HRP20010455A2 - Il-5 inhibiting 6-azauracil derivatives - Google Patents

Il-5 inhibiting 6-azauracil derivatives Download PDF

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Publication number
HRP20010455A2
HRP20010455A2 HR20010455A HRP20010455A HRP20010455A2 HR P20010455 A2 HRP20010455 A2 HR P20010455A2 HR 20010455 A HR20010455 A HR 20010455A HR P20010455 A HRP20010455 A HR P20010455A HR P20010455 A2 HRP20010455 A2 HR P20010455A2
Authority
HR
Croatia
Prior art keywords
alkyl
substituted
formula
alkyloxy
phenyl
Prior art date
Application number
HR20010455A
Other languages
English (en)
Croatian (hr)
Inventor
Eddy Jean Edgard Freyne
Frederik
Jean
Werner
Jerome
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HRP20010455A2 publication Critical patent/HRP20010455A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HR20010455A 1998-12-18 1999-12-16 Il-5 inhibiting 6-azauracil derivatives HRP20010455A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98204336 1998-12-18
PCT/EP1999/010169 WO2000037451A1 (en) 1998-12-18 1999-12-16 Il-5 inhibiting 6-azauracil derivatives

Publications (1)

Publication Number Publication Date
HRP20010455A2 true HRP20010455A2 (en) 2002-06-30

Family

ID=8234494

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010455A HRP20010455A2 (en) 1998-12-18 1999-12-16 Il-5 inhibiting 6-azauracil derivatives

Country Status (35)

Country Link
US (1) US6803364B1 (da)
EP (1) EP1140873B1 (da)
JP (1) JP2002533331A (da)
KR (1) KR100635721B1 (da)
CN (1) CN100343239C (da)
AR (1) AR021887A1 (da)
AT (1) ATE365723T1 (da)
AU (1) AU773780B2 (da)
BG (1) BG105602A (da)
BR (1) BR9916366A (da)
CA (1) CA2354511A1 (da)
CO (1) CO5150147A1 (da)
CZ (1) CZ20012062A3 (da)
DE (1) DE69936396T2 (da)
DK (1) DK1140873T3 (da)
EA (1) EA004806B1 (da)
EE (1) EE200100320A (da)
ES (1) ES2289835T3 (da)
HK (1) HK1042491A1 (da)
HR (1) HRP20010455A2 (da)
HU (1) HUP0104641A3 (da)
ID (1) ID28880A (da)
IL (1) IL143766A (da)
MY (1) MY125808A (da)
NO (1) NO319814B1 (da)
NZ (1) NZ512748A (da)
PL (1) PL198205B1 (da)
PT (1) PT1140873E (da)
SA (1) SA00201030B1 (da)
SK (1) SK8152001A3 (da)
TR (1) TR200101729T2 (da)
TW (1) TWI249530B (da)
UA (1) UA73107C2 (da)
WO (1) WO2000037451A1 (da)
ZA (1) ZA200104942B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8466096B2 (en) * 2007-04-26 2013-06-18 Afton Chemical Corporation 1,3,2-dioxaphosphorinane, 2-sulfide derivatives for use as anti-wear additives in lubricant compositions
RU2523651C2 (ru) * 2012-05-22 2014-07-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Владивостокский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ВГМУ Минздравсоцразвития России) Способ дифференцированного контроля базисного противовоспалительного лечения бронхиальной астмы у детей и подростков
RU2506045C1 (ru) * 2012-09-05 2014-02-10 Федеральное государственное бюджетное учреждение "Дальневосточный научный центр физиологии и патологии дыхания" Сибирского отделения РАМН Способ прогнозирования достижения контроля бронхиальной астмы
CN119161311B (zh) * 2024-11-20 2025-02-11 北京纳百生物科技有限公司 一种地克珠利抗原及其合成方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2149645A1 (de) 1970-10-07 1972-09-14 Pfizer 2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose
US3912723A (en) 1971-03-29 1975-10-14 Pfizer 2-Phenyl-as-triazine-3,5(2H,4H)diones
US3883528A (en) 1974-04-19 1975-05-13 Pfizer Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats
US4631278A (en) 1984-08-01 1986-12-23 Janssen Pharmaceutica N.V. Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor
CA1244024A (en) 1984-08-01 1988-11-01 Gustaaf M. Boeckx .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES
GB8602342D0 (en) 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
CA1331757C (en) 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
EP0476439A1 (de) 1990-09-18 1992-03-25 Bayer Ag Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
DE4120138A1 (de) 1991-06-19 1992-12-24 Bayer Ag Substituierte hexahydro-1,2,4-triazindione, verfahren zu ihrer herstellung, zwischenprodukte dafuer und ihre verwendung
TW263495B (da) 1992-12-23 1995-11-21 Celltech Ltd
GB9304920D0 (en) 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
TW403741B (en) 1993-10-15 2000-09-01 Takeda Chemical Industries Ltd Triazine derivative, production and use thereof
TW332201B (en) 1995-04-06 1998-05-21 Janssen Pharmaceutica Nv 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
DE69615601T2 (de) 1995-04-14 2002-07-11 Takeda Schering-Plough Animal Health K.K., Osaka Verfahren zur Herstellung von Triazinderivate
CN1128141C (zh) * 1996-08-30 2003-11-19 武田舍林-普劳动物保健株式会社 1,2,4－三嗪－3,5－二酮衍生物,其制备和用途
BR9811678A (pt) * 1997-07-10 2000-09-19 Janssen Pharmaceutica Nv Derivados de 6-azauracila de inibição de il-5
HRP990333A2 (en) * 1997-07-10 2000-04-30 Janssen Pharmaceutica Nv 6-azauracil derivatives as il-5 inhibitors

