HRP20020522A2 - Processes for preparing clarithromycin polymorphs and novel polymorph iv - Google Patents

Processes for preparing clarithromycin polymorphs and novel polymorph iv Download PDF

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Publication number
HRP20020522A2
HRP20020522A2 HRP20020522A HRP20020522A2 HR P20020522 A2 HRP20020522 A2 HR P20020522A2 HR P20020522 A HRP20020522 A HR P20020522A HR P20020522 A2 HRP20020522 A2 HR P20020522A2
Authority
HR
Croatia
Prior art keywords
clarithromycin
erythromycin
clarithromycin form
water
oxime
Prior art date
Application number
Other languages
English (en)
Croatian (hr)
Inventor
Edi Schwartz
Ilya Avrutov
Igor Lifshitz
Ronen Borochovitz
Basem Masarwa
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of HRP20020522A2 publication Critical patent/HRP20020522A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicinal Preparation (AREA)
HRP20020522 1999-12-16 2000-12-15 Processes for preparing clarithromycin polymorphs and novel polymorph iv HRP20020522A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17122199P 1999-12-16 1999-12-16
US17183999P 1999-12-22 1999-12-22
PCT/US2000/033845 WO2001044262A1 (en) 1999-12-16 2000-12-15 Processes for preparing clarithromycin polymorphs and novel polymorph iv

Publications (1)

Publication Number Publication Date
HRP20020522A2 true HRP20020522A2 (en) 2004-12-31

Family

ID=26866853

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20020522 HRP20020522A2 (en) 1999-12-16 2000-12-15 Processes for preparing clarithromycin polymorphs and novel polymorph iv

Country Status (20)

Country Link
US (2) US6599884B2 (de)
EP (1) EP1254146B1 (de)
JP (1) JP2003516999A (de)
KR (1) KR20020070991A (de)
CN (2) CN1666991A (de)
AT (1) ATE302786T1 (de)
AU (1) AU783055B2 (de)
CA (1) CA2395555A1 (de)
CZ (1) CZ20021999A3 (de)
DE (1) DE60022230T2 (de)
ES (1) ES2244491T3 (de)
HR (1) HRP20020522A2 (de)
HU (1) HUP0204091A3 (de)
IL (1) IL150227A0 (de)
PL (1) PL364880A1 (de)
PT (1) PT1254146E (de)
RU (1) RU2002116232A (de)
SK (1) SK8322002A3 (de)
WO (1) WO2001044262A1 (de)
YU (1) YU45602A (de)

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US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
KR20030047873A (ko) * 2000-02-29 2003-06-18 테바 파마슈티컬 인더스트리즈 리미티드 클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물
AU2001263812B2 (en) * 2000-03-28 2004-09-23 Sandoz Ag Granulated particles with masked taste
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
JP2006528185A (ja) 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
AU2004258953B2 (en) 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
AU2004258949B2 (en) 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
CA2535177A1 (en) 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
US8062672B2 (en) 2003-08-12 2011-11-22 Shionogi Inc. Antibiotic product, use and formulation thereof
AU2004270170B2 (en) 2003-08-29 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
CA2538064C (en) 2003-09-15 2013-12-17 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005061524A2 (en) * 2003-12-22 2005-07-07 Ranbaxy Laboratories Limited Process for the preparation of form ii clarithromycin
AU2004308419B2 (en) * 2003-12-24 2011-06-02 Victory Pharma, Inc. Enhanced absorption of modified release dosage forms
CA2572292A1 (en) 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
JP2009500356A (ja) * 2005-07-07 2009-01-08 エラン ファーマ インターナショナル リミテッド ナノ粒子クラリスロマイシン製剤
WO2007036951A2 (en) * 2005-08-31 2007-04-05 Alembic Limited Process to obtain 6-o-methylerythromycin a (clarithromycin)_form ii
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
DE102007016367A1 (de) 2007-04-03 2008-10-09 Grünenthal GmbH Polymorph von Clarithromycin (Form V)
EP2030613A1 (de) 2007-08-17 2009-03-04 Abbott GmbH & Co. KG Herstellung von Zusammensetzungen mit hauptsächlich nichtkristallinen eingebetteten Makrolid-Antibiotika
US9119769B2 (en) 2011-12-30 2015-09-01 The Curators Of The University Of Missouri Method for transforming pharmaceutical crystal forms
CN103087130B (zh) * 2013-02-06 2015-12-23 浙江国邦药业有限公司 一种克拉霉素晶型转换方法
MY180626A (en) 2013-11-15 2020-12-03 Akebia Therapeutics Inc Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof

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JPS4954572A (de) * 1972-09-29 1974-05-27
FR2473525A1 (fr) 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
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US5892008A (en) 1997-12-16 1999-04-06 Abbott Laboratories Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
KR100377159B1 (ko) 1998-09-09 2003-08-19 한미약품공업 주식회사 잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법
AU4942800A (en) * 1999-06-11 2001-01-02 Ranbaxy Laboratories Limited Novel amorphous form of clarithromycin
AU2261901A (en) * 2000-01-11 2001-07-24 Teva Pharma Processes for preparing clarithromycin polymorphs
KR20030047873A (ko) * 2000-02-29 2003-06-18 테바 파마슈티컬 인더스트리즈 리미티드 클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물

Also Published As

Publication number Publication date
EP1254146B1 (de) 2005-08-24
WO2001044262A1 (en) 2001-06-21
DE60022230T2 (de) 2006-01-26
EP1254146A4 (de) 2003-04-16
EP1254146A1 (de) 2002-11-06
DE60022230D1 (de) 2005-09-29
KR20020070991A (ko) 2002-09-11
PT1254146E (pt) 2005-10-31
HUP0204091A2 (hu) 2003-04-28
AU783055B2 (en) 2005-09-22
RU2002116232A (ru) 2004-01-10
HUP0204091A3 (en) 2003-05-28
IL150227A0 (en) 2002-12-01
AU2431101A (en) 2001-06-25
CZ20021999A3 (cs) 2003-02-12
CN1666991A (zh) 2005-09-14
PL364880A1 (en) 2004-12-27
YU45602A (sh) 2005-06-10
US20020026038A1 (en) 2002-02-28
US20040058879A1 (en) 2004-03-25
ATE302786T1 (de) 2005-09-15
CN1217951C (zh) 2005-09-07
JP2003516999A (ja) 2003-05-20
SK8322002A3 (en) 2003-02-04
CA2395555A1 (en) 2001-06-21
US6599884B2 (en) 2003-07-29
ES2244491T3 (es) 2005-12-16
CN1434829A (zh) 2003-08-06

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