HRP970455A2 - Spirocyclic dopamine receptor subtype ligands - Google Patents
Spirocyclic dopamine receptor subtype ligandsInfo
- Publication number
- HRP970455A2 HRP970455A2 HR60/024,797A HRP970455A HRP970455A2 HR P970455 A2 HRP970455 A2 HR P970455A2 HR P970455 A HRP970455 A HR P970455A HR P970455 A2 HRP970455 A2 HR P970455A2
- Authority
- HR
- Croatia
- Prior art keywords
- psychosis
- mammals
- compound according
- spiro
- disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Furan Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2479796P | 1996-08-26 | 1996-08-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP970455A2 true HRP970455A2 (en) | 1998-08-31 |
Family
ID=21822443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR60/024,797A HRP970455A2 (en) | 1996-08-26 | 1997-08-22 | Spirocyclic dopamine receptor subtype ligands |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6664258B1 (fr) |
| EP (1) | EP0925291B1 (fr) |
| JP (1) | JP3152941B2 (fr) |
| AP (1) | AP9701075A0 (fr) |
| AR (1) | AR013836A1 (fr) |
| AT (1) | ATE311377T1 (fr) |
| AU (1) | AU3632297A (fr) |
| CA (1) | CA2264549C (fr) |
| CO (1) | CO4560554A1 (fr) |
| DE (1) | DE69734774D1 (fr) |
| GT (1) | GT199700096A (fr) |
| HN (1) | HN1997000117A (fr) |
| HR (1) | HRP970455A2 (fr) |
| ID (1) | ID18076A (fr) |
| IL (1) | IL128050A0 (fr) |
| IS (1) | IS4969A (fr) |
| MA (1) | MA26437A1 (fr) |
| PA (1) | PA8436501A1 (fr) |
| PE (1) | PE108498A1 (fr) |
| TN (1) | TNSN97143A1 (fr) |
| WO (1) | WO1998008835A1 (fr) |
| ZA (1) | ZA977597B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0953567A3 (fr) | 1998-04-29 | 2003-04-02 | Pfizer Products Inc. | Dérivés de piperazin-, piperidine- et tetrahydropyridine bicyclique substitués, leur préparation et leur utilisation comme agents a activité dopaminergique (recepteur D4 de la dopamine) centrale |
| ES2300151T3 (es) * | 1998-09-22 | 2008-06-01 | Astellas Pharma Inc. | Derivados de cianofenilo. |
| EP1177792A3 (fr) * | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Ligands dopamine d4 destines au traitement des troubles associees a la cherche de la nouveaute |
| GB0328906D0 (en) | 2003-12-12 | 2004-01-14 | Syngenta Participations Ag | Chemical compounds |
| AU2012338581B2 (en) | 2011-11-18 | 2016-12-08 | Nxera Pharma Uk Limited | Muscarinic M1 receptor agonists |
| GB201404922D0 (en) | 2014-03-19 | 2014-04-30 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201513743D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
| GB201519352D0 (en) | 2015-11-02 | 2015-12-16 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
| GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819961D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB202020191D0 (en) | 2020-12-18 | 2021-02-03 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE758919A (fr) * | 1969-11-15 | 1971-05-13 | Merck Patent Gmbh | Spiro-composes |
| US4025558A (en) * | 1974-04-12 | 1977-05-24 | The Upjohn Company | Organic compounds |
| US4010201A (en) * | 1974-04-12 | 1977-03-01 | The Upjohn Company | Organic compounds |
| US3932425A (en) * | 1974-04-12 | 1976-01-13 | The Upjohn Company | Benzospiran derivatives |
| DE2818329A1 (de) * | 1978-04-26 | 1979-11-08 | Yoshitomi Pharmaceutical | Spiro eckige klammer auf cyclohexan- 1,9'-thioxanthen eckige klammer zu -verbindungen |
| CA2091204C (fr) * | 1992-03-11 | 1997-04-08 | Ronald J. Mattson | Piperazinyl- et piperidinylcyclohexanes contre l'ischemie |
| DE69325662T2 (de) | 1992-10-23 | 2000-02-10 | Merck Sharp & Dohme Ltd., Hoddesdon | Dopamin rezeptor subtyp liganden |
| GB9317631D0 (en) | 1993-08-25 | 1993-10-13 | Bxl Plastics Ltd | Multi-layered composite |
| US5403846A (en) * | 1993-11-22 | 1995-04-04 | Merck & Co., Inc. | Spirocycles |
| JPH10500112A (ja) * | 1994-05-06 | 1998-01-06 | ファーマコピーア，インコーポレイテッド | 組合せ ジヒドロベンゾピラン ライブラリー |
| GB9410031D0 (en) | 1994-05-19 | 1994-07-06 | Merck Sharp & Dohme | Therapeutic agents |
-
1997
- 1997-08-08 AU AU36322/97A patent/AU3632297A/en not_active Abandoned
- 1997-08-08 DE DE69734774T patent/DE69734774D1/de not_active Expired - Lifetime
- 1997-08-08 EP EP97932964A patent/EP0925291B1/fr not_active Expired - Lifetime
- 1997-08-08 JP JP51143198A patent/JP3152941B2/ja not_active Expired - Fee Related
- 1997-08-08 AT AT97932964T patent/ATE311377T1/de not_active IP Right Cessation
- 1997-08-08 US US09/242,819 patent/US6664258B1/en not_active Expired - Fee Related
- 1997-08-08 WO PCT/IB1997/000978 patent/WO1998008835A1/fr not_active Ceased
- 1997-08-08 CA CA002264549A patent/CA2264549C/fr not_active Expired - Fee Related
- 1997-08-08 IL IL12805097A patent/IL128050A0/xx unknown
- 1997-08-12 HN HN1997000117A patent/HN1997000117A/es unknown
- 1997-08-19 PE PE1997000731A patent/PE108498A1/es not_active Application Discontinuation
- 1997-08-21 AP APAP/P/1997/001075A patent/AP9701075A0/en unknown
- 1997-08-22 HR HR60/024,797A patent/HRP970455A2/hr not_active Application Discontinuation
- 1997-08-22 PA PA19978436501A patent/PA8436501A1/es unknown
- 1997-08-22 CO CO97048585A patent/CO4560554A1/es unknown
- 1997-08-22 AR ARP970103835A patent/AR013836A1/es unknown
- 1997-08-25 MA MA24775A patent/MA26437A1/fr unknown
- 1997-08-25 TN TNTNSN97143A patent/TNSN97143A1/fr unknown
- 1997-08-25 ZA ZA977597A patent/ZA977597B/xx unknown
- 1997-08-25 GT GT199700096A patent/GT199700096A/es unknown
- 1997-08-25 ID IDP972950A patent/ID18076A/id unknown
-
1999
- 1999-02-05 IS IS4969A patent/IS4969A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000502360A (ja) | 2000-02-29 |
| MA26437A1 (fr) | 2004-12-20 |
| JP3152941B2 (ja) | 2001-04-03 |
| CO4560554A1 (es) | 1998-02-10 |
| ZA977597B (en) | 1999-02-25 |
| AR013836A1 (es) | 2001-01-31 |
| WO1998008835A1 (fr) | 1998-03-05 |
| HN1997000117A (es) | 1997-12-26 |
| AP9701075A0 (en) | 1997-10-31 |
| PE108498A1 (es) | 1999-01-29 |
| GT199700096A (es) | 1999-02-16 |
| CA2264549A1 (fr) | 1998-03-05 |
| ATE311377T1 (de) | 2005-12-15 |
| ID18076A (id) | 1998-02-26 |
| DE69734774D1 (de) | 2006-01-05 |
| EP0925291B1 (fr) | 2005-11-30 |
| CA2264549C (fr) | 2004-09-14 |
| IL128050A0 (en) | 1999-11-30 |
| IS4969A (is) | 1999-02-05 |
| AU3632297A (en) | 1998-03-19 |
| PA8436501A1 (es) | 2000-05-24 |
| TNSN97143A1 (fr) | 2005-03-15 |
| US6664258B1 (en) | 2003-12-16 |
| EP0925291A1 (fr) | 1999-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 19980822 Year of fee payment: 2 |
|
| A1OB | Publication of a patent application | ||
| ODBC | Application rejected |