HRP20201848T1 - Bispecifična egfr/c-met antitijela - Google Patents

Bispecifična egfr/c-met antitijela Download PDF

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HRP20201848T1
HRP20201848T1 HRP20201848TT HRP20201848T HRP20201848T1 HR P20201848 T1 HRP20201848 T1 HR P20201848T1 HR P20201848T T HRP20201848T T HR P20201848TT HR P20201848 T HRP20201848 T HR P20201848T HR P20201848 T1 HRP20201848 T1 HR P20201848T1
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cancer
antibody
egfr
met
amino acid
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Mark Chiu
Sheri MOORES
Joost Neijssen
Paul Parren
Janine Schuurman
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Janssen Biotech, Inc.
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Claims (11)

1. Izolirano bispecifično (c-Met) antitijelo specifično za receptor epidermalnog faktora rasta (EGFR)/receptor faktora rasta hepatocita, koje sadrži: a) prvi teški lanac (HC1) koji sadrži HC1 konstantnu domenu 3 (HC1 CH3) i HC1 varijabilnu regiju 1 (VH1); b) drugi teški lanac (HC2) koji sadrži HC2 konstantnu domenu 3 (HC2 CH3) i HC2 varijabilnu regiju 2 (VH2); c) prvi laki lanac (LC1) koji sadrži varijabilnu regiju 1 lakog lanca (VL1); i d) drugi laki lanac (LC2) koji sadrži varijabilnu regiju 2 lakog lanca (VL2), pri čemu se VH1 i VL1 spajaju radi stvaranja prvog mjesta za vezivanje antigena koji specifično veže EGFR, VH2 i VL2 se spajaju radi stvaranja drugog mjesta za vezivanje antigena koji specifično veže c-Met, HC1 sadrži najmanje jednu zamjenu u HC1 CH3 i HC2 sadrži najmanje jednu zamjenu u HC2 CH3, i zamjenu u HC1 CH3 i zamjenu u HC2 CH3 koja se pojavljuje na različitim položajima ostatka aminokiselina, kada je numeriranje ostataka u skladu sa EU indeksom, gdje i) VH1 sadrži regiju određivanja komplementarnosti teškog lanca (HCDR) 1 (HCDR1), HCDR2 i HCDR3 aminokiselinskih sekvenci SEQ ID NOs: 210, 211 i 212, tim redom; i ii) VL1 sadrži regiju određivanja komplementarnosti lakog lanca (LCDR) 1 (LCDR1), LCDR2 i LCDR3 aminokiselinskih sekvenci SEQ ID NOs: 213, 214 i 215, tim redom; i iii) VH2 sadrži HCDR1, HCDR2, i HCDR3 aminokiselinskih sekvenci SEQ ID NOs: 216, 217 i 218, tim redom; i iv) VL2 sadrži LCDR1, LCDR2 i LCDR3 aminokiselinskih sekvenci SEQ ID NOs: 219, 220 i 221, tim redom.
2. Bispecifično antitijelo prema zahtjevu 1, gdje: a) antitijelo je ljudsko antitijelo u kome VH1, VL1, VH2 i VH2 sadrže sekvencu aminokiselina SEQ ID NOs: 189, 190, 193 i 194, tim redom; i/ili b) antitijelo inhibira fosforilaciju kinaza 1 i 2 koje su povezane sa izvanstaničnim signalom (ERK1/2) u NCI-H292, NCI-H1975 ili SKMES-1 staničnoj liniji sa IC50 vrijednosti koja je najmanje 10-puta manja, najmanje 20-puta manja, najmanje 30-puta manja, najmanje 40-puta manja, najmanje 50-puta manja ili najmanje 60-puta manja u usporedbi sa IC50 vrijednosti inhibiranja fosforilacije ERK1/2 u NCI-H292, NCI-H1975 ili SKMES-1 staničnim linijama sa smjesom kontrolnog monovalentnog EGFR antitijela koji sadrži teški lanac 3 (HC3) i laki lanac 3 (LC3) i kontrolno monovalentno c-Met antitijelo koje sadrži teški lanac 4 (HC4) i laki lanac 4 (LC4), pri čemu HC3 i HC1, LC3 i LC1, HC4 i HC2, i LC4 i LC2 imaju redom identične sekvence aminokiselina, i fosforilacija ERK1/2 se mjeri u cijelim staničnim lizatima pomoću sendvič imunotesta upotrebom antifosfo ERK1/2 antitijela kao antitijela za hvatanje i antitijela koja se vežu za nefosforilni i fosforilni ERK1/2 koji je konjugiran sa elektrohemiluminscentnim spojem kao antitijelom za detekciju, opcionalno gdje: i) antitijelo inhibira fosforilaciju ERK1/2 sa IC50 vrijednosti 2x10-9 M ili manje, 1x10-9 M ili manje, ili 1x10-10 M ili manje; i/ili ii) ERK1 je fosforilan na položajima Thr202 i Tyr204, i ERK2 je fosforilan na ostacima Thr185 i Tyr197; i/ili i/ili; c) antitijelo koje inhibira fosforilaciju proteina kinaze B (AKT) na Ser473 u NCI-H1975 staničnoj liniji sa IC50 vrijednosti koja je najmanje 70-puta manja kada se usporedi sa IC50 vrijednosti inhibiranja fosforilacije AKT na Ser473 u NCI-H1975 