HUE032157T2 - Triazine compounds as p13 kinase and mtor inhibitors - Google Patents

Description

PKMs and more IsMBHordk

TalálmánymïAmÀwmmw? E The present invention relates to the chemical compounds of the present invention. in which one of mMMs is MrsihifepimHl or dMdropiraöií ostgmst and & me-

for the production of PB kinase and sLORA, as well as for their preparation for spermatozoa, and for the treatment of latexes containing them.

YOUR BOOK ¥ BACKGROUNDS | t IbsxratMonitoringManualsYou are here: ^ fe: .42 «ImuiklyÄe« has made it clear that »FI tea sketápt passport & s ^ pt plüii jslárlilii Also. It is well known for its H * ^ 3) -fei $ ÄÄ ÇPÎ (4,5) P2 or BIP2} di & quotes and: Ιηοζ1? ~ (1 ASMrifosrJftíá dspá> Balls for Fascination Fonts%; ö; ^ protein kinase C melting at the melting potassium permeate of the melting enzyme (MJ Bsrridge et al., Nat.?, P? i? O? O, Bsshsaka, Science, 225, 365 (1984))

BitMiMdlHrmZib-3 HANDS '^' Wp 'Alytt »? enzyme, tmrely, moves of hystodilozite: & 3-Subtitle 332. 664 p988)], There are many subtypes of M3K. The subtype M of the P13K braam was identified by the in vgrb specification specification and the first of the three.

The la. Class P13K1 subtype has been smashed with feglmoazIvABps Until now. The la. subspecies of the subspeciesMo rest are («, (1, &amp; á)», which are a subspace of 110 kl3a subunits and SWS M4a ^ s subspaces are subtle scattered. Ptddnefe Ãidby start factor ^ «s ^^ ÄBsrt ^ Maptor ^ kfcwlákéfc bet: thus, the P1M4 lokalMpk is the internal chromosomalA The internal shrinkage is transformed into the alpha-PIPA by fi08 ^^ Η ^ 23Η3,4,5- · Μ8ζβ) δ2 £ έίχ . δ &amp; φ '.%. "WM · and Akt Downstream sub-storm locate the internal hub nsjnbrásha, where: and Akt 0MvÄ5Ä ^ älk;; ^ ÄMU.Akt:; jW6nMI« hinds the apzytes of kbztl In the class I, the PUK alMpesok ^ l ^^ fe'l ^^ kSt & Amp (BBP), atlies allow activated Eaa a; It is another one of the most important elements of the B13U rhymbian beliefs. # for the underworld of speech The FloK / Who / mToH signal signal path k »^! tmti ^^^ j ^ fefia.iP :: Ck8ÎÔit6sé8: 8ttt..ô ^ ily ^ t :: related word form! 1: The most signi fi cant class of 1H3K4; 1. I <is the most common in the class, FI, P1 and P (4J) P 2, of which P1 (4,5) P2 is the most preferred, Class I of the P3Ks were further divided into two groups, the la class and the ib class due to their activation meehsoiMassfe1 and their subunits that regulate lymph. F13K Ib, osr-Sage is fxi Hb ', which is activated by the action of kdlcstm with G protein clips. For example, Iby and O protein coupling receptors have a more potent effect on 10, <3? and 84 kSa-SS regulatory subunits], P1 and P1 {4) P are PI3K4: Class H. &amp; PIs (4A | P2 som streptocyte and onyx for enzymes. The POKs in H. class include P53K C2y. C20 and C2y Isoforms, which are 02 ÊMikWhat is the name &amp; that their activity is controlled by kuruuro ions, class P HIs are the astrophysics of P1 to ba | t0? .ô.PÄi ^ kÄv ^ lW »8lc rndgment have been discovered; míndegvik subtype has its own activitivity * 82abi | jp5i «^ jlaæiæmuss • mrSÄsxin * * that the activation .mechammus (s) are some of the appropriate parts of the P13K: .ipii ^ M'RpÄÄ illegg, A PlftF · 0 ~ 4- (4 "min.t5i} {> it id3, .2,: 4.5] fio tio | 3,2-diptrirnieltn'2« lJ) &amp; oi} PBKa and FI3Kg "i have It also inhibits tnTOR enzymes with 2, 3, and 50-80 nM ICs. For Ekeys 1 P, feed in vegpIeMlÄ: bUKtM: tumißar: xa »0 ^ ratt models. 0pcs: gböbkts2tem bsa: (PTlSbliaitlJ Ü87M1% prostate ·· (PC3), flushing (MDA-MB468 and MDA-MR-43S) antispasmodic libs (MCT 1: 16¾ and scalpel caremia in SKOV.1). IGROY-Π; [Raynaud et al., Pharmacologie Characterization of the Potent Inhibitor of Class I to Phosphatidyl Inosifide 3-Kotting Cancer Re ·, 63: 384-5-5850 (2 (H)?)]. k. Compound ESTK.474 {2- (2-diylhorme® «2Simid2ol-I-HV416" <i> Ofo) tnO ", 1,3-tria / 0 inhibits PBKlaA Is iS: P3 &amp; gb denem inhibits nVïï.) R: Enzymes :, ^C ^ values 16, 4.6, and ΊΟΟΟΟηΜ fTinin Kong is l'alíso ¥ áworl, 2ST3 &amp; 424: the ATP eompetitive inhibitor k e &amp; p IpKisphatidylitositol 5 kinase IsoibiSí Cancer Seénee , $ 8 :: 1: 6 1638-1: 642 (20 (17)], Oral Coolers of the ZSTR434 Cricket Crackers «xetmgraR Cancer Models Tumble for Growth, Non-Small Cell Masses 1-6849), Prostate Cancer Where (KAI) and Vasiagbiai tl. [Yagucht et al., Antitumor Activity of 26ΤΚ474 * a: Nmv Pbs ^ Mi% lTÄiiÖKS ~ Ki »aa0.1fthlMtÖtjÀ hlaí!> Cancer last, 98; 546-6661, M m &amp; wmmchiolite 2-methicyp- (3'-methyl-C0-6-cyclohexyldichlorobutylphenyl) nitrile inhibits both P13K.a and P13K.g and mTOR; 4 ′ S and ″ anomalies of 1¾ values Tested in human models of prostate {PC-31 and gohyostomy (U-87) cancer cancer tested on human shoulder of the human shoulder of the human shoulder. Cancer &amp; examinations were carried out in December 2006 [(Verheijen, JC) and Eask, A., Phosphatidyleneditol Dahlase PíSK.} inhibitor as antieancer drags, Drap Fut, 32 (6): 533-647 (2802}].

