HRP20020143B1 - Ðew process for the preparation of spiro [(4-cyclohexanone)-[3h]indol-2'[1'h]-one derivatives - Google Patents

Ðew process for the preparation of spiro [(4-cyclohexanone)-[3h]indol-2'[1'h]-one derivatives

Info

Publication number
HRP20020143B1
HRP20020143B1 HR20020143A HRP20020143A HRP20020143B1 HR P20020143 B1 HRP20020143 B1 HR P20020143B1 HR 20020143 A HR20020143 A HR 20020143A HR P20020143 A HRP20020143 A HR P20020143A HR P20020143 B1 HRP20020143 B1 HR P20020143B1
Authority
HR
Croatia
Prior art keywords
general formula
group
defined above
derivatives
compound
Prior art date
Application number
HR20020143A
Other languages
English (en)
Croatian (hr)
Inventor
G�nczi Csaba
Csik�s �va
Hermecz Istv�n
H�ja Gergely
Ill�r �rp�d
Nagy Lajos
S�nt�n� Csutor Andrea
Simon Attila
Simon K�lm�n
Smelk�n� Esek �gota
Szomor Tiborn�
Szvoboda Gy�rgyn�
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of HRP20020143A2 publication Critical patent/HRP20020143A2/hr
Publication of HRP20020143B1 publication Critical patent/HRP20020143B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR20020143A 1999-07-15 2000-07-13 Ðew process for the preparation of spiro [(4-cyclohexanone)-[3h]indol-2'[1'h]-one derivatives HRP20020143B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9902374A HUP9902374A3 (en) 1999-07-15 1999-07-15 Process for producing spiro[(4-cyclohexanone)-[3h]indol-2'[1'h]-on derivatives and intermediates
PCT/HU2000/000081 WO2001005760A2 (en) 1999-07-15 2000-07-13 New process for the preparation of spiro [(4-cyclohexanone)-[3h]indol]-2'[1'h]-one derivatives

Publications (2)

Publication Number Publication Date
HRP20020143A2 HRP20020143A2 (en) 2003-10-31
HRP20020143B1 true HRP20020143B1 (en) 2010-11-30

Family

ID=89998733

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020143A HRP20020143B1 (en) 1999-07-15 2000-07-13 Ðew process for the preparation of spiro [(4-cyclohexanone)-[3h]indol-2'[1'h]-one derivatives

Country Status (17)

Country Link
US (2) US6573386B1 (cs)
EP (1) EP1200404B1 (cs)
JP (1) JP2003505371A (cs)
CN (1) CN1149194C (cs)
AT (1) ATE238989T1 (cs)
AU (1) AU6308400A (cs)
BR (1) BR0012473B1 (cs)
CA (1) CA2378201C (cs)
CZ (1) CZ2002147A3 (cs)
DE (1) DE60002472T2 (cs)
ES (1) ES2197106T3 (cs)
HR (1) HRP20020143B1 (cs)
HU (1) HUP9902374A3 (cs)
MX (1) MXPA01013341A (cs)
PL (1) PL198521B1 (cs)
SK (1) SK286875B6 (cs)
WO (1) WO2001005760A2 (cs)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638548B2 (en) * 2006-11-09 2009-12-29 Hoffmann-La Roche Inc. Spiroindolinone derivatives
EA201790185A1 (ru) 2014-07-15 2017-07-31 Грюненталь Гмбх Замещенные азаспиро(4.5)декановые производные
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395156A (en) * 1965-08-16 1968-07-30 American Home Prod 1'-phenylspiro (cyclohexane-1, 3'-indoline)-2', 4-dione
WO1997015556A1 (fr) * 1995-10-24 1997-05-01 Sanofi Derives 3-spiro-indolin-2-one comme ligands des recepteurs de la vasopressine et/ou de l'ocytocine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849780A (en) * 1992-01-30 1998-12-15 Sanofi 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
US5663431A (en) * 1992-01-30 1997-09-02 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
US5686624A (en) * 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
GB9707800D0 (en) * 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
FR2757157B1 (fr) * 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
WO1999032489A1 (en) * 1997-12-23 1999-07-01 Alcon Laboratories, Inc. Muscarinic agents and use thereof to treat glaucoma, myopia and various other conditions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395156A (en) * 1965-08-16 1968-07-30 American Home Prod 1'-phenylspiro (cyclohexane-1, 3'-indoline)-2', 4-dione
WO1997015556A1 (fr) * 1995-10-24 1997-05-01 Sanofi Derives 3-spiro-indolin-2-one comme ligands des recepteurs de la vasopressine et/ou de l'ocytocine

Also Published As

Publication number Publication date
WO2001005760A3 (en) 2001-07-19
CZ2002147A3 (cs) 2003-02-12
CN1149194C (zh) 2004-05-12
HU9902374D0 (en) 1999-10-28
US6573386B1 (en) 2003-06-03
MXPA01013341A (es) 2002-08-12
SK286875B6 (sk) 2009-07-06
JP2003505371A (ja) 2003-02-12
US20030212278A1 (en) 2003-11-13
HRP20020143A2 (en) 2003-10-31
EP1200404B1 (en) 2003-05-02
SK482002A3 (en) 2003-05-02
BR0012473B1 (pt) 2011-05-03
BR0012473A (pt) 2002-04-02
ES2197106T3 (es) 2004-01-01
CN1360576A (zh) 2002-07-24
HUP9902374A2 (hu) 2001-05-28
US6884895B2 (en) 2005-04-26
ATE238989T1 (de) 2003-05-15
AU6308400A (en) 2001-02-05
CA2378201A1 (en) 2001-01-25
DE60002472D1 (de) 2003-06-05
WO2001005760A2 (en) 2001-01-25
PL352477A1 (en) 2003-08-25
PL198521B1 (pl) 2008-06-30
DE60002472T2 (de) 2004-02-26
EP1200404A2 (en) 2002-05-02
CA2378201C (en) 2007-10-16
HUP9902374A3 (en) 2002-11-28

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: SANOFI-AVENTIS, FR

ODRP Renewal fee for the maintenance of a patent

Payment date: 20100813

Year of fee payment: 11

B1PR Patent granted
PBON Lapse due to non-payment of renewal fee

Effective date: 20110714