HRP20161676T1 - Oralni farmaceutski pripravci dezmopresina - Google Patents
Oralni farmaceutski pripravci dezmopresina Download PDFInfo
- Publication number
- HRP20161676T1 HRP20161676T1 HRP20161676TT HRP20161676T HRP20161676T1 HR P20161676 T1 HRP20161676 T1 HR P20161676T1 HR P20161676T T HRP20161676T T HR P20161676TT HR P20161676 T HRP20161676 T HR P20161676T HR P20161676 T1 HRP20161676 T1 HR P20161676T1
- Authority
- HR
- Croatia
- Prior art keywords
- desmopressin
- effective amount
- therapeutically effective
- pharmaceutical preparation
- oral
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Claims (9)
1. Farmaceutski pripravak koji se sastoji od terapijski učinkovite količine dezmopresina ili njegove farmaceutski prikladne soli,
jednog ili više konzervansa, antibakterijskih ili antifungalnih tvari, odabranih između parabena te njihovih soli ili mješavina,
jedne ili više kiselina za podešavanje pH pripravka i vode, odabrano iz skupine koju čine klorovodična kiselina, dušična kiselina, fosforna kiselina, sulfatna kiselina, octena kiselina i limunska kiselina, i njihove mješavine,
taj farmaceutski pripravak je stabilan i tekuć pripravak fleksibilne jačine s pH između 3.5 i 5.0 za oralnu primjenu.
2. Farmaceutski pripravak prema zahtjevu 1, gdje se terapijski učinkovita količina dezmopresina primjenjuje u obliku dezmopresin acetata.
3. Farmaceutski pripravak prema bilo kojem od zahtjeva 1 ili 2, gdje je terapijski učinkovita količina dezmopresina između 0.001 mg/ml i 5 mg/ml.
4. Farmaceutski pripravak prema zahtjevu 3, gdje je terapijski učinkovita količina dezmopresina između 0.01 mg/ml i 2 mg/ml.
5. Farmaceutski pripravak prema zahtjevu 4, gdje je terapijski učinkovita količina dezmopresina između 0.1 mg i 1 mg/ml.
6. Farmaceutski pripravak prema zahtjevu 1, gdje se parabeni odabiru između metilparabena, etilparabena, propilparabena, butilparabena, izobutilparabena, izopropilparabena, benzilparabena, njihovih soli ili mješavina.
7. Farmaceutski pripravak prema bilo kojem od prethodnih zahtjeva, gdje su konačni oblik kapi za oralnu primjenu koje se apsorbiraju kroz oralnu i/ili sublingvalnu sluznicu.
8. Farmaceutski pripravak prema bilo kojem od zahtjeva 1 do 7, gdje je konačni oblik sirup za oralnu gastrointestinalnu primjenu ili sirup za oralnu primjenu koji se apsorbira kroz oralnu i/ili sublingvalnu sluznicu.
9. Farmaceutski pripravak prema bilo kojem od zahtjeva 1 do 8, za uporabu u liječenju centralnog dijabetes insipidusa, primarne noćne enureze, krvarenja u bolesnika s hemofilijom A, bolesnika s Willebrand-Jürgensovom bolesti te postoperativnog krvarenja.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200702215A ES2319054B1 (es) | 2007-08-06 | 2007-08-06 | Composicion farmaceutica oral de desmopresina. |
| EP08805367.3A EP2174652B1 (en) | 2007-08-06 | 2008-08-01 | Oral pharmaceutical desmopressin composition |
| PCT/ES2008/000539 WO2009027561A2 (es) | 2007-08-06 | 2008-08-01 | Composición farmacéutica oral de desmopresina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161676T1 true HRP20161676T1 (hr) | 2017-02-24 |
Family
ID=40032884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161676TT HRP20161676T1 (hr) | 2007-08-06 | 2008-08-01 | Oralni farmaceutski pripravci dezmopresina |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8993521B2 (hr) |
| EP (1) | EP2174652B1 (hr) |
| JP (1) | JP5626682B2 (hr) |
| CN (2) | CN101808621A (hr) |
| AR (1) | AR068337A1 (hr) |
| BR (1) | BRPI0814835B8 (hr) |
| CY (1) | CY1118459T1 (hr) |
| DK (1) | DK2174652T3 (hr) |
| ES (2) | ES2319054B1 (hr) |
| HR (1) | HRP20161676T1 (hr) |
| HU (1) | HUE032667T2 (hr) |
| LT (1) | LT2174652T (hr) |
| MX (1) | MX2010001456A (hr) |
| PL (1) | PL2174652T3 (hr) |
| PT (1) | PT2174652T (hr) |
