HU220189B - Gyengített légzési syncytialis vírus vakcinakészítmények - Google Patents

Gyengített légzési syncytialis vírus vakcinakészítmények Download PDF

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Publication number
HU220189B
HU220189B HU9403023A HU9403023A HU220189B HU 220189 B HU220189 B HU 220189B HU 9403023 A HU9403023 A HU 9403023A HU 9403023 A HU9403023 A HU 9403023A HU 220189 B HU220189 B HU 220189B
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Hungary
Prior art keywords
virus
rsv
attenuated
vaccine composition
cpts
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Application number
HU9403023A
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English (en)
Hungarian (hu)
Other versions
HUT69992A (en
HU9403023D0 (en
Inventor
Robert Chanock
Mark Connors
James Earl Crowe
Alan Robert Davis
Kuo-Hom Lee Hsu
Michael David Lubeck
Brian Robert Murphy
Bernard Hugh Selling
Original Assignee
American Home Products Corp.
The United States Of America As Represented By The Department Of Health And Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp., The United States Of America As Represented By The Department Of Health And Human Services filed Critical American Home Products Corp.
Publication of HU9403023D0 publication Critical patent/HU9403023D0/hu
Publication of HUT69992A publication Critical patent/HUT69992A/hu
Publication of HU220189B publication Critical patent/HU220189B/hu

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/155Paramyxoviridae, e.g. parainfluenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/543Mucosal route intranasal
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18511Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18511Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18561Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Vertical, Hearth, Or Arc Furnaces (AREA)
HU9403023A 1992-04-21 1993-04-20 Gyengített légzési syncytialis vírus vakcinakészítmények HU220189B (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87274692A 1992-04-21 1992-04-21
US3994593A 1993-04-09 1993-04-09
PCT/US1993/003670 WO1993021310A1 (en) 1992-04-21 1993-04-20 Attenuated respiratory syncytial virus vaccine compositions

Publications (3)

Publication Number Publication Date
HU9403023D0 HU9403023D0 (en) 1994-12-28
HUT69992A HUT69992A (en) 1995-09-28
HU220189B true HU220189B (hu) 2001-11-28

Family

ID=26716607

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9403023A HU220189B (hu) 1992-04-21 1993-04-20 Gyengített légzési syncytialis vírus vakcinakészítmények

Country Status (18)

Country Link
US (3) US5922326A (de)
EP (1) EP0640128B1 (de)
JP (1) JP3883202B2 (de)
KR (1) KR100257171B1 (de)
AT (1) ATE181359T1 (de)
AU (1) AU683840B2 (de)
CA (1) CA2118509C (de)
DE (1) DE69325370T2 (de)
DK (1) DK0640128T3 (de)
ES (1) ES2132233T3 (de)
GR (1) GR3031208T3 (de)
HU (1) HU220189B (de)
IL (1) IL105456A (de)
MX (1) MX9302278A (de)
NZ (1) NZ252857A (de)
RU (1) RU2139729C1 (de)
UA (1) UA41315C2 (de)
WO (1) WO1993021310A1 (de)