Also Published As

Publication number Publication date
CA2354511A1 (en) 2000-06-29
PT1140873E (pt) 2007-10-10
CN1330643A (zh) 2002-01-09
ATE365723T1 (de) 2007-07-15
SA00201030B1 (ar) 2006-10-11
ID28880A (id) 2001-07-12
EP1140873B1 (en) 2007-06-27
JP2002533331A (ja) 2002-10-08
ZA200104942B (en) 2002-06-18
NO20012987D0 (no) 2001-06-15
AU773780B2 (en) 2004-06-03
EE200100320A (et) 2002-10-15
PL198205B1 (pl) 2008-06-30
HUP0104641A2 (hu) 2002-04-29
EP1140873A1 (en) 2001-10-10
HUP0104641A3 (en) 2003-01-28
US6803364B1 (en) 2004-10-12
NO20012987L (no) 2001-08-17
NZ512748A (en) 2004-05-28
IL143766A0 (en) 2002-04-21
AR021887A1 (es) 2002-08-07
HK1042491A1 (zh) 2002-08-16
SK8152001A3 (en) 2002-04-04
DK1140873T3 (da) 2007-10-15
BG105602A (en) 2002-01-31
DE69936396D1 (de) 2007-08-09
CN100343239C (zh) 2007-10-17
CO5150147A1 (es) 2002-04-29
KR100635721B1 (ko) 2006-10-17
TR200101729T2 (tr) 2001-10-22
NO319814B1 (no) 2005-09-19
EA004806B1 (ru) 2004-08-26
BR9916366A (pt) 2001-09-18
KR20010080617A (ko) 2001-08-22
IL143766A (en) 2005-11-20
DE69936396T2 (de) 2008-06-19
MY125808A (en) 2006-08-30
WO2000037451A1 (en) 2000-06-29
TWI249530B (en) 2006-02-21
CZ20012062A3 (cs) 2002-03-13
ES2289835T3 (es) 2008-02-01
UA73107C2 (en) 2005-06-15
AU2100100A (en) 2000-07-12
EA200100677A1 (ru) 2001-12-24

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