| RU (1) | RU2474414C2 (hr) |
| SI (1) | SI2174652T1 (hr) |
| WO (1) | WO2009027561A2 (hr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3400B1 (ar) * | 2010-09-30 | 2019-10-20 | Ferring Bv | مركب صيدلاني من كاربيتوسين |
| WO2024211393A2 (en) | 2023-04-04 | 2024-10-10 | Tulex Pharmaceuticals Inc. | Desmopressin oral compositions |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8306367L (sv) | 1983-11-18 | 1985-05-19 | Ferring Ab | Antidiuretiskt verkande farmaceutiskt preparat |
| DE69010518T2 (de) * | 1989-01-30 | 1994-11-03 | Corint Ltd | Wässerige Desmopressin-CMC enthaltende Arzneizubereitung. |
| JP2653255B2 (ja) * | 1990-02-13 | 1997-09-17 | 武田薬品工業株式会社 | 長期徐放型マイクロカプセル |
| AU653026B2 (en) | 1991-06-07 | 1994-09-15 | Teikoku Seiyaku Kabushiki Kaisha | Physiologically active polypeptide-containing pharmaceutical composition |
| US5298256A (en) | 1992-04-28 | 1994-03-29 | Corint, Ltd. | Desmopressin buccal patch composition |
| IT1255460B (it) | 1992-07-28 | 1995-11-02 | Poli Ind Chimica Spa | Composizioni farmaceutiche in forma di microemulsioni o di dispersioni liposomiali bioadesive per la somministrazione transmucosale di sostanze peptidiche e di proteine farmacologicamente attive |
| SE9300937L (sv) | 1993-03-19 | 1994-09-20 | Anne Fjellestad Paulsen | Komposition för oral administrering av peptider |
| US5482931A (en) * | 1993-06-29 | 1996-01-09 | Ferring Ab | Stabilized pharmaceutical peptide compositions |
| SE9400918L (sv) | 1994-03-18 | 1995-09-19 | Anne Fjellstad Paulsen | Stabiliserad komposition för oral administrering av peptider |
| US5763398A (en) * | 1996-06-20 | 1998-06-09 | Ferring B.V. | Nasal administration of desmopressin |
| US20030095926A1 (en) * | 1997-10-01 | 2003-05-22 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the gastrointestinal tract or urinary tract |
| AU766913B2 (en) * | 1998-11-02 | 2003-10-23 | Alza Corporation | Electrotransport device including a compatible antimicrobial agent |
| US6894026B1 (en) | 2000-01-11 | 2005-05-17 | Atossa Healthcare, Inc. | Long-acting oxytocin analogues for the treatment and prevention of breast cancer and psychiatric disorders |
| EP1121935B1 (en) * | 2000-02-04 | 2008-08-13 | Patents Exploitation Company B.V. | Pharmaceutical composition containing a small or medium size peptide |
| AT409081B (de) * | 2000-02-16 | 2002-05-27 | Gebro Pharma Gmbh | Stabile, nasal, oral oder sublingual anwendbare pharmazeutische zubereitung |
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| WO2003097080A1 (en) * | 2002-05-15 | 2003-11-27 | Sun Pharmaceutical Industries Limited | A stable aqueous composition of a peptide |
| ITMI20021684A1 (it) | 2002-07-29 | 2004-01-29 | Therapicon Srl | Composizione farmaceutica di peptide nasale |
| EP1617823B1 (en) * | 2003-01-24 | 2019-01-09 | Nicachet AB | A pouch comprising a nicotine composition for transmucosal delivery |
| EP1473029B1 (en) | 2003-04-30 | 2005-03-23 | Ferring B.V. | Solid dosage form comprising desmopressin |
| ATE301990T1 (de) | 2003-07-25 | 2005-09-15 | Ferring Bv | Pharmazeutische desmopressin-zubereitung als feste darreichungsform und methode zu ihrer herstellung |
| EP2322195A2 (en) | 2003-11-10 | 2011-05-18 | Reprise Biopharmaceutics, LLC | Pharmaceutical compositions including low dosages of desmopressin |
| GB0406048D0 (en) | 2004-03-18 | 2004-04-21 | Ardana Bioscience Ltd | Drug formulations |
| US20050244502A1 (en) | 2004-04-28 | 2005-11-03 | Mathias Neil R | Composition for enhancing absorption of a drug and method |
-
2007
- 2007-08-06 ES ES200702215A patent/ES2319054B1/es active Active
-
2008
- 2008-08-01 SI SI200831737A patent/SI2174652T1/sl unknown
- 2008-08-01 HU HUE08805367A patent/HUE032667T2/en unknown
