HRP20120168T1 - Postupak i međuprodukti kod dobivanja derivata n-(1-benzhidrilazetidin-3-il)-n-fenilmetilsulfonamida - Google Patents

Postupak i međuprodukti kod dobivanja derivata n-(1-benzhidrilazetidin-3-il)-n-fenilmetilsulfonamida Download PDF

Info

Publication number
HRP20120168T1
HRP20120168T1 HR20120168T HRP20120168T HRP20120168T1 HR P20120168 T1 HRP20120168 T1 HR P20120168T1 HR 20120168 T HR20120168 T HR 20120168T HR P20120168 T HRP20120168 T HR P20120168T HR P20120168 T1 HRP20120168 T1 HR P20120168T1
Authority
HR
Croatia
Prior art keywords
unbranched
carbon atoms
branched alkyl
formula
product
Prior art date
Application number
HR20120168T
Other languages
English (en)
Croatian (hr)
Inventor
Boffelli Philippe
Delthil Michel
Grondard Luc
Lampilas Maxime
Malpart Joel
Mutti St�Phane
Nait Bouda Lahlou
Rieke-Zapp Joerg
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of HRP20120168T1 publication Critical patent/HRP20120168T1/hr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20120168T 2004-10-14 2005-10-10 Postupak i međuprodukti kod dobivanja derivata n-(1-benzhidrilazetidin-3-il)-n-fenilmetilsulfonamida HRP20120168T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0410845A FR2876689B1 (fr) 2004-10-14 2004-10-14 Nouveau procede et intermediaires de preparation de derives de n-(1-benzhydryl-azetidin-3-yl)-n-phenyl-methylsulfonamide
PCT/FR2005/002489 WO2006040464A1 (fr) 2004-10-14 2005-10-10 Procede et intermediaires de preparation de derives de n-(1-benzhydryl-azetidin-3-yl)-n-phenyl-methylsulfonamide

Publications (1)

Publication Number Publication Date
HRP20120168T1 true HRP20120168T1 (hr) 2012-03-31

Family

ID=34953744

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20120168T HRP20120168T1 (hr) 2004-10-14 2005-10-10 Postupak i međuprodukti kod dobivanja derivata n-(1-benzhidrilazetidin-3-il)-n-fenilmetilsulfonamida

Country Status (32)

Country Link
US (3) US7429668B2 (de)
EP (1) EP1802571B1 (de)
JP (1) JP4971986B2 (de)
KR (1) KR20070063540A (de)
CN (1) CN101039903A (de)
AR (1) AR051389A1 (de)
AT (1) ATE534624T1 (de)
AU (1) AU2005293453A1 (de)
BR (1) BRPI0516526A (de)
CA (1) CA2581781A1 (de)
CR (1) CR9008A (de)
CY (1) CY1112390T1 (de)
DK (1) DK1802571T3 (de)
EA (2) EA012523B1 (de)
ES (1) ES2378181T3 (de)
FR (1) FR2876689B1 (de)
HR (1) HRP20120168T1 (de)
IL (1) IL182277A0 (de)
MA (1) MA29005B1 (de)
ME (1) ME01297B (de)
MX (1) MX2007004483A (de)
NO (1) NO20072431L (de)
PL (1) PL1802571T3 (de)
PT (1) PT1802571E (de)
RS (1) RS52132B (de)
SG (2) SG144921A1 (de)
SI (1) SI1802571T1 (de)
TN (1) TNSN07115A1 (de)
TW (1) TW200626542A (de)
UY (1) UY29165A1 (de)
WO (1) WO2006040464A1 (de)
ZA (1) ZA200703011B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2925050B1 (fr) * 2007-12-14 2010-01-08 Sanofi Aventis Nouveau procede de preparation de derives d'azetidine
HRP20130485T1 (en) * 2009-06-29 2013-06-30 Merz Pharma Gmbh & Co. Kgaa Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane
HRP20130486T1 (en) * 2009-06-29 2013-06-30 Merz Pharma Gmbh & Co. Kgaa Method of preparing neramexane
CN107089918B (zh) * 2017-04-08 2020-06-16 迪嘉药业集团有限公司 一种盐酸二苯甲胺的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714129D0 (en) * 1997-07-04 1997-09-10 Pfizer Ltd Azetidines
US6566356B2 (en) * 2000-03-03 2003-05-20 Aventis Pharma S.A. Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation
FR2805817B1 (fr) * 2000-03-03 2002-04-26 Aventis Pharma Sa Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation
FR2814678B1 (fr) * 2000-10-04 2002-12-20 Aventis Pharma Sa Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite

Also Published As

Publication number Publication date
US7652154B2 (en) 2010-01-26
JP2008516931A (ja) 2008-05-22
KR20070063540A (ko) 2007-06-19
FR2876689B1 (fr) 2008-02-22
ATE534624T1 (de) 2011-12-15
JP4971986B2 (ja) 2012-07-11
CN101039903A (zh) 2007-09-19
US20080312205A1 (en) 2008-12-18
IL182277A0 (en) 2007-07-24
TNSN07115A1 (fr) 2008-06-02
EA200700842A1 (ru) 2007-08-31
RS52132B (sr) 2012-08-31
MX2007004483A (es) 2007-06-13
SG144920A1 (en) 2008-08-28
CY1112390T1 (el) 2015-12-09
EA012523B1 (ru) 2009-10-30
US7429668B2 (en) 2008-09-30
TW200626542A (en) 2006-08-01
UY29165A1 (es) 2006-05-31
WO2006040464A1 (fr) 2006-04-20
BRPI0516526A (pt) 2008-09-09
ZA200703011B (en) 2009-09-30
NO20072431L (no) 2007-07-04
CA2581781A1 (fr) 2006-04-20
DK1802571T3 (da) 2012-03-12
AU2005293453A1 (en) 2006-04-20
MA29005B1 (fr) 2007-11-01
CR9008A (es) 2007-10-01
EP1802571A1 (de) 2007-07-04
EP1802571B1 (de) 2011-11-23
AR051389A1 (es) 2007-01-10
EA200801990A1 (ru) 2009-06-30
SG144921A1 (en) 2008-08-28
US20100087414A1 (en) 2010-04-08
US8071788B2 (en) 2011-12-06
US20070244084A1 (en) 2007-10-18
ES2378181T3 (es) 2012-04-09
FR2876689A1 (fr) 2006-04-21
SI1802571T1 (sl) 2012-03-30
PT1802571E (pt) 2012-03-05
ME01297B (me) 2013-12-20
PL1802571T3 (pl) 2012-04-30

Similar Documents

Publication Publication Date Title
AU2014373961B2 (en) 5-fluoro-4-imino-3-(alkyl/substituted alkyl)-1-(arylsulfonyl)-3,4-dihydropyrimidin-2(1H)-one and processes for their preparation
Wang et al. Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes
JP6732008B2 (ja) シュウ酸アミド系配位子および銅触媒によるハロゲン化アリールのカップリング反応におけるその使用
RU2014128826A (ru) Дисоли малоновой кислоты и способ получения малонилдигалогенидов
KR20040030051A (ko) 아미노피리미딘 화합물의 제조 방법
JP2014525414A (ja) ベンゾオキサジノンをアミンと反応させることによるテトラゾール置換アントラニル酸ジアミド誘導体の製造方法
JP6954456B2 (ja) スルファミン酸リチウムの製造方法及び新規スルファミン酸リチウム
Jiang et al. Selective monofluorination of active methylene compounds: the important role of ZnCl 2 in inhibiting overfluorination
HRP20120168T1 (hr) Postupak i međuprodukti kod dobivanja derivata n-(1-benzhidrilazetidin-3-il)-n-fenilmetilsulfonamida
EP3812369B1 (de) Verfahren zur bromierung von m-diamidverbindungen
JP6400869B1 (ja) 4,5−ジシアノ−2−(フルオロアルキル)イミダゾールの製造方法
IL185884A (en) A method for making converted pyrimidines
US7569703B2 (en) Fluorinating agent and method for producing fluorine-containing compound using the same
JP6407645B2 (ja) 芳香族化合物のパーフルオロアルキル化反応
CA2672256A1 (en) Processes for the preparation of 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2h)-yl)-n,4-dimethylbenzamide
TWI476183B (zh) Pyrimidinyl acetonitrile derivatives and their synthesis intermediates
AU2006240772B2 (en) Method for producing nicotinic acid derivative or salt thereof
JP6994498B2 (ja) 3-アミノ-1-(2,6-二置換フェニル)ピラゾール類を調製する方法
JP6183053B2 (ja) テトラヒドロピラニルピリミジン化合物の製造方法
JP4738763B2 (ja) 3,7(9)−ジヒドロ−1h−プリン−2,6−ジチオン化合物の製造方法
CN115724768A (zh) 一种双酰胺类化合物及其制备方法和应用
JP2006124367A5 (de)
JP2005206522A (ja) 2−シアノ−2−(4−テトラヒドロピラニル)酢酸エステルの製法
JP2005097138A (ja) スルファモイルオキシ基またはスルフィナモイルオキシ基が置換された芳香族化合物と求核剤との反応による芳香族化合物誘導体の製造方法