staničnoj liniji s smjesom kontrolnog monovalentnog EGFR antitijela koje sadrži HC3 i LC3 i kontrolnog monovalentnog c-Met antitijela koje sadrži HC4 i LC4, gdje HC3 i HC1, LC3 i LC1, HC4 i HC2, i LC4 i LC2 imaju redom identične sekvence aminokiselina, i fosforilacija AKT na Ser473 se mjeri u cijelim staničnim lizatima sendvič imunotestom upotrebom antitijela koje se veže za nefosforilni i fosforilni AKT kao antitijelo za hvatanje i anti-fosfoAKT Ser473 antitijelom konjugiranim s elektrohemiluminiscentnim spojem kao antitijelo za detekciju, opcionalno gdje antitijelo inhibira fosforilaciju AKT na Ser473 s IC50 vrijednosti 1x10-9 M ili manje; i/ili d) antitijelo koje inhibira fosforilaciju AKT na Thr308 u NCI-H1975 staničnoj liniji s IC50 vrijednosti koja je najmanje 100-puta manja u usporedbi s IC50 vrijednosti inhibiranja fosforilacije AKT na Thr308 u NCIH1975 staničnoj liniji s smjesnom kontrolnog monovalentnog EGFR antitijela koje sadrži HC3 i LC3 kontrolno monovalentno c-Met antitijelo koje sadrži HC4 i LC4, gdje HC3 i HC1, LC3 i LC1, HC4 i HC2, i LC4 i LC2 imaju redom identične sekvence aminokiselina, i fosforilacija AKT na Thr308 se mjeri u cijelim staničnim lizatima sendvič imunotestom upotrebom antitijela koje se vezuje za nefosforilni i fosforilni AKT kao antitijelo za hvatanje i antifosfo AKT Thr308 antitijelom konjugiranim s elektrohemiluminiscentnim spojem kao antitijelo za detekciju, opcionalno gdje antitijelo inhibira fosforilaciju AKT na Thr308 s IC50 vrijednosti od 1x10-9 M ili manje; i/ili; e) bispecifično antitijelo veže EGFR koje ima sekvencu aminokiselina prikazanu u SEQ ID NO: 73 na EGFR ostacima K489, 1491, K467 i S492 i c-Met na ostacima PEFRDSYPIKYVHAF (SEQ ID NO: 238) i FAQSKPDSAEPMDRSA (SEQ ID NO: 239); i/ili f) antitijelo inhibira rast NCI-H292 ili NCI-H1975 stanica s IC50 vrijednosti koja je najmanje 300-puta manja, najmanje 400-puta manja, najmanje 500-puta manja, najmanje 600-puta manja, najmanje 700-puta manja ili najmanje 800-puta manja u usporedbi s IC50 vrijednosti inhibiranja rasta NCI-H292 ili NCI-H1975 stanica sa cetuksimabom kada se NCI-H292 ili NCI-H1975 stanice uzgajaju u uvjetima koji osiguravaju nisko vezivanje; i/ili g) antitijelo inhibira rast SKMES-1 tumorskih stanica koje eksprimiraju HGF u SCID Beige miševima s postotkom (%) T/C vrijednosti od najmanje 500-puta manje u danu 36 u usporedbi scetuksimabom, kada se bispecifično antitijelo i cetuksimab daju u dozi od 20 mg/kg ; i/ili; h) antitijelo neutralizira EGFR i c-Met signalne puteve.
3. Bispecifično antitijelo prema zahtjevu 1 ili zahtjevu 2, pri čemu HC1 i HC2 su od IgG1, IgG2, IgG3 ili IgG4 izotipa, na primjer gdje HC1 i HC2 su od IgG1 izotipa; opcionalno gdje HC1 CH3 sadrži najmanje jedan, dva, tri, četiri, pet, šest, sedam ili osam zamjena i HC2 CH3 sadrži najmanje jednu, dvije, tri, četiri, pet, šest, sedam ili osam zamjena na položajima ostatka 350, 366, 368, 370, 399, 405, 407 ili 409, pri čemu je numeriranje ostataka u skladu sa EU indeksom, što je a) gdje HC1 CH3 sadrži najmanje jednu, dvije, tri ili četiri zamjene i HC2 CH3 sadrži najmanje jednu, dvije, tri ili četiri zamjene na položajima ostataka 350, 370, 405 ili 409; b) gdje HC1 CH3 sadrži najmanje jednu zamjenu i HC2 CH3 sadrži najmanje jednu zamjenu na položajima ostataka 405 ili 409; c) gdje HC1 CH3 sadrži K409R ili F405L zamjenu i HC2 CH3 sadrži K409R ili F405L zamjenu; ili d) gdje HC1 CH3 sadrži F405L zamjenu i HC2 CH3 sadrži K409R zamjenu.
4. Bispecifično antitijelo prema bilo kojem od zahtjeva 1 do 3, (a) koje dalje sadrži 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 ili 15 konzervativnih zamjena aminokiselina u HC1, LC1, HC2 ili LC2, koji opcionalno sadrži zamjenu M252Y/S254T/T256E u HC1 i/ili HC2, pri čemu je numeriranje ostataka u skladu sa EU indeksom; i/ili (b) gdje antitijelo ima biantenarnu strukturu glikana sa sadržajem fukoze između 1 do 15%.
5. Farmaceutski sastav koji sadrži bispecifično antitijelo prema bilo kojem od zahtjeva 1 do 4 i farmaceutsko prihvatljivi nosač.