- 2008-08-01 LT LTEP08805367.3T patent/LT2174652T/lt unknown
- 2008-08-01 BR BRPI0814835A patent/BRPI0814835B8/pt not_active IP Right Cessation
- 2008-08-01 ES ES08805367.3T patent/ES2608816T3/es active Active
- 2008-08-01 MX MX2010001456A patent/MX2010001456A/es active IP Right Grant
- 2008-08-01 RU RU2010105031/15A patent/RU2474414C2/ru active
- 2008-08-01 CN CN200880105631A patent/CN101808621A/zh active Pending
- 2008-08-01 HR HRP20161676TT patent/HRP20161676T1/hr unknown
- 2008-08-01 DK DK08805367.3T patent/DK2174652T3/en active
- 2008-08-01 US US12/672,255 patent/US8993521B2/en active Active
- 2008-08-01 PL PL08805367T patent/PL2174652T3/pl unknown
- 2008-08-01 JP JP2010519481A patent/JP5626682B2/ja not_active Expired - Fee Related
- 2008-08-01 WO PCT/ES2008/000539 patent/WO2009027561A2/es not_active Ceased
- 2008-08-01 CN CN201610700664.8A patent/CN106265494A/zh active Pending
- 2008-08-01 PT PT88053673T patent/PT2174652T/pt unknown
- 2008-08-01 EP EP08805367.3A patent/EP2174652B1/en active Active
- 2008-08-06 AR ARP080103430A patent/AR068337A1/es not_active Application Discontinuation
-
2017
- 2017-01-03 CY CY20171100005T patent/CY1118459T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009027561A3 (es) | 2009-07-16 |
| CN101808621A (zh) | 2010-08-18 |
| EP2174652A2 (en) | 2010-04-14 |
| BRPI0814835B1 (pt) | 2020-10-27 |
| US8993521B2 (en) | 2015-03-31 |
| SI2174652T1 (sl) | 2017-04-26 |
| BRPI0814835A2 (pt) | 2015-03-31 |
| ES2319054A1 (es) | 2009-05-01 |
| CY1118459T1 (el) | 2017-07-12 |
| PL2174652T3 (pl) | 2017-06-30 |
| EP2174652B1 (en) | 2016-10-05 |
| JP5626682B2 (ja) | 2014-11-19 |
| LT2174652T (lt) | 2017-02-27 |
| AR068337A1 (es) | 2009-11-11 |
| RU2474414C2 (ru) | 2013-02-10 |
| RU2010105031A (ru) | 2011-09-20 |
| DK2174652T3 (en) | 2017-01-23 |
| MX2010001456A (es) | 2010-06-02 |
| ES2608816T3 (es) | 2017-04-17 |
| WO2009027561A2 (es) | 2009-03-05 |
| PT2174652T (pt) | 2016-12-23 |
| BRPI0814835B8 (pt) | 2021-05-25 |
| HUE032667T2 (en) | 2017-10-30 |
| ES2319054B1 (es) | 2010-02-12 |
| JP2010535745A (ja) | 2010-11-25 |
| CN106265494A (zh) | 2017-01-04 |
| US20110251123A1 (en) | 2011-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013544259A5 (hr) | ||
| WO2005107719A3 (en) | Pharmaceutical composition comprising hydrophobic drug having improved solubility | |
| ES2799309T3 (es) | Compuestos y composiciones para el tratamiento de esclerosis múltiple | |
| ES2700473T3 (es) | Biodisponibilidad cerebral mejorada de galantamina mediante formulaciones seleccionadas y administración transmucosa de profármacos lipofílicos | |
| JP2005503340A5 (hr) | ||
| CN102427782A (zh) | 双层和单层剂型 | |
| HRP20161676T1 (hr) | Oralni farmaceutski pripravci dezmopresina | |
| CA2900982A1 (en) | Ultrapure tetrahydrocannabinol-11-oic acids | |
| CN102283949B (zh) | 含有薁磺酸钠的口腔溃疡喷剂 | |
| CN106361689A (zh) | 一种福多司坦口服溶液及其制备方法 | |
| CA2509899A1 (fr) | Enantiomere (-) du tenatoprazole et son application en therapeutique | |
| WO2010035751A1 (ja) | 機能性消化管障害の予防及び／又は治療剤 | |
| JP2017511350A5 (hr) | ||
| CN101406496A (zh) | 一种治疗前列腺炎及其它男性生殖系统疾病的配方 | |
| Shah et al. | Swotting effective hypertension therapy: ramipril versus telmisartan | |
| Mahdi | Oral jellies for improving oral drug delivery in dysphagia | |
| CA2976314C (en) | Compositions and methods for the treatment of epilepsy and neurological disorders | |
| CN109010837A (zh) | 一种具有高溶解性的塞来昔布组合物 | |
| CN1209120C (zh) | 止泻外敷膏 | |
| CN107400157B (zh) | 一种具有抗脑卒中作用的化合物及其制备方法和用途 | |
| CN106389445A (zh) | 一种治疗慢性咽炎的西药复方制剂 | |
| CN106727607A (zh) | 一种治疗咽喉炎的西药复方制剂 | |
| CN121370912A (zh) | 一种盐酸米诺环素-褪黑素复方结肠靶向胶囊及其制备方法 | |
| WO2014006528A2 (en) | Compositions and methods for the treatment of neurological degenerative disorders | |
| CN104606174B (zh) | 一种治疗功能性消化不良的药物组合物及其应用 |