawn
- 1999-04-20 SK SK1634-2000A patent/SK16342000A3/sk unknown
- 1999-04-20 IL IL13901999A patent/IL139019A0/xx unknown
- 1999-04-20 HR HR20000739A patent/HRP20000739A2/hr not_active Application Discontinuation
- 1999-04-20 BR BR9910095-9A patent/BR9910095A/pt not_active Application Discontinuation
- 1999-04-20 WO PCT/US1999/008654 patent/WO1999057100A1/en not_active Ceased
- 1999-04-20 HU HU0102243A patent/HUP0102243A2/hu unknown
- 1999-04-20 EP EP99918711A patent/EP1084108A4/en not_active Withdrawn
- 1999-04-20 AU AU36562/99A patent/AU3656299A/en not_active Abandoned
- 1999-04-20 CA CA002330856A patent/CA2330856A1/en not_active Abandoned
- 1999-04-20 CZ CZ20004052A patent/CZ20004052A3/cs unknown
- 1999-04-20 US US09/673,675 patent/US6340699B1/en not_active Expired - Fee Related
-
2000
- 2000-10-10 ZA ZA200005563A patent/ZA200005563B/en unknown
- 2000-10-31 NO NO20005479A patent/NO20005479L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6340699B1 (en) | 2002-01-22 |
| EA200001140A1 (ru) | 2001-04-23 |
| WO1999057100A1 (en) | 1999-11-11 |
| EP1084108A1 (en) | 2001-03-21 |
| KR20010043190A (ko) | 2001-05-25 |
| CN1299348A (zh) | 2001-06-13 |
| IL139019A0 (en) | 2001-11-25 |
| CA2330856A1 (en) | 1999-11-11 |
| SK16342000A3 (sk) | 2002-04-04 |
| EP1084108A4 (en) | 2005-01-12 |
| JP2002513783A (ja) | 2002-05-14 |
| ID27153A (id) | 2001-03-08 |
| PL343708A1 (en) | 2001-08-27 |
| NO20005479L (no) | 2000-12-20 |
| BR9910095A (pt) | 2000-12-26 |
| TR200003194T2 (tr) | 2001-03-21 |
| HUP0102243A2 (hu) | 2001-10-28 |
| AU3656299A (en) | 1999-11-23 |
| ZA200005563B (en) | 2002-01-10 |
| NO20005479D0 (no) | 2000-10-31 |
| CZ20004052A3 (cs) | 2002-05-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4313819B2 (ja) | 治療におけるｃｒｔｈ２アンタゴニストの使用 | |
| JP2000516251A (ja) | １，３―ジヘテロ環式メタロプロテアーゼ阻害剤類 | |
| AU688458B2 (en) | 1H-indole-3-glyoxylamide sPLA2 inhibitors | |
| JP2000515166A (ja) | 複素環式メタロプロテアーゼ阻害剤 | |
| JP2000515167A (ja) | 基質メタロプロテアーゼ インヒビターとしてのホスフィン酸アミド | |
| JPH11502523A (ja) | ラクタム含有ヒドロキサム酸誘導体、その製造およびメタロプロテアーゼ基質の阻害剤としての使用 | |
| US9199917B2 (en) | N-substituted benzenepropanamide or benzenepropenamide derivatives for use in the treatment of pain and inflammation | |
| JP2013527124A (ja) | オピオイドの新規カルバマートアミノ酸およびペプチドプロドラッグならびにその使用 | |
| CN101282718A (zh) | 脱乙酰酶抑制剂的使用方法 | |
| US6340699B1 (en) | SPLA2 inhibitor compounds for treatment of disease | |
| US20010056112A1 (en) | Synthetic compounds for treatment of inflammation | |
| US6436983B1 (en) | Treatment for alzheimer's disease | |
| WO2001058489A1 (en) | Preventives/remedies for postoperative stress | |
| US20030087944A1 (en) | Method for the treatment of renal dysfunction with spla2 inhibitors | |
| JP2001520991A (ja) | インドールｓＰＬＡ２阻害剤のＮ，Ｎ−ジエチルグリコールアミドエステルプロドラッグ | |
| JP4564669B2 (ja) | インドールｓＰＬＡ２インヒビターのモルホリノ−Ｎ−エチルエステル誘導体 | |
| MXPA00010463A (en) | Spla2 | |
| SK161197A3 (en) | Use of pyrrolidine derivatives for treating alcoholism | |
| US6589975B2 (en) | Synthetic compounds for treatment of inflammation | |
| CN114340672A (zh) | 包含hdac抑制剂和抗pd1抗体或抗pd-l1抗体的药物组合物 | |
| CN115605455B (zh) | 酮洛芬、赖氨酸和加巴喷丁的共晶、药物组合物及其医药用途 | |
| RU2675237C1 (ru) | Соединение (6-{ [(1S)-1(5-фтор-4-оксо-3-фенил-3,4-дигидрохиназолин-2-ил)пропил]амино} -9Н-пурин-9-ил)метилацетат как ингибитор p110δ - дельта-изоформы фосфоинозитид-3-киназы (PI3K), способы его получения (варианты) и применения | |
| JP2025533120A (ja) | イミダゾリジニルバニリン酸エーテル誘導体の線維化を伴う疾患の治療における使用 | |
| CN101264082B (zh) | 治疗胃损伤的化合物 | |
| HK40072774A (en) | Pharmaceutical composition comprising hdac inhibitor and anti-pd1 antibody or anti pd-l1 antibody |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| OBST | Application withdrawn |