HRP20060402A2 - Derivati piridina alkilnih oksindola kao 5-ht7 receptorski aktivni agensi - Google Patents

Derivati piridina alkilnih oksindola kao 5-ht7 receptorski aktivni agensi

Info

Publication number
HRP20060402A2
HRP20060402A2 HR20060402A HRP20060402A HRP20060402A2 HR P20060402 A2 HRP20060402 A2 HR P20060402A2 HR 20060402 A HR20060402 A HR 20060402A HR P20060402 A HRP20060402 A HR P20060402A HR P20060402 A2 HRP20060402 A2 HR P20060402A2
Authority
HR
Croatia
Prior art keywords
alkyl
active agents
oxindoles
pyridine derivatives
receptor active
Prior art date
Application number
HR20060402A
Other languages
English (en)
Croatian (hr)
Inventor
Volk Bal�zs
Bark�czy J�zsef
Simig Gyula
Mezei Tibor
Kapillern� Dezsofi Rita
Gacs�lyi Istv�n
Pallagi Katalin
Gigler G�bor
L�vay Gy�rgy
M�ricz Krisztina
Leveleki Csilla
Sziray N�ra
Sz�n�si G�bor
Egyed Andr�s
G�bor H�rsing L�szl�
Original Assignee
Egis Gy�gyszergy�r Nyrt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0400956A external-priority patent/HU0400956D0/hu
Priority claimed from HU0500462A external-priority patent/HUP0500462A3/hu
Application filed by Egis Gy�gyszergy�r Nyrt. filed Critical Egis Gy�gyszergy�r Nyrt.
Publication of HRP20060402A2 publication Critical patent/HRP20060402A2/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HR20060402A 2004-05-11 2005-05-10 Derivati piridina alkilnih oksindola kao 5-ht7 receptorski aktivni agensi HRP20060402A2 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0400956A HU0400956D0 (en) 2004-05-11 2004-05-11 Pyridine derivatives of alkyl oxindoles
HU0500462A HUP0500462A3 (en) 2005-05-05 2005-05-05 Pyridine derivatives of alkyloxindoles as 5ht7 receptor active agents
PCT/HU2005/000047 WO2005108388A1 (en) 2004-05-11 2005-05-10 Pyridine derivatives of alkyl oxindoles as 5-ht7 receptor active agents

Publications (1)

Publication Number Publication Date
HRP20060402A2 true HRP20060402A2 (hr) 2007-06-30

Family

ID=89985996

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20060402A HRP20060402A2 (hr) 2004-05-11 2005-05-10 Derivati piridina alkilnih oksindola kao 5-ht7 receptorski aktivni agensi

Country Status (18)

Country Link
US (2) US20070265300A1 (pl)
EP (1) EP1751134A1 (pl)
JP (1) JP2007537225A (pl)
KR (1) KR20070011552A (pl)
AU (1) AU2005240841A1 (pl)
BG (1) BG109767A (pl)
CA (1) CA2565061A1 (pl)
CZ (1) CZ2006769A3 (pl)
EA (1) EA010154B1 (pl)
HR (1) HRP20060402A2 (pl)
IL (1) IL178891A0 (pl)
MX (1) MXPA06012991A (pl)
NO (1) NO20065696L (pl)
NZ (1) NZ551543A (pl)
PL (1) PL381612A1 (pl)
RS (1) RS20060619A (pl)
SK (1) SK51052006A3 (pl)
WO (1) WO2005108388A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
ES2808920T3 (es) 2015-11-06 2021-03-02 Hoffmann La Roche Derivados de indolin-2-ona
EP3371169B1 (en) * 2015-11-06 2019-07-17 H. Hoffnabb-La Roche Ag Indolin-2-one derivatives for use in the treatment of cns and related disorders
CN108137561B (zh) 2015-11-06 2021-03-26 豪夫迈·罗氏有限公司 二氢吲哚-2-酮衍生物
CN108137555B (zh) * 2015-11-06 2021-02-19 豪夫迈·罗氏有限公司 可用于治疗cns疾病的二氢吲哚-2-酮衍生物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
ES2243999T3 (es) * 1996-06-28 2005-12-01 Meiji Seika Kaisha Ltd. Compuestos de tetrahidrobencindol.
WO1998008816A1 (en) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Oxindole derivatives and psychotropic drugs
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
US6498251B1 (en) * 1997-12-25 2002-12-24 Meiji Seika Kaisha, Ltd. Tetrahydrobenzindole derivatives
JPH11189585A (ja) * 1997-12-25 1999-07-13 Meiji Seika Kaisha Ltd 5−ht7受容体結合能を有するテトラヒドロベンズインドール誘導体
US6407112B1 (en) * 1998-04-22 2002-06-18 Meiji Seika Kaisha, Ltd. Optically active tetrahydrobenzindole derivative
JP2004231514A (ja) * 2000-08-31 2004-08-19 Meiji Seika Kaisha Ltd 5−ht7受容体結合能を有し、かつ代謝的に安定なテトラヒドロベンズインドール誘導体
AR035521A1 (es) * 2000-12-22 2004-06-02 Lundbeck & Co As H Derivados de 3-indolina y composicion farmaceutica que los comprende
AU2003257407A1 (en) * 2002-08-29 2004-03-19 H. Lundbeck A/S S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof
WO2005108390A1 (en) * 2004-05-11 2005-11-17 Egis Gyógyszergyár Nyrt. Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders

Also Published As

Publication number Publication date
AU2005240841A1 (en) 2005-11-17
NZ551543A (en) 2009-12-24
US20070265300A1 (en) 2007-11-15
BG109767A (bg) 2008-05-30
KR20070011552A (ko) 2007-01-24
NO20065696L (no) 2007-02-08
US20090306144A1 (en) 2009-12-10
PL381612A1 (pl) 2007-06-11
CZ2006769A3 (cs) 2007-03-14
CA2565061A1 (en) 2005-11-17
EA200602081A1 (ru) 2007-04-27
EA010154B1 (ru) 2008-06-30
MXPA06012991A (es) 2007-05-04
IL178891A0 (en) 2007-03-08
WO2005108388A1 (en) 2005-11-17
JP2007537225A (ja) 2007-12-20
EP1751134A1 (en) 2007-02-14
RS20060619A (sr) 2008-06-05
SK51052006A3 (sk) 2007-05-03

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