61? -12126 (LY-294002, i.e., 2-i-4-morpholine) -8 'feaik4H-i-benzopyran-4On? KV vs.?} Is a "pea-PI3R inhibitor", Aktixi pmsAata-eitriF, ovarian, lung , in the models of the mouse mouse multiplex and pituitary mouse mouse, [Yerheijen, JC and Eask, A., PbospbatidylinosiKd 3-kase (P.! 3K.) Inhibitors, as naticancer drags, Drugs Fnkt 32f6}: S37-547 (Although it seems clear that their word blockage is fundamental to Ibatpicity.) PI3K Ihbibitorek digests -lertes activity, mm is clear that a specific PI8K taste orma sectective inhibitor »less does: expects !: leads to a biological effect, I am telling you that non-PÏ3Ko 1. 8 and y) the oncogenesis of cells with abnormalities I have ,. which can provide nero-isolbnoa - speei-specific botobitomyla kiii: Waiting for therapy with specific inhibitors. Selectivity towards other related kinases is also an important factor. 6 PI3K inhibitors cloning week, selective inhibitors may be beneficial. To avoid unwanted side effects, many people have: - the fact that the FlixAct, excavated: the inhibition of t6bb eeijmnl (for example, PilKt and ntTOR sjelnibsbk raparnicin-peppe)]: larger IjacanthyHo: lead, libelous, '. Protein kinase inhibitors from non-selective inbibitors Can also be inserted into the cynomolgus, öm fömifeöfe iipmlőfe eléliysnia, m * # signMtvö fehdipy uterus regulates κ ^ φΜ ^ ίώ, its response to nutrients and growth factor-inducing growth and stimulation. # δ *:. &amp;. '' Arphyte eodotelial growth iÈtomr, g, VI £ &amp;p; g > 4 &amp; R: teesapi A ** & OR MtMy hunger for stos soy and * &amp; «« »». Ä * # y «* MMm. mm mm binds to Plane: mTOR kinase. There is at least one Ibwtös Drinking Water. I am mTOR, the PBF is going over a doAOstreat. REPLAY / ACTIVITY PRICE M. gddad PücE> iNtItNeNg In many cancers and uterus; special winter mTORmmmmm mm sMk circular mm> m ttpsiream path bug nude! Mlffct would cause W JrfStSR &amp; «ÂÉ> Ásööbáfc ®Wk In the presence of inhibitors this is ibiyamat gáti«. The inhibitory effect prevents signal transduction of nascent mTOKs to n downstream pathways that regulate stgt growth. Excessive activity of the PBE / Akt kinase pathway often involves mutations in the FJEN gin, digging in frequent cancers and helping; iaegjonAonknteiy tumors will respond to the mTOR mhtbg throat - The second effect of inhibition of tni'OK is the aiti-angiogenesis by reducing VBÖP levels.

