HRP970271A2 - Process for preparing biologically active derivatives of 1,2,4-triazol and intermediates used in this process - Google Patents

Process for preparing biologically active derivatives of 1,2,4-triazol and intermediates used in this process

Info

Publication number: HRP970271A2
Authority: HR; Croatia
Prior art keywords: triazol; difluorophenyl; formula; biologically active; intermediates used
Prior art date: 1996-05-21

Application number

HRP-9600165A

Other languages

English (en)

Inventor

Alberto Palomo Coll

Sonia Serra Mortes

Original Assignee

Krka Tovarna Zdravil

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-21

Filing date

1997-05-20

Publication date

1998-04-30

1997-05-20 Application filed by Krka Tovarna Zdravil filed Critical Krka Tovarna Zdravil

1998-04-30 Publication of HRP970271A2 publication Critical patent/HRP970271A2/xx

Links

NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical class C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 3
JIHQDMXYYFUGFV-UHFFFAOYSA-N 1,3,5-triazine Chemical compound C1=NC=NC=N1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 abstract 1
125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 abstract 1
ADUNKYLYKJXTGR-UHFFFAOYSA-N 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-1-ol Chemical compound C1=NC=NN1C(O)C(C=1C(=CC(F)=CC=1)F)CN1C=NC=N1 ADUNKYLYKJXTGR-UHFFFAOYSA-N 0.000 abstract 1
LGWJTZHRHNUYJS-UHFFFAOYSA-N 2-(2,4-difluorophenyl)-1-hydrazinylpropan-2-ol Chemical class NNCC(O)(C)C1=CC=C(F)C=C1F LGWJTZHRHNUYJS-UHFFFAOYSA-N 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 abstract 1
229960004884 fluconazole Drugs 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010992 reflux Methods 0.000 abstract 1
125000001425 triazolyl group Chemical group 0.000 abstract 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C241/02—Preparation of hydrazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
- C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C243/18—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

HRP-9600165A 1996-05-21 1997-05-20 Process for preparing biologically active derivatives of 1,2,4-triazol and intermediates used in this process HRP970271A2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SI9600165A SI9600165A (en)	1996-05-21	1996-05-21	Process for preparation of biological active derivative of 1,2,4- triazole and intermediates useful in this process

Publications (1)

Publication Number	Publication Date
HRP970271A2 true HRP970271A2 (en)	1998-04-30

Family

ID=20431850

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HRP-9600165A HRP970271A2 (en)	1996-05-21	1997-05-20	Process for preparing biologically active derivatives of 1,2,4-triazol and intermediates used in this process

Country Status (13)

Country	Link
EP (1)	EP0967210B1 (de)
KR (1)	KR20000015811A (de)
AT (1)	ATE242221T1 (de)
AU (1)	AU1098297A (de)
DE (1)	DE69628597T2 (de)
HR (1)	HRP970271A2 (de)
HU (1)	HU223570B1 (de)
NO (1)	NO985408L (de)
RU (1)	RU2170736C2 (de)
SI (1)	SI9600165A (de)
UA (1)	UA64712C2 (de)
WO (1)	WO1997044330A1 (de)
YU (1)	YU19097A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100341688B1 (ko) *	1999-04-16	2002-06-24	윤재승	플루코나졸의 제조방법
KR100327818B1 (ko) *	1999-04-16	2002-03-09	윤재승	플루코나졸의 제조방법
WO2004018485A1 (en) *	2002-08-26	2004-03-04	Ranbaxy Laboratories Limited	Azole derivatives as antifungal agents
EP2984080B1 (de) *	2013-04-12	2017-08-30	Bayer CropScience Aktiengesellschaft	Neuartige triazolderivate
BR102013027313B1 (pt) *	2013-10-23	2019-06-18	Iharabras S.A. Indústrias Químicas	Processo para a preparação seletiva de (1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2099818A (en) *	1981-06-06	1982-12-15	Pfizer Ltd	Triazoles
IT1249211B (it) *	1990-06-08	1995-02-20	Ind Chimica Srl	Processo per la preparazione di triazolil isopropanoli in particolare fluconazolo
CA2106032C (en) *	1993-09-13	1995-11-07	Gamini Weeratunga	Methods for the manufacture of fluconazole and forms thereof, intermediates useful in the manufacture thereof, and combinations comprising fluconazole
HU212424B (en) *	1993-09-23	1996-06-28	Richter Gedeon Vegyeszet	New propan-2-ol derivatives substituted with triazole or imidazole and process for producing them
GB9415617D0 (en) *	1994-08-02	1994-09-21	Zeneca Ltd	Pharmaceutical compound
GB9415544D0 (en) *	1994-08-02	1994-09-21	Zeneca Ltd	Chemical process and intermediates

