HU9302425D0 - Neuroleptic perhydro-1h-puyrido/1,2a/pyrazines - Google Patents

Neuroleptic perhydro-1h-puyrido/1,2a/pyrazines

Info

Publication number: HU9302425D0
Authority: HU; Hungary
Prior art keywords: alkyl; nz1z2; alkoxy; phenyl; represent
Prior art date: 1992-08-27

Application number

HU9302425A

Other languages

English (en)

Other versions

HU217623B (hu

HUT64957A (en

Inventor

Andre Bachy

Laurent Fraisse

Peter Keane

Etienne Mendes

Jean-Claude Vernieres

Jacques Simiand

Original Assignee

Sanofi Elf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-27

Filing date

1993-08-26

Publication date

1993-11-29

1993-08-26 Application filed by Sanofi Elf filed Critical Sanofi Elf

1993-11-29 Publication of HU9302425D0 publication Critical patent/HU9302425D0/hu

1994-03-28 Publication of HUT64957A publication Critical patent/HUT64957A/hu

2000-03-28 Publication of HU217623B publication Critical patent/HU217623B/hu

Links

239000003176 neuroleptic agent Substances 0.000 title 1
230000000701 neuroleptic effect Effects 0.000 title 1
150000003216 pyrazines Chemical class 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
125000001544 thienyl group Chemical group 0.000 abstract 2
125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 1
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
-1 benzyloxy, benzyl Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrrole Compounds (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Toys (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

HU9302425A 1992-08-27 1993-08-26 Eljárás kondenzált tieno- és pirrolo [3,2-c]piridin-2-karbonsav-származékok valamint e vegyületeket tartalmazó gyógyászati készítmények előállítására HU217623B (hu)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9210329A FR2695126B1 (fr)	1992-08-27	1992-08-27	Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.

Publications (3)

Publication Number	Publication Date
HU9302425D0 true HU9302425D0 (en)	1993-11-29
HUT64957A HUT64957A (en)	1994-03-28
HU217623B HU217623B (hu)	2000-03-28

Family

ID=9433050

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9302425A HU217623B (hu)	1992-08-27	1993-08-26	Eljárás kondenzált tieno- és pirrolo [3,2-c]piridin-2-karbonsav-származékok valamint e vegyületeket tartalmazó gyógyászati készítmények előállítására

Country Status (17)

Country	Link
US (2)	US5360799A (hu)
EP (1)	EP0587473B1 (hu)
JP (1)	JPH06184145A (hu)
KR (1)	KR100267802B1 (hu)
AT (1)	ATE173258T1 (hu)
AU (1)	AU659027B2 (hu)
CA (1)	CA2104883A1 (hu)
DE (1)	DE69322033T2 (hu)
DK (1)	DK0587473T3 (hu)
ES (1)	ES2125315T3 (hu)
FI (1)	FI103889B (hu)
FR (1)	FR2695126B1 (hu)
GR (1)	GR3029283T3 (hu)
HU (1)	HU217623B (hu)
MX (1)	MX9305181A (hu)
NO (1)	NO300845B1 (hu)
NZ (1)	NZ248498A (hu)

Families Citing this family (34)

