HRP920948B1 - Nitratoalkanecarbone acid derivatives, process for the preparation thereof, the use of the same and drugs containing them - Google Patents

Nitratoalkanecarbone acid derivatives, process for the preparation thereof, the use of the same and drugs containing them

Info

Publication number
HRP920948B1
HRP920948B1 HRP-630/91A HRP920948A HRP920948B1 HR P920948 B1 HRP920948 B1 HR P920948B1 HR P920948 A HRP920948 A HR P920948A HR P920948 B1 HRP920948 B1 HR P920948B1
Authority
HR
Croatia
Prior art keywords
acid derivatives
nitratoalkanecarbone
preparation
same
general formula
Prior art date
Application number
HRP-630/91A
Other languages
English (en)
Inventor
Klaus Sandrock
Eike Noack
Edgar Fritschi
Ralf Kanzler
Martin Feelisch
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of HRP920948A2 publication Critical patent/HRP920948A2/hr
Publication of HRP920948B1 publication Critical patent/HRP920948B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HRP-630/91A 1990-04-10 1992-10-02 Nitratoalkanecarbone acid derivatives, process for the preparation thereof, the use of the same and drugs containing them HRP920948B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4011505A DE4011505C2 (de) 1990-04-10 1990-04-10 Nitratoalkancarbonsäure-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
YU63091A YU48610B (sh) 1990-04-10 1991-04-08 Derivati nitratoalkankarbonskih kiselina i postupak za njihovo dobijanje

Publications (2)

Publication Number Publication Date
HRP920948A2 HRP920948A2 (en) 1997-10-31
HRP920948B1 true HRP920948B1 (en) 2000-04-30

Family

ID=6404098

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP-630/91A HRP920948B1 (en) 1990-04-10 1992-10-02 Nitratoalkanecarbone acid derivatives, process for the preparation thereof, the use of the same and drugs containing them

Country Status (18)

Country Link
EP (1) EP0451760B1 (cs)
JP (1) JP2848979B2 (cs)
AT (1) ATE127787T1 (cs)
CZ (1) CZ279744B6 (cs)
DE (2) DE4011505C2 (cs)
DK (1) DK0451760T3 (cs)
ES (1) ES2079506T3 (cs)
FI (1) FI111074B (cs)
GR (1) GR3017418T3 (cs)
HR (1) HRP920948B1 (cs)
HU (1) HU218202B (cs)
IE (1) IE68060B1 (cs)
PL (1) PL167089B1 (cs)
PT (1) PT97279B (cs)
RU (1) RU2017748C1 (cs)
SI (1) SI9110630B (cs)
SK (1) SK278385B6 (cs)
YU (1) YU48610B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4321306A1 (de) * 1993-06-26 1995-01-05 Sanol Arznei Schwarz Gmbh Disulfide
GB9504350D0 (en) * 1995-03-04 1995-04-26 Sod Conseils Rech Applic Arginine derivatives
US5929063A (en) * 1995-03-24 1999-07-27 Children's Hospital Medical Center Mercapto and seleno derivatives as inhibitors of nitric oxide synthase
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
DE19634793A1 (de) * 1996-08-29 1998-03-05 Sanol Arznei Schwarz Gmbh S- und O-Nitratoacylverbindungen
WO2003013432A2 (en) * 2001-08-10 2003-02-20 Nitromed, Inc. Methods of use for novel sulfur containing organic nitrate compounds
CN103739499B (zh) 2011-10-24 2016-09-07 尼科斯科学爱尔兰公司 醌基一氧化氮供体化合物
JP6313758B2 (ja) * 2012-07-10 2018-04-18 エックスピーディ・ホールディングス・リミテッド・ライアビリティ・カンパニーＸＰＤ Ｈｏｌｄｉｎｇｓ ＬＬＣ 安定化された多機能抗酸化化合物およびその使用方法
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3443998A1 (de) * 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3512627A1 (de) * 1985-04-06 1986-10-09 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel
JP2628756B2 (ja) * 1988-09-15 1997-07-09 シュバルツファルマ アクチェンゲゼルシャフト 新規有機ニトレート及びそれらの製造方法

Also Published As

Publication number Publication date
DK0451760T3 (da) 1996-01-02
IE911023A1 (en) 1991-10-23
IE68060B1 (en) 1996-05-15
CS9100984A2 (en) 1991-11-12
EP0451760B1 (de) 1995-09-13
PT97279A (pt) 1991-12-31
JPH05178804A (ja) 1993-07-20
HU911143D0 (en) 1991-10-28
HUT57707A (en) 1991-12-30
FI111074B (fi) 2003-05-30
SK278385B6 (en) 1997-02-05
RU2017748C1 (ru) 1994-08-15
HU218202B (hu) 2000-06-28
PT97279B (pt) 1998-08-31
DE4011505C2 (de) 1995-01-12
YU48610B (sh) 1999-03-04
DE4011505A1 (de) 1991-10-24
SK98491A3 (en) 1995-07-11
PL167089B1 (pl) 1995-07-31
FI911703A0 (fi) 1991-04-09
JP2848979B2 (ja) 1999-01-20
SI9110630B (sl) 2000-08-31
EP0451760A1 (de) 1991-10-16
YU63091A (sh) 1994-01-20
ATE127787T1 (de) 1995-09-15
SI9110630A (en) 1997-06-30
DE59106452D1 (de) 1995-10-19
HRP920948A2 (en) 1997-10-31
GR3017418T3 (en) 1995-12-31
ES2079506T3 (es) 1996-01-16
FI911703A7 (fi) 1991-10-11
CZ279744B6 (cs) 1995-06-14

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Legal Events

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B1PR Patent granted
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Payment date: 20030321

Year of fee payment: 13

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Effective date: 20040409