HRP20080134T3 - New process for synthesizing (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile and its application in the synthesis of agomelatine - Google Patents

New process for synthesizing (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile and its application in the synthesis of agomelatine

Info

Publication number: HRP20080134T3
Authority: HR; Croatia
Prior art keywords: methoxy; synthesis; naphtalenyl; agomelatine; dihydro
Prior art date: 2004-02-13

Application number

HR20080134T

Other languages

English (en)

Croatian (hr)

Inventor

Souvie Jean-Claude

Gonzalez Blanco Isaac

Original Assignee

Les Laboratoires Servier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-02-13

Filing date

2008-03-25

Publication date

2008-05-31

2008-03-25 Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier

2008-05-31 Publication of HRP20080134T3 publication Critical patent/HRP20080134T3/xx

Links

230000015572 biosynthetic process Effects 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 title 3
YJYPHIXNFHFHND-UHFFFAOYSA-N agomelatine Chemical compound C1=CC=C(CCNC(C)=O)C2=CC(OC)=CC=C21 YJYPHIXNFHFHND-UHFFFAOYSA-N 0.000 title 1
229960002629 agomelatine Drugs 0.000 title 1
230000002194 synthesizing effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
MLIREBYILWEBDM-UHFFFAOYSA-N cyanoacetic acid Chemical compound OC(=O)CC#N MLIREBYILWEBDM-UHFFFAOYSA-N 0.000 abstract 2
GABLTKRIYDNDIN-UHFFFAOYSA-N 7-methoxy-3,4-dihydro-2h-naphthalen-1-one Chemical compound C1CCC(=O)C2=CC(OC)=CC=C21 GABLTKRIYDNDIN-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/33—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

HR20080134T 2004-02-13 2008-03-25 New process for synthesizing (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile and its application in the synthesis of agomelatine HRP20080134T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0401436A FR2866336B1 (fr)	2004-02-13	2004-02-13	Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine

Publications (1)

Publication Number	Publication Date
HRP20080134T3 true HRP20080134T3 (en)	2008-05-31

Family

ID=34685016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20080134T HRP20080134T3 (en)	2004-02-13	2008-03-25	New process for synthesizing (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile and its application in the synthesis of agomelatine

Country Status (32)

Country	Link
US (1)	US7479569B2 (de)
EP (1)	EP1564204B1 (de)
JP (1)	JP4192155B2 (de)
KR (1)	KR100682699B1 (de)
CN (1)	CN1293048C (de)
AR (1)	AR048235A1 (de)
AT (1)	ATE382603T1 (de)
AU (1)	AU2005200618B8 (de)
BR (1)	BRPI0501093B1 (de)
CA (1)	CA2495628C (de)
CY (1)	CY1107156T1 (de)
DE (1)	DE602005004044T2 (de)
DK (1)	DK1564204T3 (de)
EA (1)	EA007795B1 (de)
ES (1)	ES2298964T3 (de)
FR (1)	FR2866336B1 (de)
GE (1)	GEP20063955B (de)
HR (1)	HRP20080134T3 (de)
MA (1)	MA27515A1 (de)
ME (1)	ME01401B (de)
MX (1)	MXPA05001632A (de)
MY (1)	MY143266A (de)
NO (1)	NO333483B1 (de)
NZ (1)	NZ538194A (de)
PL (1)	PL1564204T3 (de)
PT (1)	PT1564204E (de)
RS (1)	RS50545B (de)
SG (1)	SG114704A1 (de)
SI (1)	SI1564204T1 (de)
UA (1)	UA76649C2 (de)
WO (1)	WO2005077888A1 (de)
ZA (1)	ZA200501254B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2866334B1 (fr) *	2004-02-13	2006-05-26	Servier Lab	Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine
FR2889522B1 (fr) *	2005-08-03	2007-12-28	Servier Lab	Nouvelle forme cristalline iv de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2889523B1 (fr) *	2005-08-03	2007-12-28	Servier Lab	Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2889521B1 (fr) *	2005-08-03	2007-12-28	Servier Lab	Nouvelle forme cristalline iii de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
WO2007079317A2 (en) *	2005-12-06	2007-07-12	Neurocrine Biosciences, Inc.	Use of sedative hypnotics for treating obesity or maintaining weight loss
CN101638376B (zh)	2008-07-29	2011-04-27	江苏恩华药业股份有限公司	阿戈美拉汀的制备方法及其中间体
CN102276492B (zh)	2010-06-08	2013-04-10	上海医药工业研究院	阿戈美拉汀中间体及其制备方法
WO2011154140A2 (en)	2010-06-10	2011-12-15	Gador S.A.	New process for the preparation of n-[2-(7-methoxy-1-naphthyl)-ethyl]acetamide and new crystalline form
CN102060733B (zh) *	2010-12-06	2014-01-29	威海迪素制药有限公司	(7-甲氧基-3,4-二氢-1-萘基)乙腈的制备方法
WO2013054273A2 (en)	2011-10-11	2013-04-18	Ranbaxy Laboratories Limited	Process for the preparation of agomelatine
EP2785681A1 (de)	2011-12-01	2014-10-08	Ranbaxy Laboratories Limited	Verfahren zur herstellung von agomelatin
WO2014001939A1 (en) *	2012-06-30	2014-01-03	Alembic Pharmaceuticals Limited	Process for preparation of agomelatine and crystalline form i thereof
ITMI20121444A1 (it)	2012-08-27	2014-02-28	Procos Spa	Processo per la produzione di agomelatine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US432702A (en) *		1890-07-22		Car-seat
US3931188A (en) *	1974-05-06	1976-01-06	Bristol-Myers Company	3-Hydroxy-5,6-benzomorphinan derivatives
US3992403A (en) *	1975-05-30	1976-11-16	Schering Corporation	2-Imidazolines and their use as hypoglycemic agents
FR2658818B1 (fr) *	1990-02-27	1993-12-31	Adir Cie	Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2866334B1 (fr) *	2004-02-13	2006-05-26	Servier Lab	Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine

2004
- 2004-02-13 FR FR0401436A patent/FR2866336B1/fr not_active Expired - Fee Related
2005
- 2005-02-01 CA CA002495628A patent/CA2495628C/fr not_active Expired - Lifetime
- 2005-02-04 US US11/051,869 patent/US7479569B2/en active Active
- 2005-02-07 SG SG200500678A patent/SG114704A1/en unknown
- 2005-02-07 MY MYPI20050475A patent/MY143266A/en unknown
- 2005-02-10 MX MXPA05001632A patent/MXPA05001632A/es active IP Right Grant
- 2005-02-11 DE DE602005004044T patent/DE602005004044T2/de not_active Expired - Lifetime
- 2005-02-11 NO NO20050738A patent/NO333483B1/no unknown
- 2005-02-11 AU AU2005200618A patent/AU2005200618B8/en not_active Expired
- 2005-02-11 WO PCT/FR2005/000324 patent/WO2005077888A1/fr not_active Ceased
- 2005-02-11 PL PL05290309T patent/PL1564204T3/pl unknown
- 2005-02-11 ES ES05290309T patent/ES2298964T3/es not_active Expired - Lifetime
- 2005-02-11 MA MA28098A patent/MA27515A1/fr unknown
- 2005-02-11 PT PT05290309T patent/PT1564204E/pt unknown
- 2005-02-11 GE GEAP8622A patent/GEP20063955B/en unknown
- 2005-02-11 AR ARP050100499A patent/AR048235A1/es unknown
- 2005-02-11 EP EP05290309A patent/EP1564204B1/de not_active Expired - Lifetime
- 2005-02-11 RS RSP-2008/0039A patent/RS50545B/sr unknown
- 2005-02-11 ME MEP-2008-946A patent/ME01401B/de unknown
- 2005-02-11 ZA ZA2005/01254A patent/ZA200501254B/en unknown
- 2005-02-11 DK DK05290309T patent/DK1564204T3/da active
- 2005-02-11 NZ NZ538194A patent/NZ538194A/en not_active IP Right Cessation
- 2005-02-11 AT AT05290309T patent/ATE382603T1/de active
- 2005-02-11 SI SI200530155T patent/SI1564204T1/sl unknown
- 2005-02-11 UA UAA200501279A patent/UA76649C2/uk unknown
- 2005-02-12 KR KR1020050011750A patent/KR100682699B1/ko not_active Expired - Lifetime
- 2005-02-14 BR BRPI0501093-4A patent/BRPI0501093B1/pt active IP Right Grant
- 2005-02-14 EA EA200500202A patent/EA007795B1/ru unknown
- 2005-02-14 JP JP2005035755A patent/JP4192155B2/ja not_active Expired - Lifetime
- 2005-02-16 CN CNB2005100077521A patent/CN1293048C/zh not_active Expired - Lifetime
2008
- 2008-01-28 CY CY20081100095T patent/CY1107156T1/el unknown
- 2008-03-25 HR HR20080134T patent/HRP20080134T3/xx unknown

Also Published As

Publication number	Publication date
US7479569B2 (en)	2009-01-20
SI1564204T1 (sl)	2008-04-30
DE602005004044D1 (de)	2008-02-14
ATE382603T1 (de)	2008-01-15
BRPI0501093A (pt)	2005-11-16
SG114704A1 (en)	2005-09-28
EP1564204A1 (de)	2005-08-17
FR2866336A1 (fr)	2005-08-19
BRPI0501093B1 (pt)	2018-07-10
CA2495628A1 (fr)	2005-08-13
CA2495628C (fr)	2007-11-27
EA007795B1 (ru)	2007-02-27
PL1564204T3 (pl)	2008-03-31
AU2005200618B2 (en)	2011-05-19
EA200500202A1 (ru)	2005-08-25
ME01401B (de)	2010-05-07
KR100682699B1 (ko)	2007-02-15
HK1078565A1 (en)	2006-03-17
ZA200501254B (en)	2005-11-30
JP2005239716A (ja)	2005-09-08
CN1293048C (zh)	2007-01-03
AU2005200618A8 (en)	2011-06-02
JP4192155B2 (ja)	2008-12-03
MY143266A (en)	2011-04-15
WO2005077888A1 (fr)	2005-08-25
UA76649C2 (en)	2006-08-15
MA27515A1 (fr)	2005-09-01
RS50545B (sr)	2010-05-07
AU2005200618B8 (en)	2011-06-02
KR20060041904A (ko)	2006-05-12
ES2298964T3 (es)	2008-05-16
NO20050738L (no)	2005-08-15
FR2866336B1 (fr)	2006-03-24
NO20050738D0 (no)	2005-02-11
GEP20063955B (en)	2006-10-25
AR048235A1 (es)	2006-04-12
PT1564204E (pt)	2008-01-29
NO333483B1 (no)	2013-06-24
AU2005200618A1 (en)	2005-09-01
CY1107156T1 (el)	2012-10-24
CN1680295A (zh)	2005-10-12
DE602005004044T2 (de)	2009-01-15
EP1564204B1 (de)	2008-01-02
NZ538194A (en)	2006-01-27
MXPA05001632A (es)	2005-08-19
DK1564204T3 (da)	2008-05-13
US20050182268A1 (en)	2005-08-18

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