HRP970653B1 - 4-hydroxy-piperidine derivatives - Google Patents

4-hydroxy-piperidine derivatives

Info

Publication number: HRP970653B1
Authority: HR; Croatia
Prior art keywords: hydroxy; piperidine derivatives; piperidine; derivatives
Prior art date: 1996-12-03

Application number

HR970653A

Other languages

English (en)

Inventor

Alexander Alanine

Bernd Buettelmann

Marie-Paule Heitz Niedhart

Emmanuel Pinard

Rene Wyler

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-03

Filing date

1997-12-03

Publication date

2001-12-31

1997-12-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1998-10-31 Publication of HRP970653A2 publication Critical patent/HRP970653A2/hr

2001-12-31 Publication of HRP970653B1 publication Critical patent/HRP970653B1/xx

Links

HDOWRFHMPULYOA-UHFFFAOYSA-N piperidin-4-ol Chemical class OC1CCNCC1 HDOWRFHMPULYOA-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

HR970653A 1996-12-03 1997-12-03 4-hydroxy-piperidine derivatives HRP970653B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP96119345		1996-12-03

Publications (2)

Publication Number	Publication Date
HRP970653A2 HRP970653A2 (en)	1998-10-31
HRP970653B1 true HRP970653B1 (en)	2001-12-31

Family

ID=8223458

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR970653A HRP970653B1 (en)	1996-12-03	1997-12-03	4-hydroxy-piperidine derivatives

Country Status (29)

Country	Link
US (1)	US6359138B1 (cs)
JP (1)	JP3045988B2 (cs)
KR (1)	KR100257947B1 (cs)
CN (2)	CN1086702C (cs)
AR (1)	AR009641A1 (cs)
AT (1)	ATE205830T1 (cs)
AU (1)	AU736597B2 (cs)
BR (1)	BR9705509B1 (cs)
CA (1)	CA2220649C (cs)
CO (1)	CO4910155A1 (cs)
CZ (1)	CZ376997A3 (cs)
DE (1)	DE69706813T2 (cs)
DK (1)	DK0846683T3 (cs)
ES (1)	ES2163086T3 (cs)
HR (1)	HRP970653B1 (cs)
ID (1)	ID17678A (cs)
IL (1)	IL122352A0 (cs)
MA (1)	MA24410A1 (cs)
NO (1)	NO975541L (cs)
NZ (1)	NZ329271A (cs)
PE (1)	PE20499A1 (cs)
PL (1)	PL323447A1 (cs)
PT (1)	PT846683E (cs)
RU (1)	RU2184112C2 (cs)
SG (1)	SG71062A1 (cs)
TR (1)	TR199701488A2 (cs)
UY (1)	UY24797A1 (cs)
YU (1)	YU46997A (cs)
ZA (1)	ZA9710653B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU227197B1 (en) *	2000-10-24	2010-10-28	Richter Gedeon Nyrt	Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
ITMI20012060A1 (it) *	2001-10-05	2003-04-05	Recordati Chem Pharm	Nuovi eterocilcli n-acilati
US7005432B2 (en) *	2002-05-16	2006-02-28	Hoffman-La Roche Inc.	Substituted imidazol-pyridazine derivatives
EP1600447A1 (en) *	2004-05-28	2005-11-30	Neuropharma S.A.U.	Butyrylcholinesterase selective inhibitors
HUP0401522A2 (en) *	2004-07-29	2006-04-28	Richter Gedeon Vegyeszet	New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
TW200621677A (en) *	2004-09-21	2006-07-01	Astellas Pharma Inc	Cyclic amine derivative or salt thereof
KR101233223B1 (ko) *	2004-12-21	2013-02-14	제이엔씨 석유 화학 주식회사	크로만환을 가지는 액정 화합물, 액정 조성물 및 이 액정조성물을 함유하는 액정 표시소자
RU2538982C1 (ru) *	2013-11-19	2015-01-10	Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Нижегородский Государственный Университет Им. Н.И. Лобачевского"	Производное n-(1s)-1',2',3'-триметокси-6,7-дигидро-1н-бензо[5',6':5,4]циклогепта-[3,2-f]бензофуран-1-ил)ацетамида и его применение
EP3233077B1 (en) *	2014-12-19	2026-05-06	The Broad Institute, Inc.	Dopamine d2 receptor ligands

