HRP20020452A2 - 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof - Google Patents

1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof Download PDF

Info

Publication number: HRP20020452A2
Authority: HR; Croatia
Prior art keywords: diaza; dibenzo; azulen; dimethyl; amine
Prior art date: 2002-05-23

Application number

HR20020452A

Other languages

English (en)

Croatian (hr)

Inventor

Mladen Mercep

Milan Mesic

Dijana Peueic

Original Assignee

Pliva D D

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-23

Filing date

2002-05-23

Publication date

2004-02-29

2002-05-23 Application filed by Pliva D D filed Critical Pliva D D

2002-05-23 Priority to HR20020452A priority Critical patent/HRP20020452A2/hr

2003-05-20 Priority to AU2003232368A priority patent/AU2003232368A1/en

2003-05-20 Priority to PCT/HR2003/000022 priority patent/WO2003099822A2/en

2003-05-20 Priority to US10/515,709 priority patent/US7550498B2/en

2003-05-20 Priority to PL03374341A priority patent/PL374341A1/xx

2003-05-20 Priority to AT03755234T priority patent/ATE398621T1/de

2003-05-20 Priority to JP2004507479A priority patent/JP2006500322A/ja

2003-05-20 Priority to CNA038167042A priority patent/CN1671712A/zh

2003-05-20 Priority to DE60321724T priority patent/DE60321724D1/de

2003-05-20 Priority to YU100204A priority patent/RS100204A/sr

2003-05-20 Priority to CA002487015A priority patent/CA2487015A1/en

2003-05-20 Priority to ES03755234T priority patent/ES2306888T3/es

2003-05-20 Priority to EP03755234A priority patent/EP1587807B1/de

2003-05-23 Priority to ARP030101803A priority patent/AR040039A1/es

2004-02-29 Publication of HRP20020452A2 publication Critical patent/HRP20020452A2/hr