6. Bispecifično antitijelo prema bilo kojem od zahtjeva 1 do 4 za upotrebu u postupku liječenja raka, koji obuhvaća davanje terapeutski efikasne količine bispecifičnog EGFR/c-Met antitijela pacijentu kojem je potrebno u vremenskom periodu koji je dovoljan za liječenje raka, opciono gdje: a) rak je povezan sa mutacijom koja aktivira EGFR, umnožavanjem gena za EGFR, povećanim nivoima kruženja HGF, mutacijom koja aktivira c-Met, umnožavanjem gena za c-Met ili mutiranim KRAS, kao što je: (i) mutacija koja aktivira EGFR je G719A, G719X (pri čemu je X bilo koja aminokiselina), L861X (pri čemu je X bilo koja aminokiselina), L858R, E746K, L747S, E749Q, A750P, A755V, V765M, L858P ili T790M zamjena, brisanje E746-A750, brisanje R748-P753, unos Ala (A) između M766 i A767, unos Ser, Val i Ala (SVA) između S768 i V769, i unos Asn i Ser (NS) između P772 i H773, opcionalno gdje mutacija koja aktivira EGFR je L858R, del(E476, A750) i/ili T790M zamjena; ili (ii) mutirani KRAS ima G12V ili G12C zamjenu; ili (iii) subjekt je otporan ili je stekao otpornost na liječenje s erlotinibom, gefitinibom, afatinibom, CO-1686, AZD9192 ili cetuksimabom; ili (iv) rak je rak epitelnih stanica, rak grudi, rak jajnika, rak pluća, ne-sitnostanični rak pluća (NSCLC), adenokarcinom pluća, rak malih stanica pluća, kolorektalni rak, analni rak, rak prostate, rak bubrega, rak mjehura, rak glave i vrata, rak ždrijela, rak nosa, rak gušterače, rak kože, oralni rak, rak jezika, rak jednjaka, vaginalni rak, i rak vrata maternice, rak slezena, rak testisa, rak želuca, rak prsne žlijezde, rak debelog crijeva, rak štitne žlijezde, rak jetre, hepatocelularni rak (HCC) ili sporedni ili sporadični rak papilarnih bubrežnih stanica(PRCC); ili b) subjekt je homozigot za fenilalanin na položaju 158 od CD16 ili heterozigot za valin i fenilalanin na položaju 158 od CD16.
7. Bispecifično antitijelo za upotrebu prema zahtjevu 6 (a)(iv), koja obuhvaća davanje drugog terapeutskog sredstva, opcionalno gdje: a) drugo terapeutsko sredstvo je hemoterapeutsko sredstvo ili ciljana protiv raka terapija, kao što je: i) hemioterapeutsko sredstvo je cisplatin ili vinblastin; ili ii) hemioterapeutsko sredstvo ili ciljana protiv raka terapija je tirozin kinazni inhibitor EGFR, c-Met, HER2, HER3, HER4 ili VEGFR, opcionalno gdje je tirozin kinazni inhibitor erlotinib, gefitinib ili afatinib; ili b) drugo terapeutsko sredstvo se daje istovremeno, stupnjevito ili odvojeno.
8. Postupak in vitro inhibiranja rasta ili proliferacije stanica koje eksprimiraju EGFR i/ili c-Met, koji obuhvaća kontakt stanica sa bispecifičnim antitijelom prema bilo kojem od zahtjeva 1-4.
9. Bispecifično antitijelo prema bilo kojem od zahtjeva 1 do 4 za upotrebu u postupku inhibiranja rasta ili metastaza tumora ili stanica raka koje eksprimiraju EGFR i/ili c-Met kod subjekta koji obuhvaća davanje subjektu efikasne količine bispecifičnog antitijela za inhibiranje rasta ili metastaza tumora ili raka stanica koje eksprimiraju EGFR i/ili c-Met, opcionalno gdje je tumor koji eksprimira EGFR i/ili c-Met rak epitelnih stanica, rak grudi, rak jajnika, rak pluća, ne-sitnostanični rak pluća (NSCLC), adenokarcinom pluća, rak malih stanica pluća, kolorektalni rak, analni rak, rak prostate, rak bubrega, rak mjehura, rak glave i vrata, rak ždrijela, rak nosa, rak gušterače, rak kože, oralni rak, rak jezika, rak jednjaka, vaginalni rak, rak vrata maternice, rak slezena, rak testisa, rak želuca, rak prsne žlijezde, rak debelog crijeva, rak štitne žlijezde, rak jetre, hepatocelularni karcinom (HCC) ili sporedni ili nasljedni rak papilarnih stanica (PRCC), kao što gdje je tumor koji eksprimira EGFR i/ili c-Met povezan sa mutacijom koja aktivira EGFR, umnožavanjem gena za EGFR, povećanim nivoima kruženja HGF, mutacijom koja aktivira c-Met, umnožavanjem gena za c-Met ili mutiranog KRAS, opcionalno gdje: a) mutacija koja aktivira EGFR je G719A, G719X (pri čemu je X bilo koja aminokiselina), L861X (pri čemu je X bilo koja aminokiselina), L858R, E746K, L747S, E749Q, A750P, A755V, V765M, L858P ili T790M zamjena, brisanje E746-A750, brisanje R748-P753, unos Ala (A) između M766 i A767, i unos Ser, Val i Ala (SVA) između S768 i V769, i unos Asn i Ser (NS) između P772 i H773; ili b) mutirani KRAS ima G12V ili G12C zamjenu.
10. Bispecifično antitijelo prema bilo kojem od zahtjeva 1 do 4 za upotrebu u terapiji, kao što je za upotrebu u liječenju raka, opcionalno kada je rak rak epitelnih stanica, rak grudi, rak jajnika, rak pluća, ne-sitnostanični rak pluća (NSCLC), adenokarcinom pluća, rak malih stanica pluća, kolorektalni rak, analni rak, rak prostate, rak bubrega, rak mjehura, rak glave i vrata, rak ždrijela, rak nosa, rak gušterače, rak kože, oralni rak, rak jezika, rak jednjaka, vaginalni rak, rak vrata maternice, rak slezena, rak testisa, rak želuca, rak prsne žlijezde, rak debelog crijeva, rak štitne žlijezde, rak jetre, hepatocelularni karcinom (HCC) ili sporedni ili nasljedni karcinom papilarnih stanica bubrega (PRCC).
11. Bispecifično antitijelo za upotrebu prema zahtjevu 10, gdje je bispecifično antitijelo davano u kombinaciji s drugim terapeutskim agensom, istovremeno, stupnjevito ili odvojeno, opcionalno gdje drugi terapeutski agens je hemoterapeutski agens, kao što su: a) alkilirajuće sredstvo kao što su tiotepa i ciklosfosfamid; b) alkil sulfonat kao što su busulfan, improsulfan i piposulfan; c) aziridini kao što su benzodopa, karbohion, meturedopa, i uredopa; d) etilenimin i metilamelamin uključujući altretamin, trietilenmelamin, trietilenfosforamid, trietilentiofosfaoramid i trimetilolomelamin; e) azotni iperit kao što su hlorambucil, hlornafazin, holofosfamid, estramustin, ifosfamid, mehloretamin, mehloretamin oksid hidrohlorid, melfalan, novembihin, fenesterin, prednimustin, trofosfamid, uracil iperit; f) nitrozurea kao što su karmustin, hlorozotocin, fotemustin, lomustin, nimustin, ranimustin; g) antibiotik kao što je aklacinomisini, aktinomicin, autramicin, azaserin, bleomicini, kaktinomicin, kaliheamicin, karabicin, karminomicin, karzinofilin, hromomicini, daktinomicin, daunorubicin, detorubicin, 6-diazo-5-okso-L-norleucin, doksorubicin, epirubicin, ezorubicin, idarubicin, marcelomicin, mitomicini, mikofenolna kiselina, nogalamicin, olivomicini, peplomicin, potfiromicin, puromicin, hielamicin, rodorubicin, streptonigrin, streptozocin, tubercidin, ubenimeks, zinostatin, zorubicin; h) anti-metabolit kao što je metotreksat i 5-FU; i) analog folne kiseline kao što su denopterin, metotreksat, pteropterin, trimetreksat; j) purinski analog kao što su fludarabin, 6-merkaptopurin, tiamiprin, tioguanin; k) analog pirimidina kao što su ancitabin, azacitidin, 6-azauridin, karmofur, citarabin, dideoksiuridin, doksifluridin, enocitabin, floksuridin; l) androgen kao što su kalusteron, dromostanolon propionat, epitiostanol, mepitiostan, testolakton; m) anti-andrenalni kao što su aminoglutetimid, mitotan, trilostan; n) dopuna folne kiseline kao što je frolinska kiselina; o) aceglaton; aldofosfamid glikozid; aminolevulinska kiselina; amsakrin; bestrabucil; bisantren; edatraksat; defofamin; demekolcin; diazihion; elfornitin; eliptinium acetat; etoglucid; galijum nitrat; hidroksiurea; lentinan; jonidamin; mitoguazon; mitoksantron; mopidamol; nitracrin; pentostatin; fenamet; pirarubicin; podofilin kiselina; 2-etilhidrazid; prokarbazin; PSK®; razoksan; sizofiran; spirogermanijum; tenuazonska kiselina; triazihion; 2,2’,2"-trihlorotrietilamin; uretan; vindezin; dakarbazin; manomustin; mitobronitol; mitolaktol; pipobroman; gakitozin; arabinozid; ciklofosfamid; ili tiotepa; p) član taksoida ili obitelji taksana, kao što su paklitaksel i njihovi analozi; hlorambucil; gemcitabin; 6-tioguanin; merkaptopurin; metotreksat; q) analog platine kao što su cisplatin i karboplatin; r) vinblastin; platina; etopozid (VP-16); ifosfamid; mitomicin C; mitoksantron; vinkristin; vinorelbin; navelbin; novantron; tenipozid; daunomicin; aminopterin; kseloda; ibandronat; CPT-11; inhibitor topoizomeraze RFS 2000; difluorometilornitin (DMFO); retinoinska kiselina; esperamicini; ili kapecitabin; s) inhibitor receptorskih tirozin kinaza i/ili angiogeneze, uključujući sorafenib, sunitinib pazopanib, toceranib, vandetanib, cediranib, regorafenib, aksitinib (AG013736), lestaurtinib, erlotinib, gefitinib, BIBW 2992, lapatinib, neratinib t) anti-hormonalno sredstvo koje djeluje tako što regulira ili inhibira djelovanje hormona na tumore kao što su anti-estrogeni uključujući na primjer tamoksifen, raloksifen, aromataza inhibirajuće 4(5)-imidazole, 4-hidroksitamoksifen, trioksifen, keoksifen, LI 117018, onapriston, i toremifen; ili u) anti-androgen kao što su flutamid, nilutamid, bikalutamid, leuprolid, i goserelin; i farmaceutski prihvatljive soli, kiseline ili derivate od bilo koga gore navedenog.
