HRP20080363T3 - Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora - Google Patents

Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora

Info

Publication number: HRP20080363T3
Authority: HR; Croatia
Prior art keywords: cycloalkyl; alkyl; optionally substituted; hydrogen; pyrazoles
Prior art date: 2004-06-01

Application number

HR20080363T

Other languages

English (en)

Croatian (hr)

Inventor

Buettelmann Bernd

Maria Ceccarelli Simona

Jaeschke Georg

Kolczewski Sabine

Hugh Philip Porter Richard

Vieira Eric

Spurr Paul

Original Assignee

F. Hoffmann - La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-01

Filing date

2005-05-23

Publication date

2008-09-30

2004-06-01 Priority claimed from PCT/EP2004/005881 external-priority patent/WO2004108701A1/fr

2005-05-23 Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag

2005-05-23 Priority claimed from PCT/EP2005/005559 external-priority patent/WO2005118568A1/fr

2008-09-30 Publication of HRP20080363T3 publication Critical patent/HRP20080363T3/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

HR20080363T 2004-06-01 2005-05-23 Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora HRP20080363T3 (hr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
PCT/EP2004/005881 WO2004108701A1 (fr)	2003-06-05	2004-06-01	Derives d'imidazole utilises comme antagonistes du recepteur du glutamate
EP04021216		2004-09-07
PCT/EP2005/005559 WO2005118568A1 (fr)	2004-06-01	2005-05-23	Pyridin-4-yl-ethynyl-imidazoles et pyrazoles, antagonistes du recepteur mglur5

Publications (1)

Publication Number	Publication Date
HRP20080363T3 true HRP20080363T3 (hr)	2008-09-30

Family

ID=35758209

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20080363T HRP20080363T3 (hr)	2004-06-01	2005-05-23	Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora

Country Status (20)

Country	Link
US (2)	US20060030559A1 (fr)
JP (1)	JP4690395B2 (fr)
KR (2)	KR101057032B1 (fr)
AR (1)	AR054072A1 (fr)
AU (1)	AU2005250101B2 (fr)
BR (1)	BRPI0511678A (fr)
CA (1)	CA2568725C (fr)
CR (1)	CR8742A (fr)
CY (1)	CY1108232T1 (fr)
DK (1)	DK1756086T3 (fr)
EA (1)	EA011722B1 (fr)
EC (1)	ECSP067039A (fr)
ES (1)	ES2307182T3 (fr)
HR (1)	HRP20080363T3 (fr)
IL (1)	IL179524A (fr)
MA (1)	MA28602B1 (fr)
NZ (1)	NZ551253A (fr)
PT (1)	PT1756086E (fr)
SI (1)	SI1756086T1 (fr)
TW (1)	TWI297683B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8329703B2 (en) *	2005-02-15	2012-12-11	Xtl Biopharmaceuticals Ltd.	Pyrazole compounds
US8334287B2 (en) *	2009-07-17	2012-12-18	Hoffmann-La Roche Inc.	Imidazoles
US20120040008A1 (en) *	2010-08-11	2012-02-16	Ashish Chatterji	Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
US20120039999A1 (en) *	2010-08-11	2012-02-16	Ashish Chatterji	Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
JP7082484B2 (ja)	2015-04-01	2022-06-08	中外製薬株式会社	ポリペプチド異種多量体の製造方法
EP3400220B1 (fr) *	2016-01-05	2021-03-24	Hua Medicine (Shanghai) Ltd.	Dérivés de pyrazole
EP3436009B1 (fr) *	2016-03-30	2024-03-06	Sinntaxis AB	Modulateurs allostériques négatifs de mglur5 utiles dans le traitement de lésions du cerveau mature
BR112022024760A2 (pt)	2020-06-05	2023-03-07	Noema Pharma Ag	Métodos de tratamento do complexo de esclerose tuberosa
BR112023001621A2 (pt) *	2020-07-30	2023-04-04	Noema Pharma Ag	Métodos de tratamento de neuralgia trigeminal

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3033199A (en) *	1959-10-13	1962-05-08	Jacobs Clifford Roy	Closure for protective device
US3045022A (en)	1960-04-07	1962-07-17	Reilly Tar & Chem Corp	Process of preparing ethynylpyridines
US3303199A (en)	1963-07-15	1967-02-07	Geigy Chem Corp	Certain imidazolone derivatives and process for making same
US3341548A (en) *	1964-04-29	1967-09-12	Hoffmann La Roche	Nitroimidazoles and their preparation
DE2035905A1 (de)	1970-07-20	1972-02-03	Chemische Fabrik Stockhausen & Cie.,4150Krefeld	Imidazolverbindungen und deren Herstellungsverfahren
CA1174673A (fr)	1981-02-27	1984-09-18	Walter Hunkeler	Imidazodiazepines
US4508560A (en)	1981-11-11	1985-04-02	Ciba Geigy Corporation	Certain pyridylacetylene compounds, compositions containing same and herbicidal methods of use
US4711962A (en) *	1984-10-18	1987-12-08	Stauffer Chemical Company	Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles
SG52709A1 (en)	1989-06-30	1998-09-28	Du Pont	Substituted imidazoles
TW544448B (en) *	1997-07-11	2003-08-01	Novartis Ag	Pyridine derivatives
CA2297732C (fr)	1997-08-14	2008-04-29	F. Hoffmann-La Roche Ag	Ethers heterocycliques de vinyle utiles contre des troubles neurologiques
JP4815083B2 (ja) *	1999-08-31	2011-11-16	メルク・シャープ・エンド・ドーム・コーポレイション	複素環化合物およびそれの使用方法
ATE261945T1 (de)	1999-10-15	2004-04-15	Hoffmann La Roche	Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
IL136553A0 (en)	2000-06-05	2001-06-14	Compugen Ltd	SPLICE VARIANT OF mGluR
JP5154728B2 (ja)	2000-07-24	2013-02-27	クレニツキー・ファーマシューティカルズ，インコーポレイテッド	神経栄養活性を有する置換５−アルキニルピリミジン
WO2002046166A1 (fr)	2000-12-04	2002-06-13	F. Hoffmann-La Roche Ag	Derives phenylethenyle ou phenylethinyle servant d'antagonistes de recepteur de glutamate
EP1238586A1 (fr)	2001-03-09	2002-09-11	Basf Aktiengesellschaft	2-alkynyl-pyri(mi)dines herbicides
US6596731B2 (en)	2001-03-27	2003-07-22	Hoffmann-La Roche Inc.	Substituted imidazo[1,2-A] pyridine derivatives
JP4303109B2 (ja)	2001-10-04	2009-07-29	メルクエンドカムパニーインコーポレーテッド	代謝共役型グルタミン酸受容体−５のヘテロアリール置換テトラゾール調節剤
US20030187026A1 (en)	2001-12-13	2003-10-02	Qun Li	Kinase inhibitors
WO2003053922A2 (fr)	2001-12-19	2003-07-03	Merck & Co., Inc.	Imidazoles substitues par heteroaryle modulateurs du recepteur metabotropique du glutamate de type 5
JP2006513996A (ja)	2002-10-24	2006-04-27	メルク　エンド　カムパニー　インコーポレーテッド	代謝調節型グルタミン酸受容体結合用トレーサーとしてのアルキン誘導体
ITMI20030151A1 (it)	2003-01-30	2004-07-31	Recordati Ind Chimica E Farma Ceutica S P A	Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore.
TWI292318B (en) *	2003-03-10	2008-01-11	Hoffmann La Roche	Imidazol-4-yl-ethynyl-pyridine derivatives
UA80888C2 (en)	2003-06-05	2007-11-12	Hoffmann La Roche	Imidazole derivatives as glutmate receptor antagonists
US7531529B2 (en)	2003-06-05	2009-05-12	Roche Palo Alto Llc	Imidazole derivatives
US7091222B2 (en) *	2003-07-03	2006-08-15	Hoffmann-La Roche Inc.	Imidazole derivatives
US7452909B2 (en) *	2003-09-04	2008-11-18	Hoffman-La Roche Inc.	Imidazole derivatives
DE102004032567A1 (de)	2004-07-05	2006-03-02	Grünenthal GmbH	Substituierte 1-Propiolyl-piperazine

