HU194049B - Process for producing antiphlogistic compositions - Google Patents
Process for producing antiphlogistic compositions Download PDFInfo
- Publication number
- HU194049B HU194049B HU853942A HU394285A HU194049B HU 194049 B HU194049 B HU 194049B HU 853942 A HU853942 A HU 853942A HU 394285 A HU394285 A HU 394285A HU 194049 B HU194049 B HU 194049B
- Authority
- HU
- Hungary
- Prior art keywords
- thiazole
- imidazolyl
- guanidino
- methyl
- piroxicam
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 32
- 238000000034 method Methods 0.000 title claims abstract description 23
- 230000008569 process Effects 0.000 title claims description 8
- 239000002260 anti-inflammatory agent Substances 0.000 title description 11
- 230000001741 anti-phlogistic effect Effects 0.000 title 1
- 229960002702 piroxicam Drugs 0.000 claims description 55
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims description 54
- -1 2-methyl-4-imidazolyl Chemical group 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 22
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 10
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 7
- ZLDMZLSTTZLPBL-UHFFFAOYSA-N 4-(2-methyl-1h-imidazol-5-yl)-1,3-thiazole Chemical compound N1C(C)=NC=C1C1=CSC=N1 ZLDMZLSTTZLPBL-UHFFFAOYSA-N 0.000 claims description 4
- MRWSUSYJSOYXKO-UHFFFAOYSA-N 2-(2-methyl-1H-imidazol-5-yl)-1,3-thiazole Chemical compound S1C(=NC=C1)C1=CN=C(N1)C MRWSUSYJSOYXKO-UHFFFAOYSA-N 0.000 claims description 2
- 125000001245 hexylamino group Chemical group [H]N([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract description 48
- GIMNAEMRNXUAQP-UHFFFAOYSA-N 2-[4-(2-methyl-1h-imidazol-5-yl)-1,3-thiazol-2-yl]guanidine Chemical compound N1C(C)=NC=C1C1=CSC(N=C(N)N)=N1 GIMNAEMRNXUAQP-UHFFFAOYSA-N 0.000 abstract description 25
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- QIFAUHLPIKAQLF-UHFFFAOYSA-N 2-[4-[2-(hexylamino)-1h-imidazol-5-yl]-1,3-thiazol-2-yl]guanidine Chemical compound N1C(NCCCCCC)=NC(C=2N=C(NC(N)=N)SC=2)=C1 QIFAUHLPIKAQLF-UHFFFAOYSA-N 0.000 abstract description 2
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
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- 208000009386 Experimental Arthritis Diseases 0.000 description 4
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- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
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- GSVCNPRYQWGKBC-UHFFFAOYSA-N sodium dicyanide Chemical compound [Na+].[C-]#N.[C-]#N GSVCNPRYQWGKBC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Eine verbesserte entzuendungshemmende Zusammensetzung und ein Verfahren zur Behandlung von Entzuendungen, unter Verwendung einer Kombination eines entzuendungshemmenden Mittels (z. B. Indomethacin oder ein Oxicam) mit einem Histamin-H2-Antagonisten, ausgewaehlt aus der Gruppe, welche aus 2-Guanidino-4-(4-imidazolyl)thiazol, 2-Guanidino-4-(2-methyl-4-imidazolyl)thiazol, 2-(N-Benzyl-N-guanidino)-4-(2-methyl-4-imidazolyl)thiazol, 2-(N-Pentyl-N-guanidino)-4-(2-methyl-4-imidazolyl)thiazol und 2-Guanidino-4-(2-(hexylamino)-4-imidazolyl)thiazol besteht.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65975284A | 1984-10-11 | 1984-10-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT38837A HUT38837A (en) | 1986-07-28 |
| HU194049B true HU194049B (en) | 1988-01-28 |
Family
ID=24646684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU853942A HU194049B (en) | 1984-10-11 | 1985-10-10 | Process for producing antiphlogistic compositions |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS61112017A (de) |
| DD (1) | DD238918A5 (de) |
| HU (1) | HU194049B (de) |
| ZA (1) | ZA857787B (de) |
-
1985
- 1985-10-09 ZA ZA857787A patent/ZA857787B/xx unknown
- 1985-10-10 HU HU853942A patent/HU194049B/hu not_active IP Right Cessation
- 1985-10-10 DD DD85281623A patent/DD238918A5/de not_active IP Right Cessation
- 1985-10-11 JP JP60226666A patent/JPS61112017A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61112017A (ja) | 1986-05-30 |
| HUT38837A (en) | 1986-07-28 |
| DD238918A5 (de) | 1986-09-10 |
| ZA857787B (en) | 1987-05-27 |
| JPH0415768B2 (de) | 1992-03-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |