HRP20100149T1 - Postupak priprave tiotropijevih soli - Google Patents

Postupak priprave tiotropijevih soli Download PDF

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Publication number
HRP20100149T1
HRP20100149T1 HR20100149T HRP20100149T HRP20100149T1 HR P20100149 T1 HRP20100149 T1 HR P20100149T1 HR 20100149 T HR20100149 T HR 20100149T HR P20100149 T HRP20100149 T HR P20100149T HR P20100149 T1 HRP20100149 T1 HR P20100149T1
Authority
HR
Croatia
Prior art keywords
formula
kat
compounds
denotes
alkyl
Prior art date
Application number
HR20100149T
Other languages
English (en)
Croatian (hr)
Inventor
Banholzer Rolf
Pfrengle Waldemar
Sieger Peter
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20100149(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of HRP20100149T1 publication Critical patent/HRP20100149T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20100149T 2003-11-03 2004-10-29 Postupak priprave tiotropijevih soli HRP20100149T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025075 2003-11-03
PCT/EP2004/012268 WO2005042526A1 (de) 2003-11-03 2004-10-29 Verfahren zur herstellung von tiotropiumsalze, tiotropiumsalze sowie arzneimitte lformulierungen diese enthaltend

Publications (1)

Publication Number Publication Date
HRP20100149T1 true HRP20100149T1 (hr) 2010-04-30

Family

ID=34530660

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20100149T HRP20100149T1 (hr) 2003-11-03 2004-10-29 Postupak priprave tiotropijevih soli

Country Status (34)

Country Link
US (1) US8686148B2 (pl)
EP (3) EP1682541B1 (pl)
JP (1) JP5165244B2 (pl)
KR (1) KR20060117334A (pl)
CN (3) CN102070630B (pl)
AR (1) AR046317A1 (pl)
AT (1) ATE460414T1 (pl)
AU (1) AU2004285683C1 (pl)
BR (1) BRPI0416136A (pl)
CA (1) CA2544348A1 (pl)
CO (1) CO5690553A2 (pl)
CY (2) CY1110048T1 (pl)
DE (1) DE502004010885D1 (pl)
DK (2) DK2067779T3 (pl)
EA (1) EA012326B1 (pl)
ES (2) ES2422729T3 (pl)
HR (1) HRP20100149T1 (pl)
IL (1) IL175023A (pl)
ME (1) ME00361B (pl)
MX (1) MXPA06004697A (pl)
MY (1) MY143364A (pl)
NO (1) NO335814B1 (pl)
NZ (1) NZ547276A (pl)
PE (1) PE20050446A1 (pl)
PL (2) PL1682541T3 (pl)
PT (2) PT1682541E (pl)
RS (2) RS51758B (pl)
SG (1) SG137859A1 (pl)
SI (2) SI1682541T1 (pl)
TW (2) TWI435876B (pl)
UA (1) UA82413C2 (pl)
UY (1) UY28590A1 (pl)
WO (1) WO2005042526A1 (pl)
ZA (1) ZA200602342B (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
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UY28590A1 (es) 2003-11-03 2005-06-30 Boehringer Ingelheim Int Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen.
EP2083007B1 (de) * 2003-11-03 2013-04-24 Boehringer Ingelheim International Gmbh Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
RU2418796C2 (ru) * 2005-06-15 2011-05-20 Берингер Ингельхайм Интернациональ Гмбх Способ получения новых солей тиотропия
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
KR101395881B1 (ko) * 2005-12-19 2014-05-21 시코르, 인크. 브롬화 티오트로피움의 신규한 형태 및 이의 제조 방법
ATE500825T1 (de) * 2006-01-04 2011-03-15 Boehringer Ingelheim Int Verwendung von tiotropium-salzen bei der behandlung von mässigem persistierendem asthma
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs) 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
JP6042197B2 (ja) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 肺障害治療剤

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DE50103666D1 (de) 2000-10-12 2004-10-21 Boehringer Ingelheim Pharma Kristallines monohydrat von tiotropiumbromid, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels
PL200063B1 (pl) 2000-10-12 2008-12-31 Boehringer Ingelheim Pharma Nowe proszki do inhalacji zawierające tiotropium
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DE10056104A1 (de) 2000-11-13 2002-05-23 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
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EP2083007B1 (de) * 2003-11-03 2013-04-24 Boehringer Ingelheim International Gmbh Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
UY28590A1 (es) 2003-11-03 2005-06-30 Boehringer Ingelheim Int Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen.
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
RU2418796C2 (ru) * 2005-06-15 2011-05-20 Берингер Ингельхайм Интернациональ Гмбх Способ получения новых солей тиотропия

Also Published As

Publication number Publication date
ZA200602342B (en) 2007-06-27
DK2067779T3 (da) 2013-07-29
US20050131007A1 (en) 2005-06-16
PT2067779E (pt) 2013-07-25
EP2336126A1 (de) 2011-06-22
EP1682541B1 (de) 2010-03-10
CN101407514B (zh) 2013-05-29
AU2004285683C1 (en) 2011-09-08
IL175023A (en) 2011-02-28
EP1682541A1 (de) 2006-07-26
EA200600886A1 (ru) 2006-10-27
TWI435876B (zh) 2014-05-01
DE502004010885D1 (de) 2010-04-22
EA012326B1 (ru) 2009-08-28
AU2004285683A1 (en) 2005-05-12
US8686148B2 (en) 2014-04-01
CN1882582A (zh) 2006-12-20
IL175023A0 (en) 2006-08-20
CN102070630A (zh) 2011-05-25
CN101407514A (zh) 2009-04-15
CN100549010C (zh) 2009-10-14
NO20061440L (no) 2006-07-12
ES2422729T3 (es) 2013-09-13
ATE460414T1 (de) 2010-03-15
NO335814B1 (no) 2015-02-23
EP2067779B1 (de) 2013-04-24
CN102070630B (zh) 2013-04-17
HK1129111A1 (en) 2009-11-20
EP2067779A1 (de) 2009-06-10
KR20060117334A (ko) 2006-11-16
TWI363758B (en) 2012-05-11
MXPA06004697A (es) 2006-07-05
PE20050446A1 (es) 2005-08-02
PT1682541E (pt) 2010-04-14
ME00361B (me) 2011-10-10
SG137859A1 (en) 2007-12-28
SI1682541T1 (sl) 2010-06-30
AR046317A1 (es) 2005-11-30
MY143364A (en) 2011-04-29
RS51758B (sr) 2011-12-31
UA82413C2 (uk) 2008-04-10
TW201231465A (en) 2012-08-01
HK1153409A1 (en) 2012-03-30
JP5165244B2 (ja) 2013-03-21
CY1114157T1 (el) 2016-08-31
EP2067779B9 (de) 2013-10-16
BRPI0416136A (pt) 2007-01-02
TW200526653A (en) 2005-08-16
PL1682541T3 (pl) 2010-08-31
RS20060292A (sr) 2008-08-07
NZ547276A (en) 2009-08-28
CY1110048T1 (el) 2015-01-14
MEP51308A (en) 2011-05-10
HK1099748A1 (zh) 2007-08-24
JP2007509893A (ja) 2007-04-19
ES2342468T3 (es) 2010-07-07
SI2067779T1 (sl) 2013-08-30
AU2004285683B2 (en) 2011-04-21
CA2544348A1 (en) 2005-05-12
WO2005042526A1 (de) 2005-05-12
PL2067779T3 (pl) 2013-09-30
CO5690553A2 (es) 2006-10-31
DK1682541T3 (da) 2010-06-28
UY28590A1 (es) 2005-06-30

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