2004-11-29 Priority to IS7565A priority patent/IS7565A/is

Links

238000002360 preparation method Methods 0.000 title claims description 21
238000004519 manufacturing process Methods 0.000 title claims description 9
239000003112 inhibitor Substances 0.000 title claims description 6
239000000543 intermediate Substances 0.000 title claims description 6
VYGQJWDTNALGCW-UHFFFAOYSA-N 4,5-diazatetracyclo[12.4.0.02,6.08,13]octadeca-1(18),2,4,6,8,10,12,14,16-nonaene Chemical compound N1=NC=C2C3=C(C4=C(C=C12)C=CC=C4)C=CC=C3 VYGQJWDTNALGCW-UHFFFAOYSA-N 0.000 title claims description 4
108060008682 Tumor Necrosis Factor Proteins 0.000 title description 38
102000003390 tumor necrosis factor Human genes 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 105
238000006243 chemical reaction Methods 0.000 claims description 39
-1 C1-C4-alkoxycarbonyl Chemical group 0.000 claims description 37
238000000034 method Methods 0.000 claims description 36
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
229910052760 oxygen Inorganic materials 0.000 claims description 25
229910052717 sulfur Inorganic materials 0.000 claims description 25
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 24
125000003118 aryl group Chemical group 0.000 claims description 22
125000001424 substituent group Chemical group 0.000 claims description 20
229910052739 hydrogen Inorganic materials 0.000 claims description 16
239000001257 hydrogen Substances 0.000 claims description 14
125000000623 heterocyclic group Chemical group 0.000 claims description 13
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125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 12
238000011282 treatment Methods 0.000 claims description 12
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 11
125000001072 heteroaryl group Chemical group 0.000 claims description 11
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125000003435 aroyl group Chemical group 0.000 claims description 10
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201000010099 disease Diseases 0.000 claims description 10
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 9
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150000002431 hydrogen Chemical group 0.000 claims description 9
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125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims description 8
125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 8
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YANZLGBXNAQDIV-UHFFFAOYSA-N 2-[(17-chloro-13-oxa-3,4-diazatetracyclo[12.4.0.02,6.07,12]octadeca-1(14),2,5,7,9,11,15,17-octaen-5-yl)methoxy]-N,N-dimethylethanamine Chemical compound C12=CC=CC=C2OC2=CC=C(Cl)C=C2C2=C1C(COCCN(C)C)=NN2 YANZLGBXNAQDIV-UHFFFAOYSA-N 0.000 claims description 6
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NERIFWMTKMHWEE-UHFFFAOYSA-N [3-(11-chloro-2h-8-oxa-1,2-diaza-dibenzo[e,h]azulene-3-ylmethoxy)-propyl]-dimethyl-amine Chemical compound C12=CC=CC=C2OC2=CC=C(Cl)C=C2C2=C1C(COCCCN(C)C)=NN2 NERIFWMTKMHWEE-UHFFFAOYSA-N 0.000 claims description 6
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MQZSPUGWYQBOKC-UHFFFAOYSA-N dimethyl-[2-(2h-8-oxa-1,2-diaza-dibenzo[e,h]azulene-3-ylmethoxy)-ethyl]-amine Chemical compound C12=CC=CC=C2OC2=CC=CC=C2C2=C1C(COCCN(C)C)=NN2 MQZSPUGWYQBOKC-UHFFFAOYSA-N 0.000 claims description 6
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239000012453 solvate Substances 0.000 claims description 5
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UVEPFSHWFPMRCP-UHFFFAOYSA-N 2-(13-thia-3,4-diazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),2(6),4,7,9,11,14,16-octaen-3-yl)ethanol Chemical compound C12=CC=CC=C2SC2=CC=CC=C2C2=C1N(CCO)N=C2 UVEPFSHWFPMRCP-UHFFFAOYSA-N 0.000 claims description 3
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HGHNLYCAHYTBAW-UHFFFAOYSA-N S1C2=CC=CC=C2C2=C(COCCN(C)C)N(COCC[Si](C)(C)C)N=C2C2=CC=CC=C21 Chemical compound S1C2=CC=CC=C2C2=C(COCCN(C)C)N(COCC[Si](C)(C)C)N=C2C2=CC=CC=C21 HGHNLYCAHYTBAW-UHFFFAOYSA-N 0.000 claims description 3
125000005161 aryl oxy carbonyl group Chemical group 0.000 claims description 3
125000004104 aryloxy group Chemical group 0.000 claims description 3
ZROPZNHOTFSEOT-UHFFFAOYSA-N dimethyl-{2-[2-(2-trimethylsilyl-ethoxymethyl)-2h-8-oxa-1,2-diaza-dibenzo[e,h]azulene-3-ylmethoxy]-ethyl}-amine Chemical compound O1C2=CC=CC=C2C2=C(COCCN(C)C)N(COCC[Si](C)(C)C)N=C2C2=CC=CC=C21 ZROPZNHOTFSEOT-UHFFFAOYSA-N 0.000 claims description 3
BBIBDYKIEBZRIB-UHFFFAOYSA-N dimethyl-{3-[2-(2-trimethylsilyl-ethoxymethyl)-2h-8-thia-1,2-diaza-dibenzo[e,h]azulene-3-ylmethoxy]-propyl}-amine Chemical compound S1C2=CC=CC=C2C2=C(COCCCN(C)C)N(COCC[Si](C)(C)C)N=C2C2=CC=CC=C21 BBIBDYKIEBZRIB-UHFFFAOYSA-N 0.000 claims description 3
125000001841 imino group Chemical group [H]N=* 0.000 claims description 3
238000011321 prophylaxis Methods 0.000 claims description 3
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 3
RNUCXKMYAZGUIL-UHFFFAOYSA-N {3-[11-chloro-2-(2-trimethylsilyl-ethoxymethyl)-2h-8-oxa-1,2-diaza-dibenzo[e,h]azulene-3-ylmethoxy]-propyl}-dimethyl-amine Chemical compound O1C2=CC=CC=C2C2=C(COCCCN(C)C)N(COCC[Si](C)(C)C)N=C2C2=CC(Cl)=CC=C21 RNUCXKMYAZGUIL-UHFFFAOYSA-N 0.000 claims description 3
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CJNGRUIFSWBIQU-UHFFFAOYSA-N N,N-dimethyl-2-[2-(13-thia-3,4-diazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),2,5,7,9,11,14,16-octaen-4-yl)ethoxy]ethanamine Chemical compound S1C2=CC=CC=C2C2=CN(CCOCCN(C)C)N=C2C2=CC=CC=C21 CJNGRUIFSWBIQU-UHFFFAOYSA-N 0.000 claims description 2
LDHRBGSGDCSPQC-UHFFFAOYSA-N N,N-dimethyl-2-[3-phenyl-1-(13-thia-3,4-diazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),2,5,7,9,11,14,16-octaen-5-yl)propoxy]ethanamine Chemical compound N1N=C(C2=CC=CC=C2SC2=CC=CC=C22)C2=C1C(OCCN(C)C)CCC1=CC=CC=C1 LDHRBGSGDCSPQC-UHFFFAOYSA-N 0.000 claims description 2
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125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
238000000926 separation method Methods 0.000 description 1
230000036303 septic shock Effects 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
229960001967 tacrolimus Drugs 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
LXIKEPCNDFVJKC-QXMHVHEDSA-N tenidap Chemical compound C12=CC(Cl)=CC=C2N(C(=O)N)C(=O)\C1=C(/O)C1=CC=CS1 LXIKEPCNDFVJKC-QXMHVHEDSA-N 0.000 description 1
229960003676 tenidap Drugs 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical compound [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
150000003568 thioethers Chemical class 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
125000004306 triazinyl group Chemical group 0.000 description 1
WTVXIBRMWGUIMI-UHFFFAOYSA-N trifluoro($l^{1}-oxidanylsulfonyl)methane Chemical group [O]S(=O)(=O)C(F)(F)F WTVXIBRMWGUIMI-UHFFFAOYSA-N 0.000 description 1
ZWYJZAQTIJBVJR-UHFFFAOYSA-N trimethyl-[2-(13-thia-3,4-diazatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),2,5,7,9,11,14,16-octaen-4-ylmethoxy)ethyl]silane Chemical compound S1C2=CC=CC=C2C2=CN(COCC[Si](C)(C)C)N=C2C2=CC=CC=C21 ZWYJZAQTIJBVJR-UHFFFAOYSA-N 0.000 description 1
208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
LQUPKVMEAATBSL-UHFFFAOYSA-L zinc;2,3,4-trichlorophenolate Chemical compound [Zn+2].[O-]C1=CC=C(Cl)C(Cl)=C1Cl.[O-]C1=CC=C(Cl)C(Cl)=C1Cl LQUPKVMEAATBSL-UHFFFAOYSA-L 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

