HU195801B - Process for producing 1-ethyl-6-fluoro-7-piperazino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid - Google Patents

Process for producing 1-ethyl-6-fluoro-7-piperazino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid Download PDF

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Publication number
HU195801B
HU195801B HU469485A HU469485A HU195801B HU 195801 B HU195801 B HU 195801B HU 469485 A HU469485 A HU 469485A HU 469485 A HU469485 A HU 469485A HU 195801 B HU195801 B HU 195801B
Authority
HU
Hungary
Prior art keywords
formula
ethyl
fluoro
oxo
acid
Prior art date
Application number
HU469485A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT44250A (en
Inventor
Istvan Hermecz
DEBRECZY Lelle VASVARINE
Maria Balogh
Tamas Szuets
Aniko Pajor
Geza Keresztuti
Agnes Horvath
Gabor Kovacs
Peter Ritli
Judit Sipos
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Priority to HU469485A priority Critical patent/HU195801B/hu
Priority to CA000524724A priority patent/CA1306750C/en
Priority to PCT/HU1986/000069 priority patent/WO1987003587A1/en
Priority to SI8612106A priority patent/SI8612106A8/sl
Priority to AT87900247T priority patent/ATE82569T1/de
Priority to KR1019870700686A priority patent/KR940008287B1/ko
Priority to CS869091A priority patent/CS264345B2/cs
Priority to EP89116178A priority patent/EP0351889B1/de
Priority to JP62500206A priority patent/JPH0768219B2/ja
Priority to AT89116178T priority patent/ATE107920T1/de
Priority to YU210686A priority patent/YU45810B/sh
Priority to EP87900247A priority patent/EP0249620B1/de
Priority to DD86297303A priority patent/DD250929A5/de
Priority to NO873248A priority patent/NO170154C/no
Priority to FI873380A priority patent/FI86419C/fi
Priority to DK412287A priority patent/DK412287A/da
Priority to SU874203111A priority patent/SU1722228A3/ru
Publication of HUT44250A publication Critical patent/HUT44250A/hu
Publication of HU195801B publication Critical patent/HU195801B/hu
Priority to US07/295,439 priority patent/US4981966A/en
Priority to DK568389A priority patent/DK568389A/da
Priority to US07/583,296 priority patent/US5294712A/en
Priority to US07/691,633 priority patent/US5284950A/en
Priority to HRP-2106/86A priority patent/HRP930555B1/xx

