HRP20090324T1 - Moduliranje interakcije između hgf beta lanca i c-met - Google Patents
Moduliranje interakcije između hgf beta lanca i c-met Download PDFInfo
- Publication number
- HRP20090324T1 HRP20090324T1 HR20090324T HRP20090324T HRP20090324T1 HR P20090324 T1 HRP20090324 T1 HR P20090324T1 HR 20090324 T HR20090324 T HR 20090324T HR P20090324 T HRP20090324 T HR P20090324T HR P20090324 T1 HRP20090324 T1 HR P20090324T1
- Authority
- HR
- Croatia
- Prior art keywords
- chain
- hgf
- substance
- activated
- molecule
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47677803P | 2003-06-06 | 2003-06-06 | |
| US53211703P | 2003-12-23 | 2003-12-23 | |
| PCT/US2004/017901 WO2005001486A1 (en) | 2003-06-06 | 2004-06-04 | Modulating the interaction between hgf beta chain and c-met |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090324T1 true HRP20090324T1 (hr) | 2010-02-28 |
Family
ID=33555430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090324T HRP20090324T1 (hr) | 2003-06-06 | 2004-06-04 | Moduliranje interakcije između hgf beta lanca i c-met |
Country Status (16)
| Country | Link |
|---|---|
| US (8) | US20060035278A9 (pl) |
| EP (3) | EP1636593B9 (pl) |
| JP (1) | JP2007526447A (pl) |
| KR (2) | KR101148657B1 (pl) |
| AT (1) | ATE425463T1 (pl) |
| AU (1) | AU2004252475A1 (pl) |
| CA (1) | CA2528343A1 (pl) |
| DE (1) | DE602004019919D1 (pl) |
| DK (1) | DK1636593T5 (pl) |
| ES (1) | ES2323425T3 (pl) |
| HR (1) | HRP20090324T1 (pl) |
| MX (1) | MXPA05013181A (pl) |
| PL (1) | PL1636593T3 (pl) |
| PT (1) | PT1636593E (pl) |
| SI (1) | SI1636593T1 (pl) |
| WO (1) | WO2005001486A1 (pl) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040208876A1 (en) | 2003-04-18 | 2004-10-21 | Kim Kyung Jin | Monoclonal antibodies to hepatocyte growth factor |
| KR101254371B1 (ko) * | 2003-07-18 | 2013-05-02 | 암젠 프레몬트 인코포레이티드 | 간세포 성장인자에 결합하는 분리된 항체 |
| DE602005022474D1 (de) | 2004-10-20 | 2010-09-02 | Peas Inst Ab | Beurteilung der biologischen aktivität von hgf (hepatocyte growth factor) |
| ATE486872T1 (de) | 2005-02-09 | 2010-11-15 | Arqule Inc | Maleimid-derivate, pharmazeutische zusammensetzungen und verfahren zur behandlung von krebs |
| AU2006229990A1 (en) * | 2005-03-25 | 2006-10-05 | Genentech, Inc. | C-met mutations in lung cancer |
| WO2006104911A2 (en) * | 2005-03-25 | 2006-10-05 | Genentech, Inc. | Methods and compositions for modulating hyperstabilized c-met |
| SG161281A1 (en) * | 2005-04-15 | 2010-05-27 | Genentech Inc | Hgf beta chain variants |
| AR059922A1 (es) | 2006-04-01 | 2008-05-07 | Galaxy Biotech Llc | Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos |
| JP2009539878A (ja) * | 2006-06-08 | 2009-11-19 | アレイ バイオファーマ、インコーポレイテッド | キノリン化合物および使用方法 |
| TWI577695B (zh) | 2006-12-19 | 2017-04-11 | 建南德克公司 | 用於輔助及先導性輔助療法之血管內皮生長因子(vegf)-特異性拮抗劑及早期腫瘤之治療 |
| AU2008268613A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
| EP2392574B1 (en) | 2007-06-22 | 2013-12-18 | ArQule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
| WO2009002806A1 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
| US8247374B2 (en) * | 2007-11-09 | 2012-08-21 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium using cytokines and variants thereof |
| RU2601892C2 (ru) * | 2008-03-06 | 2016-11-10 | Дженентек, Инк. | Комбинированная терапия антагонистами с-мет и egfr |
| EP2446274B1 (en) * | 2009-06-26 | 2017-08-09 | PEAS Institut AB | Method for determining biologically active hgf |
| EP2491059B1 (en) | 2009-10-22 | 2015-02-25 | F.Hoffmann-La Roche Ag | Anti-hepsin antibodies and methods using same |
| EP3511342B1 (en) | 2010-03-10 | 2024-01-17 | Genmab A/S | Monoclonal antibodies against c-met |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| CN102643268B (zh) | 2011-12-30 | 2014-05-21 | 沈阳药科大学 | 喹啉类及噌啉类化合物及其应用 |
| WO2013143376A1 (zh) | 2012-03-26 | 2013-10-03 | 武汉盛云生物医药科技有限责任公司 | 含1,2,4-三嗪-3,5-二酮的喹啉类化合物及其应用 |
| CN104837502B (zh) | 2012-10-12 | 2018-08-10 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其结合物 |
| CA2905181C (en) | 2013-03-13 | 2020-06-02 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof for providing targeted therapy |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| EP3122900A1 (en) | 2014-03-24 | 2017-02-01 | F. Hoffmann-La Roche AG | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression |
| JP6531166B2 (ja) | 2014-09-10 | 2019-06-12 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びそのコンジュゲート |
| CN107613974B (zh) | 2015-03-16 | 2021-01-15 | 塞尔德克斯医疗公司 | 抗-met抗体及其使用方法 |
| CN109862919A (zh) | 2016-10-11 | 2019-06-07 | 免疫医疗有限公司 | 抗体-药物缀合物联合免疫介导的治疗剂 |
| TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法 |
| CA3098103A1 (en) | 2018-05-23 | 2019-11-28 | Adc Therapeutics Sa | Molecular adjuvant |
| JP7380999B2 (ja) * | 2018-09-06 | 2023-11-15 | 国立大学法人 東京大学 | 環状ペプチド |
| US11896682B2 (en) | 2019-09-16 | 2024-02-13 | Regeneron Pharmaceuticals, Inc. | Radiolabeled MET binding proteins for immuno-PET imaging and methods of use thereof |
| US20230372528A1 (en) | 2020-10-16 | 2023-11-23 | University Of Georgia Research Foundation, Inc. | Glycoconjugates |
| GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
| CN117980327A (zh) | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
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| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
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-
2004
- 2004-06-04 MX MXPA05013181A patent/MXPA05013181A/es active IP Right Grant
- 2004-06-04 US US10/862,192 patent/US20060035278A9/en not_active Abandoned
- 2004-06-04 ES ES04754499T patent/ES2323425T3/es not_active Expired - Lifetime
- 2004-06-04 DK DK04754499T patent/DK1636593T5/da active
- 2004-06-04 HR HR20090324T patent/HRP20090324T1/hr unknown
- 2004-06-04 JP JP2006515232A patent/JP2007526447A/ja active Pending
- 2004-06-04 EP EP04754499A patent/EP1636593B9/en not_active Revoked
- 2004-06-04 AT AT04754499T patent/ATE425463T1/de active
- 2004-06-04 EP EP20090002616 patent/EP2093570A1/en not_active Withdrawn
- 2004-06-04 DE DE602004019919T patent/DE602004019919D1/de not_active Expired - Lifetime
- 2004-06-04 PT PT04754499T patent/PT1636593E/pt unknown
- 2004-06-04 AU AU2004252475A patent/AU2004252475A1/en not_active Abandoned
- 2004-06-04 KR KR1020057023299A patent/KR101148657B1/ko not_active Expired - Fee Related
- 2004-06-04 WO PCT/US2004/017901 patent/WO2005001486A1/en not_active Ceased
- 2004-06-04 EP EP20100009373 patent/EP2367008A3/en not_active Withdrawn
- 2004-06-04 PL PL04754499T patent/PL1636593T3/pl unknown
- 2004-06-04 CA CA002528343A patent/CA2528343A1/en not_active Abandoned
- 2004-06-04 SI SI200431128T patent/SI1636593T1/sl unknown
- 2004-06-04 KR KR1020117022830A patent/KR20110117728A/ko not_active Withdrawn
-
2006
- 2006-10-02 US US11/537,753 patent/US20070129301A1/en not_active Abandoned
-
2009
- 2009-10-21 US US12/582,934 patent/US20100040634A1/en not_active Abandoned
-
2010
- 2010-12-22 US US12/975,828 patent/US20110177058A1/en not_active Abandoned
-
2011
- 2011-12-07 US US13/313,983 patent/US20130143813A1/en not_active Abandoned
-
2014
- 2014-06-26 US US14/316,621 patent/US20150126448A1/en not_active Abandoned
-
2016
- 2016-05-23 US US15/162,372 patent/US20170106042A1/en not_active Abandoned
-
2018
- 2018-03-15 US US15/921,827 patent/US20190054138A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2323425T3 (es) | 2009-07-15 |
| SI1636593T1 (sl) | 2009-08-31 |
| DK1636593T5 (da) | 2009-07-27 |
| US20060035278A9 (en) | 2006-02-16 |
| DK1636593T3 (da) | 2009-06-15 |
| US20190054138A1 (en) | 2019-02-21 |
| US20100040634A1 (en) | 2010-02-18 |
| EP2093570A1 (en) | 2009-08-26 |
| KR20060017634A (ko) | 2006-02-24 |
| DE602004019919D1 (de) | 2009-04-23 |
| US20150126448A1 (en) | 2015-05-07 |
| US20170106042A1 (en) | 2017-04-20 |
| WO2005001486A1 (en) | 2005-01-06 |
| ATE425463T1 (de) | 2009-03-15 |
| US20070129301A1 (en) | 2007-06-07 |
| US20050037431A1 (en) | 2005-02-17 |
| JP2007526447A (ja) | 2007-09-13 |
| PT1636593E (pt) | 2009-06-03 |
| EP1636593B1 (en) | 2009-03-11 |
| CA2528343A1 (en) | 2005-01-06 |
| MXPA05013181A (es) | 2006-06-23 |
| EP2367008A3 (en) | 2014-12-24 |
| EP1636593A1 (en) | 2006-03-22 |
| KR20110117728A (ko) | 2011-10-27 |
| EP2367008A2 (en) | 2011-09-21 |
| AU2004252475A1 (en) | 2005-01-06 |
| PL1636593T3 (pl) | 2009-08-31 |
| US20130143813A1 (en) | 2013-06-06 |
| US20110177058A1 (en) | 2011-07-21 |
| KR101148657B1 (ko) | 2012-07-05 |
| HK1092872A1 (zh) | 2007-02-16 |
| EP1636593B9 (en) | 2009-12-16 |
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