HR20020452A 2002-05-23 2002-05-23 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof HRP20020452A2 (en)

Priority Applications (15)

Application Number	Priority Date	Filing Date	Title
HR20020452A HRP20020452A2 (en)	2002-05-23	2002-05-23	1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
CNA038167042A CN1671712A (zh)	2002-05-23	2003-05-20	作为肿瘤坏死因子产生的抑制剂的1,2－二氮杂－二苯并薁类和制备该类化合物的中间体
DE60321724T DE60321724D1 (de)	2002-05-23	2003-05-20	1,2-diaza-dibenzoazulene als inhibitoren der produfür deren herstellung
US10/515,709 US7550498B2 (en)	2002-05-23	2003-05-20	1,2-Diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
PL03374341A PL374341A1 (en)	2002-05-23	2003-05-20	1,2-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
AT03755234T ATE398621T1 (de)	2002-05-23	2003-05-20	1,2-diaza-dibenzoazulene als inhibitoren der produktion von tumornekrosefaktor und zwischenprodukte für deren herstellung
JP2004507479A JP2006500322A (ja)	2002-05-23	2003-05-20	腫瘍壊死因子産生の阻害剤としての１，２−ジアザ−ジベンゾアズレン類及びその製造用中間体
AU2003232368A AU2003232368A1 (en)	2002-05-23	2003-05-20	1,2-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
PCT/HR2003/000022 WO2003099822A2 (en)	2002-05-23	2003-05-20	1,2-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
YU100204A RS100204A (sr)	2002-05-23	2003-05-20	1,2-diaza-dibenzoazuleni kao inhibitori stvaranja faktora tumorske nekroze i međuproizvodi za njihovo pripremanje
CA002487015A CA2487015A1 (en)	2002-05-23	2003-05-20	1,2-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
ES03755234T ES2306888T3 (es)	2002-05-23	2003-05-20	1,2-diaza-dibenzoazulenos como inhibidores de la produccion del factor de necrosis de tumores e intermedios para su preparacion.
EP03755234A EP1587807B1 (de)	2002-05-23	2003-05-20	1,2-diaza-dibenzoazulene als inhibitoren der produktion von tumornekrosefaktor und zwischenprodukte für deren herstellung
ARP030101803A AR040039A1 (es)	2002-05-23	2003-05-23	1,2-diaza-dibenzoazulenos para la inhibicion de la produccion del factor de necrosis tumoral e intermediarios para su preparacion
IS7565A IS7565A (is)	2002-05-23	2004-11-29	1,2-díasa-díbensóasúlen sem latar æxlisdrepþáttarframleiðslu og milliefni til framleiðslu á þeim

