ATE242221T1 - Verfahren zur herstellung biologisch aktiver derivate des 1,2,4-triazols und in diesem verfahren nuetzliche zwischenprodukte - Google Patents

Verfahren zur herstellung biologisch aktiver derivate des 1,2,4-triazols und in diesem verfahren nuetzliche zwischenprodukte

Info

Publication number: ATE242221T1
Authority: AT; Austria
Prior art keywords: triazole; biologically active; difluorophenyl; intermediate products; formula
Prior art date: 1996-05-21

Application number

AT96941664T

Other languages

English (en)

Inventor

Coll Alberto Palomo

Original Assignee

Krka Tovarna Zdravil D D Novo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-21

Filing date

1996-12-20

Publication date

2003-06-15

1996-12-20 Application filed by Krka Tovarna Zdravil D D Novo filed Critical Krka Tovarna Zdravil D D Novo

2003-06-15 Application granted granted Critical

2003-06-15 Publication of ATE242221T1 publication Critical patent/ATE242221T1/de

Links

NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical class C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 3
JIHQDMXYYFUGFV-UHFFFAOYSA-N 1,3,5-triazine Chemical compound C1=NC=NC=N1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 abstract 1
125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 abstract 1
ADUNKYLYKJXTGR-UHFFFAOYSA-N 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-1-ol Chemical compound C1=NC=NN1C(O)C(C=1C(=CC(F)=CC=1)F)CN1C=NC=N1 ADUNKYLYKJXTGR-UHFFFAOYSA-N 0.000 abstract 1
LGWJTZHRHNUYJS-UHFFFAOYSA-N 2-(2,4-difluorophenyl)-1-hydrazinylpropan-2-ol Chemical class NNCC(O)(C)C1=CC=C(F)C=C1F LGWJTZHRHNUYJS-UHFFFAOYSA-N 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 abstract 1
229960004884 fluconazole Drugs 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000010992 reflux Methods 0.000 abstract 1
125000001425 triazolyl group Chemical group 0.000 abstract 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C241/02—Preparation of hydrazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/12—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
- C07C243/16—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C243/18—Hydrazines having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT96941664T 1996-05-21 1996-12-20 Verfahren zur herstellung biologisch aktiver derivate des 1,2,4-triazols und in diesem verfahren nuetzliche zwischenprodukte ATE242221T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SI9600165A SI9600165A (en)	1996-05-21	1996-05-21	Process for preparation of biological active derivative of 1,2,4- triazole and intermediates useful in this process
PCT/ES1996/000245 WO1997044330A1 (es)	1996-05-21	1996-12-20	Procedimiento para la preparacion de derivados biologicamente activos de 1,2,4-triazol e intermedios utiles en este procedimiento

Publications (1)

Publication Number	Publication Date
ATE242221T1 true ATE242221T1 (de)	2003-06-15

Family

ID=20431850

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96941664T ATE242221T1 (de)	1996-05-21	1996-12-20	Verfahren zur herstellung biologisch aktiver derivate des 1,2,4-triazols und in diesem verfahren nuetzliche zwischenprodukte

Country Status (13)

Country	Link
EP (1)	EP0967210B1 (de)
KR (1)	KR20000015811A (de)
AT (1)	ATE242221T1 (de)
AU (1)	AU1098297A (de)
DE (1)	DE69628597T2 (de)
HR (1)	HRP970271A2 (de)
HU (1)	HU223570B1 (de)
NO (1)	NO985408L (de)
RU (1)	RU2170736C2 (de)
SI (1)	SI9600165A (de)
UA (1)	UA64712C2 (de)
WO (1)	WO1997044330A1 (de)
YU (1)	YU19097A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100341688B1 (ko) *	1999-04-16	2002-06-24	윤재승	플루코나졸의 제조방법
KR100327818B1 (ko) *	1999-04-16	2002-03-09	윤재승	플루코나졸의 제조방법
WO2004018485A1 (en) *	2002-08-26	2004-03-04	Ranbaxy Laboratories Limited	Azole derivatives as antifungal agents
EP2984080B1 (de) *	2013-04-12	2017-08-30	Bayer CropScience Aktiengesellschaft	Neuartige triazolderivate
BR102013027313B1 (pt) *	2013-10-23	2019-06-18	Iharabras S.A. Indústrias Químicas	Processo para a preparação seletiva de (1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2099818A (en) *	1981-06-06	1982-12-15	Pfizer Ltd	Triazoles
IT1249211B (it) *	1990-06-08	1995-02-20	Ind Chimica Srl	Processo per la preparazione di triazolil isopropanoli in particolare fluconazolo
CA2106032C (en) *	1993-09-13	1995-11-07	Gamini Weeratunga	Methods for the manufacture of fluconazole and forms thereof, intermediates useful in the manufacture thereof, and combinations comprising fluconazole
HU212424B (en) *	1993-09-23	1996-06-28	Richter Gedeon Vegyeszet	New propan-2-ol derivatives substituted with triazole or imidazole and process for producing them
GB9415617D0 (en) *	1994-08-02	1994-09-21	Zeneca Ltd	Pharmaceutical compound
GB9415544D0 (en) *	1994-08-02	1994-09-21	Zeneca Ltd	Chemical process and intermediates