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AU2003256650A1 (en) *	2002-07-19	2004-02-09	Pharmacia Corporation	Substituted thiophene carboxamide compounds for the treatment of inflammation
GB0522715D0 (en)	2005-11-08	2005-12-14	Helperby Therapeutics Ltd	New use
HUE028588T2 (hu)	2005-12-13	2016-12-28	Incyte Holdings Corp	Heteroaril-szubsztituált pirrolo[2,3-b]piridinek és pirrolo[2,3-b]pirimidinek mint Janus-kináz inhibitorok
EP2481735A1 (en) *	2007-05-09	2012-08-01	Pfizer Inc.	Substituted heterocyclic derivatives and compositions and their pharmaceutical use as antibacterials
KR20100036306A (ko) *	2007-06-08	2010-04-07	헬리콘 테라퓨틱스 인코퍼레이티드	치료용 피라졸로나프티리딘 유도체
ES2423932T3 (es)	2007-08-27	2013-09-25	Basf Se	Compuestos de pirazol para controlar plagas de invertebrados
CN102015705B (zh) *	2008-02-26	2013-11-13	武田药品工业株式会社	稠合的杂环衍生物及其用途
TWI607996B (zh)	2008-09-24	2017-12-11	巴地斯顏料化工廠	控制無脊椎害蟲之吡唑化合物
BRPI1012108B8 (pt)	2009-05-22	2021-05-25	Incyte Corp	composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico
NZ596479A (en)	2009-05-22	2014-01-31	Incyte Corp	N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
ES2472918T3 (es)	2009-07-06	2014-07-03	Basf Se	Compuestos de piridazina para controlar plagas de invertebrados
JP2013500246A (ja)	2009-07-24	2013-01-07	ビーエーエスエフソシエタス・ヨーロピア	無脊椎動物系害虫防除用ピリジン誘導体化合物
TW201113285A (en)	2009-09-01	2011-04-16	Incyte Corp	Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
CA2792508C (en)	2010-03-10	2018-01-16	Incyte Corporation	Piperidin-4-yl azetidine derivatives as jak1 inhibitors
CA2818542A1 (en)	2010-11-19	2012-05-24	Incyte Corporation	Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
US8691807B2 (en)	2011-06-20	2014-04-08	Incyte Corporation	Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors
TW201313721A (zh)	2011-08-18	2013-04-01	Incyte Corp	作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk)	2011-09-07	2016-06-24	Інсайт Холдінгс Корпорейшн	Способи і проміжні сполуки для отримання інгібіторів jak
TW201406761A (zh)	2012-05-18	2014-02-16	Incyte Corp	做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
CA2888816A1 (en)	2012-11-01	2014-05-08	Incyte Corporation	Tricyclic fused thiophene derivatives as jak inhibitors
KR102242077B1 (ko)	2012-11-15	2021-04-20	인사이트 홀딩스 코포레이션	룩솔리티니브의 서방성 제형
EP3489239B1 (en)	2013-03-06	2021-09-15	Incyte Holdings Corporation	Processes and intermediates for making a jak inhibitor
MX376856B (es)	2013-08-07	2025-03-07	Incyte Holdings Corp	Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
SG11201609016VA (en)	2014-04-30	2016-11-29	Incyte Corp	Processes of preparing a jak1 inhibitor and new forms thereto
WO2015184305A1 (en)	2014-05-30	2015-12-03	Incyte Corporation	TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
US10407423B2 (en)	2015-11-16	2019-09-10	Fundación Para La Investigación Médica Aplicada	Compounds as inhibitors of DNA methyltransferases
KR20260080448A (ko)	2018-03-30	2026-06-02	인사이트 코포레이션	Jak 억제제를 사용하는 화농성 한선염의 치료
US11833155B2 (en)	2020-06-03	2023-12-05	Incyte Corporation	Combination therapy for treatment of myeloproliferative neoplasms
KR20240101561A (ko)	2021-10-14	2024-07-02	인사이트 코포레이션	Kras의 저해제로서의 퀴놀린 화합물
US11897883B1 (en)	2023-09-01	2024-02-13	King Faisal University	Pyrrolo[3,2-c][1,6]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
US11891377B1 (en)	2023-09-06	2024-02-06	King Faisal University	Pyrrolo[3,2-c][2,7]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
US11866437B1 (en)	2023-09-15	2024-01-09	King Faisal University	1,2-dioxo-2,3-dihydro-1H-pyrrolo[2,3-c]quinoline-7-carboxylic acid compounds as CK2 inhibitors
US11952378B1 (en)	2023-12-14	2024-04-09	King Faisal University	Pyrrolo[2,3-c]isoquinoline-1,2-dione compounds as CK2 inhibitors
WO2026076207A1 (en) *	2024-10-04	2026-04-09	Incyte Corporation	Tricyclic heteroaryl compounds as inhibitors of tyk2 and/or jak1

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US3887570A (en) *	1973-09-28	1975-06-03	Squibb & Sons Inc	Derivatives of pyrazolo(3,4-b)thieno(2,3-d)pyridine-2-carboxylic acids

1992
- 1992-08-27 FR FR9210329A patent/FR2695126B1/fr not_active Expired - Fee Related
1993
- 1993-08-19 US US08/109,073 patent/US5360799A/en not_active Expired - Fee Related
- 1993-08-20 AU AU44747/93A patent/AU659027B2/en not_active Ceased
- 1993-08-25 NZ NZ248498A patent/NZ248498A/en unknown
- 1993-08-25 ES ES93402095T patent/ES2125315T3/es not_active Expired - Lifetime
- 1993-08-25 AT AT93402095T patent/ATE173258T1/de not_active IP Right Cessation
- 1993-08-25 EP EP93402095A patent/EP0587473B1/fr not_active Expired - Lifetime
- 1993-08-25 DK DK93402095T patent/DK0587473T3/da active
- 1993-08-25 DE DE69322033T patent/DE69322033T2/de not_active Expired - Fee Related
- 1993-08-26 JP JP5211451A patent/JPH06184145A/ja active Pending
- 1993-08-26 FI FI933756A patent/FI103889B/fi active
- 1993-08-26 HU HU9302425A patent/HU217623B/hu not_active IP Right Cessation
- 1993-08-26 NO NO933051A patent/NO300845B1/no not_active IP Right Cessation
- 1993-08-26 MX MX9305181A patent/MX9305181A/es not_active IP Right Cessation
- 1993-08-26 CA CA002104883A patent/CA2104883A1/fr not_active Abandoned
- 1993-08-27 KR KR1019930017022A patent/KR100267802B1/ko not_active Expired - Fee Related
1994
- 1994-07-12 US US08/273,943 patent/US5468750A/en not_active Expired - Fee Related
1999
- 1999-02-03 GR GR990400363T patent/GR3029283T3/el unknown

Also Published As

Publication number	Publication date
EP0587473A1 (fr)	1994-03-16
KR100267802B1 (ko)	2000-11-01
GR3029283T3 (en)	1999-05-28
EP0587473B1 (fr)	1998-11-11
NO933051L (no)	1994-02-28
FI933756A0 (fi)	1993-08-26
DE69322033D1 (de)	1998-12-17
DE69322033T2 (de)	1999-06-17
AU659027B2 (en)	1995-05-04
NO933051D0 (no)	1993-08-26
FR2695126B1 (fr)	1994-11-10
ES2125315T3 (es)	1999-03-01
NZ248498A (en)	1994-09-27
DK0587473T3 (da)	1999-07-26
NO300845B1 (no)	1997-08-04
US5360799A (en)	1994-11-01
AU4474793A (en)	1994-03-03
ATE173258T1 (de)	1998-11-15
JPH06184145A (ja)	1994-07-05
FI933756L (fi)	1994-02-28
MX9305181A (es)	1994-06-30
HU217623B (hu)	2000-03-28
HUT64957A (en)	1994-03-28
US5468750A (en)	1995-11-21
FI103889B1 (fi)	1999-10-15
CA2104883A1 (fr)	1994-02-28
FI103889B (fi)	1999-10-15
FR2695126A1 (fr)	1994-03-04
KR940003958A (ko)	1994-03-14

Legal Events

Date	Code	Title	Description
2001-02-28	HPC4	Succession in title of patentee	Owner name: SANOFI-SYNTHELABO S.A., FR
2002-05-28	HMM4	Cancellation of final prot. due to non-payment of fee

Publication	Publication Date	Title
HUT64957A (en)	1994-03-28	Neuroleptic perhydro-1h-puyrido/1,2a/pyrazines
IL147651A0 (en)	2002-08-14	Isoxazoline derivative and herbicide containing the same as the active ingredient
DK370682A (da)	1983-02-20	Fremgangsmaade til fremstilling af carbapenemderivater
TW231258B (hu)	1994-10-01
NZ260159A (en)	1995-01-27	N-bicyclic nitrogen compounds and medicaments
IL89475A0 (en)	1989-09-10	Biocidal composition comprising imidazole compounds
DE69202166D1 (de)	1995-06-01	Verwendung von Tetrahydrothienopyridinderivate als Angiogenese-Inhibitoren.
ZA937308B (en)	1994-04-22	Ellipticine compounds a process for their preparation and pharmaceutical compositions containing them
DE69231464D1 (de)	2000-10-26	Antibiotische Cephalosporine einen substituierten Benzyloxyimino-Radikal in Position 7 tragend
AU603232B2 (en)	1990-11-08	Herbicidal agents
GR3005865T3 (hu)	1993-06-07
DE3277815D1 (en)	1988-01-21	Herbicidal compositions containing heterocyclic pentalenes
IL101379A0 (en)	1992-11-15	Light screening compositions containing isoxazolones,certain such novel compounds and their preparation
GR3004231T3 (hu)	1993-03-31
ES8201587A1 (es)	1982-01-01	Procedimiento de producir compuestos cefalosporinicos anti- microbianos