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE546389C (de)	1927-12-30	1932-03-14	Ralph Mayhew	Vorrichtung zur Bedienung von Tasteninstrumenten
US3476760A (en)	1967-03-06	1969-11-04	Smithkline Corp	Substituted piperidinoalkylthianaphthenes and benzofurans
US3506671A (en) *	1967-11-01	1970-04-14	Smithkline Corp	1-naphthylalkyl-4-phenylpiperidine derivatives
US3557123A (en) *	1967-11-01	1971-01-19	Smith Kline French Lab	1-naphthylalkyl-4-phenylpiperidine derivatives
US4016281A (en)	1975-02-22	1977-04-05	Merck Patent Gesellschaft Mit Beschrankter Haftung	Tetralone and indanone compounds
DE2507782A1 (de)	1975-02-22	1976-09-02	Merck Patent Gmbh	Tetralon- und indanon-derivate sowie verfahren zu ihrer herstellung
US4039676A (en)	1975-06-23	1977-08-02	Ciba-Geigy Corporation	2-piperidinoalkyl-1,4-benzodioxans
DE3660628D1 (en) *	1985-02-01	1988-10-06	Lafon Labor	1-ethyl- 3-hydroxy-3-phenylpiperidine, process for its preparation and its therapeutical use
GB8515389D0 (en)	1985-06-18	1985-07-17	Ici Plc	Heterocyclic compounds
GB8515388D0 (en)	1985-06-18	1985-07-17	Ici Plc	Heterocyclic compounds
EP0554247B1 (en)	1990-05-10	2000-04-26	Pfizer Inc.	Neuroprotective indolone and related derivatives
AU655840B2 (en) *	1991-07-17	1995-01-12	Pfizer Inc.	2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
DE4140542A1 (de)	1991-12-09	1993-06-17	Bayer Ag	Piperdylmethyl substituierte chormanderivate
US5436255A (en)	1992-07-23	1995-07-25	Pfizer Inc.	Method of treating diseases susceptable to treatment by blocking NMDA-receptors

1997
- 1997-11-10 CA CA002220649A patent/CA2220649C/en not_active Expired - Fee Related
- 1997-11-14 SG SG1997004062A patent/SG71062A1/en unknown
- 1997-11-24 US US08/976,540 patent/US6359138B1/en not_active Expired - Fee Related
- 1997-11-26 PE PE1997001073A patent/PE20499A1/es not_active Application Discontinuation
- 1997-11-26 ZA ZA9710653A patent/ZA9710653B/xx unknown
- 1997-11-27 IL IL12235297A patent/IL122352A0/xx unknown
- 1997-11-27 CZ CZ973769A patent/CZ376997A3/cs unknown
- 1997-11-27 NZ NZ329271A patent/NZ329271A/xx unknown
- 1997-11-27 YU YU46997A patent/YU46997A/sh unknown
- 1997-11-28 AR ARP970105596A patent/AR009641A1/es active IP Right Grant
- 1997-12-01 CO CO97070180A patent/CO4910155A1/es unknown
- 1997-12-01 MA MA24880A patent/MA24410A1/fr unknown
- 1997-12-01 JP JP9329891A patent/JP3045988B2/ja not_active Expired - Fee Related
- 1997-12-01 PT PT97121040T patent/PT846683E/pt unknown
- 1997-12-01 AT AT97121040T patent/ATE205830T1/de not_active IP Right Cessation
- 1997-12-01 UY UY24797A patent/UY24797A1/es unknown
- 1997-12-01 ES ES97121040T patent/ES2163086T3/es not_active Expired - Lifetime
- 1997-12-01 DK DK97121040T patent/DK0846683T3/da active
- 1997-12-01 DE DE69706813T patent/DE69706813T2/de not_active Expired - Lifetime
- 1997-12-02 NO NO975541A patent/NO975541L/no not_active Application Discontinuation
- 1997-12-02 PL PL97323447A patent/PL323447A1/xx unknown
- 1997-12-02 TR TR97/01488A patent/TR199701488A2/xx unknown
- 1997-12-02 AU AU46841/97A patent/AU736597B2/en not_active Ceased
- 1997-12-02 CN CN97123066A patent/CN1086702C/zh not_active Expired - Fee Related
- 1997-12-02 CN CNB011370645A patent/CN1162425C/zh not_active Expired - Fee Related
- 1997-12-02 BR BRPI9705509-3A patent/BR9705509B1/pt not_active IP Right Cessation
- 1997-12-02 ID IDP973819A patent/ID17678A/id unknown
- 1997-12-03 HR HR970653A patent/HRP970653B1/xx not_active IP Right Cessation
- 1997-12-03 KR KR1019970065495A patent/KR100257947B1/ko not_active Expired - Fee Related
- 1997-12-03 RU RU97120624/04A patent/RU2184112C2/ru not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2220649A1 (en)	1998-06-03
DK0846683T3 (da)	2001-11-05
DE69706813D1 (de)	2001-10-25
DE69706813T2 (de)	2002-04-04
SG71062A1 (en)	2000-03-21
HK1011859A1 (en)	1999-07-23
HRP970653A2 (en)	1998-10-31
BR9705509A (pt)	2000-03-14
CO4910155A1 (es)	2000-04-24
CZ376997A3 (cs)	1998-06-17
YU46997A (sh)	2000-12-28
AU736597B2 (en)	2001-08-02
PT846683E (pt)	2002-02-28
CN1162425C (zh)	2004-08-18
ES2163086T3 (es)	2002-01-16
CN1188111A (zh)	1998-07-22
RU2184112C2 (ru)	2002-06-27
NO975541L (no)	1998-06-04
NO975541D0 (no)	1997-12-02
ID17678A (id)	1998-01-22
TR199701488A2 (xx)	1998-06-22
CA2220649C (en)	2007-02-13
JP3045988B2 (ja)	2000-05-29
PE20499A1 (es)	1999-03-05
ZA9710653B (en)	1998-06-03
MA24410A1 (fr)	1998-07-01
AU4684197A (en)	1998-06-04
UY24797A1 (es)	2000-12-29
KR19980063726A (ko)	1998-10-07
US6359138B1 (en)	2002-03-19
PL323447A1 (en)	1998-06-08
CN1349989A (zh)	2002-05-22
KR100257947B1 (ko)	2000-07-01
JPH10168060A (ja)	1998-06-23
IL122352A0 (en)	1998-04-05
CN1086702C (zh)	2002-06-26
BR9705509B1 (pt)	2009-01-13
ATE205830T1 (de)	2001-10-15
NZ329271A (en)	1998-12-23
AR009641A1 (es)	2000-04-26

