HRP20171949T1 - Poboljšana veziva za tnf - Google Patents

Poboljšana veziva za tnf Download PDF

Info

Publication number: HRP20171949T1
Authority: HR; Croatia
Prior art keywords: tnf binders; improved tnf; improved; binders; isvd
Prior art date: 2015-11-12

Application number

HRP20171949TT

Other languages

English (en)

Croatian (hr)

Inventor

Marie-Ange Buyse

Joachim Boucneau

Peter Casteels

Gino Van Heeke

Original Assignee

Ablynx Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-11-12

Filing date

2016-11-14

Publication date

2018-01-26

2016-11-14 Application filed by Ablynx Nv filed Critical Ablynx Nv

2018-01-26 Publication of HRP20171949T1 publication Critical patent/HRP20171949T1/hr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Dermatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicinal Preparation (AREA)
Organic Insulating Materials (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)

HRP20171949TT 2015-11-12 2016-11-14 Poboljšana veziva za tnf HRP20171949T1 (hr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201562254375P	2015-11-12	2015-11-12
EP16798122.4A EP3191511B1 (en)	2015-11-12	2016-11-14	Improved tnf binders
PCT/EP2016/077595 WO2017081320A1 (en)	2015-11-12	2016-11-14	Improved tnf binders

Publications (1)

Publication Number	Publication Date
HRP20171949T1 true HRP20171949T1 (hr)	2018-01-26

Family

ID=57348648

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HRP20171949TT HRP20171949T1 (hr)	2015-11-12	2016-11-14	Poboljšana veziva za tnf

Country Status (37)

Country	Link
US (2)	US10544211B2 (2)
EP (2)	EP3191511B1 (2)
JP (2)	JP6962915B2 (2)
KR (2)	KR20240029115A (2)
CN (1)	CN108473563B (2)
AU (2)	AU2016352943B2 (2)
BR (1)	BR112018009714A8 (2)
CA (2)	CA3005085C (2)
CL (1)	CL2018001291A1 (2)
CO (1)	CO2018005915A2 (2)
CR (1)	CR20180311A (2)
CY (1)	CY1120303T1 (2)
DK (1)	DK3191511T3 (2)
DO (1)	DOP2018000122A (2)
EC (1)	ECSP18042569A (2)
ES (1)	ES2662418T3 (2)
GT (1)	GT201800095A (2)
HK (1)	HK1248716A1 (2)
HR (1)	HRP20171949T1 (2)
HU (1)	HUE035805T2 (2)
IL (2)	IL310373A (2)
LT (1)	LT3191511T (2)
MA (1)	MA41653A (2)
MD (1)	MD3191511T2 (2)
ME (1)	ME02954B (2)
MX (1)	MX385207B (2)
NO (1)	NO2768984T3 (2)
PE (1)	PE20181317A1 (2)
PH (1)	PH12018501025A1 (2)
PL (1)	PL3191511T3 (2)
PT (1)	PT3191511T (2)
RS (1)	RS56676B1 (2)
SG (1)	SG11201803975SA (2)
SI (1)	SI3191511T1 (2)
SM (1)	SMT201700590T1 (2)
TN (1)	TN2018000159A1 (2)
WO (1)	WO2017081320A1 (2)

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US11644471B2 (en)	2010-09-30	2023-05-09	Ablynx N.V.	Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
DK2723769T4 (da)	2011-06-23	2022-09-05	Ablynx Nv	Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner
KR20250099289A (ko)	2014-05-16	2025-07-01	아블린쓰 엔.브이.	개선된 면역글로불린 가변 도메인
PL3248986T3 (pl)	2014-05-16	2022-05-16	Ablynx Nv	Domeny zmienne immunoglobuliny
NO2768984T3 (2) *	2015-11-12	2018-06-09
GB201522394D0 (en)	2015-12-18	2016-02-03	Ucb Biopharma Sprl	Antibodies
JP7657797B2 (ja)	2019-12-06	2025-04-07	アブリンクスエン．ヴェー．	ＴＮＦαおよびＩＬ－２３を標的化する免疫グロブリン単一可変ドメインを含むポリペプチド
PH12022551231A1 (en) *	2019-12-06	2023-07-31	Ablynx Nv	Polypeptides comprising immunoglobulin single variable domains targeting tnfa and ox40l
CN112300289B (zh) *	2019-12-30	2022-06-10	中国药科大学	RGD4C融合抗TNFα纳米抗体蛋白、制备方法及其应用
KR20230123497A (ko) *	2020-12-18	2023-08-23	아블린쓰 엔.브이.	IL-6 및 TNF-α를 표적화하는 면역글로불린 단일 가변도메인을 포함하는 폴리펩티드
TW202330596A (zh) *	2021-11-29	2023-08-01	大陸商江蘇恆瑞醫藥股份有限公司	經修飾的蛋白或多肽
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AR131494A1 (es)	2022-12-23	2025-03-26	Ablynx Nv	Vehículos de conjugación a base de proteína
JP2026506075A (ja)	2023-02-17	2026-02-20	アブリンクスエン．ヴェー．	新生児型ｆｃ受容体に結合するポリペプチド