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Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2139924B1 (en) 2007-03-29 2016-07-06 Genmab A/S Bispecific antibodies and methods for production thereof
PL2506871T3 (pl) * 2009-11-30 2017-03-31 Janssen Biotech, Inc Przeciwciała ze zmutowanymi regionami Fc i utraconymi funkcjami efektorowymi
ES2993335T3 (en) 2010-03-10 2024-12-27 Genmab As Monoclonal antibodies against c-met
PL2560993T3 (pl) * 2010-04-20 2024-11-04 Genmab A/S Heterodimeryczne białka zawierające region FC przeciwciała i sposoby ich wytwarzania
CA3051311A1 (en) 2010-05-27 2011-12-01 Genmab A/S Monoclonal antibodies against her2
HUE044633T2 (hu) 2011-10-27 2019-11-28 Genmab As Heterodimer fehérjék elõállítása
US9695228B2 (en) * 2012-11-21 2017-07-04 Janssen Biotech, Inc. EGFR and c-Met fibronectin type III domain binding molecules
AU2013347962B2 (en) * 2012-11-21 2018-10-25 Janssen Biotech, Inc. Bispecific EGFR/c-Met antibodies
US20170275367A1 (en) 2012-11-21 2017-09-28 Janssen Biotech, Inc. Bispecific EGFR/C-Met Antibodies
CN105899226B (zh) 2013-10-14 2020-05-12 詹森生物科技公司 半胱氨酸工程化iii型纤连蛋白域结合分子
LT3103453T (lt) * 2014-02-04 2020-05-11 Astellas Pharma Inc. Vaisto kompozicija, apimanti diamino heterociklinį karboksamido junginį kaip aktyvų ingredientą
ES2816624T3 (es) 2014-02-28 2021-04-05 Merus Nv Anticuerpos que se unen a EGFR y ERBB3
KR102309881B1 (ko) 2014-11-21 2021-10-06 삼성전자주식회사 c-Met 및 EGFR의 이중 저해제 및 IGF-1R 저해제를 포함하는 병용 투여용 약학 조성물
EP3226869A4 (en) * 2014-12-03 2018-07-18 Auckland UniServices, Ltd. Kinase inhibitor prodrug for the treatment of cancer
US11384350B2 (en) 2014-12-15 2022-07-12 The Regents Of The University Of California Cytotoxic molecules responsive to intracellular ligands for selective T cell mediated killing
WO2016100232A1 (en) 2014-12-15 2016-06-23 The Regents Of The University Of California Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
US10865253B2 (en) 2014-12-19 2020-12-15 Genmab A/S Rodent bispecific heterodimeric proteins
KR102548827B1 (ko) * 2014-12-22 2023-06-30 시스트이뮨, 인코포레이티드 이중특이적 4가 항체 및 이의 제조 및 사용방법
GB201506870D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
WO2016182513A1 (en) * 2015-05-13 2016-11-17 Singapore Health Services Pte Ltd Profiling of hepatocellular carcinoma and applications thereof
KR20250157457A (ko) 2015-10-23 2025-11-04 메뤼스 엔.페. 암 성장을 억제하는 결합 분자
EP3909984A1 (en) * 2015-11-03 2021-11-17 Merck Patent GmbH Affinity matured c-met antibodies
SMT202200118T1 (it) 2015-11-03 2022-05-12 Janssen Biotech Inc Anticorpi che legano specificamente pd-1 e loro usi
IL260937B2 (en) * 2016-02-06 2024-07-01 Epimab Biotherapeutics Inc Fabs-in-tandem immunoglobulin and uses thereof
CN109311858B (zh) 2016-05-26 2021-12-03 里科瑞尔姆Ip控股有限责任公司 Egfr抑制剂化合物
KR101985299B1 (ko) * 2016-06-03 2019-09-03 삼성전자주식회사 항-c-Met/항-Nrp1 이중 특이 항체
JP2019527540A (ja) * 2016-06-21 2019-10-03 ヤンセン バイオテツク，インコーポレーテツド システイン操作フィブロネクチンｉｉｉ型ドメイン結合分子
KR20190057308A (ko) 2016-09-02 2019-05-28 더 리전츠 오브 더 유니버시티 오브 캘리포니아 인터류킨-6 수용체 알파-결합 단일 사슬 가변 단편을 포함하는 방법 및 조성물
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
US11702480B2 (en) 2016-11-18 2023-07-18 The Regents Of The University Of California Engineered antibodies and uses thereof
EP3554535A4 (en) 2016-12-14 2020-10-21 Janssen Biotech, Inc. PD-L1 BINDING FIBRONECTIN TYPE III DOMAINS
AU2017378226A1 (en) 2016-12-14 2019-06-20 Janssen Biotech, Inc. CD8A-binding fibronectin type III domains
EP3554561B1 (en) 2016-12-14 2023-06-28 Janssen Biotech, Inc. Cd137 binding fibronectin type iii domains
CN110248672A (zh) * 2017-02-06 2019-09-17 中央研究院 重组蛋白及其用途
WO2018182422A1 (en) 2017-03-31 2018-10-04 Merus N.V. Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene
CN111148764B (zh) 2017-05-17 2025-08-12 美勒斯公司 用于乳腺癌的ErbB-2/ErbB-3双特异性抗体与内分泌治疗的组合
RU2751720C2 (ru) * 2017-05-30 2021-07-16 Чонг Кун Данг Фармасьютикал Корп. Новое анти-с-мет антитело и его применение
WO2018221969A1 (en) * 2017-05-30 2018-12-06 Chong Kun Dang Pharmaceutical Corp. A novel anti-c-met antibody and use thereof
PL3665198T3 (pl) * 2017-08-09 2025-06-09 Merus N.V. Przeciwciała wiążące egfr i cmet
EP3672611A4 (en) * 2017-08-25 2021-07-14 Janssen Biotech, Inc. TYPE III DOMAINS OF FIBRONECTIN BINDER FCyRII, THEIR CONJUGATES AND MULTISPECIFIC MOLECULES INCLUDING THEM
CN109912716B (zh) * 2017-12-13 2022-08-23 凯惠科技发展(上海)有限公司 一种egfr抗体及其制备方法和应用
US20190184028A1 (en) * 2017-12-14 2019-06-20 Janssen Biotech, Inc. Targeting with firbronectin type iii like domain molecules
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
PE20211916A1 (es) 2018-05-24 2021-09-28 Janssen Biotech Inc Agentes aglutinantes del psma y usos de estos
US20200061015A1 (en) 2018-08-23 2020-02-27 Janssen Biotech, Inc. Lipase Degradation Resistant Surfactants for Use in Large Molecule Therapeutic Formulations
CA3111980A1 (en) * 2018-09-10 2020-03-19 Mirati Therapeutics, Inc. Combination therapies
IL281344B2 (en) 2018-09-10 2025-09-01 Mirati Therapeutics Inc Combination of adagrasib and cetuximab for cancer treatment
KR20210081389A (ko) 2018-10-22 2021-07-01 얀센 파마슈티카 엔.브이. 글루카곤 유사 펩티드 1(glp1)-성장 분화 인자 15(gdf15) 융합 단백질 및 이의 용도
CA3112129A1 (en) 2018-12-05 2020-06-11 Mirati Therapeutics, Inc. Combination therapies
TWI874341B (zh) * 2018-12-18 2025-03-01 美商健生生物科技公司 產生異二聚體抗體之方法
MX2021010265A (es) * 2019-02-26 2021-09-23 Janssen Biotech Inc Terapias de combinacion y estratificacion de pacientes con anticuerpos anti-egfr/c-met biespecificos.