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR20020452A HRP20020452A2 (en)	2002-05-23	2002-05-23	1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof

Publications (1)

Publication Number	Publication Date
HRP20020452A2 true HRP20020452A2 (en)	2004-02-29

Family

ID=29559973

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20020452A HRP20020452A2 (en)	2002-05-23	2002-05-23	1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof

Country Status (15)

Country	Link
US (1)	US7550498B2 (de)
EP (1)	EP1587807B1 (de)
JP (1)	JP2006500322A (de)
CN (1)	CN1671712A (de)
AR (1)	AR040039A1 (de)
AT (1)	ATE398621T1 (de)
AU (1)	AU2003232368A1 (de)
CA (1)	CA2487015A1 (de)
DE (1)	DE60321724D1 (de)
ES (1)	ES2306888T3 (de)
HR (1)	HRP20020452A2 (de)
IS (1)	IS7565A (de)
PL (1)	PL374341A1 (de)
RS (1)	RS100204A (de)
WO (1)	WO2003099822A2 (de)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1668014T1 (sl)	2003-09-17	2009-06-30	Janssen Pharmaceutica Nv	Kondenzirane heterociklične spojine kot modulatorji serotoninskih receptorjev
HRP20030956A2 (en) *	2003-11-21	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU
EP2308866A1 (de)	2009-10-09	2011-04-13	Bayer CropScience AG	Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
WO2012175513A1 (en)	2011-06-20	2012-12-27	Bayer Intellectual Property Gmbh	Thienylpyri(mi)dinylpyrazole

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CH532038A (de)	1970-05-25	1972-12-31	Ciba Geigy Ag	Verfahren zur Herstellung von neuen Cycloheptenderivaten
US3859439A (en)	1970-05-26	1975-01-07	Ciba Geigy Corp	2,3-dihydro-5 -trifluoromethyl-1h-dibenzo(2,3:6,7) thiepino (4,5-c) pyrroles as cns-depressants
US3711489A (en)	1971-03-31	1973-01-16	Pfizer	Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles
CA967573A (en)	1972-12-22	1975-05-13	Joseph G. Lombardino	Tetracyclic anti-inflammatory agents
US4112110A (en)	1974-02-22	1978-09-05	Ciba-Geigy Corporation	Oxygenated azatetracyclic compounds
US4271179A (en)	1976-05-24	1981-06-02	Akzona Incorporated	1,2,3,3a,8,12b-Hexahydro-dibenzo[1,2;5,6]cyclohepta[3,4-C]pyrroles and pharmaceutical use thereof
US4198421A (en)	1978-11-30	1980-04-15	E. I. Du Pont De Nemours And Company	Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles
US4267184A (en)	1979-02-08	1981-05-12	E. I. Du Pont De Nemours And Company	Antiinflammatory 4,5-diaryl-2-(substituted-thio)pyrroles and their corresponding sulfoxides and sulfones
US4267190A (en)	1980-04-18	1981-05-12	E. I. Du Pont De Nemours And Company	Antiinflammatory 4,5-diaryl-α,α-bis(polyfluoromethyl)-1H-pyrrole-2-methanethiols
FR2504140A1 (fr)	1981-04-16	1982-10-22	Centre Nat Rech Scient	Nouveaux derives tetracycliques de la dibenzazepine, leur procede de preparation et les compositions pharmaceutiques en renfermant
FI841399L (fi)	1983-04-12	1984-10-13	Ciba Geigy Ag	Polycykliska karboxylsyrafoereningar, foerfarande foer deras framstaellning och dessa karboxylsyrafoereningar innehaollande preparat samt deras anvaendning.
IE62754B1 (en)	1988-08-26	1995-02-22	Akzo Nv	Tetracyclic antidepressants
US5166214A (en)	1988-12-05	1992-11-24	Du Pont Merck Pharmaceutical Company	Use of imidazoles for the treatment of atherosclerosis
CA2003283A1 (en)	1988-12-05	1990-06-05	C. Anne Higley	Imidazoles for the treatment of atherosclerosis
PL337027A1 (en)	1997-05-26	2000-07-31	Akzo Nobel Nv	Salts of aromatic sulphonic acids
HRP20000310A2 (en)	2000-05-17	2002-02-28	Pliva Farmaceutska Ind Dioniko	New dibenzoazulene compounds as tumor necrosis factor inhibitors
HRP20020305A8 (en) *	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020440B1 (en)	2002-05-21	2008-02-29	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof

2002
- 2002-05-23 HR HR20020452A patent/HRP20020452A2/hr not_active Application Discontinuation
2003
- 2003-05-20 RS YU100204A patent/RS100204A/sr unknown
- 2003-05-20 AU AU2003232368A patent/AU2003232368A1/en not_active Abandoned
- 2003-05-20 AT AT03755234T patent/ATE398621T1/de not_active IP Right Cessation
- 2003-05-20 WO PCT/HR2003/000022 patent/WO2003099822A2/en not_active Ceased
- 2003-05-20 PL PL03374341A patent/PL374341A1/xx not_active Application Discontinuation
- 2003-05-20 US US10/515,709 patent/US7550498B2/en not_active Expired - Fee Related
- 2003-05-20 DE DE60321724T patent/DE60321724D1/de not_active Expired - Fee Related
- 2003-05-20 EP EP03755234A patent/EP1587807B1/de not_active Expired - Lifetime
- 2003-05-20 ES ES03755234T patent/ES2306888T3/es not_active Expired - Lifetime
- 2003-05-20 JP JP2004507479A patent/JP2006500322A/ja active Pending
- 2003-05-20 CA CA002487015A patent/CA2487015A1/en not_active Abandoned
- 2003-05-20 CN CNA038167042A patent/CN1671712A/zh active Pending
- 2003-05-23 AR ARP030101803A patent/AR040039A1/es not_active Application Discontinuation
2004
- 2004-11-29 IS IS7565A patent/IS7565A/is unknown

Also Published As

Publication number	Publication date
DE60321724D1 (de)	2008-07-31
CA2487015A1 (en)	2003-12-04
ES2306888T3 (es)	2008-11-16
JP2006500322A (ja)	2006-01-05
EP1587807B1 (de)	2008-06-18
PL374341A1 (en)	2005-10-17
IS7565A (is)	2004-11-29
AU2003232368A1 (en)	2003-12-12
AU2003232368A8 (en)	2003-12-12
CN1671712A (zh)	2005-09-21
US7550498B2 (en)	2009-06-23
RS100204A (sr)	2006-10-27
ATE398621T1 (de)	2008-07-15
WO2003099822A2 (en)	2003-12-04
EP1587807A2 (de)	2005-10-26
US20050209296A1 (en)	2005-09-22
AR040039A1 (es)	2005-03-09
EP1587807A3 (de)	2005-11-16
WO2003099822A3 (en)	2005-09-29

Legal Events

Date	Code	Title	Description
2004-02-29	A1OB	Publication of a patent application
2004-07-20	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2007-01-08	PNAN	Change of the applicant name, address/residence	Owner name: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.,
2007-01-08	PPPP	Transfer of rights	Owner name: PLIVA-ISTRAZIVACKI INSTITUT D.O.O., HR
2008-04-21	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20080421 Year of fee payment: 7
2012-11-05	ODBI	Application refused

Publication	Publication Date	Title
EP1506202B1 (de)	2007-08-08	1-azadibenzoazulene als inhibitoren der produktion von tumornekrosefaktor und zwischenprodukte für deren herstellung
HRP20020453A2 (en)	2003-12-31	1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20020303A2 (en)	2003-10-31	Benzonaphthoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20020441A2 (en)	2003-12-31	1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof
HRP20020451A2 (en)	2003-12-31	1-tia-3-aza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
HRP20020452A2 (en)	2004-02-29	1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof
WO2003084962A1 (en)	2003-10-16	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
EP1492797B1 (de)	2006-03-15	1-oxa-3-aza-dibenzoazulene als inhibitoren der produktion von tumornekrosefaktor und zwischenprodukte für deren herstellung
HRP20030160A2 (en)	2005-04-30	1-thiadibenzoazulene derivatives and biological action thereof
HK1081950B (en)	2007-11-23	1-oxa-dibenzoazulenes as inhibitors of thmour necrosis factor production and intermediates for the preparation thereof