HRP20010301A2 - New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases - Google Patents

New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases Download PDF

Info

Publication number: HRP20010301A2
Authority: HR; Croatia
Prior art keywords: acid; use according; azithromycin; agents; active ingredient
Prior art date: 2001-04-27

Application number

HR20010301A

Other languages

English (en)

Croatian (hr)

Inventor

Ulić Ognjen

Eraković Vesna

Parnham Michael

Original Assignee

Pliva D D

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-27

Filing date

2001-04-27

Publication date

2001-12-31

2001-04-27 Application filed by Pliva D D filed Critical Pliva D D

2001-04-27 Priority to HR20010301A priority Critical patent/HRP20010301A2/hr

2001-12-31 Publication of HRP20010301A2 publication Critical patent/HRP20010301A2/hr

2002-04-10 Priority to BR0209276-0A priority patent/BR0209276A/pt

2002-04-10 Priority to MXPA03009849A priority patent/MXPA03009849A/es

2002-04-10 Priority to SK13352003A priority patent/SK13352003A3/sk

2002-04-10 Priority to US10/476,377 priority patent/US20050054587A1/en

2002-04-10 Priority to CNA028089162A priority patent/CN1582158A/zh

2002-04-10 Priority to PCT/EP2002/003984 priority patent/WO2002087596A2/en

2002-04-10 Priority to YU84503A priority patent/YU84503A/sh

2002-04-10 Priority to IL15823602A priority patent/IL158236A0/xx

2002-04-10 Priority to CZ20032932A priority patent/CZ20032932A3/cs

2002-04-10 Priority to EA200301187A priority patent/EA200301187A1/ru

2002-04-10 Priority to JP2002584941A priority patent/JP2004531539A/ja

2002-04-10 Priority to EP02737939A priority patent/EP1392327A2/en

2002-04-10 Priority to CA002443381A priority patent/CA2443381A1/en

2002-04-10 Priority to PL02364086A priority patent/PL364086A1/xx

2002-04-10 Priority to HU0303988A priority patent/HUP0303988A2/hu

2002-04-26 Priority to ARP020101524A priority patent/AR034223A1/es

2003-10-23 Priority to BG108286A priority patent/BG108286A/bg

2003-11-17 Priority to ZA200308933A priority patent/ZA200308933B/en

Links

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AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
229940001474 sodium thiosulfate Drugs 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
229960001294 spiramycin Drugs 0.000 description 1
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235000019372 spiramycin Nutrition 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000003206 sterilizing agent Substances 0.000 description 1
229940041030 streptogramins Drugs 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
150000003900 succinic acid esters Chemical class 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
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238000012360 testing method Methods 0.000 description 1
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229960000984 tocofersolan Drugs 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
238000012546 transfer Methods 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
230000003827 upregulation Effects 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
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230000002792 vascular Effects 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
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239000011709 vitamin E Substances 0.000 description 1
239000002676 xenobiotic agent Substances 0.000 description 1
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239000002076 α-tocopherol Substances 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

HR20010301A 2001-04-27 2001-04-27 New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases HRP20010301A2 (en)

Priority Applications (19)

Application Number	Priority Date	Filing Date	Title
HR20010301A HRP20010301A2 (en)	2001-04-27	2001-04-27	New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
HU0303988A HUP0303988A2 (hu)	2001-04-27	2002-04-10	Azitromicin alkalmzása nem fertőző gyulladásos betegségek kezelésére szolgáló gyógyszerkészítmény előállítására
IL15823602A IL158236A0 (en)	2001-04-27	2002-04-10	Pharmaceutical compositions containing azithromycin and derivatives thereof
EA200301187A EA200301187A1 (ru)	2001-04-27	2002-04-10	Применение азитромицина для производства лекарственного средства для лечения неинфекционных воспалительных заболеваний
SK13352003A SK13352003A3 (en)	2001-04-27	2002-04-10	Use of azithromycin for the manufacture of a medicament for treatment of non-infective inflammatory diseases
US10/476,377 US20050054587A1 (en)	2001-04-27	2002-04-10	Novel therapeutic indication of azithromycin for treatment of non-infective inflamatory diseases
CNA028089162A CN1582158A (zh)	2001-04-27	2002-04-10	阿奇霉素用于生产治疗非感染性炎症疾病的药物的用途
PCT/EP2002/003984 WO2002087596A2 (en)	2001-04-27	2002-04-10	Use of azithromycin for the manufacture of a medicament for treatment of non-infective inflammatory diseases
YU84503A YU84503A (sh)	2001-04-27	2002-04-10	Upotreba azitromicina za pripremanje leka za lečenje neinfektivnih inflamatornih oboljenja
BR0209276-0A BR0209276A (pt)	2001-04-27	2002-04-10	Uso da azitromicina para a preparação de um medicamento para tratamento de doenças inflamatórias não infecciosas
CZ20032932A CZ20032932A3 (cs)	2001-04-27	2002-04-10	Nová terapeutická indikace azithromycinu pro léčení neinfekčních zánětlivých nemocí
MXPA03009849A MXPA03009849A (es)	2001-04-27	2002-04-10	Uso de azitromicina para la fabricacion de un medicamento para el tratamiento de enfermedades inflamatorias no infecciosas.
JP2002584941A JP2004531539A (ja)	2001-04-27	2002-04-10	非感染性炎症性疾患を治療するためのアジスロマイシンの新規治療適応
EP02737939A EP1392327A2 (en)	2001-04-27	2002-04-10	Use of azithromycin for the manufacture of a medicament for treatment of non-infective inflammatory diseases
CA002443381A CA2443381A1 (en)	2001-04-27	2002-04-10	Use of azithromycin for the manufacture of a medicament for treatment of non-infective inflammatory diseases
PL02364086A PL364086A1 (en)	2001-04-27	2002-04-10	Use of azithromycin for the manufacture of a medicament for treatment of non-infective inflammatory diseases
ARP020101524A AR034223A1 (es)	2001-04-27	2002-04-26	Novedosa indicacion terapeutica de azitromicina para el tratamiento de enfermedades inflamatorias no infecciosas
BG108286A BG108286A (bg)	2001-04-27	2003-10-23	Използване на азитромицин за получаване на фармацевтично средство за лечение на възпалителни неинфекциозни заболявания
ZA200308933A ZA200308933B (en)	2001-04-27	2003-11-17	Use of azithromycin for the manufacture of a medicament for treatment of non-infective inflammatory diseases.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR20010301A HRP20010301A2 (en)	2001-04-27	2001-04-27	New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases

Publications (1)

Publication Number	Publication Date
HRP20010301A2 true HRP20010301A2 (en)	2001-12-31

Family

ID=10947306

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20010301A HRP20010301A2 (en)	2001-04-27	2001-04-27	New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases

Country Status (19)

Country	Link
US (1)	US20050054587A1 (cs)
EP (1)	EP1392327A2 (cs)
JP (1)	JP2004531539A (cs)
CN (1)	CN1582158A (cs)
AR (1)	AR034223A1 (cs)
BG (1)	BG108286A (cs)
BR (1)	BR0209276A (cs)
CA (1)	CA2443381A1 (cs)
CZ (1)	CZ20032932A3 (cs)
EA (1)	EA200301187A1 (cs)
HR (1)	HRP20010301A2 (cs)
HU (1)	HUP0303988A2 (cs)
IL (1)	IL158236A0 (cs)
MX (1)	MXPA03009849A (cs)
PL (1)	PL364086A1 (cs)
SK (1)	SK13352003A3 (cs)
WO (1)	WO2002087596A2 (cs)
YU (1)	YU84503A (cs)
ZA (1)	ZA200308933B (cs)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020231A2 (en)	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
HRP20020614A2 (en)	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB0315671D0 (en)	2003-07-04	2003-08-13	Chelsea And Westminster Nhs Tr	Improvements in or relating to organic compounds
JP2007516951A (ja) *	2003-12-30	2007-06-28	アステラス製薬株式会社	気道閉塞症の治療または予防のためのマクロライドの使用
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
WO2006115494A1 (en) *	2005-04-26	2006-11-02	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
JP3933683B2 (ja)	2004-07-02	2007-06-20	わかもと製薬株式会社	アジスロマイシン含有水性医薬組成物及びその調製方法
WO2006097849A1 (en) *	2005-01-14	2006-09-21	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	9a-carbamoyl and thiocarbamoyl azalides with anti-inflammatory activity
US20060293261A1 (en)	2005-06-24	2006-12-28	Taisho Pharmaceutical Co., Ltd.	Clarithromycin or a salt thereof for the treatment or prevention of pulmonary disorders caused by the destruction of pulmonary alveoli
EP2010153A2 (en) *	2006-04-03	2009-01-07	Teva Pharmaceutical Industries Limited	Drug microparticles
RU2455308C2 (ru)	2006-05-01	2012-07-10	Тайсо Фармасьютикал Ко., Лтд.	Макролидные производные
US7704959B2 (en) *	2006-10-03	2010-04-27	Dow Pharmaceutical Sciences	Azithromycin for the treatment of nodular acne
JP2011527709A (ja) *	2008-07-10	2011-11-04	インスパイアーファーマシューティカルズ，インコーポレイティド	眼瞼炎の治療方法
WO2010062787A1 (en)	2008-11-03	2010-06-03	Washington University	Bioluminescence imaging of myeloperoxidase activity in vivo, methods, compositions and apparatuses therefor
EP2393355A4 (en) *	2009-01-23	2012-07-25	Inspire Pharmaceuticals Inc	METHOD FOR TREATING A DRY EYE WITH AZITHROMYCIN
CN102378763A (zh)	2009-01-30	2012-03-14	葛兰素集团有限公司	消炎的大环内酯
WO2011116312A1 (en) *	2010-03-19	2011-09-22	Catabasis Pharmaceuticals, Inc.	Fatty acid macrolide derivatives and their uses
WO2017010382A1 (ja) *	2015-07-14	2017-01-19	国立大学法人大阪大学	筋強直性ジストロフィー治療薬
CN113209084A (zh) *	2021-05-18	2021-08-06	南开大学	化合物cp0119在制备用于治疗炎性肠病的药物中的应用
WO2025235305A1 (en)	2024-05-06	2025-11-13	Baxter International Inc.	Azithromycin premix formulation and product, methods of preparing same, and methods of using same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU43116B (en) *	1979-04-02	1989-04-30	Pliva Pharm & Chem Works	Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
SI8110592A8 (en) *	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
YU45590A (sh) *	1990-03-07	1992-07-20	PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o.	Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje
SI9011409A (en) *	1990-07-18	1995-10-31	Pliva Pharm & Chem Works	O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
AU7957994A (en) *	1993-10-01	1995-05-01	Procter & Gamble Company, The	Use of azithromycin for the treatment of adult periodontitis and topical compositions for this use
US5605889A (en) *	1994-04-29	1997-02-25	Pfizer Inc.	Method of administering azithromycin
HUT77530A (hu) *	1994-05-06	1998-05-28	Pfizer Inc.	Azitromicint tartalmazó, szabályozott hatóanyag-felszabadítású dózisformák
GB9723669D0 (en) *	1997-11-07	1998-01-07	Univ Aberdeen	Skin penetration enhancing components
DE19850445A1 (de) *	1998-11-02	2000-05-04	Falk Pharma Gmbh	Arzneimittel zur topischen Behandlung entzündlicher Darmerkrankungen
AU5820400A (en) *	1999-06-29	2001-01-31	Biochemie S.A.	Macrolides
IT1313610B1 (it) *	1999-08-09	2002-09-09	S I F I Societa Ind Farmaceuti	Processo per la preparazione di formulazioni acquose per uso oftalmico
IL141438A0 (en) *	2000-02-23	2002-03-10	Pfizer Prod Inc	Method of increasing the bioavailability and tissue penetration of azithromycin

