HRP980108B1 - Atropisomers of 3-heteroaryl-4 (3h)-quinazolinones - Google Patents

Atropisomers of 3-heteroaryl-4 (3h)-quinazolinones

Info

Publication number: HRP980108B1
Authority: HR; Croatia
Prior art keywords: quinazolinones; atropisomers; heteroaryl
Prior art date: 1997-02-28

Application number

HR980108A

Other languages

English (en)

Inventor

Willard Mckowan Welch

Bertrand Leo Chenard

Keith Michael Devries

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-28

Filing date

1998-02-27

Publication date

2004-10-31

1998-02-27 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

1998-12-31 Publication of HRP980108A2 publication Critical patent/HRP980108A2/hr

2004-10-31 Publication of HRP980108B1 publication Critical patent/HRP980108B1/xx

Links

AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HR980108A 1997-02-28 1998-02-27 Atropisomers of 3-heteroaryl-4 (3h)-quinazolinones HRP980108B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US3854097P	1997-02-28	1997-02-28

Publications (2)

Publication Number	Publication Date
HRP980108A2 HRP980108A2 (en)	1998-12-31
HRP980108B1 true HRP980108B1 (en)	2004-10-31

Family

ID=21900535

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR980108A HRP980108B1 (en)	1997-02-28	1998-02-27	Atropisomers of 3-heteroaryl-4 (3h)-quinazolinones

Country Status (40)

Country	Link
US (1)	US6380204B1 (fr)
EP (1)	EP0964860B1 (fr)
JP (1)	JP3299990B2 (fr)
KR (1)	KR20000075812A (fr)
CN (1)	CN1248254A (fr)
AP (1)	AP9801202A0 (fr)
AR (1)	AR011886A1 (fr)
AT (1)	ATE264854T1 (fr)
AU (1)	AU732448B2 (fr)
BG (1)	BG103687A (fr)
BR (1)	BR9807807A (fr)
CA (1)	CA2282279C (fr)
CO (1)	CO4950615A1 (fr)
DE (1)	DE69823339T2 (fr)
DK (1)	DK0964860T3 (fr)
DZ (1)	DZ2438A1 (fr)
EA (1)	EA001961B1 (fr)
ES (1)	ES2218801T3 (fr)
GT (1)	GT199800039A (fr)
HN (1)	HN1998000028A (fr)
HR (1)	HRP980108B1 (fr)
HU (1)	HUP0000935A3 (fr)
ID (1)	ID23435A (fr)
IL (1)	IL130897A0 (fr)
IS (1)	IS5141A (fr)
MA (1)	MA24485A1 (fr)
NO (1)	NO994178L (fr)
NZ (1)	NZ336627A (fr)
OA (1)	OA11088A (fr)
PA (1)	PA8446901A1 (fr)
PE (1)	PE57999A1 (fr)
PL (1)	PL335307A1 (fr)
PT (1)	PT964860E (fr)
SK (1)	SK113199A3 (fr)
TN (1)	TNSN98034A1 (fr)
TR (1)	TR199902094T2 (fr)
TW (1)	TW530055B (fr)
UA (1)	UA58536C2 (fr)
WO (1)	WO1998038187A1 (fr)
ZA (1)	ZA981665B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6323208B1 (en) *	1997-09-05	2001-11-27	Pfizer Inc	Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
JPH11279158A (ja) *	1998-02-09	1999-10-12	Pfizer Prod Inc	キナゾリン―４―オン誘導体の製造方法
US6890930B1 (en) *	1999-09-28	2005-05-10	3-Dimensional Pharmaceuticals, Inc.	Quinazolinones
US20080146562A1 (en) *	2003-08-08	2008-06-19	Ulysses Pharmaceutical Products Inc.,	Halogenated quinazolinyl nitrofurans as antibacterial agents
EP1660486A4 (fr) *	2003-08-08	2006-12-13	Ulysses Pharmaceutical Product	Quinazolinyl nitrofuranes halogenes utilises comme agents antibacteriens
GB0416730D0 (en)	2004-07-27	2004-09-01	Novartis Ag	Organic compounds
GB0507298D0 (en)	2005-04-11	2005-05-18	Novartis Ag	Organic compounds
EP1954283A2 (fr) *	2005-11-04	2008-08-13	Hydra Biosciences, Inc.	Composés destinés à moduler la fonction de trpv3
CA2663436A1 (fr) *	2006-10-04	2008-04-10	Pfizer Products Inc.	Derives de pyrido[4,3-d]pyrimidin-4(3h)-one utilises en tant qu'antagonistes du recepteur calcique
WO2008140750A1 (fr)	2007-05-10	2008-11-20	Hydra Biosciences Inc.	Composés modulant la fonction du trp v3
CA2756347A1 (fr) *	2009-03-24	2010-09-30	Gilead Calistoga Llc	Atropisomeres de derives de 2-purinyl-3-tolyl-quinazolinone et procedes d'utilisation
EP2435048B1 (fr) *	2009-05-29	2019-07-03	Merck Sharp & Dohme Corp.	Inhibiteurs de pde10 radio-marqués
WO2013105985A1 (fr) *	2011-02-28	2013-07-18	Philadelphia Health & Education Corporation	Inhibiteurs à petites molécules de la recombinase rad51 et procédés associés
WO2021154966A1 (fr)	2020-01-29	2021-08-05	Kamari Pharma Ltd.	Composés et compositions pour leur utilisation dans le traitement de troubles cutanés

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1298603A (en)	1970-04-06	1972-12-06	Karamchand Premchand Private	Quinazolinone derivatives
US4183931A (en)	1977-09-08	1980-01-15	Research Corporation	2-Ketoalkyl-4(3H)-quinazolinones
WO1992013535A1 (fr)	1991-02-06	1992-08-20	Research Corporation Technologies, Inc.	Quinazolones substituees a activite anticonvulsivante
PT901487E (pt)	1996-05-15	2003-08-29	Pfizer	4(3h)-quinazolinonas 2,3,6-trissubstituidas
EP0807633B1 (fr) *	1996-05-15	2002-11-06	Pfizer Inc.	(5,6)-Pyrimidin-4-ones condensées à hétéroaryle, substituées en 2,3

1998
- 1998-02-06 JP JP53744998A patent/JP3299990B2/ja not_active Expired - Fee Related
- 1998-02-06 BR BR9807807-0A patent/BR9807807A/pt not_active Application Discontinuation
- 1998-02-06 DK DK98901424T patent/DK0964860T3/da active
- 1998-02-06 US US09/380,114 patent/US6380204B1/en not_active Expired - Fee Related
- 1998-02-06 ID IDW990935D patent/ID23435A/id unknown
- 1998-02-06 DE DE69823339T patent/DE69823339T2/de not_active Expired - Fee Related
- 1998-02-06 SK SK1131-99A patent/SK113199A3/sk unknown
- 1998-02-06 TR TR1999/02094T patent/TR199902094T2/xx unknown
- 1998-02-06 IL IL13089798A patent/IL130897A0/xx unknown
- 1998-02-06 KR KR1019997007885A patent/KR20000075812A/ko not_active Abandoned
- 1998-02-06 NZ NZ336627A patent/NZ336627A/xx unknown
- 1998-02-06 AT AT98901424T patent/ATE264854T1/de not_active IP Right Cessation
- 1998-02-06 EA EA199900689A patent/EA001961B1/ru not_active IP Right Cessation
- 1998-02-06 PT PT98901424T patent/PT964860E/pt unknown
- 1998-02-06 WO PCT/IB1998/000151 patent/WO1998038187A1/fr not_active Ceased
- 1998-02-06 PL PL98335307A patent/PL335307A1/xx unknown
- 1998-02-06 EP EP98901424A patent/EP0964860B1/fr not_active Expired - Lifetime
- 1998-02-06 ES ES98901424T patent/ES2218801T3/es not_active Expired - Lifetime
- 1998-02-06 CA CA002282279A patent/CA2282279C/fr not_active Expired - Fee Related
- 1998-02-06 AU AU57759/98A patent/AU732448B2/en not_active Ceased
- 1998-02-06 HU HU0000935A patent/HUP0000935A3/hu unknown
- 1998-02-06 CN CN98802796A patent/CN1248254A/zh active Pending
- 1998-02-09 HN HN1998000028A patent/HN1998000028A/es unknown
- 1998-02-17 PA PA19988446901A patent/PA8446901A1/es unknown
- 1998-02-19 GT GT199800039A patent/GT199800039A/es unknown
- 1998-02-23 PE PE1998000127A patent/PE57999A1/es not_active Application Discontinuation
- 1998-02-25 MA MA24979A patent/MA24485A1/fr unknown
- 1998-02-25 TN TNTNSN98034A patent/TNSN98034A1/fr unknown
- 1998-02-25 TW TW087102713A patent/TW530055B/zh not_active IP Right Cessation
- 1998-02-25 CO CO98010303A patent/CO4950615A1/es unknown
- 1998-02-25 DZ DZ980048A patent/DZ2438A1/fr active
- 1998-02-26 AP APAP/P/1998/001202A patent/AP9801202A0/en unknown
- 1998-02-26 AR ARP980100872A patent/AR011886A1/es unknown
- 1998-02-27 ZA ZA9801665A patent/ZA981665B/xx unknown
- 1998-02-27 HR HR980108A patent/HRP980108B1/xx not_active IP Right Cessation
- 1998-06-02 UA UA99084850A patent/UA58536C2/uk unknown
1999
- 1999-07-30 IS IS5141A patent/IS5141A/is unknown
- 1999-08-20 OA OA9900186A patent/OA11088A/fr unknown
- 1999-08-24 BG BG103687A patent/BG103687A/xx unknown
- 1999-08-27 NO NO994178A patent/NO994178L/no unknown

Also Published As

Publication number	Publication date
CA2282279A1 (fr)	1998-09-03
OA11088A (en)	2002-03-15
HN1998000028A (es)	1999-02-09
HUP0000935A2 (hu)	2001-04-28
ID23435A (id)	2000-04-20
AU5775998A (en)	1998-09-18
BR9807807A (pt)	2000-02-22
NZ336627A (en)	2000-12-22
NO994178D0 (no)	1999-08-27
JP2000509732A (ja)	2000-08-02
EA001961B1 (ru)	2001-10-22
DK0964860T3 (da)	2004-07-26
DE69823339T2 (de)	2005-05-12
MA24485A1 (fr)	1998-10-01
TNSN98034A1 (fr)	2005-03-15
AP9801202A0 (en)	1999-08-26
CO4950615A1 (es)	2000-09-01
US6380204B1 (en)	2002-04-30
PL335307A1 (en)	2000-04-10
CA2282279C (fr)	2004-11-02
WO1998038187A1 (fr)	1998-09-03
PE57999A1 (es)	1999-06-21
AR011886A1 (es)	2000-09-13
GT199800039A (es)	1999-08-13
EP0964860B1 (fr)	2004-04-21
PA8446901A1 (es)	2000-05-24
IL130897A0 (en)	2001-01-28
KR20000075812A (ko)	2000-12-26
ES2218801T3 (es)	2004-11-16
IS5141A (is)	1999-07-30
HRP980108A2 (en)	1998-12-31
TR199902094T2 (xx)	1999-12-21
DE69823339D1 (de)	2004-05-27
JP3299990B2 (ja)	2002-07-08
UA58536C2 (uk)	2003-08-15
BG103687A (en)	2000-06-30
HUP0000935A3 (en)	2002-04-29
CN1248254A (zh)	2000-03-22
DZ2438A1 (fr)	2003-01-11
ATE264854T1 (de)	2004-05-15
TW530055B (en)	2003-05-01
SK113199A3 (en)	2001-10-08
AU732448B2 (en)	2001-04-26
NO994178L (no)	1999-08-27
PT964860E (pt)	2004-07-30
EP0964860A1 (fr)	1999-12-22
ZA981665B (en)	1999-08-17
EA199900689A1 (ru)	2000-02-28

Legal Events

Date	Code	Title	Description
1998-02-27	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
1998-12-31	A1OB	Publication of a patent application
2004-08-12	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20040812 Year of fee payment: 7
2004-10-31	B1PR	Patent granted
2005-08-28	PBON	Lapse due to non-payment of renewal fee	Effective date: 20050228

Publication	Publication Date	Title
ZA981666B (en)	1999-08-27	Atropisomers of 3-aryl-4(3H)-quinazolinones.
PL337442A1 (en)	2000-08-14	Expression adjustment of quinolane phosphoribozyltransferase
EG24291A (en)	2009-01-08	Novel form of s-omeprazole
PL323066A1 (en)	1998-03-02	Derivatives of quinazoline
PL313541A1 (en)	1996-10-14	Derivatives of quinazoline
ZA981665B (en)	1999-08-17	Atropisomers of 3-heteroaryl-4(3H)-quinazolinones.
ZA985326B (en)	1999-03-23	Aminospiropiperidine quinazoline derivatives
TW317091U (en)	1997-10-01	Structure improvement of hats
EP1143998A4 (fr)	2002-06-26	Traitement de l'hypertension
PL327430A1 (en)	1999-01-18	Set of shaped components
TW312301U (en)	1997-08-01	Improved structure of earmask
TW319017U (en)	1997-11-01	Improved structure of mousetraps
GB9721978D0 (en)	1997-12-17	Treatment of depression
TW409833U (en)	2000-10-21	Improvement of burner structure
TW357554U (en)	1999-05-01	Improvement of shinguards
TW314733U (en)	1997-09-01	Structure of hairclip
TW316466U (en)	1997-09-21	Structure of hangtag
TW332992U (en)	1998-06-01	Improved structure of earring
TW393958U (en)	2000-06-11	Structural improvement of chair
TW312131U (en)	1997-08-01	Improved structure of earflaps
TW317745U (en)	1997-10-11	Improved structure of mini-duster
TW323471U (en)	1997-12-21	Improved structure of hairclip
TW358333U (en)	1999-05-11	Improvement of pendant structure
GB9708700D0 (en)	1997-06-18	Treatment of depression
HU9802548D0 (en)	1999-01-28	Set of tiles