HU190846B - Process for the production derivatives of pyrimidinones and of their acid addition salts - Google Patents

Process for the production derivatives of pyrimidinones and of their acid addition salts Download PDF

Info

Publication number
HU190846B
HU190846B HU831976A HU197683A HU190846B HU 190846 B HU190846 B HU 190846B HU 831976 A HU831976 A HU 831976A HU 197683 A HU197683 A HU 197683A HU 190846 B HU190846 B HU 190846B
Authority
HU
Hungary
Prior art keywords
phenyl
hydroxy
formula
methyl
methoxy
Prior art date
Application number
HU831976A
Other languages
English (en)
Hungarian (hu)
Inventor
Joachim Heider
Original Assignee
Dr Karl Thomae Gmbh,De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae Gmbh,De filed Critical Dr Karl Thomae Gmbh,De
Publication of HU190846B publication Critical patent/HU190846B/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Die Erfindung betrifft ein Verfahren zur Herstellung von Pyrimidinonen fuer die Anwendung als Arzneimittel. Ziel der Erfindung ist die Bereitstellung von Verbindungen mit blutdrucksenkender, antiarrhythmischer und beta-Rezeptoren-blockierender Wirkung. Erfindungsgemaess werden Pyrimidinone der allgemeinen Formel I hergestellt, in der beispielsweise bedeuten: A und B zusammen mit den beiden dazwischenliegenden Kohlenstoffatomen einen gegebenenfalls substituierten Phenylring o. einen Pyridinring, D eine Alkylen-o. Hydroxyalkylengruppe, R tief 3 u. R tief 5 je ein Wasserstoffatom o. eine Alkylgruppe, R tief 4 ein Wasserstoffatom o. eine Alkoxygruppe u. R tief 6 eine Alkylgruppe, eine Alkylen- o. Hydroxyalkylengruppe, welche endstaendig durch eine gegebenenfalls substituierte Phenyl- oder Phenoxygruppe substituiert ist, und deren Salze.
HU831976A 1982-06-03 1983-06-02 Process for the production derivatives of pyrimidinones and of their acid addition salts HU190846B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823220898 DE3220898A1 (de) 1982-06-03 1982-06-03 Verfahren zur herstellung von pyrimidinonen und ihren saeureadditionssalzen

Publications (1)

Publication Number Publication Date
HU190846B true HU190846B (en) 1986-11-28

Family

ID=6165198

Family Applications (1)

Application Number Title Priority Date Filing Date
HU831976A HU190846B (en) 1982-06-03 1983-06-02 Process for the production derivatives of pyrimidinones and of their acid addition salts

Country Status (10)

Country Link
KR (1) KR840005107A (de)
CA (1) CA1217768A (de)
DD (1) DD210904A5 (de)
DE (1) DE3220898A1 (de)
DK (1) DK250883A (de)
ES (2) ES8403115A1 (de)
FI (1) FI831914A7 (de)
HU (1) HU190846B (de)
NO (1) NO831994L (de)
PT (1) PT76806B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
CA2444704C (en) * 2001-04-23 2012-07-10 University Of Virginia Patent Foundation Synthesis and evaluation of phthalimide mimics as anti-angiogenic agents
AU2003291761A1 (en) * 2002-11-04 2004-06-07 Nps Pharmaceuticals, Inc. Quinazolinone compounds as calcilytics
WO2005115993A1 (ja) 2004-05-31 2005-12-08 Banyu Pharmaceutical Co., Ltd. キナゾリン誘導体
CN101531638B (zh) * 2008-03-13 2011-12-28 中国科学院广州生物医药与健康研究院 用作雌激素相关受体调节剂的化合物及其应用
CN101628913B (zh) 2008-07-18 2013-01-23 中国科学院广州生物医药与健康研究院 用作雌激素相关受体调节剂的化合物及其应用

Also Published As

Publication number Publication date
ES522898A0 (es) 1984-03-01
DK250883D0 (da) 1983-06-02
FI831914A0 (fi) 1983-05-30
NO831994L (no) 1983-12-05
DD210904A5 (de) 1984-06-27
FI831914L (fi) 1983-12-04
ES8403115A1 (es) 1984-03-01
FI831914A7 (fi) 1983-12-04
PT76806A (de) 1983-07-01
PT76806B (de) 1986-04-09
ES8406450A1 (es) 1984-08-01
KR840005107A (ko) 1984-11-03
ES527906A0 (es) 1984-08-01
DE3220898A1 (de) 1983-12-08
DK250883A (da) 1983-12-04
CA1217768A (en) 1987-02-10

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