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Verfahren zur Herstellung von 1-Aethyl-6-fluor-7-(4-gegebenenfalls substituierten Piperazin)-4-oxo-1,4-dihydro-chinolin-3-carbonsaeuren.Die Erfindung betrifft ein Verfahren zur Herstellung von 1-Aethyl-6-fluor-7-(4-gegebenenfalls substituierten Piperazin)-4-oxo-1,4-dihydro-chinolin-3-carbonsaeuren der allgemeinen Formel I, worin R Wasserstoff oder Methyl bedeutet. Die obigen Verbindungen sind bekannt. Sie zeichnen sich durch ihre ausgezeichneten antibakteriellen Wirkungen aus. Mit der Erfindung wird ein kostenguenstiges Verfahren zur Herstellung dieser Verbindungen bereitgestellt. Beispielsweise wird ein Gemisch aus Borsaeure und Propionsaeureanhydrid mit Aethyl-(1-aethyl-6-fluor-7-chlor-4-oxo-1,4-dihydro-chinolin-3-carboxylat) umgesetzt, um 1-Aethyl-6-fluor-7-chlor-4-oxo-1,4-dihydro-chinolin-3-carbonsaeure-bor-di(propionyloxy)-anhydrid zu erhalten. Formel I
HU469485A 1985-12-09 1985-12-09 Process for producing 1-ethyl-6-fluoro-7-piperazino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid HU195801B (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
HU469485A HU195801B (en) 1985-12-09 1985-12-09 Process for producing 1-ethyl-6-fluoro-7-piperazino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
CA000524724A CA1306750C (en) 1985-12-09 1986-12-08 Process for the preparation of quinoline carboxylic acide
EP87900247A EP0249620B1 (de) 1985-12-09 1986-12-09 Herstellung von chinolincarbonsäuren
SI8612106A SI8612106A8 (sl) 1985-12-09 1986-12-09 Postopek za pripravo kinolin karboksilnih kislin
AT87900247T ATE82569T1 (de) 1985-12-09 1986-12-09 Herstellung von chinolincarbonsaeuren.
KR1019870700686A KR940008287B1 (ko) 1985-12-09 1986-12-09 퀴놀린 카복실산의 제조방법
CS869091A CS264345B2 (en) 1985-12-09 1986-12-09 Process for preparing quinolincarboxylic acids
EP89116178A EP0351889B1 (de) 1985-12-09 1986-12-09 Verfahren zur Herstellung einer Chinolincarbonsäure
JP62500206A JPH0768219B2 (ja) 1985-12-09 1986-12-09 キノリンカルボン酸の製造法
AT89116178T ATE107920T1 (de) 1985-12-09 1986-12-09 Verfahren zur herstellung einer chinolincarbonsäure.
YU210686A YU45810B (sh) 1985-12-09 1986-12-09 Postupak za dobijanje hinolin karboksilnih kiselina
PCT/HU1986/000069 WO1987003587A1 (en) 1985-12-09 1986-12-09 Process for the preparation of quinoline carboxylic acids
DD86297303A DD250929A5 (de) 1985-12-09 1986-12-09 Verfahren zur herstellung von chinolincarbonsaeuren
NO873248A NO170154C (no) 1985-12-09 1987-08-03 Fremgangsmaate for fremstilling av kinolincarboxylsyrer
FI873380A FI86419C (fi) 1985-12-09 1987-08-04 Foerfarande foer framstaellning av kinolinkarboxylsyraderivat.
DK412287A DK412287A (da) 1985-12-09 1987-08-07 Fremgangsmaade til fremstilling af 1-ethyl-6-fluor-7-(4- eventuelt substitueret piperazino)-4-oxo-1,4-dihydro-quinolin-3-carboxylsyrederivater samt ved fremgangsmaaden anvendelige mellem-produkter
SU874203111A SU1722228A3 (ru) 1985-12-09 1987-08-07 Способ получени производных хинолинкарбоновой кислоты или ее метансульфонатной соли
US07/295,439 US4981966A (en) 1985-12-09 1989-01-10 Process for the preparation of quinoline carboxylic acids
DK568389A DK568389A (da) 1985-12-09 1989-11-13 Fremgangsmaade til fremstilling af 1-ethyl-6fluor-7-(4-methyl-piperazino)-4-oxo-1,4-dihydroquinolin-3-carboxylsyre eller farmaceutisk acceptable salte deraf
US07/583,296 US5294712A (en) 1985-12-09 1990-09-14 Process for the preparation of quinoline carboxylic acids
US07/691,633 US5284950A (en) 1985-12-09 1991-04-25 Process for the preparation of quinoline carboxyolic acids
HRP-2106/86A HRP930555B1 (en) 1985-12-09 1993-03-26 Process for the preparation of quinoline carboxilic acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU469485A HU195801B (en) 1985-12-09 1985-12-09 Process for producing 1-ethyl-6-fluoro-7-piperazino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Publications (2)

Publication Number Publication Date
HUT44250A HUT44250A (en) 1988-02-29
HU195801B true HU195801B (en) 1988-07-28

Family

ID=10968691

Family Applications (1)

Application Number Title Priority Date Filing Date
HU469485A HU195801B (en) 1985-12-09 1985-12-09 Process for producing 1-ethyl-6-fluoro-7-piperazino-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Country Status (2)

Country Link
DD (1) DD250929A5 (de)
HU (1) HU195801B (de)

Also Published As

Publication number Publication date
HUT44250A (en) 1988-02-29
DD250929A5 (de) 1987-10-28

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee