HRP20120008T1 - INDUSTRIJSKI POSTUPAK ZA SINTEZU 17-ACETOKSI-11ß-[4-(DIMETILAMINO)-FENIL]-21-METOKSI-19-NORPREGNA-4,9-DIEN-3,20-DIONA I KLJUČNI INTERMEDIJERI U TOM POSTUPKU - Google Patents

INDUSTRIJSKI POSTUPAK ZA SINTEZU 17-ACETOKSI-11ß-[4-(DIMETILAMINO)-FENIL]-21-METOKSI-19-NORPREGNA-4,9-DIEN-3,20-DIONA I KLJUČNI INTERMEDIJERI U TOM POSTUPKU Download PDF

Info

Publication number: HRP20120008T1
Authority: HR; Croatia
Prior art keywords: oxy; formula; bis; ethanediyl; phenyl
Prior art date: 2007-06-27

Application number

HR20120008T

Other languages

English (en)

Croatian (hr)

Inventor

B�di J�zsef

Visky Gy�rgy

Sz�les J�nos

Mah Sndor

Snta Csaba

Csrgei Jnos

Tuba Zolt�n

Terdy L�szl�

Moln�r Csaba

Aranyi Antal

Horv�th Zolt�n

Balogh G�bor

Original Assignee

Richter Gedeon Nyrt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-27

Filing date

2008-06-19

Publication date

2012-01-31

2008-06-19 Application filed by Richter Gedeon Nyrt. filed Critical Richter Gedeon Nyrt.

2012-01-31 Publication of HRP20120008T1 publication Critical patent/HRP20120008T1/hr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Gynecology & Obstetrics (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HR20120008T 2007-06-27 2008-06-19 INDUSTRIJSKI POSTUPAK ZA SINTEZU 17-ACETOKSI-11ß-[4-(DIMETILAMINO)-FENIL]-21-METOKSI-19-NORPREGNA-4,9-DIEN-3,20-DIONA I KLJUČNI INTERMEDIJERI U TOM POSTUPKU HRP20120008T1 (hr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0700439A HU228636B1 (en)	2007-06-27	2007-06-27	Industrial method for the synthesis of 17-acetoxy-11betha-4[-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process
PCT/HU2008/000073 WO2009001148A2 (en)	2007-06-27	2008-06-19	INDUSTRIAL METHOD FOR THE SYNTHESIS OF 17-ACETOXY-11β-[4-(DIMETHYLAMINO)-PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIEN-3,20-DIONE AND THE KEY INTERMEDIATES OF THE PROCESS

Publications (1)

Publication Number	Publication Date
HRP20120008T1 true HRP20120008T1 (hr)	2012-01-31

Family

ID=89987607

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20120008T HRP20120008T1 (hr)	2007-06-27	2008-06-19	INDUSTRIJSKI POSTUPAK ZA SINTEZU 17-ACETOKSI-11ß-[4-(DIMETILAMINO)-FENIL]-21-METOKSI-19-NORPREGNA-4,9-DIEN-3,20-DIONA I KLJUČNI INTERMEDIJERI U TOM POSTUPKU

Country Status (27)

Country	Link
US (1)	US8183402B2 (de)
EP (1)	EP2160398B1 (de)
JP (1)	JP5261481B2 (de)
KR (1)	KR101535686B1 (de)
CN (1)	CN101622268B (de)
AR (1)	AR067189A1 (de)
AT (1)	ATE528313T1 (de)
AU (1)	AU2008269531B2 (de)
BR (1)	BRPI0813654B8 (de)
CA (1)	CA2677195C (de)
CY (1)	CY1112529T1 (de)
DK (1)	DK2160398T3 (de)
EA (1)	EA015478B1 (de)
ES (1)	ES2375320T3 (de)
HR (1)	HRP20120008T1 (de)
HU (1)	HU228636B1 (de)
IL (1)	IL200124A (de)
MX (1)	MX2009011861A (de)
MY (1)	MY149296A (de)
NZ (1)	NZ579029A (de)
PL (1)	PL2160398T3 (de)
PT (1)	PT2160398E (de)
SI (1)	SI2160398T1 (de)
TW (1)	TWI411616B (de)
UA (1)	UA100241C2 (de)
WO (1)	WO2009001148A2 (de)
ZA (1)	ZA200907030B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0900171A2 (hu)	2009-03-20	2010-12-28	Richter Gedeon Nyrt	17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására
HUP0900487A2 (hu) *	2009-08-05	2011-03-28	Richter Gedeon Nyrt	17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos polimorf módosulata és eljárás elõállítására
CN102516345B (zh) *	2011-11-01	2014-11-26	上海优拓医药科技有限公司	醋酸乌利司他及其关键中间体的制备方法
CN102942612A (zh) *	2012-10-30	2013-02-27	四川大学	一种合成醋酸乌利司他的新方法
CA2907320A1 (en) *	2013-03-15	2014-09-18	Prevacus, Inc.	Synthesis of ent-progesterone and intermediates thereof
HU230319B1 (hu)	2013-10-01	2016-01-28	Richter Gedeon Nyrt.	Ipari eljárás szteroid hatóanyagok előállítására
CN103601785A (zh) *	2013-11-25	2014-02-26	四川大学	一种醋酸优力斯特新的合成方法
HU230397B1 (hu)	2013-11-25	2016-04-28	Richter Gedeon Nyrt.	Eljárás (11b,17a)-17-acetoxi-11-metil-19-norpregn-4-én-3,20-dion előállítására
HU230381B1 (hu) *	2014-02-17	2016-03-29	Richter Gedeon Nyrt	Ipari eljárás szteroid intermedier előállítására
CN107200770B (zh) *	2016-03-18	2019-11-01	华东师范大学	特拉司酮合成中环氧异构体的高效分离和循环利用方法
CN109575098B (zh) *	2019-01-18	2021-01-01	湖南成大生物科技有限公司	诺孕美特的合成方法
CN115536529B (zh) *	2022-09-26	2024-06-25	浦拉司科技（上海）有限责任公司	一种3,5-二（2-氰基-异丙基）-甲苯的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3722486A1 (de) *	1987-07-03	1989-01-12	Schering Ag	Neues epoxidierungs-reagenz und seine verwendung
US4954490A (en) *	1988-06-23	1990-09-04	Research Triangle Institute	11 β-substituted progesterone analogs
DE69702450T2 (de) *	1996-05-01	2001-03-08	The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer	21-substituierte progesteron derivate als antigestagene
US6900193B1 (en) *	1996-05-01	2005-05-31	The United States Of America As Represented By The Department Of Health And Human Services	Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
US6768014B2 (en)	1999-12-29	2004-07-27	The United States Of America As Represented By The Department Of Health And Human Services	PROCESS FOR PREPARING 17α-ACETOXY-11β-[4-N,N(DIMETHYLAMINO)PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIENE-3,20-DIONE, INTERMEDIATES USEFUL IN THE PROCESS , AND PROCESSES FOR PREPARING SUCH INTERMEDIATES
DK1265911T3 (da) *	2000-03-17	2008-09-29	Us Gov Health & Human Serv	17-alfa-substitueret-11-beta-substitueret-4-aryl og 21-substitueret 19-norpregnadiendion som antiprogestationelle midler

2007
- 2007-06-27 HU HU0700439A patent/HU228636B1/hu unknown
2008
- 2008-06-19 BR BRPI0813654A patent/BRPI0813654B8/pt active IP Right Grant
- 2008-06-19 MY MYPI20093980A patent/MY149296A/en unknown
- 2008-06-19 US US12/598,163 patent/US8183402B2/en active Active
- 2008-06-19 UA UAA201000779A patent/UA100241C2/uk unknown
- 2008-06-19 PL PL08762676T patent/PL2160398T3/pl unknown
- 2008-06-19 AU AU2008269531A patent/AU2008269531B2/en active Active
- 2008-06-19 DK DK08762676.8T patent/DK2160398T3/da active
- 2008-06-19 KR KR1020097017565A patent/KR101535686B1/ko active Active
- 2008-06-19 EP EP08762676A patent/EP2160398B1/de active Active
- 2008-06-19 CA CA2677195A patent/CA2677195C/en active Active
- 2008-06-19 SI SI200830476T patent/SI2160398T1/sl unknown
- 2008-06-19 MX MX2009011861A patent/MX2009011861A/es active IP Right Grant
- 2008-06-19 NZ NZ579029A patent/NZ579029A/en unknown
- 2008-06-19 PT PT08762676T patent/PT2160398E/pt unknown
- 2008-06-19 WO PCT/HU2008/000073 patent/WO2009001148A2/en not_active Ceased
- 2008-06-19 AT AT08762676T patent/ATE528313T1/de active
- 2008-06-19 CN CN2008800063272A patent/CN101622268B/zh active Active
- 2008-06-19 ES ES08762676T patent/ES2375320T3/es active Active
- 2008-06-19 HR HR20120008T patent/HRP20120008T1/hr unknown
- 2008-06-19 JP JP2010514149A patent/JP5261481B2/ja active Active
- 2008-06-19 EA EA201070061A patent/EA015478B1/ru unknown
- 2008-06-23 TW TW097123350A patent/TWI411616B/zh active
- 2008-06-26 AR ARP080102767A patent/AR067189A1/es active IP Right Grant
2009
- 2009-07-28 IL IL200124A patent/IL200124A/en active IP Right Grant
- 2009-10-08 ZA ZA200907030A patent/ZA200907030B/xx unknown
2011
- 2011-12-14 CY CY20111101242T patent/CY1112529T1/el unknown

Also Published As

Publication number	Publication date
TWI411616B (zh)	2013-10-11
CA2677195A1 (en)	2008-12-31
EA015478B1 (ru)	2011-08-30
PT2160398E (pt)	2012-01-06
HUP0700439A2 (en)	2009-11-30
MX2009011861A (es)	2009-11-18
CN101622268B (zh)	2012-09-05
EA201070061A1 (ru)	2010-04-30
HU0700439D0 (en)	2007-08-28
JP2010531346A (ja)	2010-09-24
WO2009001148A3 (en)	2009-03-19
MY149296A (en)	2013-08-30
AR067189A1 (es)	2009-09-30
EP2160398B1 (de)	2011-10-12
KR20100036218A (ko)	2010-04-07
JP5261481B2 (ja)	2013-08-14
AU2008269531A1 (en)	2008-12-31
CY1112529T1 (el)	2015-12-09
NZ579029A (en)	2011-09-30
PL2160398T3 (pl)	2012-03-30
UA100241C2 (uk)	2012-12-10
ATE528313T1 (de)	2011-10-15
TW200918549A (en)	2009-05-01
CN101622268A (zh)	2010-01-06
WO2009001148A2 (en)	2008-12-31
HU228636B1 (en)	2013-04-29
BRPI0813654B8 (pt)	2021-05-25
US20100137622A1 (en)	2010-06-03
BRPI0813654A2 (pt)	2014-12-30
EP2160398A2 (de)	2010-03-10
AU2008269531B2 (en)	2013-07-04
KR101535686B1 (ko)	2015-07-24
SI2160398T1 (sl)	2012-01-31
IL200124A (en)	2011-10-31
DK2160398T3 (da)	2012-01-23
ES2375320T3 (es)	2012-02-28
US8183402B2 (en)	2012-05-22
IL200124A0 (en)	2010-04-15
BRPI0813654B1 (pt)	2021-05-04
CA2677195C (en)	2014-08-05
ZA200907030B (en)	2010-07-28

Publication	Publication Date	Title
WO2009001148A3 (en)	2009-03-19	INDUSTRIAL METHOD FOR THE SYNTHESIS OF 17-ACETOXY-11β-[4-(DIMETHYLAMINO)-PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIEN-3,20-DIONE AND THE KEY INTERMEDIATES OF THE PROCESS
AU2007258955B2 (en)	2012-09-20	Industrial process for the synthesis of 17alpha-acetoxy-11beta-[4-(N,N-dimethyl-amino)- phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process
EA034739B1 (ru)	2020-03-16	6-альфа-алкил-3,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
CA2968310A1 (en)	2016-05-26	6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators
TWI222976B (en)	2004-11-01	New preparation process for 16 alpha-methyl steroids
FI87791C (fi)	1993-02-25	Foerfarande foer framstaellning av 17 -(cyklopropyloxi)androst-5-en-3 -ol och naerstaoende foereningar, som aer anvaendbara som c17-20 lyas inhibitorer
BR0306736A (pt)	2004-12-28	Processo para a preparação de 7alfa-metilesteróides, e, composto
US7297801B2 (en)	2007-11-20	Process for the production of 2-oxa-3-one androstane derivatives
JP4926071B2 (ja)	2012-05-09	ステロイド化合物の製造法
HRP20140938T1 (hr)	2014-12-05	Postupak za pripravu 17-(3-hidroksipropil)-17-hidroksisteroida
Gertosio et al.	2000	Synthesis of 10β, 17α‐Dimethyl‐17β‐(1, 2‐dioxopropyl) estra‐5, 9‐diene‐3‐ketal
TW387894B (en)	2000-04-21	New preparation process for 16 alpha-methylated steroids
HU216343B (hu)	1999-06-28	Eljárás egy 17-béta-karboxi-szteroid-származék előállítására
JPH05202092A (ja)	1993-08-10	２−アセチルオキシ−３−オキシ置換−エストロゲンの製法
JPWO2005095432A1 (ja)	2008-02-21	５α−プレグナン誘導体の製造方法
NZ731924B2 (en)	2021-03-19	6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators
HK1244286B (en)	2021-02-26	6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators