HRP970211A2 - Pyrazinone thrombin inhibitors - Google Patents

Pyrazinone thrombin inhibitors

Info

Publication number
HRP970211A2
HRP970211A2 HR60/043,009A HRP970211A HRP970211A2 HR P970211 A2 HRP970211 A2 HR P970211A2 HR P970211 A HRP970211 A HR P970211A HR P970211 A2 HRP970211 A2 HR P970211A2
Authority
HR
Croatia
Prior art keywords
thrombin inhibitors
pyrazinone
pyrazinone thrombin
inhibitors
compounds
Prior art date
Application number
HR60/043,009A
Other languages
English (en)
Croatian (hr)
Inventor
Richard J Varsolona
Philip E Sanderson
Terry A Lyle
Original Assignee
Richard J. Varsolona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609714.2A external-priority patent/GB9609714D0/en
Application filed by Richard J. Varsolona filed Critical Richard J. Varsolona
Publication of HRP970211A2 publication Critical patent/HRP970211A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR60/043,009A 1996-04-23 1997-04-21 Pyrazinone thrombin inhibitors HRP970211A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1604196P 1996-04-23 1996-04-23
GBGB9609714.2A GB9609714D0 (en) 1996-05-09 1996-05-09 Pyridinone thrombin inhibitors
US4300997P 1997-04-14 1997-04-14

Publications (1)

Publication Number Publication Date
HRP970211A2 true HRP970211A2 (en) 1998-06-30

Family

ID=27268274

Family Applications (1)

Application Number Title Priority Date Filing Date
HR60/043,009A HRP970211A2 (en) 1996-04-23 1997-04-21 Pyrazinone thrombin inhibitors

Country Status (21)

Country Link
EP (1) EP0900207B1 (de)
JP (1) JP3140790B2 (de)
KR (1) KR20000010650A (de)
AT (1) ATE209191T1 (de)
AU (1) AU714985B2 (de)
BG (1) BG102948A (de)
BR (1) BR9708859A (de)
CA (1) CA2252964A1 (de)
CZ (1) CZ340898A3 (de)
DE (1) DE69709727T2 (de)
EE (1) EE9800353A (de)
HR (1) HRP970211A2 (de)
IL (1) IL126404A0 (de)
IS (1) IS4853A (de)
NO (1) NO984928L (de)
NZ (1) NZ331993A (de)
PE (1) PE13399A1 (de)
PL (1) PL329441A1 (de)
SK (1) SK145398A3 (de)
TR (1) TR199802133T2 (de)
WO (1) WO1997040024A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU746024B2 (en) * 1996-04-23 2002-04-11 Merck & Co., Inc. Pyrazinone thrombin inhibitors
US6159980A (en) * 1996-09-16 2000-12-12 Dupont Pharmaceuticals Company Pyrazinones and triazinones and their derivatives thereof
CA2283704A1 (en) * 1997-03-24 1998-10-01 Merck & Co., Inc. Thrombin inhibitors
US6011038A (en) * 1997-09-05 2000-01-04 Merck & Co., Inc. Pyrazinone thrombin inhibitors
US6147078A (en) * 1998-05-19 2000-11-14 Merck & Co., Inc. Pyrazinone thrombin inhibitors
WO1999059591A1 (en) * 1998-05-19 1999-11-25 Merck & Co., Inc. Pyrazinone thrombin inhibitors
EP1082324A4 (de) * 1998-05-26 2002-01-02 Merck & Co Inc Imidazopyridinverbindungen als thrombininhibitoren
JP4554077B2 (ja) 1998-06-11 2010-09-29 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ピラジノンプロテアーゼインヒビター
EP0997474B1 (de) * 1998-08-14 2003-10-29 Pfizer Inc. Antithrombosemittel
EP1117660A4 (de) * 1998-09-28 2002-01-09 Merck & Co Inc Thrombin-inhibitoren
WO2000026210A1 (en) 1998-10-30 2000-05-11 Merck & Co., Inc. Thrombin inhibitors
CA2348734A1 (en) 1998-10-30 2000-05-11 Merck & Co., Inc. Thrombin inhibitors
WO2000038683A1 (en) * 1998-12-23 2000-07-06 Du Pont Pharmaceuticals Company THROMBIN OR FACTOR Xa INHIBITORS
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
IL146245A0 (en) * 1999-05-19 2002-07-25 Pharmacia Corp Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
EP1586565A1 (de) * 1999-05-19 2005-10-19 Pharmacia Corporation Substituierte polycyclische aryl und heteroarylpyrazinone zur selektiven Hemmung von der Blutgerinnungskaskade
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
UA58636C2 (uk) * 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням
ES2274795T3 (es) 1999-07-19 2007-06-01 Merck Frosst Canada Ltd. Pirazinonas, composiciones que contienen tales compuestos.
JP2003514905A (ja) 1999-11-23 2003-04-22 メルク エンド カムパニー インコーポレーテッド ピラジノン系トロンビン阻害薬
WO2001068605A1 (en) 2000-03-13 2001-09-20 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
CA2403558A1 (en) 2000-03-23 2001-09-27 Merck & Co., Inc. Thrombin inhibitors
EP1268428A2 (de) 2000-04-05 2003-01-02 Pharmacia Corporation Polyzyklische aryl und heteroaryl substituierte 4-pyridon-derivate verwendbar zur selektiven hemmung der blutgerinnungskaskade
ATE289299T1 (de) 2000-04-05 2005-03-15 Pharmacia Corp Polyzyclisch aryl und heteroaryl substituierte 4- pyronen verwendbar als selektive hemmung von dem koagulationsprozess
US6506761B1 (en) 2000-04-14 2003-01-14 Corvas International, Inc. Substituted hydrazinyl heteroaromatic inhibitors of thrombin
AU2001255410A1 (en) * 2000-04-14 2001-10-30 Corvas International, Inc. Substituted hydrazinyl heteroaromatic inhibitors of thrombin
US6506760B1 (en) 2000-04-14 2003-01-14 Corvas International, Inc. Substituted hydrazinyl heteroaromatic inhibitors of thrombin
JP2004501077A (ja) 2000-04-17 2004-01-15 ファルマシア・コーポレーション 凝固カスケードの選択的阻害に有用な多環式アリールおよびヘテロアリール置換１，４−キノン
CA2415932A1 (en) 2000-07-17 2002-01-24 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine pyrazinones as protease inhibitors
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
EP1351686A2 (de) 2000-11-20 2003-10-15 Pharmacia Corporation Substituierte polycyclische aryl- und heteroarylpyridine für die selektive hemmung der koagulationskaskade
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
WO2003093242A2 (en) 2001-10-03 2003-11-13 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
MXPA04003163A (es) 2001-10-03 2004-07-08 Pharmacia Corp Compuestos heterociclicos de 6 elementos utiles para inhibicion selectiva de la casdada de coagulacion.
RS52392B (sr) 2002-02-14 2013-02-28 Pharmacia Corporation Supstituisani piridinoni kao modulatori p38 map kinaze
GB0306615D0 (en) * 2003-03-22 2003-04-30 Astrazeneca Ab New use
EP1526131A1 (de) * 2003-10-22 2005-04-27 Graffinity Pharmaceuticals Aktiengesellschaft Aminoalkyl-Pyrazinone und -Pyridone verwendbar als Thrombininhibitoren
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
WO2006135323A1 (en) * 2005-06-17 2006-12-21 Astrazeneca Ab Thrombin inhibiting 2-oxo-1, 2, 5, 6-tetrahydropyridine derivatives
CN108271369A (zh) 2015-10-23 2018-07-10 法尔玛赞公司 用于制备色胺及其衍生物的新工艺

