HRP931309A2 - New substituted azetidinones as anti-inflammatory and antidegenerative agents - Google Patents
New substituted azetidinones as anti-inflammatory and antidegenerative agentsInfo
- Publication number
- HRP931309A2 HRP931309A2 HR07/991,838A HRP931309A HRP931309A2 HR P931309 A2 HRP931309 A2 HR P931309A2 HR P931309 A HRP931309 A HR P931309A HR P931309 A2 HRP931309 A2 HR P931309A2
- Authority
- HR
- Croatia
- Prior art keywords
- chem
- inflammatory
- substituted azetidinones
- new substituted
- antidegenerative agents
- Prior art date
Links
- 230000001796 anti-degenerative effect Effects 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003602 elastase inhibitor Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96680092A | 1992-10-27 | 1992-10-27 | |
| US99183892A | 1992-12-17 | 1992-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP931309A2 true HRP931309A2 (en) | 1997-02-28 |
Family
ID=27130493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR07/991,838A HRP931309A2 (en) | 1992-10-27 | 1993-10-19 | New substituted azetidinones as anti-inflammatory and antidegenerative agents |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0595557B1 (da) |
| JP (1) | JPH082868B2 (da) |
| KR (1) | KR950704250A (da) |
| CN (1) | CN1043884C (da) |
| AT (1) | ATE270273T1 (da) |
| AU (1) | AU663806B2 (da) |
| CA (1) | CA2108584C (da) |
| CY (1) | CY2529B1 (da) |
| CZ (1) | CZ106895A3 (da) |
| DE (1) | DE69333563T2 (da) |
| DK (1) | DK0595557T3 (da) |
| DZ (1) | DZ1724A1 (da) |
| ES (1) | ES2224095T3 (da) |
| FI (1) | FI951992A0 (da) |
| HR (1) | HRP931309A2 (da) |
| HU (2) | HUT72084A (da) |
| IL (1) | IL107321A (da) |
| LV (1) | LV13338B (da) |
| MX (1) | MX9306666A (da) |
| MY (1) | MY128261A (da) |
| NO (1) | NO305697B1 (da) |
| NZ (1) | NZ257755A (da) |
| PL (1) | PL308545A1 (da) |
| PT (1) | PT595557E (da) |
| RU (1) | RU2148056C1 (da) |
| SI (1) | SI9300566A (da) |
| SK (1) | SK53795A3 (da) |
| TW (1) | TW275621B (da) |
| WO (1) | WO1994010142A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420010A (en) * | 1993-07-30 | 1995-05-30 | Merck & Co., Inc. | Assay for evaluating inhibition of polymorphonuclear leukocyte elastase by N-substituted azetidinones |
| WO1996029307A1 (en) * | 1995-03-23 | 1996-09-26 | Japan Tobacco Inc. | Diphenylmethyl-azetidinone compounds and elastase inhibitor |
| US5523233A (en) * | 1995-05-03 | 1996-06-04 | Merck & Co., Inc. | Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters |
| AU701386B2 (en) * | 1995-10-31 | 1999-01-28 | Merck & Co., Inc. | Process for preparing substituted azetidinones |
| US5808056A (en) * | 1995-10-31 | 1998-09-15 | Merck & Co., Inc. | Process for preparing substituted azetidinones |
| EP0869943A1 (en) * | 1995-12-08 | 1998-10-14 | Smithkline Beecham Plc | Monocyclic beta-lactame derivatives for treatment of atherosclerosis |
| CZ341098A3 (cs) * | 1996-04-26 | 1999-03-17 | Smithkline Beecham Plc | Azetidinonové deriváty pro ošetřování aterosklerózy |
| CA2336003A1 (en) * | 1998-06-25 | 1999-12-29 | Zhongmin Xu | Amidino and guanidino azetidinone tryptase inhibitors |
| WO2000005204A1 (en) * | 1998-07-23 | 2000-02-03 | Shionogi & Co., Ltd. | MONOCYCLIC β-LACTAM COMPOUNDS AND CHYMASE INHIBITORS CONTAINING THE SAME |
| RU2191570C1 (ru) * | 2001-04-25 | 2002-10-27 | Закрытое акционерное общество "ВЕРОФАРМ" | Твердая лекарственная форма антимикробного средства |
| RU2207115C1 (ru) * | 2001-12-27 | 2003-06-27 | Закрытое акционерное общество "Брынцалов-А" | Противомикробное средство тариферид |
| RU2217196C2 (ru) * | 2002-02-28 | 2003-11-27 | Небольсин Владимир Евгеньевич | Способ индукции дифференцировки клеток |
| FR2861991B1 (fr) * | 2003-11-07 | 2008-01-18 | Centre Nat Rech Scient | Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
| FR2937972B1 (fr) * | 2008-11-04 | 2013-03-29 | Galderma Res & Dev | Derives d'oxoazetidine, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
| CN102341385B (zh) * | 2009-03-09 | 2014-01-15 | 大鹏药品工业株式会社 | 能够抑制前列腺素d合酶的哌嗪化合物 |
| FR2981933B1 (fr) * | 2011-11-02 | 2013-11-15 | Galderma Res & Dev | Derives d'oxoazetidine, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ228600A (en) * | 1988-04-11 | 1992-02-25 | Merck & Co Inc | 1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives |
| IL99658A0 (en) * | 1990-10-15 | 1992-08-18 | Merck & Co Inc | Substituted azetidinones and pharmaceutical compositions containing them |
| WO1993000332A1 (en) * | 1991-06-25 | 1993-01-07 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
-
1993
- 1993-10-18 CA CA002108584A patent/CA2108584C/en not_active Expired - Lifetime
- 1993-10-18 MY MYPI93002128A patent/MY128261A/en unknown
- 1993-10-18 TW TW082108642A patent/TW275621B/zh active
- 1993-10-19 IL IL10732193A patent/IL107321A/en not_active IP Right Cessation
- 1993-10-19 HR HR07/991,838A patent/HRP931309A2/xx not_active Application Discontinuation
- 1993-10-22 DK DK93308421T patent/DK0595557T3/da active
- 1993-10-22 PT PT93308421T patent/PT595557E/pt unknown
- 1993-10-22 EP EP93308421A patent/EP0595557B1/en not_active Expired - Lifetime
- 1993-10-22 DE DE69333563T patent/DE69333563T2/de not_active Expired - Lifetime
- 1993-10-22 ES ES93308421T patent/ES2224095T3/es not_active Expired - Lifetime
- 1993-10-22 AT AT93308421T patent/ATE270273T1/de active
- 1993-10-26 MX MX9306666A patent/MX9306666A/es not_active IP Right Cessation
- 1993-10-26 PL PL93308545A patent/PL308545A1/xx unknown
- 1993-10-26 CN CN93119648A patent/CN1043884C/zh not_active Expired - Fee Related
- 1993-10-26 NZ NZ257755A patent/NZ257755A/en unknown
- 1993-10-26 AU AU50283/93A patent/AU663806B2/en not_active Expired
- 1993-10-26 CZ CZ951068A patent/CZ106895A3/cs unknown
- 1993-10-26 WO PCT/US1993/010268 patent/WO1994010142A1/en not_active Ceased
- 1993-10-26 RU RU95109936A patent/RU2148056C1/ru active
- 1993-10-26 SK SK537-95A patent/SK53795A3/sk unknown
- 1993-10-26 HU HU9501184A patent/HUT72084A/hu unknown
- 1993-10-27 DZ DZ930115A patent/DZ1724A1/fr active
- 1993-10-27 JP JP5292692A patent/JPH082868B2/ja not_active Expired - Lifetime
- 1993-10-27 SI SI9300566A patent/SI9300566A/sl unknown
-
1995
- 1995-04-26 NO NO951593A patent/NO305697B1/no not_active IP Right Cessation
- 1995-04-26 FI FI951992A patent/FI951992A0/fi unknown
- 1995-04-27 KR KR1019950701629A patent/KR950704250A/ko not_active Ceased
- 1995-06-30 HU HU95P/P00639P patent/HU211619A9/hu unknown
-
2005
- 2005-06-08 LV LVP-05-69A patent/LV13338B/en unknown
- 2005-08-29 CY CY0500046A patent/CY2529B1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| ODBI | Application refused |