CN113747944A (zh) 2019-04-19 2021-12-03 詹森生物科技公司 用抗psma/cd3抗体治疗前列腺癌的方法
JP2022531980A (ja) * 2019-05-14 2022-07-12 ヤンセン バイオテツク，インコーポレーテツド 二重特異性抗ｅｇｆｒ／ｃ－ｍｅｔ抗体と第３世代ｅｇｆｒチロシンキナーゼ阻害剤との併用療法
US11850248B2 (en) 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors
JOP20210304A1 (ar) 2019-05-14 2023-01-30 Janssen Biotech Inc علاجات مركبة باستخدام الأجسام المضادة ثنائية النوعية المضادة لمستقبل عامل نمو البشرة (EGFR)/ مستقبل عامل نمو خلايا الكبد (c-Met) ومثبطات كيناز التيروسين الخاصة بمستقبل عامل نمو البشرة (EGFR) من الجيل الثالث
CN114340684B (zh) 2019-09-16 2025-09-12 瑞泽恩制药公司 用于免疫pet成像的放射性标记的met结合蛋白
US12491255B2 (en) 2019-10-14 2025-12-09 Aro Biotherapeutics Company EPCAM binding fibronectin type III domains
WO2021076574A2 (en) 2019-10-14 2021-04-22 Aro Biotherapeutics Company Fn3 domain-sirna conjugates and uses thereof
EP4045061A4 (en) 2019-10-14 2024-04-17 ARO Biotherapeutics Company CD71-BINDING FIBRONECTIN TYPE III DOMAINS
JOP20220184A1 (ar) * 2020-02-12 2023-01-30 Janssen Biotech Inc علاج مصابي السرطان ممن لديهم طفرات تخطي c-Met إكسون14
TW202207940A (zh) 2020-04-14 2022-03-01 美商健生生物科技公司 包含胺基嘧啶衍生物或其醫藥上可接受之鹽、水合物、或溶劑化物之用於經口投予之醫藥組成物
US12528869B2 (en) 2020-08-25 2026-01-20 Janssen Biotech, Inc. Treatment of non-small cell lung cancer with EGFR mutations
AR123340A1 (es) * 2020-08-26 2022-11-23 Janssen Biotech Inc FORMULACIONES ESTABLES QUE COMPRENDEN UN ANTICUERPO BIESPECÍFICO PARA EGFR / c-MET
AU2021339962A1 (en) 2020-09-14 2023-05-25 Janssen Pharmaceutica Nv Fgfr inhibitor combination therapies
JP2024504758A (ja) 2021-01-28 2024-02-01 ヤンセン バイオテツク，インコーポレーテツド Ｐｓｍａ結合タンパク質及びその使用
AU2022233518A1 (en) 2021-03-09 2023-10-26 Janssen Biotech, Inc. Treatment of cancers lacking egfr-activating mutations
KR20240031947A (ko) 2021-04-14 2024-03-08 에이알오 바이오테라퓨틱스 컴패니 Fn3 도메인-시르나 접합체 및 이의 용도
CA3214552A1 (en) 2021-04-14 2022-10-20 Russell C. Addis Cd71 binding fibronectin type iii domains
TW202308689A (zh) * 2021-04-21 2023-03-01 美商健生生物科技公司 高濃度的雙特異性抗體調配物
TW202309094A (zh) 2021-05-18 2023-03-01 美商健生生物科技公司 用於識別癌症患者以進行組合治療之方法
CN117480180A (zh) * 2021-07-14 2024-01-30 江苏恒瑞医药股份有限公司 特异性结合hgfr和egfr的抗原结合分子及其医药用途
US12441816B2 (en) 2021-09-21 2025-10-14 Qilu Puget Sound Biotherapeutics Corporation Heterodimeric Fc for making fusion proteins and bispecific antibodies
CA3232216A1 (en) * 2021-10-18 2023-04-27 Tavotek Biotherapeutics (Hong Kong) Limited Anti-egfr antibodies, anti-cmet antibodies, anti-vegf antibodies, multispecific antibodies, and uses thereof
US20230183360A1 (en) * 2021-12-09 2023-06-15 Janssen Biotech, Inc. Use of Amivantamab to Treat Colorectal Cancer
WO2023142996A1 (zh) 2022-01-28 2023-08-03 上海岸阔医药科技有限公司 预防或治疗与抗肿瘤剂相关的疾病或病症的方法
TW202342057A (zh) 2022-02-07 2023-11-01 美商健生生物科技公司 用於減少用ｅｇｆｒ／ｍｅｔ雙特異性抗體治療之患者的輸注相關反應之方法
KR20240150493A (ko) 2022-02-21 2024-10-15 온퀄리티 파마슈티컬스 차이나 리미티드 화합물 및 그 용도
CN114740108B (zh) * 2022-03-28 2023-07-14 天津键凯科技有限公司 一种聚合物修饰抗体类药物的修饰度的测定方法
CN119487075A (zh) * 2022-06-29 2025-02-18 百奥赛图(北京)医药科技股份有限公司 抗egfr/met抗体及其用途
US20240317866A1 (en) * 2022-06-30 2024-09-26 Janssen Biotech, Inc. Use of Anti-EGFR/Anti-Met Antibody to Treat Gastric or Esophageal Cancer
WO2025017409A1 (en) 2023-07-14 2025-01-23 Janssen Biotech, Inc. Dosing regimen for therapies comprising bispecific antiegfr/c-met antibodies
JP2025539837A (ja) * 2022-11-24 2025-12-09 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 Ｈｇｆｒとｅｇｆｒに特異的に結合する二重特異性抗体を含む医薬組成物
KR20250158056A (ko) 2023-03-13 2025-11-05 얀센 바이오테크 인코포레이티드 이중특이성 항-egfr/c-met 항체 및 항-pd-1 항체를 사용한 병용 요법
EP4680648A1 (en) * 2023-03-17 2026-01-21 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Anti-her3 and anti-met antibodies and uses thereof
EP4454706A1 (en) * 2023-04-24 2024-10-30 Universität Stuttgart Novel egfr binding proteins
EP4713360A1 (en) 2023-05-19 2026-03-25 Les Laboratoires Servier Anti-met antibodies, antibody-drug conjugates, compositions and uses thereof
CA3228195A1 (en) 2023-05-23 2025-06-30 Janssen Biotech, Inc. Methods for treatment of non-small cell lung cancer (nsclc)
AU2024305352A1 (en) 2023-06-12 2025-12-04 Amgen Inc. Lymphotoxin beta receptor agonist binding proteins
