HRP20050681A2 - Triazole compounds useful in therapy - Google Patents

Triazole compounds useful in therapy Download PDF

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Publication number
HRP20050681A2
HRP20050681A2 HR20050681A HRP20050681A HRP20050681A2 HR P20050681 A2 HRP20050681 A2 HR P20050681A2 HR 20050681 A HR20050681 A HR 20050681A HR P20050681 A HRP20050681 A HR P20050681A HR P20050681 A2 HRP20050681 A2 HR P20050681A2
Authority
HR
Croatia
Prior art keywords
image
mmol
compound
chloro
tetrahydro
Prior art date
Application number
HR20050681A
Other languages
English (en)
Croatian (hr)
Inventor
Stephen Bryans Justin
Stephen Johnson Patrick
Jane Russell Rachel
Ryckmans Thomas
Stobie Alan
Peter Wayman Christopher
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0303852.8A external-priority patent/GB0303852D0/en
Priority claimed from GBGB0317227.7A external-priority patent/GB0317227D0/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HRP20050681A2 publication Critical patent/HRP20050681A2/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Anesthesiology (AREA)
HR20050681A 2003-02-19 2004-02-09 Triazole compounds useful in therapy HRP20050681A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0303852.8A GB0303852D0 (en) 2003-02-19 2003-02-19 Triazole compounds useful in therapy
GBGB0317227.7A GB0317227D0 (en) 2003-07-23 2003-07-23 Treatment of male sexual dysfunction
PCT/IB2004/000432 WO2004074291A1 (fr) 2003-02-19 2004-02-09 Composes de triazole utilises en therapie

Publications (1)

Publication Number Publication Date
HRP20050681A2 true HRP20050681A2 (en) 2005-12-31

Family

ID=34889119

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20050681A HRP20050681A2 (en) 2003-02-19 2004-02-09 Triazole compounds useful in therapy

Country Status (25)

Country Link
EP (1) EP1597260B1 (fr)
JP (2) JP4033886B2 (fr)
KR (1) KR100750028B1 (fr)
AP (1) AP2005003376A0 (fr)
AT (1) ATE349449T1 (fr)
AU (1) AU2004213242B2 (fr)
BR (1) BRPI0407676A (fr)
CA (1) CA2516557C (fr)
DE (1) DE602004003914T2 (fr)
DK (1) DK1597260T3 (fr)
EA (1) EA009460B1 (fr)
EC (1) ECSP055973A (fr)
ES (1) ES2277237T3 (fr)
GE (1) GEP20074089B (fr)
HR (1) HRP20050681A2 (fr)
IS (1) IS2450B (fr)
MA (1) MA27712A1 (fr)
MX (1) MXPA05008923A (fr)
NO (1) NO20054053L (fr)
OA (1) OA13029A (fr)
PL (1) PL378747A1 (fr)
PT (1) PT1597260E (fr)
RS (1) RS20050638A (fr)
SI (1) SI1597260T1 (fr)
TN (1) TNSN05200A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200904403A (en) * 2007-04-25 2009-02-01 Daiichi Sankyo Co Ltd Tricyclic aryl compounds
EP2501685A1 (fr) * 2009-11-16 2012-09-26 Mellitech Dérivés de [1,5]-diazocine
US8420633B2 (en) * 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) * 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) * 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) * 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US9006450B2 (en) 2010-07-01 2015-04-14 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical compositions and uses thereof
CN105793263B (zh) * 2013-12-05 2019-08-23 豪夫迈·罗氏有限公司 一种苯并[e]薁化合物及其晶型的合成
HU231206B1 (hu) * 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
GB8823475D0 (en) * 1988-10-06 1988-11-16 Merck Sharp & Dohme Chemical compounds
US5438035A (en) * 1994-06-24 1995-08-01 American Cyanamid Company Methods for controlling undesirable plant species with benzodiazepine compounds
US5753648A (en) * 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
CA2268327C (fr) * 1996-11-01 2002-05-21 American Home Products Corporation Derives 3-carboxamide de 5h-pyrrolo[2,1-c][1,4]-benzodiazepines
ES2207333T7 (es) * 1999-01-19 2009-06-18 Orto-Mcneil Pharmaceutical, Inc. Benzodiazepinas triciclicas utilizadas como antagonistas del receptor de la vasopresina.
US7109193B2 (en) * 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
GB0224919D0 (en) * 2002-10-25 2002-12-04 Pfizer Ltd Triazole compounds useful in therapy

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KR20050106443A (ko) 2005-11-09
JP2007045838A (ja) 2007-02-22
PT1597260E (pt) 2007-01-31
DK1597260T3 (da) 2007-04-02
CA2516557A1 (fr) 2004-09-02
JP2006517921A (ja) 2006-08-03
EA009460B1 (ru) 2007-12-28
MXPA05008923A (es) 2006-03-09
AU2004213242B2 (en) 2007-04-19
OA13029A (en) 2006-11-10
EP1597260A1 (fr) 2005-11-23
BRPI0407676A (pt) 2006-03-01
DE602004003914D1 (de) 2007-02-08
TNSN05200A1 (fr) 2007-06-11
AP2005003376A0 (en) 2005-09-30
SI1597260T1 (sl) 2007-04-30
CA2516557C (fr) 2008-11-18
ECSP055973A (es) 2006-01-16
AU2004213242A1 (en) 2004-09-02
ATE349449T1 (de) 2007-01-15
PL378747A1 (pl) 2006-05-15
GEP20074089B (en) 2007-04-10
NO20054053L (no) 2005-10-31
KR100750028B1 (ko) 2007-08-16
RS20050638A (sr) 2007-12-31
ES2277237T3 (es) 2007-07-01
EP1597260B1 (fr) 2006-12-27
JP4033886B2 (ja) 2008-01-16
IS2450B (is) 2008-11-15
IS7957A (is) 2005-07-25
NO20054053D0 (no) 2005-08-31
MA27712A1 (fr) 2006-01-02
EA200501136A1 (ru) 2006-06-30
DE602004003914T2 (de) 2007-05-31

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