In EF I 020 462, it is known in the art of doctors that it would be known that s-triazm or nhlmldin Iximidazoil and moribiinttai have been scrambled, some of which are pharmacologically presentable acid addition salts.

In EabomtéritiOb's studies, some spider chaotic Mooras were found to be more effective, »in the presence of inmbltorpk, ó. and mammals, Canner KeseareSk, et al., 152 / - 1Sri (2001) 1, have further investigated a number of myeloma lesions in the presence of mRNA inhibitors. There are three mTÖRs inbihi which have been clinically investigated. These # chemicals are the active ingredient of Wyeth's farm, which is known as 4H ^? Dn> Xj4? P ^ CCl-2? 9; Novartis everolimosza, which is 42A) 22 - hkkoxietyl> rapan5; and also known as Ariad AP23I22, atnely 42 <dimethylibsmoil-nipamÎta ”. The EDA has authorized the treatment of advanced 3-cardiomyopathy of 3 nmeit. In addition: Torkei's active sknt lymphoblastic leukemia in the NOS / SCjD kenog mouse model (Teaehey and nymph stroke Hiö,: |; f? P% 1140-1155 (2006) |, 3Ö09, m &amp; Pt $ 04 »M-A & M Food * and Foolish% - {F0 # <$ p * overgrown everofimus (Al-ÍNITOR ™) for advanced chisel-cramp, patient treatment. The AP235?> Aí &amp; orphan: Nothing and Accelerated $ YYYY $ 0 «; MFÖA; (for the treatment of bed tissue and bone sarcoma. Z Non-synaptic, but reproducible macromycin profile of three rn αOR initiators). grow, A, burglary: compound is a synthetic substance: derivative: natural macros! amíbiottki «» rsrmtntdnmtk. okinetikru behavior.

BRIEF DESCRIPTION OF THE INVENTION The present invention (Figs.

Ey is a prestigious and femfekit »mspdbit, as well as a pseudo-fever-dfgdfd. and vegptetemTÖRs> #s FO Looks InMhorsors are also useful :, the Pösimáhy is also a myamksflamation of which one or bibb of the above-mentioned compound is: &amp; s,: &nbsp; in the treatment of p13k ~ vîïi: tesdeMeoity or nvFOILrat: in the treatment of rerafluseness associated with tesdeMeoity, the FldtL-vAl kapiamlahts regglutegg or ax otTOR-a-ai can be used. alpha-skeletal bone mabeitetmshog.,. arthritis, deactivation pathway, psoriasis, well-known prostate blpertro. atems ^ icróaís, gpillaMs, angiogenesis, invnntKdégla regency, dysphagia • inflammation, lumbar vertebrae and cancer cervical strap. isitiartetößk: eMsBs are the end-of-the-rolls of the present invention. furthermore, methods of using the invention are embedded. for example, the procedure is NTTOR inhibited, «broth FI3 kinase. inhibition and procedures for the initiation of various Ibrtniasis. DETAILED DESCRIPTION OF THE INVENTION Malány relates, on the one hand, to compound compounds of formula (I). where where