CN121443646A (zh) * 2023-07-07 2026-01-30 四川科伦博泰生物医药股份有限公司 EGFR/c-MET双特异性结合蛋白及其用途
WO2025025434A1 (zh) * 2023-08-02 2025-02-06 百泰生物药业有限公司 EGFR/c-Met双特异性抗体及其应用
WO2025052273A1 (en) 2023-09-05 2025-03-13 Janssen Biotech, Inc. Methods of treating non-small cell lung cancer
WO2025067492A1 (zh) * 2023-09-28 2025-04-03 上海翰森生物医药科技有限公司 一种双特异性抗体在制备治疗癌症的药物中的用途
WO2025079020A1 (en) 2023-10-12 2025-04-17 Janssen Biotech, Inc. First line treatment in egfr exon 20 insertion-mutated advanced non-small cell lung cancer
CN120000805A (zh) * 2023-11-15 2025-05-16 四川科伦博泰生物医药股份有限公司 靶向EGFR/c-MET的抗体-药物缀合物及其制备方法和用途
TW202532100A (zh) * 2023-12-22 2025-08-16 大陸商信達生物製藥（蘇州）有限公司 靶向b7h3和egfr的雙特異性抗體-藥物偶聯物及其應用
TW202547867A (zh) 2024-01-16 2025-12-16 美商健生生物科技公司 使用阿米維單抗治療結腸直腸癌
WO2025158277A1 (en) 2024-01-22 2025-07-31 Janssen Biotech, Inc. Use of amivantamab to treat head and neck cancer
WO2025191459A1 (en) 2024-03-11 2025-09-18 Janssen Biotech, Inc. Use of bispecific anti-egfr/c-met antibodies to treat solid tumors
CN121045388A (zh) * 2024-05-30 2025-12-02 英百瑞(杭州)生物医药有限公司 针对人c-Met和人EGFR的双特异性抗体及其用途
WO2025247330A1 (zh) * 2024-05-31 2025-12-04 江苏先声生物制药有限公司 抗EGFR×cMet双特异性抗体的药物偶联物及其用途
WO2026017120A1 (zh) * 2024-07-18 2026-01-22 信达生物制药(苏州)有限公司 抗cdh17/egfr/cd16a三特异性抗体及其用途
WO2026038161A1 (en) 2024-08-13 2026-02-19 Janssen Biotech, Inc. Methods for reducing dermatologic adverse events in patients treated with egfr/met bispecific antibodies
WO2026038160A1 (en) 2024-08-13 2026-02-19 Janssen Biotech, Inc. Methods for reducing infusion-related reactions in patients treated with egfr/met bispecific antibodies
WO2026042017A1 (en) 2024-08-19 2026-02-26 Janssen Biotech, Inc. Amivantamab in combination with lazertinib for the treatment of non-small cell lung cancer (nsclc)

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU22545A1 (es) 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
WO1988001649A1 (en) 1986-09-02 1988-03-10 Genex Corporation Single polypeptide chain binding molecules
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
AU639726B2 (en) 1989-09-08 1993-08-05 Duke University Structural alterations of the egf receptor gene in human gliomas
DK0494955T3 (da) 1989-10-05 1998-10-26 Optein Inc Cellefri syntese og isolering af hidtil ukendte gener og polypeptider
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
KR100240308B1 (ko) 1991-03-06 2000-01-15 플레믹 크리스티안 인간화된단클론성항체및혼성단클론성항체
ATE463573T1 (de) 1991-12-02 2010-04-15 Medimmune Ltd Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
AU5670194A (en) 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
DK0672142T3 (da) 1992-12-04 2001-06-18 Medical Res Council Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse
AUPO591797A0 (en) 1997-03-27 1997-04-24 Commonwealth Scientific And Industrial Research Organisation High avidity polyvalent and polyspecific reagents
WO1998056915A2 (en) 1997-06-12 1998-12-17 Research Corporation Technologies, Inc. Artificial antibody polypeptides
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US6472147B1 (en) 1999-05-25 2002-10-29 The Scripps Research Institute Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries
US20130226834A1 (en) 2000-04-27 2013-08-29 Networth Services, Inc. Systems and methods for determining the financial status of bonds
DE60234094D1 (de) 2001-05-11 2009-12-03 Ludwig Inst For Cancer Res Ltd Spezifische bindungsproteine und ihre verwendung
JP4298498B2 (ja) * 2001-06-13 2009-07-22 ゲンマブ エー／エス 上皮成長因子受容体（ｅｇｆｒ）に対するヒトモノクローナル抗体
US7595378B2 (en) * 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
EP1283053A1 (en) 2001-08-09 2003-02-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibitors of HER3 activity
JP4602614B2 (ja) 2001-09-26 2010-12-22 アイシン精機株式会社 自動車用ドア
DK1534830T3 (da) 2002-09-06 2011-02-14 Isogenica Ltd In vito-peptid-ekspressionsbibliotek
WO2004072117A2 (en) 2003-02-13 2004-08-26 Pharmacia Corporation Antibodies to c-met for the treatment of cancers
MXPA06000508A (es) * 2003-07-18 2006-04-05 Amgen Inc Agentes de union especifica al factor del crecimiento de los hepatocitos.
