HRP930134A2 - Novel fungal strains and the use thereof in the antibiotic production - Google Patents

Novel fungal strains and the use thereof in the antibiotic production Download PDF

Info

Publication number: HRP930134A2
Authority: HR; Croatia
Prior art keywords: lovastatin; aspergillus; oryzae; fungal; strain
Prior art date: 1992-02-10

Application number

HR930134A

Other languages

English (en)

Croatian (hr)

Inventor

Jagroop S Dahiya

Original Assignee

Novopharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-10

Filing date

1993-02-08

Publication date

1995-10-31

1992-02-27 Priority claimed from CA002062023A external-priority patent/CA2062023A1/en

1993-02-08 Application filed by Novopharm Ltd filed Critical Novopharm Ltd

1995-10-31 Publication of HRP930134A2 publication Critical patent/HRP930134A2/hr

Links

230000002538 fungal effect Effects 0.000 title claims description 15
238000004519 manufacturing process Methods 0.000 title description 18
230000003115 biocidal effect Effects 0.000 title description 5
PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims description 66
229960004844 lovastatin Drugs 0.000 claims description 66
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims description 66
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims description 64
YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 claims description 36
238000000034 method Methods 0.000 claims description 34
240000006439 Aspergillus oryzae Species 0.000 claims description 26
210000001938 protoplast Anatomy 0.000 claims description 23
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238000000855 fermentation Methods 0.000 claims description 14
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241000228212 Aspergillus Species 0.000 claims description 12
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IFIFFBWHLKGTMO-SJIDJMGWSA-N [(1s,3s,4ar,7s,8s,8as)-8-[2-[(2r,4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl] (2s)-2-methylbutanoate Chemical compound C([C@H]1[C@@H](C)C=C[C@H]2C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 IFIFFBWHLKGTMO-SJIDJMGWSA-N 0.000 description 3
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238000004458 analytical method Methods 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
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HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
239000012225 czapek media Substances 0.000 description 2
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KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
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KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
101001009252 Homo sapiens 2-hydroxyacyl-CoA lyase 1 Proteins 0.000 description 1
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LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
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235000009566 rice Nutrition 0.000 description 1
JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
229960001225 rifampicin Drugs 0.000 description 1
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239000002689 soil Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
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238000001179 sorption measurement Methods 0.000 description 1
LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
VABRZWDEEDQLRD-UHFFFAOYSA-N streptomyces antibiotic uk-63052 Chemical compound CN1C(=O)C(N(C)C(=O)C(C)NC(=O)C(COC(=O)C2(C(C2)C)N(C)C2=O)NC(=O)C=3C(=CC4=CC=CC=C4N=3)O)C(SC(C)CC)SCC2N(C)C(=O)C(C)NC(=O)C(NC(=O)C=2C(=CC3=CC=CC=C3N=2)O)COC(=O)C21CC2C VABRZWDEEDQLRD-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A20/00—Water conservation; Efficient water supply; Efficient water use
- Y02A20/40—Protecting water resources
- Y02A20/402—River restoration

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Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Plant Pathology (AREA)
Mycology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

HR930134A 1992-02-10 1993-02-08 Novel fungal strains and the use thereof in the antibiotic production HRP930134A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US83349692A	1992-02-10	1992-02-10
CA002062023A CA2062023A1 (en)	1992-02-10	1992-02-27	Novel fungal strains and use thereof in antibiotic production

Publications (1)

Publication Number	Publication Date
HRP930134A2 true HRP930134A2 (en)	1995-10-31

Family

ID=25674996

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR930134A HRP930134A2 (en)	1992-02-10	1993-02-08	Novel fungal strains and the use thereof in the antibiotic production

Country Status (18)

Country	Link
EP (1)	EP0556699A1 (cs)
JP (1)	JPH0622780A (cs)
CN (1)	CN1076965A (cs)
AU (1)	AU667498B2 (cs)
BG (1)	BG61180B1 (cs)
BR (1)	BR9300467A (cs)
CZ (1)	CZ17293A3 (cs)
EE (1)	EE03048B1 (cs)
FI (1)	FI930561A7 (cs)
HR (1)	HRP930134A2 (cs)
HU (1)	HUT67061A (cs)
IL (1)	IL104481A0 (cs)
LV (1)	LV10502B (cs)
NO (1)	NO930446L (cs)
NZ (1)	NZ245713A (cs)
PL (1)	PL297691A1 (cs)
SI (1)	SI9300068A (cs)
SK (1)	SK5593A3 (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5849881A (en) *	1989-05-05	1998-12-15	Baylor College Medicine	Production of recombinant lactoferrin and lactoferrin polypeptides using cDNA sequences in various organisms
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1993
- 1993-01-20 NZ NZ245713A patent/NZ245713A/en unknown
- 1993-01-22 IL IL104481A patent/IL104481A0/xx unknown
- 1993-01-28 AU AU32121/93A patent/AU667498B2/en not_active Ceased
- 1993-02-02 SK SK55-93A patent/SK5593A3/sk unknown
- 1993-02-03 BR BR9300467A patent/BR9300467A/pt not_active Application Discontinuation
- 1993-02-08 HR HR930134A patent/HRP930134A2/hr not_active Application Discontinuation
- 1993-02-09 FI FI930561A patent/FI930561A7/fi not_active Application Discontinuation
- 1993-02-09 EP EP93102016A patent/EP0556699A1/en not_active Withdrawn
- 1993-02-09 NO NO93930446A patent/NO930446L/no unknown
- 1993-02-09 BG BG97421A patent/BG61180B1/bg unknown
- 1993-02-10 HU HU9300330A patent/HUT67061A/hu unknown
- 1993-02-10 SI SI19939300068A patent/SI9300068A/sl unknown
- 1993-02-10 CZ CZ93172A patent/CZ17293A3/cs unknown
- 1993-02-10 LV LVP-93-115A patent/LV10502B/en unknown
- 1993-02-10 CN CN93102686A patent/CN1076965A/zh active Pending
- 1993-02-10 PL PL29769193A patent/PL297691A1/xx unknown
- 1993-02-10 JP JP5061492A patent/JPH0622780A/ja active Pending
1994
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Also Published As

Publication number	Publication date
FI930561L (fi)	1993-08-11
AU3212193A (en)	1993-08-12
PL297691A1 (en)	1994-01-24
FI930561A0 (fi)	1993-02-09
NO930446L (no)	1993-08-11
HU9300330D0 (en)	1993-04-28
LV10502B (en)	1995-08-20
JPH0622780A (ja)	1994-02-01
EP0556699A1 (en)	1993-08-25
AU667498B2 (en)	1996-03-28
NZ245713A (en)	1994-12-22
IL104481A0 (en)	1993-05-13
CZ17293A3 (en)	1993-12-15
SK5593A3 (en)	1993-12-08
EE03048B1 (et)	1997-10-15
HUT67061A (en)	1995-01-30
BR9300467A (pt)	1993-08-17
CN1076965A (zh)	1993-10-06
BG97421A (bg)	1994-03-24
NO930446D0 (no)	1993-02-09
FI930561A7 (fi)	1993-08-11
SI9300068A (en)	1993-09-30
LV10502A (lv)	1995-02-20
BG61180B1 (bg)	1997-02-28

Legal Events

Date	Code	Title
1995-10-31	A1OB	Publication of a patent application
1996-04-29	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2008-02-12	ODBC	Application rejected

Publication	Publication Date	Title
HRP930134A2 (en)	1995-10-31	Novel fungal strains and the use thereof in the antibiotic production
US5362638A (en)	1994-11-08	Fungal strains and use thereof in antibiotic production
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JP4197312B2 (ja)	2008-12-17	プラバスタチンナトリウム
EP1015600A1 (en)	2000-07-05	Statin production by fermentation
O'Connor	2012	Strategies for engineering plant natural products: the iridoid-derived monoterpene indole alkaloids of Catharanthus roseus
Cho et al.	2003	Terreulactones A, B, C, and D: novel acetylcholinesterase inhibitors produced by Aspergillus terreus I. taxonomy, fermentation, isolation and biological activities
CA2562805A1 (en)	2005-10-20	Process for the production of macrolides using a novel strain, streptomyces sp. bicc 7522
Ashtekar et al.	2021	Aspergillus terreus: taxonomy, biology, and bioactive secondary metabolites with potential applications
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ES2208221T3 (es)	2004-06-16	Conversion microbiana de 2-metilquinoxalina.
JP2797331B2 (ja)	1998-09-17	新規微生物及びジベレリン類の製造方法
US5250424A (en)	1993-10-05	Processes for preparing novel squalene synthetase inhibitors
CN121930959A (zh)	2026-04-28	一种异源合成抗烟草黑胫病菌的化合物Angulotetrone的方法
RU2252258C2 (ru)	2005-05-20	Микробный способ получения правастатина
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KR101610970B1 (ko)	2016-04-08	갈보놀라이드 생합성에 관여하는 유전자
JPH05239023A (ja)	1993-09-17	生理活性物質ｍｂｐ０３９−０６およびその製造法
CZ2000512A3 (cs)	2001-03-14	Způsob mikrobiální oxidace 2-methylchinoxalinu na 2-chinoxalinkarboxylovou kyselinu
CZ2001682A3 (cs)	2002-02-13	Mikrobiologický způsob přípravy opticky aktivních 3-hydroxypyrrolidinových derivátů
Knight	2006	Biosynthesis studies and mutasynthesis of myxobacterial secondary metabolites