1996
- 1996-05-21 SI SI9600165A patent/SI9600165A/sl unknown
- 1996-12-20 WO PCT/ES1996/000245 patent/WO1997044330A1/es not_active Ceased
- 1996-12-20 AT AT96941664T patent/ATE242221T1/de not_active IP Right Cessation
- 1996-12-20 UA UA98126691A patent/UA64712C2/uk unknown
- 1996-12-20 KR KR1019980709360A patent/KR20000015811A/ko not_active Withdrawn
- 1996-12-20 EP EP96941664A patent/EP0967210B1/de not_active Expired - Lifetime
- 1996-12-20 AU AU10982/97A patent/AU1098297A/en not_active Abandoned
- 1996-12-20 HU HU9903524A patent/HU223570B1/hu not_active IP Right Cessation
- 1996-12-20 DE DE69628597T patent/DE69628597T2/de not_active Expired - Fee Related
- 1996-12-20 RU RU98123117/04A patent/RU2170736C2/ru not_active IP Right Cessation
1997
- 1997-05-14 YU YU19097A patent/YU19097A/sh unknown
- 1997-05-20 HR HRP-9600165A patent/HRP970271A2/xx not_active Application Discontinuation
1998
- 1998-11-20 NO NO985408A patent/NO985408L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HU223570B1 (hu)	2004-09-28
NO985408D0 (no)	1998-11-20
EP0967210A1 (de)	1999-12-29
YU19097A (sh)	1999-09-27
HUP9903524A3 (en)	2001-12-28
NO985408L (no)	1999-01-20
WO1997044330A1 (es)	1997-11-27
AU1098297A (en)	1997-12-09
UA64712C2 (en)	2004-03-15
SI9600165A (en)	1997-12-31
KR20000015811A (ko)	2000-03-15
RU2170736C2 (ru)	2001-07-20
EP0967210B1 (de)	2003-06-04
HUP9903524A2 (hu)	2000-02-28
DE69628597D1 (de)	2003-07-10
DE69628597T2 (de)	2004-04-22
ATE242221T1 (de)	2003-06-15

Legal Events

Date	Code	Title
1998-04-30	A1OB	Publication of a patent application
1998-10-28	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2006-12-11	ODBC	Application rejected

Publication	Publication Date	Title
AU655544B2 (en)	1994-12-22	Azole compounds, their production and use
FI97381C (fi)	1996-12-10	Menetelmä korkeaa verenpainetta alentavien substituoitujen pyrroli-, pyratsoli- ja triatsoliyhdisteiden valmistamiseksi
US7189858B2 (en)	2007-03-13	N-phenyl substituted carbamoyloxyalkyl-azolium derivatives
AU777859B2 (en)	2004-11-04	N-substituted carbamoyloxyalkyl-azolium derivatives
IE821285L (en)	1982-12-06	Triazole antifungal agents
KR950032186A (ko)	1995-12-20	항진균제, 그의 제조 방법 및 중간체
DE3684431D1 (de)	1992-04-23	Derivate des ((4-(4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2yl)methyl)-1h-imidazol und 1h-1,2,4-triazol.
HU192942B (en)	1987-08-28	Process for preparing new subsituted phenyl-ethers
AU1098297A (en)	1997-12-09	Process for preparing biologically active derivatives of 1,2,4-triazol and intermediaries useful in this process
CA2402345A1 (en)	2001-09-13	Azole compounds as therapeutic agents for fungal infections
RU97106099A (ru)	1999-04-27	Ингибиторы 5-липоксигеназы
CA2217632A1 (en)	1996-10-24	Novel triazolones as apolipoprotein-b synthesis inhibitors
HU184383B (en)	1984-08-28	Process for producing phenoxy-amino-propanol derivatives
YU101291A (sh)	1993-11-16	Postupak za dobijanje triazolil-izopropanola
US6670363B1 (en)	2003-12-30	Azole compounds as therapeutic agents for fungal infections
Kashima et al.	1984	The compounds related to 3‐(1‐imidazolyl)‐2‐alken‐1‐ones. Preparation and reactions
WO1991017978A3 (en)	1991-12-26	Selective monoacylation of substituted hydrazines
RU98123117A (ru)	2000-10-10	Способ получения биологически активного производного 1,2,4-триазола и промежуточное соединение, используемое в данном способе
DE3268498D1 (en)	1986-02-27	3-substituted 1-azolyl-3-methyl-1-phenoxy-butan-2-on and ol, process for their preparation and their application as fungicides
KR940000456A (ko)	1994-01-03	트리아졸 유도체
NZ530613A (en)	2004-02-27	Azole compounds as therapeutic agents for fungal infections
KR900000360A (ko)	1990-01-30	2,4-디히드로-3h-1,2,4-트리아졸-온 유도체