HRP20040198B1 - POSTUPAK PROIZVODNJE BERAPROST-a I NJEGOVIH SOLI - Google Patents

POSTUPAK PROIZVODNJE BERAPROST-a I NJEGOVIH SOLI

Info

Publication number
HRP20040198B1
HRP20040198B1 HR20040198A HRP20040198A HRP20040198B1 HR P20040198 B1 HRP20040198 B1 HR P20040198B1 HR 20040198 A HR20040198 A HR 20040198A HR P20040198 A HRP20040198 A HR P20040198A HR P20040198 B1 HRP20040198 B1 HR P20040198B1
Authority
HR
Croatia
Prior art keywords
general formula
compound
defined above
salt
formula
Prior art date
Application number
HR20040198A
Other languages
English (en)
Croatian (hr)
Inventor
Szab Tibor
B�di J�zsef
Dalmadi Gyula
Baloghn� Kardos Zsuzsanna
Szever�nyi Zolt�n
Original Assignee
Chinoin Gy�gyszer �s Vegy�szeti Term�kek Gy�ra Zrt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gy�gyszer �s Vegy�szeti Term�kek Gy�ra Zrt. filed Critical Chinoin Gy�gyszer �s Vegy�szeti Term�kek Gy�ra Zrt.
Publication of HRP20040198A2 publication Critical patent/HRP20040198A2/hr
Publication of HRP20040198B1 publication Critical patent/HRP20040198B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Furan Compounds (AREA)
  • Error Detection And Correction (AREA)
HR20040198A 2001-07-30 2002-07-25 POSTUPAK PROIZVODNJE BERAPROST-a I NJEGOVIH SOLI HRP20040198B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0103089A HU227157B1 (en) 2001-07-30 2001-07-30 Production of beraprost ester by selective oxidation
PCT/HU2002/000074 WO2003011849A1 (en) 2001-07-30 2002-07-25 Process for the production of beraprost and its salts

Publications (2)

Publication Number Publication Date
HRP20040198A2 HRP20040198A2 (en) 2005-04-30
HRP20040198B1 true HRP20040198B1 (hr) 2012-02-29

Family

ID=90001541

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040198A HRP20040198B1 (hr) 2001-07-30 2002-07-25 POSTUPAK PROIZVODNJE BERAPROST-a I NJEGOVIH SOLI

Country Status (25)

Country Link
US (1) US7005527B2 (sr)
EP (1) EP1412342B1 (sr)
JP (1) JP4440506B2 (sr)
KR (1) KR100604699B1 (sr)
CN (2) CN1235896C (sr)
AT (1) ATE407127T1 (sr)
AU (1) AU2002321670B8 (sr)
BR (1) BR0211514A (sr)
CA (1) CA2453649C (sr)
CU (1) CU23324B7 (sr)
DE (1) DE60228724D1 (sr)
ES (1) ES2314083T3 (sr)
HR (1) HRP20040198B1 (sr)
HU (1) HU227157B1 (sr)
IL (2) IL159814A0 (sr)
ME (2) MEP18708A (sr)
MX (1) MXPA04000847A (sr)
NO (1) NO328695B1 (sr)
NZ (1) NZ531264A (sr)
PL (1) PL216072B1 (sr)
RS (1) RS51314B (sr)
RU (1) RU2272033C2 (sr)
UA (1) UA75692C2 (sr)
WO (1) WO2003011849A1 (sr)
ZA (1) ZA200400748B (sr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215757D0 (en) * 2002-07-08 2002-08-14 Cascade Biochem Ltd Benzoprostacyclin intermediates methods for their preparation and products derived therefrom
KR101978530B1 (ko) * 2011-06-16 2019-05-14 렁 바이오테크놀로지 피비씨 베라프로스트의 제조 방법
CN102952107B (zh) * 2011-08-29 2015-10-07 上海天伟生物制药有限公司 一种高纯度的贝前列素钠及其制备方法和用途
WO2013040068A2 (en) * 2011-09-12 2013-03-21 Irix Pharmaceuticals, Inc. Process for preparing synthetic prostacyclins
CN103509044A (zh) * 2012-06-21 2014-01-15 上海天伟生物制药有限公司 贝前列素钠中间体及其制备方法
EP2968362A4 (en) * 2013-03-15 2016-10-05 Gemmus Pharma Inc BERAPROST ISOMER AS A MEANS FOR THE TREATMENT OF VIRUS INFECTIONS
CN103242274B (zh) * 2013-05-22 2014-11-05 孙威 一种贝前列素钠化合物及其制备方法
WO2015179427A1 (en) * 2014-05-20 2015-11-26 Lung Biotechnology Pbc Methods for producing beraprost and its derivatives
JP6440896B2 (ja) * 2015-08-12 2018-12-19 ユナイテッド セラピューティクス コーポレイション ベラプロストを作製するための方法
HU231080B1 (hu) * 2016-04-05 2020-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás optikailag aktív Beraprost előállítására
HU231212B1 (hu) * 2018-04-16 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás iloprost előállítására
US10577340B1 (en) * 2018-11-26 2020-03-03 Chirogate International Inc. Beraprost-314d crystals and methods for preparation thereof
AU2021220877A1 (en) 2020-02-12 2022-09-01 Cytoagents, Inc. Compositions and methods for treating coronavirus infections
JPWO2023276983A1 (sr) * 2021-06-28 2023-01-05
CN115611838A (zh) * 2021-07-15 2023-01-17 四川国为制药有限公司 一种前列环素衍生物的晶型
TW202604473A (zh) * 2024-05-30 2026-02-01 美商細胞藥劑股份有限公司 用於製備貝前列素３１４—ｄ鈉的方法
CN119638659A (zh) * 2024-12-11 2025-03-18 常州博海威医药科技股份有限公司 贝前列腺素钠的纯化方法及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024943A1 (en) * 1979-09-03 1981-03-11 Toray Industries, Inc. 5,6,7-Trinor-4,8-inter-m-phenylene PGI2 derivatives and pharmaceutical compositions containing them

