HRP970653B1 - 4-hydroxy-piperidine derivatives - Google Patents

4-hydroxy-piperidine derivatives

Info

Publication number
HRP970653B1
HRP970653B1 HR970653A HRP970653A HRP970653B1 HR P970653 B1 HRP970653 B1 HR P970653B1 HR 970653 A HR970653 A HR 970653A HR P970653 A HRP970653 A HR P970653A HR P970653 B1 HRP970653 B1 HR P970653B1
Authority
HR
Croatia
Prior art keywords
hydroxy
piperidine derivatives
piperidine
derivatives
Prior art date
Application number
HR970653A
Other languages
English (en)
Inventor
Alexander Alanine
Bernd Buettelmann
Marie-Paule Heitz Niedhart
Emmanuel Pinard
Rene Wyler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HRP970653A2 publication Critical patent/HRP970653A2/hr
Publication of HRP970653B1 publication Critical patent/HRP970653B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
HR970653A 1996-12-03 1997-12-03 4-hydroxy-piperidine derivatives HRP970653B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96119345 1996-12-03

Publications (2)

Publication Number Publication Date
HRP970653A2 HRP970653A2 (en) 1998-10-31
HRP970653B1 true HRP970653B1 (en) 2001-12-31

Family

ID=8223458

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970653A HRP970653B1 (en) 1996-12-03 1997-12-03 4-hydroxy-piperidine derivatives

Country Status (29)

Country Link
US (1) US6359138B1 (fr)
JP (1) JP3045988B2 (fr)
KR (1) KR100257947B1 (fr)
CN (2) CN1162425C (fr)
AR (1) AR009641A1 (fr)
AT (1) ATE205830T1 (fr)
AU (1) AU736597B2 (fr)
BR (1) BR9705509B1 (fr)
CA (1) CA2220649C (fr)
CO (1) CO4910155A1 (fr)
CZ (1) CZ376997A3 (fr)
DE (1) DE69706813T2 (fr)
DK (1) DK0846683T3 (fr)
ES (1) ES2163086T3 (fr)
HR (1) HRP970653B1 (fr)
ID (1) ID17678A (fr)
IL (1) IL122352A0 (fr)
MA (1) MA24410A1 (fr)
NO (1) NO975541L (fr)
NZ (1) NZ329271A (fr)
PE (1) PE20499A1 (fr)
PL (1) PL323447A1 (fr)
PT (1) PT846683E (fr)
RU (1) RU2184112C2 (fr)
SG (1) SG71062A1 (fr)
TR (1) TR199701488A2 (fr)
UY (1) UY24797A1 (fr)
YU (1) YU46997A (fr)
ZA (1) ZA9710653B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227197B1 (en) * 2000-10-24 2010-10-28 Richter Gedeon Nyrt Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati
US7005432B2 (en) * 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
EP1600447A1 (fr) * 2004-05-28 2005-11-30 Neuropharma S.A.U. Inhibiteurs de butyrylcholinestérase selective
HUP0401522A2 (en) * 2004-07-29 2006-04-28 Richter Gedeon Vegyeszet New 4-benzylidene-piperidine derivatives, pharmaceutical compositions containing the same and process for their preparation
TW200621677A (en) * 2004-09-21 2006-07-01 Astellas Pharma Inc Cyclic amine derivative or salt thereof
KR101233223B1 (ko) * 2004-12-21 2013-02-14 제이엔씨 석유 화학 주식회사 크로만환을 가지는 액정 화합물, 액정 조성물 및 이 액정조성물을 함유하는 액정 표시소자
RU2538982C1 (ru) * 2013-11-19 2015-01-10 Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Нижегородский Государственный Университет Им. Н.И. Лобачевского" Производное n-(1s)-1',2',3'-триметокси-6,7-дигидро-1н-бензо[5',6':5,4]циклогепта-[3,2-f]бензофуран-1-ил)ацетамида и его применение
EP3233077B1 (fr) 2014-12-19 2026-05-06 The Broad Institute, Inc. Ligands des récepteurs dopaminergiques d2

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE546389C (de) 1927-12-30 1932-03-14 Ralph Mayhew Vorrichtung zur Bedienung von Tasteninstrumenten
US3476760A (en) 1967-03-06 1969-11-04 Smithkline Corp Substituted piperidinoalkylthianaphthenes and benzofurans
US3506671A (en) * 1967-11-01 1970-04-14 Smithkline Corp 1-naphthylalkyl-4-phenylpiperidine derivatives
US3557123A (en) * 1967-11-01 1971-01-19 Smith Kline French Lab 1-naphthylalkyl-4-phenylpiperidine derivatives
DE2507782A1 (de) 1975-02-22 1976-09-02 Merck Patent Gmbh Tetralon- und indanon-derivate sowie verfahren zu ihrer herstellung
US4016281A (en) 1975-02-22 1977-04-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Tetralone and indanone compounds
US4039676A (en) 1975-06-23 1977-08-02 Ciba-Geigy Corporation 2-piperidinoalkyl-1,4-benzodioxans
EP0192522B1 (fr) * 1985-02-01 1988-08-31 LABORATOIRE L. LAFON Société anonyme dite: 1-ethyl - 3-hydroxy-3-phénylpipéridine, procédé de préparation et utilisation en thérapeutique
GB8515388D0 (en) 1985-06-18 1985-07-17 Ici Plc Heterocyclic compounds
GB8515389D0 (en) 1985-06-18 1985-07-17 Ici Plc Heterocyclic compounds
RU2068414C1 (ru) 1990-05-10 1996-10-27 Пфайзер Инк. Производные индолона в виде рацемата или оптически активного изомера или их фармацевтически приемлемые аддитивные соли кислоты и кетопроизводные индолона
CZ284133B6 (cs) * 1991-07-17 1998-08-12 Pfizer Inc. 2-/4-Hydroxypiperidino/-1-alkanolové deriváty jako antiischemická činidla. způsob jejich přípravy a použití.
DE4140542A1 (de) 1991-12-09 1993-06-17 Bayer Ag Piperdylmethyl substituierte chormanderivate
US5436255A (en) 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors

Also Published As

Publication number Publication date
NZ329271A (en) 1998-12-23
PL323447A1 (en) 1998-06-08
PT846683E (pt) 2002-02-28
CN1086702C (zh) 2002-06-26
ZA9710653B (en) 1998-06-03
JPH10168060A (ja) 1998-06-23
BR9705509A (pt) 2000-03-14
UY24797A1 (es) 2000-12-29
CN1349989A (zh) 2002-05-22
DE69706813T2 (de) 2002-04-04
IL122352A0 (en) 1998-04-05
KR19980063726A (ko) 1998-10-07
CN1162425C (zh) 2004-08-18
AR009641A1 (es) 2000-04-26
PE20499A1 (es) 1999-03-05
RU2184112C2 (ru) 2002-06-27
NO975541D0 (no) 1997-12-02
NO975541L (no) 1998-06-04
SG71062A1 (en) 2000-03-21
CN1188111A (zh) 1998-07-22
DE69706813D1 (de) 2001-10-25
ES2163086T3 (es) 2002-01-16
HK1011859A1 (en) 1999-07-23
AU736597B2 (en) 2001-08-02
DK0846683T3 (da) 2001-11-05
YU46997A (sh) 2000-12-28
AU4684197A (en) 1998-06-04
TR199701488A2 (xx) 1998-06-22
CA2220649C (fr) 2007-02-13
ATE205830T1 (de) 2001-10-15
HRP970653A2 (en) 1998-10-31
CO4910155A1 (es) 2000-04-24
MA24410A1 (fr) 1998-07-01
KR100257947B1 (ko) 2000-07-01
US6359138B1 (en) 2002-03-19
CZ376997A3 (cs) 1998-06-17
ID17678A (id) 1998-01-22
BR9705509B1 (pt) 2009-01-13
JP3045988B2 (ja) 2000-05-29
CA2220649A1 (fr) 1998-06-03

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
ODRP Renewal fee for the maintenance of a patent

Payment date: 20011203

Year of fee payment: 5

B1PR Patent granted
PBON Lapse due to non-payment of renewal fee

Effective date: 20021204