Legal Events

Date	Code	Title	Description
1998-10-31	A1OB	Publication of a patent application
1999-04-12	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2001-12-03	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20011203 Year of fee payment: 5
2001-12-31	B1PR	Patent granted
2003-06-04	PBON	Lapse due to non-payment of renewal fee	Effective date: 20021204

Publication	Publication Date	Title
SG60085A1 (en)	1999-02-22	4-hydroxy-piperidine derivatives
HRP970174B1 (en)	2002-06-30	6-phenylpyridil-2-amine derivatives
ZA9710906B (en)	1999-06-09	6-Phenylpyridyl-2-amine derivatives
IL125379A (en)	2003-05-29	19-nor-pregnene derivatives
ZA974053B (en)	1998-11-09	Alkylaminobenzothiazole and -benzoxazole derivatives
HUP9701835A3 (en)	2001-04-28	Vinyl-pirrolidinone-cephalosporin derivatives
IL129418A0 (en)	2000-02-17	2-Methoxyphenylpiperazine derivatives
IL125149A0 (en)	1999-01-26	Pyrazol-4-yl-hetaroyl derivatives
ZA9710653B (en)	1998-06-03	4-hydroxy-piperidine derivatives.
HU9701479D0 (en)	1997-10-28	N-benzylazolium derivatives
PL334558A1 (en)	2000-03-13	Cephalosporinic derivatives
ZA972051B (en)	1998-09-10	Benzodiazonine derivatives
ZA972329B (en)	1998-09-18	Piperidine derivatives
GB9600063D0 (en)	1996-03-06	Guaridine derivatives
GB9603226D0 (en)	1996-04-17	Heterocyclyl-ergoline derivatives
ZA971911B (en)	1998-09-07	2-thioxo-tetrahydropyrimidin-4-one derivatives
GB9702049D0 (en)	1997-03-19	Tetrahhydroisoquinoline derivatives
IL130283A0 (en)	2000-06-01	Polysaccharide-peptide derivatives
HU9702315D0 (en)	1998-03-02	4-hydroxy-piperidine derivatives
HU9601036D0 (en)	1996-06-28	Aryl-sulfonyl-hydroxamic-acid derivatives
IL145863A0 (en)	2002-07-25	Benzothiophenecarboxamide derivatives
ZA971502B (en)	1998-08-21	Pyrazol-4-yl-hetaroyl derivatives
GB9610888D0 (en)	1996-07-31	Aralkoxy-morphinan derivatives
ZA972808B (en)	1998-12-02	aminodihydropyridine derivatives
GB9622832D0 (en)	1997-01-08	Sordarin derivatives