HU9302425D0 - Neuroleptic perhydro-1h-puyrido/1,2a/pyrazines - Google Patents

Neuroleptic perhydro-1h-puyrido/1,2a/pyrazines

Info

Publication number: HU9302425D0
Authority: HU; Hungary
Prior art keywords: alkyl; nz1z2; alkoxy; phenyl; represent
Prior art date: 1992-08-27

Application number

HU9302425A

Other languages

English (en)

Other versions

HU217623B (hu

HUT64957A (en

Inventor

Andre Bachy

Laurent Fraisse

Peter Keane

Etienne Mendes

Jean-Claude Vernieres

Jacques Simiand

Original Assignee

Sanofi Elf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-27

Filing date

1993-08-26

Publication date

1993-11-29

1993-08-26 Application filed by Sanofi Elf filed Critical Sanofi Elf

1993-11-29 Publication of HU9302425D0 publication Critical patent/HU9302425D0/hu

1994-03-28 Publication of HUT64957A publication Critical patent/HUT64957A/hu

2000-03-28 Publication of HU217623B publication Critical patent/HU217623B/hu

Links

239000003176 neuroleptic agent Substances 0.000 title 1
230000000701 neuroleptic effect Effects 0.000 title 1
150000003216 pyrazines Chemical class 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
125000001544 thienyl group Chemical group 0.000 abstract 2
125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 1
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
-1 benzyloxy, benzyl Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyrrole Compounds (AREA)
Inorganic Compounds Of Heavy Metals (AREA)
Toys (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

HU9302425A 1992-08-27 1993-08-26 Eljárás kondenzált tieno- és pirrolo [3,2-c]piridin-2-karbonsav-származékok valamint e vegyületeket tartalmazó gyógyászati készítmények előállítására HU217623B (hu)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9210329A FR2695126B1 (fr)	1992-08-27	1992-08-27	Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant.

Publications (3)

Publication Number	Publication Date
HU9302425D0 true HU9302425D0 (en)	1993-11-29
HUT64957A HUT64957A (en)	1994-03-28
HU217623B HU217623B (hu)	2000-03-28

Family

ID=9433050

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9302425A HU217623B (hu)	1992-08-27	1993-08-26	Eljárás kondenzált tieno- és pirrolo [3,2-c]piridin-2-karbonsav-származékok valamint e vegyületeket tartalmazó gyógyászati készítmények előállítására

Country Status (17)

Country	Link
US (2)	US5360799A (hu)
EP (1)	EP0587473B1 (hu)
JP (1)	JPH06184145A (hu)
KR (1)	KR100267802B1 (hu)
AT (1)	ATE173258T1 (hu)
AU (1)	AU659027B2 (hu)
CA (1)	CA2104883A1 (hu)
DE (1)	DE69322033T2 (hu)
DK (1)	DK0587473T3 (hu)
ES (1)	ES2125315T3 (hu)
FI (1)	FI103889B (hu)
FR (1)	FR2695126B1 (hu)
GR (1)	GR3029283T3 (hu)
HU (1)	HU217623B (hu)
MX (1)	MX9305181A (hu)
NO (1)	NO300845B1 (hu)
NZ (1)	NZ248498A (hu)

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BR0312780A (pt) *	2002-07-19	2005-05-03	Pharmacia Corp	Compostos de tiofeno-carboxamida substituìda para o tratamento de inflamação
GB0522715D0 (en)	2005-11-08	2005-12-14	Helperby Therapeutics Ltd	New use
SG10202003901UA (en)	2005-12-13	2020-05-28	Incyte Holdings Corp	Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
CN101679357A (zh) *	2007-05-09	2010-03-24	辉瑞大药厂	取代的杂环衍生物及其组合物和作为抗菌剂的药物用途
WO2008154447A1 (en) *	2007-06-08	2008-12-18	Helicon Therapeutics, Inc.	Therapeutic pyrazolonaphthyridine derivatives
CN101835377B (zh)	2007-08-27	2014-12-10	巴斯夫欧洲公司	用于防治无脊椎动物害虫的吡唑化合物
NZ587719A (en) *	2008-02-26	2012-04-27	Takeda Pharmaceutical	Fused heterocyclic derivative and use thereof
KR101364869B1 (ko)	2008-09-24	2014-02-21	바스프 에스이	무척추　해충을　방제하기　위한　피라졸　화합물
AR076794A1 (es)	2009-05-22	2011-07-06	Incyte Corp	Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
SI2432472T1 (sl)	2009-05-22	2019-11-29	Incyte Holdings Corp	3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK
EP2451804B1 (en)	2009-07-06	2014-04-30	Basf Se	Pyridazine compounds for controlling invertebrate pests
JP2013500246A (ja)	2009-07-24	2013-01-07	ビーエーエスエフソシエタス・ヨーロピア	無脊椎動物系害虫防除用ピリジン誘導体化合物
TW201113285A (en)	2009-09-01	2011-04-16	Incyte Corp	Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
EP3354652B1 (en)	2010-03-10	2020-05-06	Incyte Holdings Corporation	Piperidin-4-yl azetidine derivatives as jak1 inhibitors
PE20140146A1 (es)	2010-11-19	2014-02-06	Incyte Corp	Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
CN103797010B (zh)	2011-06-20	2016-02-24	因塞特控股公司	作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物
TW201313721A (zh)	2011-08-18	2013-04-01	Incyte Corp	作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk)	2011-09-07	2016-06-24	Інсайт Холдінгс Корпорейшн	Способи і проміжні сполуки для отримання інгібіторів jak
TW201406761A (zh)	2012-05-18	2014-02-16	Incyte Corp	做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
TWI646099B (zh) *	2012-11-01	2019-01-01	英塞特控股公司	作爲ｊａｋ抑制劑之三環稠合噻吩衍生物
PH12020551186B1 (en)	2012-11-15	2024-03-20	Incyte Holdings Corp	Sustained-release dosage forms of ruxolitinib
RS62867B1 (sr)	2013-03-06	2022-02-28	Incyte Holdings Corp	Postupci i intermedijeri za dobijanje inhibitora jak
SMT202000315T1 (it)	2013-08-07	2020-07-08	Incyte Corp	Forme di dosaggio a rilascio prolungato per un inibitore di jak1
MA39987A (fr)	2014-04-30	2017-03-08	Incyte Corp	Procédés de préparation d'un inhibiteur de jak1 et nouvelles formes associées
US9498467B2 (en)	2014-05-30	2016-11-22	Incyte Corporation	Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
AU2016356884A1 (en)	2015-11-16	2018-06-21	Fundación Para La Investigación Médica Aplicada	Novel compounds as inhibitors of dna methyltransferases
SMT202400306T1 (it)	2018-03-30	2024-09-16	Incyte Corp	Trattamento dell'idrosadenite suppurativa utilizzando inibitori di jak.
US11833155B2 (en)	2020-06-03	2023-12-05	Incyte Corporation	Combination therapy for treatment of myeloproliferative neoplasms
CA3235146A1 (en)	2021-10-14	2023-04-20	Incyte Corporation	Quinoline compounds as inhibitors of kras
US11897883B1 (en)	2023-09-01	2024-02-13	King Faisal University	Pyrrolo[3,2-c][1,6]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
US11891377B1 (en)	2023-09-06	2024-02-06	King Faisal University	Pyrrolo[3,2-c][2,7]naphthyridine-2-carboxylic acid compounds as CK2 inhibitors
US11866437B1 (en)	2023-09-15	2024-01-09	King Faisal University	1,2-dioxo-2,3-dihydro-1H-pyrrolo[2,3-c]quinoline-7-carboxylic acid compounds as CK2 inhibitors
US11952378B1 (en)	2023-12-14	2024-04-09	King Faisal University	Pyrrolo[2,3-c]isoquinoline-1,2-dione compounds as CK2 inhibitors
US20260098044A1 (en) *	2024-10-04	2026-04-09	Incyte Corporation	Tricyclic heteroaryl compounds as inhibitors of tyk2 and/or jak1

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US3887570A (en) *	1973-09-28	1975-06-03	Squibb & Sons Inc	Derivatives of pyrazolo(3,4-b)thieno(2,3-d)pyridine-2-carboxylic acids

1992
- 1992-08-27 FR FR9210329A patent/FR2695126B1/fr not_active Expired - Fee Related
1993
- 1993-08-19 US US08/109,073 patent/US5360799A/en not_active Expired - Fee Related
- 1993-08-20 AU AU44747/93A patent/AU659027B2/en not_active Ceased
- 1993-08-25 DE DE69322033T patent/DE69322033T2/de not_active Expired - Fee Related
- 1993-08-25 AT AT93402095T patent/ATE173258T1/de not_active IP Right Cessation
- 1993-08-25 ES ES93402095T patent/ES2125315T3/es not_active Expired - Lifetime
- 1993-08-25 DK DK93402095T patent/DK0587473T3/da active
- 1993-08-25 EP EP93402095A patent/EP0587473B1/fr not_active Expired - Lifetime
- 1993-08-25 NZ NZ248498A patent/NZ248498A/en unknown
- 1993-08-26 FI FI933756A patent/FI103889B/fi active
- 1993-08-26 JP JP5211451A patent/JPH06184145A/ja active Pending
- 1993-08-26 HU HU9302425A patent/HU217623B/hu not_active IP Right Cessation
- 1993-08-26 NO NO933051A patent/NO300845B1/no not_active IP Right Cessation
- 1993-08-26 MX MX9305181A patent/MX9305181A/es not_active IP Right Cessation
- 1993-08-26 CA CA002104883A patent/CA2104883A1/fr not_active Abandoned
- 1993-08-27 KR KR1019930017022A patent/KR100267802B1/ko not_active Expired - Fee Related
1994
- 1994-07-12 US US08/273,943 patent/US5468750A/en not_active Expired - Fee Related
1999
- 1999-02-03 GR GR990400363T patent/GR3029283T3/el unknown

Also Published As

Publication number	Publication date
NO933051L (no)	1994-02-28
KR940003958A (ko)	1994-03-14
US5360799A (en)	1994-11-01
KR100267802B1 (ko)	2000-11-01
ATE173258T1 (de)	1998-11-15
FI103889B1 (fi)	1999-10-15
FI933756A0 (fi)	1993-08-26
FR2695126B1 (fr)	1994-11-10
MX9305181A (es)	1994-06-30
EP0587473A1 (fr)	1994-03-16
ES2125315T3 (es)	1999-03-01
NO300845B1 (no)	1997-08-04
HU217623B (hu)	2000-03-28
AU4474793A (en)	1994-03-03
FI103889B (fi)	1999-10-15
GR3029283T3 (en)	1999-05-28
AU659027B2 (en)	1995-05-04
US5468750A (en)	1995-11-21
HUT64957A (en)	1994-03-28
DE69322033D1 (de)	1998-12-17
EP0587473B1 (fr)	1998-11-11
JPH06184145A (ja)	1994-07-05
CA2104883A1 (fr)	1994-02-28
NZ248498A (en)	1994-09-27
DK0587473T3 (da)	1999-07-26
FI933756L (fi)	1994-02-28
FR2695126A1 (fr)	1994-03-04
DE69322033T2 (de)	1999-06-17
NO933051D0 (no)	1993-08-26

Legal Events

Date	Code	Title	Description
2001-02-28	HPC4	Succession in title of patentee	Owner name: SANOFI-SYNTHELABO S.A., FR
2002-05-28	HMM4	Cancellation of final prot. due to non-payment of fee

Publication	Publication Date	Title
HU9302425D0 (en)	1993-11-29	Neuroleptic perhydro-1h-puyrido/1,2a/pyrazines
IL147651A0 (en)	2002-08-14	Isoxazoline derivative and herbicide containing the same as the active ingredient
NZ260159A (en)	1995-01-27	N-bicyclic nitrogen compounds and medicaments
IL89475A0 (en)	1989-09-10	Biocidal composition comprising imidazole compounds
DE69202166D1 (de)	1995-06-01	Verwendung von Tetrahydrothienopyridinderivate als Angiogenese-Inhibitoren.
ZA937308B (en)	1994-04-22	Ellipticine compounds a process for their preparation and pharmaceutical compositions containing them
AU603232B2 (en)	1990-11-08	Herbicidal agents
GR3005865T3 (hu)	1993-06-07
DE3277815D1 (en)	1988-01-21	Herbicidal compositions containing heterocyclic pentalenes
IL101379A0 (en)	1992-11-15	Light screening compositions containing isoxazolones,certain such novel compounds and their preparation
GR3004231T3 (hu)	1993-03-31
ES8201587A1 (es)	1982-01-01	Procedimiento de producir compuestos cefalosporinicos anti- microbianos