HN2004000285A (es) 2003-08-04 2006-04-27 Pfizer Prod Inc ANTICUERPOS DIRIGIDOS A c-MET
ES2564127T5 (es) 2004-06-04 2020-03-26 Genentech Inc Mutaciones en EGFR
AU2005267720B2 (en) 2004-08-05 2012-02-23 Genentech, Inc. Humanized anti-cmet antagonists
AU2005282700A1 (en) 2004-09-02 2006-03-16 Genentech, Inc. Heteromultimeric molecules
TWI671403B (zh) 2005-03-31 2019-09-11 中外製藥股份有限公司 控制組裝之多肽的製造方法
DE102005028778A1 (de) 2005-06-22 2006-12-28 SUNJÜT Deutschland GmbH Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage
EP2035456A1 (en) 2006-06-22 2009-03-18 Novo Nordisk A/S Production of bispecific antibodies
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
ES2529790T3 (es) 2007-04-13 2015-02-25 Dana-Farber Cancer Institute, Inc. Métodos de tratamiento de cáncer resistente a agentes terapéuticos de ERBB
US20090042906A1 (en) 2007-04-26 2009-02-12 Massachusetts Institute Of Technology Methods for treating cancers associated with constitutive egfr signaling
EP2190878A1 (en) 2007-09-06 2010-06-02 Genmab A/S Novel methods and antibodies for treating cancer
US8748356B2 (en) 2007-10-19 2014-06-10 Janssen Biotech, Inc. Methods for use in human-adapting monoclonal antibodies
US20110118144A1 (en) 2007-12-19 2011-05-19 Linus Hyun Engineered phage vectors for the design and the generation of a human non-antibody peptide or protein phage library via fusion to pix of m13 phage
ES2564523T3 (es) 2007-12-19 2016-03-23 Janssen Biotech, Inc. Diseño y generación de bibliotecas de presentación en fago por pIX de novo humanas mediante fusión con pIX o pVII, vectores, anticuerpos y métodos
KR20100135780A (ko) 2008-03-06 2010-12-27 제넨테크, 인크. Ｃ-ｍｅｔ 및 ｅｇｆｒ 길항제로의 조합 요법
TW201002346A (en) 2008-04-11 2010-01-16 Galaxy Biotech Llc Combination of HGF inhibitor and EGF inhibitor to treat cancer
KR20110044905A (ko) * 2008-08-15 2011-05-02 메리맥 파마슈티컬즈, 인크. 치료제에 대한 세포의 반응을 예측하는 방법 및 시스템
AU2009300328A1 (en) 2008-10-01 2010-04-08 Ludwig Institute For Cancer Research Methods for the treatment of cancer
BRPI0919881B1 (pt) 2008-10-31 2021-09-08 Centocor Ortho Biotech Inc Proteína de arcabouço e seu método de geração, biblioteca e seu método de construção, molécula de ácido nucleico, vetor de ácido nucleico, célula hospedeira, composição, dispositivo médico e artigo de fabricação
US8545839B2 (en) * 2008-12-02 2013-10-01 Pierre Fabre Medicament Anti-c-Met antibody
US20100173013A1 (en) * 2009-01-08 2010-07-08 Denis Drygin Treatment of neoplastic disorders using combination therapies
KR20110126748A (ko) * 2009-04-07 2011-11-23 로슈 글리카트 아게 이중특이적 항-ｅｒｂｂ-1/항-ｃ-ｍｅｔ 항체
CN102459346B (zh) 2009-04-27 2016-10-26 昂考梅德药品有限公司 制造异源多聚体分子的方法
KR20120060877A (ko) * 2009-09-01 2012-06-12 아보트 러보러터리즈 이원 가변 도메인 면역글로불린 및 이의 용도
PL2506871T3 (pl) 2009-11-30 2017-03-31 Janssen Biotech, Inc Przeciwciała ze zmutowanymi regionami Fc i utraconymi funkcjami efektorowymi
ES2993335T3 (en) * 2010-03-10 2024-12-27 Genmab As Monoclonal antibodies against c-met
PL2560993T3 (pl) * 2010-04-20 2024-11-04 Genmab A/S Heterodimeryczne białka zawierające region FC przeciwciała i sposoby ich wytwarzania
EP3103478B1 (en) 2010-04-30 2019-04-17 Janssen Biotech, Inc. Stabilized fibronectin domain compositions, methods and uses
CA2804335A1 (en) * 2010-06-15 2011-12-22 Alberto Bardelli Mlk4 gene, a new diagnostic and prognostic marker in cancers
WO2012042026A1 (en) * 2010-09-30 2012-04-05 Ablynx Nv Biological materials related to c-met
AU2011325833C1 (en) 2010-11-05 2017-07-13 Zymeworks Bc Inc. Stable heterodimeric antibody design with mutations in the Fc domain
CN104039809A (zh) * 2011-10-10 2014-09-10 希望之城公司 中间位和中间位结合抗体及其用途
AU2012332021B8 (en) 2011-11-04 2017-10-12 Zymeworks Bc Inc. Stable heterodimeric antibody design with mutations in the Fc domain
US9695228B2 (en) * 2012-11-21 2017-07-04 Janssen Biotech, Inc. EGFR and c-Met fibronectin type III domain binding molecules
AU2013347962B2 (en) * 2012-11-21 2018-10-25 Janssen Biotech, Inc. Bispecific EGFR/c-Met antibodies

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