HRP950414B1 - New compounds with analgetic and local anaesthetic effect - Google Patents

New compounds with analgetic and local anaesthetic effect

Info

Publication number
HRP950414B1
HRP950414B1 HRP950414A HRP950414B1 HR P950414 B1 HRP950414 B1 HR P950414B1 HR P950414 A HRP950414 A HR P950414A HR P950414 B1 HRP950414 B1 HR P950414B1
Authority
HR
Croatia
Prior art keywords
new compounds
analgetic
local anaesthetic
anaesthetic effect
effect
Prior art date
Application number
Other languages
English (en)
Inventor
Anna-Lena Ask
Olov Lars-Inge Olsson
Rune Verner Sandberg
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of HRP950414A2 publication Critical patent/HRP950414A2/hr
Publication of HRP950414B1 publication Critical patent/HRP950414B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Finger-Pressure Massage (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR9400447-0 1994-02-11 1995-07-19 New compounds with analgetic and local anaesthetic effect HRP950414B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9400447A SE9400447D0 (sv) 1994-02-11 1994-02-11 New compounds

Publications (2)

Publication Number Publication Date
HRP950414A2 HRP950414A2 (en) 1997-10-31
HRP950414B1 true HRP950414B1 (en) 2001-02-28

Family

ID=20392881

Family Applications (1)

Application Number Title Priority Date Filing Date
HR9400447-0 HRP950414B1 (en) 1994-02-11 1995-07-19 New compounds with analgetic and local anaesthetic effect

Country Status (31)

Country Link
US (2) US5756520A (de)
EP (1) EP0743940B1 (de)
JP (1) JPH09508904A (de)
CN (1) CN1067989C (de)
AT (1) ATE192435T1 (de)
AU (1) AU686760B2 (de)
BR (1) BR9506748A (de)
CA (1) CA2181068A1 (de)
CZ (1) CZ286753B6 (de)
DE (1) DE69516671T2 (de)
DK (1) DK0743940T3 (de)
EE (1) EE03252B1 (de)
ES (1) ES2148493T3 (de)
FI (1) FI963128L (de)
GR (1) GR3033999T3 (de)
HR (1) HRP950414B1 (de)
HU (1) HU216734B (de)
IL (1) IL112374A (de)
IS (1) IS1771B (de)
MX (1) MX9603092A (de)
MY (1) MY130166A (de)
NO (1) NO306718B1 (de)
NZ (1) NZ281355A (de)
PL (1) PL180212B1 (de)
PT (1) PT743940E (de)
RU (1) RU2145599C1 (de)
SE (1) SE9400447D0 (de)
SK (1) SK281931B6 (de)
TW (1) TW348176B (de)
WO (1) WO1995021821A1 (de)
ZA (1) ZA95709B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
US7799337B2 (en) * 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
DE19912889A1 (de) * 1999-03-23 2000-09-28 Daimler Chrysler Ag Verfahren zur Herstellung eines Ventilsitzes
RU2005118407A (ru) * 2002-12-13 2006-03-10 СмитКлайн Бичем Корпорейшн (US) Производные пиперидина в качестве антагонистов ccr5
US6916833B2 (en) * 2003-03-13 2005-07-12 Hoffmann-La Roche Inc. Substituted piperidines
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
CL2007002958A1 (es) * 2006-10-12 2008-05-09 Epix Delaware Inc Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr
KR20100102646A (ko) 2007-12-11 2010-09-24 가부시키가이샤 사이토파스파인더 카르복스아미드 화합물 및 케모카인 수용체 길항제로서의 이의 용도
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9320908B2 (en) * 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
US20100185249A1 (en) * 2009-01-22 2010-07-22 Wingeier Brett M Method and Devices for Adrenal Stimulation
US20220096452A1 (en) 2019-01-22 2022-03-31 Icm (Institut Du Cerveau Et De La Moelle Épinière) Local anesthetic for the treatment of neurological symptoms resulting from brain dysfunctions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2951080A (en) * 1957-08-05 1960-08-30 Lilly Co Eli Novel phenyl-substituted piperidines
NL262366A (de) * 1960-03-14
US3850935A (en) * 1971-10-16 1974-11-26 Sumitomo Chemical Co Process for producing piperidine derivatives by degrading quaternary piperidinium salts
US4369184A (en) * 1980-01-24 1983-01-18 Janssen Pharmaceutica N.V. 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives
SE8904298D0 (sv) * 1989-12-21 1989-12-21 Astra Ab New compounds
EP0673367A1 (de) * 1992-12-14 1995-09-27 MERCK SHARP & DOHME LTD. 4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenyl-piperidine als tachykinin rezeptor antagonisten

Also Published As

Publication number Publication date
CZ286753B6 (en) 2000-06-14
JPH09508904A (ja) 1997-09-09
IL112374A0 (en) 1995-03-30
IS1771B (is) 2001-05-28
NO963292L (no) 1996-08-07
RU2145599C1 (ru) 2000-02-20
NZ281355A (en) 1998-02-26
HU216734B (hu) 1999-08-30
FI963128A7 (fi) 1996-08-09
SK92896A3 (en) 1997-07-09
CZ203296A3 (en) 1996-12-11
FI963128A0 (fi) 1996-08-09
DE69516671D1 (de) 2000-06-08
EP0743940B1 (de) 2000-05-03
FI963128L (fi) 1996-08-09
BR9506748A (pt) 1997-09-16
DE69516671T2 (de) 2001-02-01
HU9602206D0 (en) 1996-10-28
DK0743940T3 (da) 2000-08-14
HRP950414A2 (en) 1997-10-31
US5968953A (en) 1999-10-19
EP0743940A1 (de) 1996-11-27
SK281931B6 (sk) 2001-09-11
ES2148493T3 (es) 2000-10-16
CN1067989C (zh) 2001-07-04
EE03252B1 (et) 2000-02-15
PL315777A1 (en) 1996-12-09
SE9400447D0 (sv) 1994-02-11
NO306718B1 (no) 1999-12-13
HUT75641A (en) 1997-05-28
AU1826995A (en) 1995-08-29
IL112374A (en) 1999-12-31
NO963292D0 (no) 1996-08-07
IS4251A (is) 1995-08-12
ATE192435T1 (de) 2000-05-15
US5756520A (en) 1998-05-26
MX9603092A (es) 1997-03-29
WO1995021821A1 (en) 1995-08-17
AU686760B2 (en) 1998-02-12
MY130166A (en) 2007-06-29
PL180212B1 (pl) 2001-01-31
CA2181068A1 (en) 1995-08-17
CN1140448A (zh) 1997-01-15
PT743940E (pt) 2000-08-31
TW348176B (en) 1998-12-21
ZA95709B (en) 1995-08-11
GR3033999T3 (en) 2000-11-30

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
ODRP Renewal fee for the maintenance of a patent

Payment date: 20000719

Year of fee payment: 6

B1PR Patent granted
PBON Lapse due to non-payment of renewal fee

Effective date: 20010720