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS59134787A (ja) * 1983-01-19 1984-08-02 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体の製造法
HU197733B (en) * 1985-05-29 1989-05-29 Chinoin Gyogyszer Es Vegyeszet Process for producing ephedrin-salts of 7-oxo-prosta-cyclin derivatives
CA1284642C (en) * 1986-03-31 1991-06-04 Hikozo Iwakura Prostacyclin (pgi ) analogues
JP2594118B2 (ja) * 1987-07-01 1997-03-26 塩野義製薬株式会社 ベンゾジオキサンプロスタサイクリン類縁体
JP2542429B2 (ja) * 1987-10-27 1996-10-09 三共株式会社 オクタヒドロナフタリン置換オキシム誘導体
GB8929059D0 (en) * 1989-12-22 1990-02-28 Leo Pharm Prod Ltd Chemical compounds
JP3025056B2 (ja) * 1991-03-12 2000-03-27 財団法人微生物化学研究会 ２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノース誘導体の製造法
JP3024298B2 (ja) * 1991-09-13 2000-03-21 住友化学工業株式会社 シクロペンテンエステル類及びその利用
DE4226615C1 (de) * 1992-08-07 1994-05-19 Schering Ag Verwendung von Prostan-Derivaten zur Behandlung von chronischer Polyarthritis
DE19530884C2 (de) * 1995-08-11 1997-07-31 Schering Ag Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis
JPH09132589A (ja) * 1995-09-08 1997-05-20 Microbial Chem Res Found 糖部分の水酸基をモノ−または−ジ−ｏ−アミノアルカノイル化された含フッ素アンスラサイクリン誘導体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024943A1 (en) * 1979-09-03 1981-03-11 Toray Industries, Inc. 5,6,7-Trinor-4,8-inter-m-phenylene PGI2 derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CU23324B7 (es) 2008-11-27
MXPA04000847A (es) 2004-03-26
JP2003055368A (ja) 2003-02-26
HRP20040198A2 (en) 2005-04-30
ZA200400748B (en) 2005-01-26
JP4440506B2 (ja) 2010-03-24
CN1680351A (zh) 2005-10-12
NZ531264A (en) 2005-09-30
WO2003011849A1 (en) 2003-02-13
PL216072B1 (pl) 2014-02-28
US7005527B2 (en) 2006-02-28
RU2004105959A (ru) 2005-03-27
KR20040043169A (ko) 2004-05-22
AU2002321670B2 (en) 2008-08-14
RU2272033C2 (ru) 2006-03-20
RS8604A (sr) 2007-02-05
MEP18708A (en) 2010-06-10
HUP0103089A3 (en) 2005-01-28
HK1068877A1 (en) 2005-05-06
CA2453649A1 (en) 2003-02-13
CN1537107A (zh) 2004-10-13
UA75692C2 (uk) 2006-05-15
PL367298A1 (en) 2005-02-21
KR100604699B1 (ko) 2006-07-31
WO2003011849A8 (en) 2004-03-11
NO328695B1 (no) 2010-04-26
US20040209945A1 (en) 2004-10-21
CN1235896C (zh) 2006-01-11
NO20040388L (no) 2004-01-29
CN100347165C (zh) 2007-11-07
CA2453649C (en) 2009-12-22
EP1412342B1 (en) 2008-09-03
HUP0103089D0 (en) 2001-10-28
DE60228724D1 (de) 2008-10-16
ES2314083T3 (es) 2009-03-16
EP1412342A1 (en) 2004-04-28
ATE407127T1 (de) 2008-09-15
HUP0103089A2 (hu) 2003-07-28
BR0211514A (pt) 2004-09-14
RS51314B (sr) 2010-12-31
HU227157B1 (en) 2010-09-28
IL159814A (en) 2008-08-07
IL159814A0 (en) 2004-06-20
HK1078857A1 (zh) 2006-03-24
AU2002321670B8 (en) 2008-09-11
ME00089B (me) 2010-10-10

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA ZRT

B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20160712

Year of fee payment: 15

PBON Lapse due to non-payment of renewal fee

Effective date: 20170725