HRP20030953A2 - PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS - Google Patents

PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS

Info

Publication number
HRP20030953A2
HRP20030953A2 HR20030953A HRP20030953A HRP20030953A2 HR P20030953 A2 HRP20030953 A2 HR P20030953A2 HR 20030953 A HR20030953 A HR 20030953A HR P20030953 A HRP20030953 A HR P20030953A HR P20030953 A2 HRP20030953 A2 HR P20030953A2
Authority
HR
Croatia
Prior art keywords
azulenes
dibenzo
aza
oxa
disorders
Prior art date
Application number
HR20030953A
Other languages
English (en)
Inventor
Merep Mladen
Mesi Milan
Pe�i� Dijana
D�apo Iva
Original Assignee
Pliva-Istra�iva�ki institut d.o.o.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva-Istra�iva�ki institut d.o.o. filed Critical Pliva-Istra�iva�ki institut d.o.o.
Priority to HR20030953A priority Critical patent/HRP20030953A2/xx
Priority to ES04798729T priority patent/ES2319904T3/es
Priority to EP04798729A priority patent/EP1687314B1/de
Priority to DE602004018675T priority patent/DE602004018675D1/de
Priority to US10/595,939 priority patent/US20070078124A1/en
Priority to JP2006540627A priority patent/JP2007511595A/ja
Priority to CNB2004800394559A priority patent/CN100429214C/zh
Priority to CA002546620A priority patent/CA2546620A1/en
Priority to PCT/HR2004/000050 priority patent/WO2005049623A1/en
Priority to AT04798729T priority patent/ATE418558T1/de
Priority to CNA2008102138307A priority patent/CN101386623A/zh
Priority to ARP040104305A priority patent/AR047130A1/es
Publication of HRP20030953A2 publication Critical patent/HRP20030953A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HR20030953A 2003-11-21 2003-11-21 PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS HRP20030953A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
HR20030953A HRP20030953A2 (en) 2003-11-21 2003-11-21 PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
ES04798729T ES2319904T3 (es) 2003-11-21 2004-11-19 Preparacion de 1-aza-2-oxa-dibenzo (e,h) azulenos u su uso para la fabricacion de formulaciones farmaceuticas para el tratamiento y la prevencion de enfermedades y trastornos del sistema nervioso central.
EP04798729A EP1687314B1 (de) 2003-11-21 2004-11-19 DARSTELLUNG VON 1-AZA-2-OXADIBENZO[e,h]AZULENEN UND DEREN VERWENDUNG BEI DER HERSTELLUNG PHARMAZEUTISCHER FORMULIERUNGEN ZUR BEHANDLUNG UND PRÄVENTION VON KRANKHEITEN UND ERKRANKUNGEN DES ZENTRALEN NERVENSYSTEMS
DE602004018675T DE602004018675D1 (de) 2003-11-21 2004-11-19 DARSTELLUNG VON 1-AZA-2-OXADIBENZOÄe,hÜAZULENEN UND DEREN VERWENDUNG BEI DER HERSTELLUNG PHARMAZEUTISCHER FORMULIERUNGEN ZUR BEHANDLUNG UND PRÄVENTIONRVENSYSTEMS
US10/595,939 US20070078124A1 (en) 2003-11-21 2004-11-19 1-Aza-2-oxa-dibenzo(e,h)azulenes and their use for the treatment of central nervous system diseases and disorders
JP2006540627A JP2007511595A (ja) 2003-11-21 2004-11-19 １−アザ−２−オキサ−ジベンゾ［ｅ，ｈ］アズレン類の製造及びその中枢神経系の疾患及び障害の治療及び予防用医薬製剤を製造するための使用
CNB2004800394559A CN100429214C (zh) 2003-11-21 2004-11-19 1-氮杂-2-氧杂-二苯并[e,h]薁的制备以及它们用于制备治疗和预防中枢神经系统疾病和障碍的药物制剂的用途
CA002546620A CA2546620A1 (en) 2003-11-21 2004-11-19 Preparation of 1-aza-2-oxa-dibenzo[e,h]azulenes and their use for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
PCT/HR2004/000050 WO2005049623A1 (en) 2003-11-21 2004-11-19 PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
AT04798729T ATE418558T1 (de) 2003-11-21 2004-11-19 Darstellung von 1-aza-2-oxadibenzoäe,hüazulenen und deren verwendung bei der herstellung pharmazeutischer formulierungen zur behandlung und prävention von krankheiten und erkrankungen des zentralen nervensystems
CNA2008102138307A CN101386623A (zh) 2003-11-21 2004-11-19 1-氮杂-2-氧杂-二苯并[e,h]薁的制备及其医药用途
ARP040104305A AR047130A1 (es) 2003-11-21 2004-11-22 Derivados de 1-aza-2-oxa-dibenzo[e,h] azulenos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR20030953A HRP20030953A2 (en) 2003-11-21 2003-11-21 PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS

Publications (1)

Publication Number Publication Date
HRP20030953A2 true HRP20030953A2 (en) 2005-10-31

Family

ID=34611157

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030953A HRP20030953A2 (en) 2003-11-21 2003-11-21 PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS

Country Status (11)

Country Link
US (1) US20070078124A1 (de)
EP (1) EP1687314B1 (de)
JP (1) JP2007511595A (de)
CN (2) CN100429214C (de)
AR (1) AR047130A1 (de)
AT (1) ATE418558T1 (de)
CA (1) CA2546620A1 (de)
DE (1) DE602004018675D1 (de)
ES (1) ES2319904T3 (de)
HR (1) HRP20030953A2 (de)
WO (1) WO2005049623A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2727585A1 (de) 2006-05-16 2014-05-07 Takeda Pharmaceutical Company Limited In-vivo Screening-Methode
EP2216023A4 (de) 2007-11-15 2013-03-13 Takeda Pharmaceutical Kondensiertes pyridinderivat und seine verwendung
JPWO2019131902A1 (ja) 2017-12-27 2020-12-10 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3711489A (en) * 1971-03-31 1973-01-16 Pfizer Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
US4198421A (en) * 1978-11-30 1980-04-15 E. I. Du Pont De Nemours And Company Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles
FR2504140A1 (fr) * 1981-04-16 1982-10-22 Centre Nat Rech Scient Nouveaux derives tetracycliques de la dibenzazepine, leur procede de preparation et les compositions pharmaceutiques en renfermant
US5552399A (en) * 1994-11-02 1996-09-03 Janssen Pharmaceutica N.V. Substituted tetracyclic azepine derivatives
DE69720709T2 (de) * 1996-04-12 2004-03-11 Janssen Pharmaceutica N.V. Substituierte tetracyclische tetrahydrofuranderivate
UA52778C2 (uk) * 1997-10-10 2003-01-15 Янссен Фармацевтика Н.В. Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі

Also Published As

Publication number Publication date
ES2319904T3 (es) 2009-05-14
CN101386623A (zh) 2009-03-18
CN1902206A (zh) 2007-01-24
WO2005049623A1 (en) 2005-06-02
EP1687314B1 (de) 2008-12-24
CA2546620A1 (en) 2005-06-02
US20070078124A1 (en) 2007-04-05
CN100429214C (zh) 2008-10-29
ATE418558T1 (de) 2009-01-15
EP1687314A1 (de) 2006-08-09
AR047130A1 (es) 2006-01-11
JP2007511595A (ja) 2007-05-10
DE602004018675D1 (de) 2009-02-05

Similar Documents

Publication Publication Date Title
EP1578421A4 (de) Pharmazeutische präparate für diebehandlung von erkrankungen und pathologischen zuständen der brust
WO2003092580A3 (en) Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor
IL163102A (en) Dihydrobenzodiazepin-2-one derivatives, process for their preparation and use thereof in the preparation of medicaments for the treatment of neurological disorders
AU2002252373A1 (en) Methods and compositions for the treatment and/or diagnosis of neurological diseases and disorders
IL169338A0 (en) Therapeutic formulations for the treatment of beta-amyloid related diseases
PL378108A1 (pl) Leczenie łączone do terapii zapalnych zaburzeń immunologicznych
IL179611A (en) History 1-Aza-bicycloalkyl, their process, their pharmaceutical preparations and their use in the preparation of drugs for the treatment of psychotic disorders
AU2002226690A1 (en) Drugs for the diagnosis of tissue-reproductive activity or the treatment of proliferative diseases
AU2001266152A1 (en) Novel substituted nitrocatechols, their use in the treatment of some central andperipheral nervous system disorders and pharmaceutical compositions containing them
ZA200707934B (en) Thereapeutic formulations for the treatment of beta-amyloid related diseases
TWI372056B (en) Novel medicament combinations for the treatment of respiratory diseases
PL1670482T5 (pl) Zastosowanie cyklezonidu w leczeniu chorób układu oddechowego
IL153831A (en) Pharmaceutical composition for therapy of neurodegenerative disease of the brain
AU2003209150A1 (en) Combination for the treatment of immunoinflammatory disorders and proliferative skin diseases
EP1660101A4 (de) Flüssige formulierungen zur prävention und behandlung von schleimhauterkrankungen und störungen
TWI347845B (en) Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
EP1605935A4 (de) Verfahren zur verwendung von und zusammensetzungen mit selektiven zyotkin-hemmenden arzneimitteln zur behandlung und versorgung von erkrankungen des zentralen nervensystems
WO2005092062A3 (en) Compounds for neurodegenerative disorders
IL177861A0 (en) Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
WO2005094790A8 (es) Formulaciones liposomales
HRP20040104A2 (en) Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
HK1098739A (en) Preparation of 1-aza-2-oxa-dibenzo [e,h] azulenes and their use for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders
ZA200505996B (en) Combination therapy for the treatment of immunoinflammatory disorders
HUP0103017A3 (en) Pharmaceutical composition for the treatment of diseases caused by impairment of cognitive functions and its use
HK1098672A (en) Use of 1-aza-dibenzo[e,h]azulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.,

ODRP Renewal fee for the maintenance of a patent

Payment date: 20081111

Year of fee payment: 6

OBST Application withdrawn