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2012
- 2012-10-19 NO NO12841612A patent/NO2768984T3/no unknown
2016
- 2016-11-13 MA MA041653A patent/MA41653A/fr unknown
- 2016-11-14 SG SG11201803975SA patent/SG11201803975SA/en unknown
- 2016-11-14 ME MEP-2017-291A patent/ME02954B/me unknown
- 2016-11-14 KR KR1020247005963A patent/KR20240029115A/ko active Pending
- 2016-11-14 IL IL310373A patent/IL310373A/en unknown
- 2016-11-14 EP EP16798122.4A patent/EP3191511B1/en active Active
- 2016-11-14 MD MDE20170066T patent/MD3191511T2/ro unknown
- 2016-11-14 SM SM20170590T patent/SMT201700590T1/it unknown
- 2016-11-14 IL IL259269A patent/IL259269B2/en unknown
- 2016-11-14 MX MX2018005992A patent/MX385207B/es unknown
- 2016-11-14 KR KR1020187016731A patent/KR102641194B1/ko active Active
- 2016-11-14 BR BR112018009714A patent/BR112018009714A8/pt active IP Right Grant
- 2016-11-14 TN TNP/2018/000159A patent/TN2018000159A1/en unknown
- 2016-11-14 CR CR20180311A patent/CR20180311A/es unknown
- 2016-11-14 PL PL16798122T patent/PL3191511T3/pl unknown
- 2016-11-14 CA CA3005085A patent/CA3005085C/en active Active
- 2016-11-14 WO PCT/EP2016/077595 patent/WO2017081320A1/en not_active Ceased
- 2016-11-14 JP JP2018524836A patent/JP6962915B2/ja active Active
- 2016-11-14 HR HRP20171949TT patent/HRP20171949T1/hr unknown
- 2016-11-14 HU HUE16798122A patent/HUE035805T2/en unknown
- 2016-11-14 PE PE2018000766A patent/PE20181317A1/es unknown
- 2016-11-14 US US15/501,011 patent/US10544211B2/en active Active
- 2016-11-14 DK DK16798122.4T patent/DK3191511T3/en active
- 2016-11-14 CN CN201680076588.6A patent/CN108473563B/zh active Active
- 2016-11-14 ES ES16798122.4T patent/ES2662418T3/es active Active
- 2016-11-14 SI SI201630013T patent/SI3191511T1/en unknown
- 2016-11-14 EP EP17184686.8A patent/EP3266798A3/en not_active Withdrawn
- 2016-11-14 PT PT167981224T patent/PT3191511T/pt unknown
- 2016-11-14 LT LTEP16798122.4T patent/LT3191511T/lt unknown
- 2016-11-14 AU AU2016352943A patent/AU2016352943B2/en active Active
- 2016-11-14 CA CA3234178A patent/CA3234178A1/en active Pending
- 2016-11-14 RS RS20171299A patent/RS56676B1/sr unknown
2017
- 2017-03-13 US US15/456,824 patent/US9745372B2/en active Active
- 2017-12-01 HK HK18108106.4A patent/HK1248716A1/en unknown
- 2017-12-19 CY CY20171101330T patent/CY1120303T1/el unknown
2018
- 2018-05-11 GT GT201800095A patent/GT201800095A/es unknown
- 2018-05-11 CL CL2018001291A patent/CL2018001291A1/es unknown
- 2018-05-11 DO DO2018000122A patent/DOP2018000122A/es unknown
- 2018-05-15 PH PH12018501025A patent/PH12018501025A1/en unknown
- 2018-06-05 EC ECIEPI201842569A patent/ECSP18042569A/es unknown
- 2018-06-08 CO CONC2018/0005915A patent/CO2018005915A2/es unknown
2021
- 2021-10-14 JP JP2021168871A patent/JP7357038B2/ja active Active
2023
- 2023-01-10 AU AU2023200113A patent/AU2023200113A1/en active Pending

Also Published As

Publication number	Publication date
CA3234178A1 (en)	2017-05-18
MX385207B (es)	2025-03-04
MD3191511T2 (ro)	2018-03-31
JP2022020666A (ja)	2022-02-01
HK1248716A1 (en)	2018-10-19
KR20240029115A (ko)	2024-03-05
TN2018000159A1 (en)	2019-10-04
CN108473563B (zh)	2022-06-14
US10544211B2 (en)	2020-01-28
PH12018501025A1 (en)	2019-01-28
HUE035805T2 (en)	2018-05-28
SMT201700590T1 (it)	2018-01-11
US9745372B2 (en)	2017-08-29
AU2016352943B2 (en)	2022-10-20
KR20180083382A (ko)	2018-07-20
GT201800095A (es)	2019-08-15
PL3191511T3 (pl)	2018-03-30
EP3191511A1 (en)	2017-07-19
CA3005085A1 (en)	2017-05-18
ES2662418T3 (es)	2018-04-06
US20170190769A1 (en)	2017-07-06
SI3191511T1 (en)	2018-01-31
MX2018005992A (es)	2019-01-31
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IL259269A (en)	2018-07-31
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