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TW275632B (de) * 1992-04-21 1996-05-11 American Cyanamid Co
RU2142817C1 (ru) 1993-08-06 1999-12-20 Коннот Лабораториз Лимитед Инактивированные вакцины респираторно-синцитиального вируса
US7223410B1 (en) 1994-08-05 2007-05-29 Sanofi Pasteur Limited Inactivated respiratory syncytial viral vaccines
US5789229A (en) * 1994-09-30 1998-08-04 Uab Research Foundation Stranded RNA virus particles
US5716821A (en) * 1994-09-30 1998-02-10 Uab Research Foundation Prevention and treatment of respiratory tract disease
US6083925A (en) 1995-06-07 2000-07-04 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
US6019980A (en) * 1995-06-07 2000-02-01 Connaught Laboratories Limited Nucleic acid respiratory syncytial virus vaccines
US7485440B2 (en) 1995-09-27 2009-02-03 The United States Of America As Represented By The Department Of Health And Human Services Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2
US6689367B1 (en) 1995-09-27 2004-02-10 The United States Of America As Represented By The Department Of Health And Human Services Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences
US20050287540A1 (en) * 1995-09-27 2005-12-29 Murphy Brian R Production of attenuated negative stranded RNA virus vaccines from cloned nucleotide sequences
US7846455B2 (en) 1996-07-15 2010-12-07 The United States Of America As Represented By The Department Of Health And Human Services Attenuated chimeric respiratory syncytial virus
US6264957B1 (en) 1995-09-27 2001-07-24 The United States Of America As Represented By The Department Of Health And Human Services Product of infectious respiratory syncytial virus from cloned nucleotide sequences
WO1997038138A1 (en) * 1996-04-04 1997-10-16 The Regents Of The University Of Michigan Attenuated respiratory syncytial virus
US6077514A (en) * 1996-04-04 2000-06-20 The Regents Of The University Of Michigan Attenuated respiratory syncytial virus
DE69720024D1 (de) * 1996-07-12 2003-04-24 Aventis Pasteur Immunisierungsverfahren in zwei schritten gegen pyramyxoviridae-viren unter verwendung abgeschwächter viraler stämme und preparation von proteinuntereinheiten
WO1998002530A1 (en) 1996-07-15 1998-01-22 The Government Of The United States Of America, As Represented By The Department Of Health And Human Services Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
US6699476B1 (en) 1996-07-15 2004-03-02 Peter L. Collins Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules
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US7632508B2 (en) 1997-05-23 2009-12-15 The United States Of America Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines
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US7951383B2 (en) 1997-05-23 2011-05-31 The United States Of America As Represented By The Department Of Health And Human Services Attenuated parainfluenza virus (PIV) vaccines
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US7662397B2 (en) 1997-07-15 2010-02-16 The United States Of America As Represented By The Department Of Health And Human Services Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes
US20040005542A1 (en) 2001-06-22 2004-01-08 Krempl Christine D Respiratory syncytial virus vaccines expressing protective antigens from promotor- proximal genes
US6579528B1 (en) 1998-08-13 2003-06-17 The University Of Pittsburgh - Of The Commonwealth System Of Higher Education Cold-adapted equine influenza viruses
US6482414B1 (en) 1998-08-13 2002-11-19 The University Of Pittsburgh-Of The Commonwealth System Of Higher Education Cold-adapted equine influenza viruses
US6177082B1 (en) 1998-08-13 2001-01-23 The University Of Pittsburgh-Of The Commonwealth System Of Higher Education Cold-adapted equine influenza viruses
AU4065500A (en) 1999-04-13 2000-11-14 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences
ATE419369T1 (de) 1999-07-09 2009-01-15 Us Gov Health & Human Serv Chimäre mensch-rinder respiratory syncytial virus vakzinen
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JP4980895B2 (ja) 2004-05-25 2012-07-18 メディミューン,エルエルシー インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体
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PT3511015T (pt) * 2012-04-13 2021-04-05 Us Health Vacina viva e atenuada e geneticamente estável contra o vírus sincicial respiratório e a sua produção
EP2968510B1 (de) * 2013-03-14 2019-10-09 President and Fellows of Harvard College Zusammensetzungen von nanopartikeln
EP3798310A1 (de) 2013-03-14 2021-03-31 Emory University Rekombinante rsv mit stillen mutationen, impfstoffe und zugehörige verfahren
MX2018005462A (es) 2015-10-29 2018-08-01 Univ Emory Composiciones inmunogénicas de rsv quimérico y métodos de uso.
EP3923983A4 (de) 2019-02-11 2023-02-22 Emory University Chimäre rsv- und hmpv-f-proteine, immunogene zusammensetzungen und verwendungsverfahren
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Also Published As

Publication number Publication date
KR950701382A (ko) 1995-03-23
US5882651A (en) 1999-03-16
KR100257171B1 (ko) 2000-05-15
CA2118509A1 (en) 1993-10-28
HUT69992A (en) 1995-09-28
MX9302278A (es) 1994-07-29
EP0640128A1 (de) 1995-03-01
UA41315C2 (uk) 2001-09-17
EP0640128B1 (de) 1999-06-16
IL105456A (en) 1996-12-05
DK0640128T3 (da) 1999-11-22
DE69325370T2 (de) 1999-10-14
AU683840B2 (en) 1997-11-27
HU9403023D0 (en) 1994-12-28
US5922326A (en) 1999-07-13
JP3883202B2 (ja) 2007-02-21
DE69325370D1 (de) 1999-07-22
RU2139729C1 (ru) 1999-10-20
JPH07505891A (ja) 1995-06-29
WO1993021310A1 (en) 1993-10-28
AU4290793A (en) 1993-11-18
IL105456A0 (en) 1993-08-18
US6284254B1 (en) 2001-09-04
CA2118509C (en) 2009-05-19
GR3031208T3 (en) 1999-12-31
RU94045898A (ru) 1996-09-20
ES2132233T3 (es) 1999-08-16
NZ252857A (en) 1997-06-24
ATE181359T1 (de) 1999-07-15

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Owner name: WYETH (DELAWARE ALLAMBAN BEJEGYZETT CEG), US

MM4A Lapse of definitive patent protection due to non-payment of fees