2005
- 2005-05-23 NZ NZ551253A patent/NZ551253A/en not_active IP Right Cessation
- 2005-05-23 HR HR20080363T patent/HRP20080363T3/xx unknown
- 2005-05-23 KR KR1020087022221A patent/KR101057032B1/ko not_active Expired - Fee Related
- 2005-05-23 SI SI200530280T patent/SI1756086T1/sl unknown
- 2005-05-23 BR BRPI0511678-3A patent/BRPI0511678A/pt not_active Application Discontinuation
- 2005-05-23 PT PT05744719T patent/PT1756086E/pt unknown
- 2005-05-23 KR KR1020067025236A patent/KR100907108B1/ko not_active Expired - Fee Related
- 2005-05-23 AU AU2005250101A patent/AU2005250101B2/en not_active Ceased
- 2005-05-23 EA EA200602154A patent/EA011722B1/ru not_active IP Right Cessation
- 2005-05-23 ES ES05744719T patent/ES2307182T3/es not_active Expired - Lifetime
- 2005-05-23 JP JP2007513776A patent/JP4690395B2/ja not_active Expired - Fee Related
- 2005-05-23 DK DK05744719T patent/DK1756086T3/da active
- 2005-05-23 CA CA2568725A patent/CA2568725C/fr not_active Expired - Fee Related
- 2005-05-27 AR ARP050102179A patent/AR054072A1/es unknown
- 2005-05-27 TW TW094117351A patent/TWI297683B/zh not_active IP Right Cessation
- 2005-05-31 US US11/141,547 patent/US20060030559A1/en not_active Abandoned
2006
- 2006-11-09 CR CR8742A patent/CR8742A/es unknown
- 2006-11-22 MA MA29482A patent/MA28602B1/fr unknown
- 2006-11-23 IL IL179524A patent/IL179524A/en not_active IP Right Cessation
- 2006-11-28 EC EC2006007039A patent/ECSP067039A/es unknown
2008
- 2008-07-31 CY CY20081100804T patent/CY1108232T1/el unknown
2009
- 2009-11-05 US US12/613,089 patent/US8293916B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
SI1756086T1 (sl)	2008-08-31
EA011722B1 (ru)	2009-04-28
KR20070021231A (ko)	2007-02-22
US8293916B2 (en)	2012-10-23
JP2008500979A (ja)	2008-01-17
ES2307182T3 (es)	2008-11-16
KR100907108B1 (ko)	2009-07-09
CY1108232T1 (el)	2014-02-12
HK1105972A1 (zh)	2008-02-29
TWI297683B (en)	2008-06-11
AR054072A1 (es)	2007-06-06
US20100048569A1 (en)	2010-02-25
ECSP067039A (es)	2006-12-29
PT1756086E (pt)	2008-08-08
JP4690395B2 (ja)	2011-06-01
EA200602154A1 (ru)	2007-06-29
TW200609222A (en)	2006-03-16
AU2005250101A1 (en)	2005-12-15
NZ551253A (en)	2010-07-30
CA2568725A1 (fr)	2005-12-15
KR101057032B1 (ko)	2011-08-16
CR8742A (es)	2007-08-28
AU2005250101B2 (en)	2011-08-25
IL179524A (en)	2012-04-30
US20060030559A1 (en)	2006-02-09
KR20080089523A (ko)	2008-10-06
BRPI0511678A (pt)	2008-01-08
IL179524A0 (en)	2007-05-15
DK1756086T3 (da)	2008-08-04
MA28602B1 (fr)	2007-05-02
CA2568725C (fr)	2012-11-27

Publication	Publication Date	Title
AU2005314155C1 (en)	2024-05-30	Method for preparing N-phenylpyrazole-1-carboxamides
HRP20070529T3 (hr)	2008-05-31	Derivati imidazola kao antagonisti receptora glutamata
MEP22008A (en)	2010-06-10	Derivatives of n-[heteroaryl(piperidine-2-yl)methyl]benzamide, preparation method thereof and application of same in therapeutics
HRP20040977B1 (hr)	2008-04-30	Derivati n-[fenil(piperidin-2-il)metil]benzamida,postupak njihovog pripravljanja i primjena istih u terapiji
MEP12608A (en)	2010-06-10	Derivatives of n-[phenyl (pyrrolidine-2-yl) methyl]benzamide and n-[(azepan-2-yl)phenylmethyl]benzamide, preparation method thereof and application of same in therapeutics
HRP20080113T3 (hr)	2008-04-30	Supstituirani piridinilni i pirimidinilni derivati kao modulatori metabolizma i liječenje bolesti koje su s tim povezane
MX301666B (en)	2012-07-25	Amide derivatives, process for production of the same, and method for application thereof as insecticide
CO6270328A2 (es)	2011-04-20	Derivados de pirrolo [2,3] pirimidina como inhibidores de proteinas quinasas b
CO5611147A2 (es)	2006-02-28	Derivados de nicotinamida utiles como inhibidores p38
PT1289955E (pt)	2005-08-31	Piperidinas para utilizacao como antagonistas dos receptores da orexina
AR049739A1 (es)	2006-08-30	Derivados de aril-piridina
CY1109680T1 (el)	2014-08-13	Υποκατεστημενες πυριδινονες ως ρυθμιστες της ρ38 μαρ κινασης
HRP20090195T1 (hr)	2009-05-31	Inhibitori mitotičkih kinezina
BR0316241A (pt)	2005-10-04	Pirrolobenzodiazepinas
EP1468990A4 (fr)	2006-01-04	Derive de piperazine
TW200744994A (en)	2007-12-16	Insecticidal 3-acylaminobenzanilides
DK1755606T3 (da)	2008-03-03	Quinazolinonderivater, der er anvendelige som vanilloid-antagonister
HRP20080363T3 (hr)	2008-09-30	Piridin-4-il-etinil-imidazoli i pirazoli kao antagonisti mglu5 receptora
WO2008155670A3 (fr)	2009-04-09	Composés d'arylamide de pyrimidone
HRP20050628A2 (en)	2006-07-31	Substituted benzoyl derivatives uses as herbicides
DE602005013975D1 (de)	2009-05-28	Neue flammhemmende polystyrene
MY146939A (en)	2012-10-15	Derivatives of 7-alkynyl-1,8-naphthyridones, preparation method thereof and use of same in therapeutics
HRP20040230B1 (hr)	2012-01-31	Agonisti muskarina
EP1854789A4 (fr)	2009-06-17	Derive de quinazoline possedant une activite inhibitrice vis-a-vis de la tyrosine kinase
AR077156A1 (es)	2011-08-10	Inhibidores de transportador de glicina-1