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3775686D1 (de) * 1986-09-26 1992-02-13 Ciba Geigy Ag Aminopyrazinone und aminotriazinone.

Also Published As

Publication number Publication date
EP0900207B1 (de) 2001-11-21
BG102948A (bg) 1999-11-30
IL126404A0 (en) 1999-05-09
EP0900207A1 (de) 1999-03-10
BR9708859A (pt) 1999-08-03
ATE209191T1 (de) 2001-12-15
KR20000010650A (ko) 2000-02-25
AU2679997A (en) 1997-11-12
EE9800353A (et) 1999-04-15
NO984928D0 (no) 1998-10-22
AU714985B2 (en) 2000-01-13
JP2000508334A (ja) 2000-07-04
WO1997040024A1 (en) 1997-10-30
PE13399A1 (es) 1999-02-11
JP3140790B2 (ja) 2001-03-05
DE69709727D1 (de) 2002-02-21
NO984928L (no) 1998-12-22
PL329441A1 (en) 1999-03-29
TR199802133T2 (xx) 2000-09-21
NZ331993A (en) 2000-04-28
DE69709727T2 (de) 2002-08-08
SK145398A3 (en) 1999-05-07
CZ340898A3 (cs) 1999-02-17
CA2252964A1 (en) 1997-10-30
IS4853A (is) 1998-09-25

Similar Documents

Publication Publication Date Title
IL126404A0 (en) Pyrazinone thrombin inhibitors
EP0772590A1 (de) Thrombin-inhibitoren
AU4905097A (en) Thrombin inhibitors
AU3832895A (en) Thrombin inhibitors
YU15299A (sh) Farmaceutski sastavi
DE69828682D1 (de) Nanomolare, non-peptidische inhibitoren von cathepsin d
IL127751A0 (en) Thrombin inhibitors
ZA971733B (en) Serine protease inhibitors.
ZA977697B (en) Bidentate metalloprotease inhibitors.
ZA971667B (en) Serine protease inhibitors.
ATE228760T1 (de) Thrombininhibitoren
AU3042697A (en) Thrombin inhibitors
ZA946325B (en) Retroviral protease inhibitors and combinations thereof.
ZA974779B (en) Thrombin inhibitors.
IL121474A0 (en) Thrombin inhibitors
AU3974997A (en) Thrombin inhibitors
AU2234497A (en) Novel protease inhibitors derived from guamerin
ZA961276B (en) Novel thrombin inhibitors.
GB9603450D0 (en) Pyridinone thrombin inhibitors
GB9609714D0 (en) Pyridinone thrombin inhibitors
GB9624292D0 (en) Thrombin inhibitors
GB9624278D0 (en) Thrombin inhibitors
GB9605163D0 (en) Thrombin inhibitors
SI0956294T1 (en) Thrombin inhibitors
GB9801005D0 (en) Pyrazinone thrombin inhibitors

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
ODBC Application rejected