2001
- 2001-04-27 HR HR20010301A patent/HRP20010301A2/hr not_active Application Discontinuation
2002
- 2002-04-10 SK SK13352003A patent/SK13352003A3/sk not_active Application Discontinuation
- 2002-04-10 CN CNA028089162A patent/CN1582158A/zh active Pending
- 2002-04-10 EA EA200301187A patent/EA200301187A1/ru unknown
- 2002-04-10 YU YU84503A patent/YU84503A/sh unknown
- 2002-04-10 PL PL02364086A patent/PL364086A1/xx not_active Application Discontinuation
- 2002-04-10 MX MXPA03009849A patent/MXPA03009849A/es unknown
- 2002-04-10 US US10/476,377 patent/US20050054587A1/en not_active Abandoned
- 2002-04-10 HU HU0303988A patent/HUP0303988A2/hu unknown
- 2002-04-10 WO PCT/EP2002/003984 patent/WO2002087596A2/en not_active Ceased
- 2002-04-10 JP JP2002584941A patent/JP2004531539A/ja active Pending
- 2002-04-10 CZ CZ20032932A patent/CZ20032932A3/cs unknown
- 2002-04-10 EP EP02737939A patent/EP1392327A2/en not_active Withdrawn
- 2002-04-10 IL IL15823602A patent/IL158236A0/xx unknown
- 2002-04-10 CA CA002443381A patent/CA2443381A1/en not_active Abandoned
- 2002-04-10 BR BR0209276-0A patent/BR0209276A/pt not_active IP Right Cessation
- 2002-04-26 AR ARP020101524A patent/AR034223A1/es unknown
2003
- 2003-10-23 BG BG108286A patent/BG108286A/bg unknown
- 2003-11-17 ZA ZA200308933A patent/ZA200308933B/en unknown

Also Published As

Publication number	Publication date
CA2443381A1 (en)	2002-11-07
YU84503A (sh)	2006-08-17
IL158236A0 (en)	2004-05-12
WO2002087596A2 (en)	2002-11-07
PL364086A1 (en)	2004-12-13
CN1582158A (zh)	2005-02-16
SK13352003A3 (en)	2004-10-05
WO2002087596A3 (en)	2003-01-03
JP2004531539A (ja)	2004-10-14
EA200301187A1 (ru)	2004-04-29
EP1392327A2 (en)	2004-03-03
ZA200308933B (en)	2004-11-17
BR0209276A (pt)	2004-06-15
MXPA03009849A (es)	2004-05-24
BG108286A (bg)	2004-09-30
HUP0303988A2 (hu)	2004-04-28
US20050054587A1 (en)	2005-03-10
AR034223A1 (es)	2004-02-04
CZ20032932A3 (cs)	2004-08-18

Legal Events

Date	Code	Title	Description
2001-12-31	A1OB	Publication of a patent application
2002-05-16	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2005-03-09	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20050309 Year of fee payment: 4
2008-02-07	ODBI	Application refused

Publication	Publication Date	Title
HRP20010301A2 (en)	2001-12-31	New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
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