1996
- 1996-05-21 SI SI9600165A patent/SI9600165A/sl unknown
- 1996-12-20 WO PCT/ES1996/000245 patent/WO1997044330A1/es not_active Ceased
- 1996-12-20 AT AT96941664T patent/ATE242221T1/de not_active IP Right Cessation
- 1996-12-20 UA UA98126691A patent/UA64712C2/uk unknown
- 1996-12-20 KR KR1019980709360A patent/KR20000015811A/ko not_active Withdrawn
- 1996-12-20 EP EP96941664A patent/EP0967210B1/de not_active Expired - Lifetime
- 1996-12-20 AU AU10982/97A patent/AU1098297A/en not_active Abandoned
- 1996-12-20 HU HU9903524A patent/HU223570B1/hu not_active IP Right Cessation
- 1996-12-20 DE DE69628597T patent/DE69628597T2/de not_active Expired - Fee Related
- 1996-12-20 RU RU98123117/04A patent/RU2170736C2/ru not_active IP Right Cessation
1997
- 1997-05-14 YU YU19097A patent/YU19097A/sh unknown
- 1997-05-20 HR HRP-9600165A patent/HRP970271A2/xx not_active Application Discontinuation
1998
- 1998-11-20 NO NO985408A patent/NO985408L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HU223570B1 (hu)	2004-09-28
NO985408D0 (no)	1998-11-20
HRP970271A2 (en)	1998-04-30
EP0967210A1 (de)	1999-12-29
YU19097A (sh)	1999-09-27
HUP9903524A3 (en)	2001-12-28
NO985408L (no)	1999-01-20
WO1997044330A1 (es)	1997-11-27
AU1098297A (en)	1997-12-09
UA64712C2 (en)	2004-03-15
SI9600165A (en)	1997-12-31
KR20000015811A (ko)	2000-03-15
RU2170736C2 (ru)	2001-07-20
EP0967210B1 (de)	2003-06-04
HUP9903524A2 (hu)	2000-02-28
DE69628597D1 (de)	2003-07-10
DE69628597T2 (de)	2004-04-22

Legal Events

Date	Code	Title	Description
2003-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
FI97381C (fi)	1996-12-10	Menetelmä korkeaa verenpainetta alentavien substituoitujen pyrroli-, pyratsoli- ja triatsoliyhdisteiden valmistamiseksi
IE821285L (en)	1982-12-06	Triazole antifungal agents
KR890006593A (ko)	1989-06-14	아르마타제 억제4(5)- 이미다졸
DE3684431D1 (de)	1992-04-23	Derivate des ((4-(4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2yl)methyl)-1h-imidazol und 1h-1,2,4-triazol.
MXPA01008672A (es)	2003-06-24	Nuevos compuestos heterociclicos de bencensulfonamida, procedimiento de preparacion y utilizacion en terapeutica.
DE69628597D1 (de)	2003-07-10	Verfahren zur herstellung biologisch aktiver derivate des 1,2,4-triazols und in diesem verfahren nuetzliche zwischenprodukte
RU97106099A (ru)	1999-04-27	Ингибиторы 5-липоксигеназы
ATE192440T1 (de)	2000-05-15	Verfahren zur herstellung von 1-(1,2,4-triazol-1- yl)-propan-2-ol-derivaten
YU101291A (sh)	1993-11-16	Postupak za dobijanje triazolil-izopropanola
DE60209708D1 (de)	2006-05-04	Azol- oder triazol-derivate, verfahren zu deren herstellung und ihre verwendung als fungizide
KR860004033A (ko)	1986-06-16	광학적으로 활성인 아졸릴카르비놀 유도체, 즉 광학적으로 활성인 2-(4-클로로페녹시메틸)-3,3-디메틸-1-(1,2,4-트리아졸-1-일)-2-부탄올의 제조방법
DE60205239D1 (de)	2005-09-01	Azol- oder triazol-derivate, verfahren zu deren herstellung und ihre verwendung als antifungale arzneimittel
WO1991017978A3 (en)	1991-12-26	Selective monoacylation of substituted hydrazines
KR940000456A (ko)	1994-01-03	트리아졸 유도체
BR8202823A (pt)	1983-04-26	Processo para a preparacao de 1-azolil-3-metil-1-fenoxibutan-2-onas e-ois-3 substituidos composicoes fungicidas processo para o combate de fungos e para a preparacao de composicoes
KR840008801A (ko)	1984-12-19	아졸 유도체의 제조방법
PT93707A (pt)	1990-11-20	Processo para a preparacao de derivados de imidazol dicloro-substituidos com accao antifungica