HRP20010869A2 - Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives - Google Patents

Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives Download PDF

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Publication number
HRP20010869A2
HRP20010869A2 HR20010869A HRP20010869A HRP20010869A2 HR P20010869 A2 HRP20010869 A2 HR P20010869A2 HR 20010869 A HR20010869 A HR 20010869A HR P20010869 A HRP20010869 A HR P20010869A HR P20010869 A2 HRP20010869 A2 HR P20010869A2
Authority
HR
Croatia
Prior art keywords
formula
alkyl
hydrogen
hydroxy
image
Prior art date
Application number
HR20010869A
Other languages
English (en)
Croatian (hr)
Inventor
Marcel Frans Leopold De Bruyn
Kristof Van Emelen
Piet Tom Bert Paul Wigerinck
Wim Gaston Verschueren
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HRP20010869A2 publication Critical patent/HRP20010869A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR20010869A 1999-06-02 2000-05-23 Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives HRP20010869A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99201746 1999-06-02
PCT/EP2000/004747 WO2000075137A1 (en) 1999-06-02 2000-05-23 Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives

Publications (1)

Publication Number Publication Date
HRP20010869A2 true HRP20010869A2 (en) 2003-08-31

Family

ID=8240259

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010869A HRP20010869A2 (en) 1999-06-02 2000-05-23 Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives

Country Status (30)

Country Link
US (2) US6900222B1 (de)
EP (1) EP1187831B1 (de)
JP (1) JP2003501428A (de)
KR (1) KR100702526B1 (de)
CN (1) CN1131862C (de)
AR (1) AR033645A1 (de)
AT (1) ATE279409T1 (de)
AU (1) AU777601B2 (de)
BG (1) BG65278B1 (de)
BR (1) BR0011247A (de)
CA (1) CA2374905C (de)
CZ (1) CZ20014167A3 (de)
DE (1) DE60014896T2 (de)
EA (1) EA004648B1 (de)
EE (1) EE04720B1 (de)
ES (1) ES2231189T3 (de)
HR (1) HRP20010869A2 (de)
HU (1) HUP0201344A3 (de)
IL (1) IL146824A0 (de)
MX (1) MXPA01012323A (de)
MY (1) MY120617A (de)
NO (1) NO319950B1 (de)
NZ (1) NZ515478A (de)
PL (1) PL198532B1 (de)
SK (1) SK286159B6 (de)
TR (1) TR200103433T2 (de)
TW (1) TW575571B (de)
UA (1) UA73123C2 (de)
WO (1) WO2000075137A1 (de)
ZA (1) ZA200109863B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE04780B1 (et) 1999-06-02 2007-02-15 Janssen Pharmaceutica N.V. Aminoalküül-asendatud bensodioksaani, bensofuraani või bensopüraani derivaadid, nende valmistamismeetod, farmatseutiline kompositsioon ja selle valmistamismeetod
JO2352B1 (en) 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
ATE527247T1 (de) * 2001-07-05 2011-10-15 Takeda Pharmaceutical Benzokondensierte 5gliedrige heterocyclische verbindungen, verfahren zu deren herstellung und deren verwendung
EP1622569B1 (de) 2003-04-24 2015-12-02 Incyte Corporation Aza-spiro-alkan-derivate als hemmer von metallproteasen
CN1696115B (zh) * 2004-05-11 2010-06-09 中国科学院上海药物研究所 合成砌块4-取代基-4-氨基-哌啶衍生物、其制备方法和用途
GB201612938D0 (en) 2016-07-26 2016-09-07 Almac Discovery Ltd Pharmaceutical compounds

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US19051A (en) * 1858-01-05 sloan
US3910930A (en) 1973-01-04 1975-10-07 Janssen Pharmaceutica Nv 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones
US3929801A (en) 1973-11-20 1975-12-30 Janssen Pharmaceutica Nv 2-Benzimidazolinones
GR71865B (de) 1978-03-20 1983-07-07 Ciba Geigy
ES469096A1 (es) 1978-04-24 1978-11-16 Antibioticos Sa Un procedimiento para la preparacion dos sustancialmente insolubles en agua.
DE2852945A1 (de) * 1978-12-07 1980-06-26 Boehringer Sohn Ingelheim Benzodioxanyl-hydroxyaethylpiperidyl- imidazolidinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4329348A (en) * 1979-02-26 1982-05-11 Ciba-Geigy Corporation N-Oxacyclic-alkylpiperidines as psychostimulants
DE3124366A1 (de) 1981-06-20 1982-12-30 Hoechst Ag, 6000 Frankfurt N-oxacyclyl-alkylpiperidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und deren verwendung
FR2533584B1 (fr) 1982-09-28 1986-03-21 Pasteur Institut Procede de detection du pouvoir mutagene de substances, susceptibles d'induire la deterioration d'adn cellulaires, mettant en jeu la production d'une reponse sos
DE3901814A1 (de) 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
DE4140540A1 (de) * 1991-12-09 1993-06-17 Bayer Ag Neue azaheterocyclylmethyl-chromane
SI9300097B (en) 1992-02-27 2001-12-31 Janssen Pharmaceutica Nv (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines
DE4319038A1 (de) * 1993-06-08 1994-12-15 Bayer Ag Verwendung von teilweise bekannten substituierten Chromanen als Arzneimittel, neue Wirkstoffe und Verfahren zu ihrer Herstellung
ES2212797T3 (es) 1993-08-19 2004-08-01 Janssen Pharmaceutica N.V. Derivados de dihidrobenzopirano vasoconstrictores.
US5541199A (en) 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
FR2744451B1 (fr) * 1996-02-01 1998-04-24 Pf Medicament Nouvelles imidazolidinones, pyrimidinones, et 1,3-diazepin-2 -ones, leur preparation et leurs applications en therapeutique
US6133277A (en) * 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
EE04780B1 (et) 1999-06-02 2007-02-15 Janssen Pharmaceutica N.V. Aminoalküül-asendatud bensodioksaani, bensofuraani või bensopüraani derivaadid, nende valmistamismeetod, farmatseutiline kompositsioon ja selle valmistamismeetod
JO2352B1 (en) 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus

Also Published As

Publication number Publication date
KR20010113951A (ko) 2001-12-28
US6900222B1 (en) 2005-05-31
CA2374905A1 (en) 2000-12-14
EE04720B1 (et) 2006-10-16
US20050159406A1 (en) 2005-07-21
CN1353708A (zh) 2002-06-12
AR033645A1 (es) 2004-01-07
MY120617A (en) 2005-11-30
UA73123C2 (en) 2005-06-15
WO2000075137A1 (en) 2000-12-14
EA004648B1 (ru) 2004-06-24
EP1187831B1 (de) 2004-10-13
ZA200109863B (en) 2003-05-28
ES2231189T3 (es) 2005-05-16
NO20015865L (no) 2002-02-01
CZ20014167A3 (cs) 2002-06-12
NO20015865D0 (no) 2001-11-30
US7358239B2 (en) 2008-04-15
HUP0201344A2 (en) 2002-08-28
EP1187831A1 (de) 2002-03-20
ATE279409T1 (de) 2004-10-15
PL352063A1 (en) 2003-07-28
BG65278B1 (bg) 2007-11-30
MXPA01012323A (es) 2002-07-22
IL146824A0 (en) 2002-07-25
DE60014896T2 (de) 2006-02-02
PL198532B1 (pl) 2008-06-30
TW575571B (en) 2004-02-11
HUP0201344A3 (en) 2005-09-28
EA200101237A1 (ru) 2002-04-25
DE60014896D1 (de) 2004-11-18
CA2374905C (en) 2010-02-23
JP2003501428A (ja) 2003-01-14
NO319950B1 (no) 2005-10-03
CN1131862C (zh) 2003-12-24
BG106157A (en) 2002-06-28
TR200103433T2 (tr) 2002-06-21
AU777601B2 (en) 2004-10-21
KR100702526B1 (ko) 2007-04-04
BR0011247A (pt) 2002-03-05
NZ515478A (en) 2003-03-28
SK16922001A3 (sk) 2002-07-02
AU4568500A (en) 2000-12-28
EE200100640A (et) 2003-02-17
SK286159B6 (sk) 2008-04-07

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JP4911860B2 (ja) 障害のある底部弛緩を処置するための組成物
HRP20010869A2 (en) Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
HRP20010868A2 (en) Aminoalkyl substituted (benzodioxan, benzofuran or benzopyran) derivatives

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