R! meaning

R ': jdenkKe ad l xisabstko · rb-NR-CORk R' is KHK '; il * denature ¥ -Q esoporbd subSRikc R Rf ög;;% Y is CIO) and Q is di (C--C £f £ diphenyl) ;) aminossoj3öRial síiii111111111ôôôôôffffffffffffffffffff::: :îîîîîîîîî • • • •••••••••• 10 3 3 3 3 3 3¾¾ododododododododod kbveveveveRRRRRRRRRRRRRRRRRRRRRR & & x x xit %kkkánánánffotootootooto p p, ptolpn, ÄlÖmRÄ »toRähsbröfed% bMdmtîoldi , lethalndmloftt, dddmbkiklöP-a. dsasablecyclo [beta] octane, oxy [beta] - dlazabkllpP, <RTI ID = 0.0> 3, I, </RTI> y-oxa- [alpha] S-dlazabic acid, <RTI ID = 0.0> S, </RTI> ixa-Sr &amp; zafefclJk * - lo |; S.2.2] øddß,: 2 * öX &amp; ^ xäfe »tepe.;] hepÄ * 54l, 2-e * ad-a2able <klop.2Jpktdv 3,6- • Dioxo-S-SiCafeP2., Ijoktân, d-osap-azdidef JJ jbspân, 3 «öxa-S-23afeífe &amp; - iop.2.í; [2.2.2] octane, 6 ~ oxa-3-AbsdfehpJJ) bepdn, 8Pxa-3 &amp; zsbiclfclbp.2.l:) <s * k $ 8AiUU 2-methyl,: S- •• dÍ3zabia (kíöPJ: Spepíátp5KI? 13β-Methyl-6'-azab-5-chloro; * J] p-propyl-d-bidoxyphen-aza-bis [beta] - [2,2, 1] -ethyl-g-3b, 7-isebl-3-oxo-3,9'-dia2-sbp. -3J] noRkK-9dk b-β-β-standard 3,3.1 lnanan-3-ΔL-3-oxa-9-azabld-1-yonan-9-one, Ip-dlexâ-b'-axabtelk ··· iopJ.rjnoeds-bdk4-methy-3,4-dshydro-2H-1,4-benzoxazm '? owl R! meaning

or gvogpzetPseeleg dripable salt. The kvdk is a compound of the formula (K1), k1, and 4 (dl; o ^ obfeoboo) plpofidkî, 1-k3b9ob: lf ?, bOv3: v (9- (9 2 ^^ 9: 00 ^ 101100-1,3,5-0 ^ 8 ^ 10-2 -))) 1031 ^^ 90-- odd ;. : S # AMSD; ? - <4 · '{IC31¾> - 3 (á 5 «3« ϊ ϊ ϊ <<ï I I I | | í s s s 3 «« ί 3 3 3 3 3 3 d imor ^! i í> s leniljlmibmbid; Ι.44 ~ {| {3δ> -3 ^^ {ο> «ßΠ ß ^ |» ^: ^ 0Κ <Ρ?; Μρ & «»% Μη! ^ Γν »^ Ν ·: '· ß4 ^ 4 ^' ^ 0 # ί1Ιδ? 4 ^ Ι.3» 5 ^ 82ΐη ^ | 1Ι) » ß- <4 {i4 '<diϊϊ-ΐΐΐί: îlaϊχίîïï >> >> ξΐϊöítítnn'll'll'll'llboííí sí))) 3- 3- 3- 3-1414141414 > ïr3síkί; ΐΐ ·> · 2> ü> fe5¾ 11: ^ - Carbam A: In the Invention of the Invention, and In addition, the following formula is used: and jybgys ^ iés ^ yi sbtwo tes ital Finding the Right Formula P3 «Chemistry» is an example: «!! bgadhöíá; Iddi ^ itj it ys ys ys ys ys észet észet észet észet észet észet észet észet észet észet észet di di di di di di di di di di di di di di di di di

Further the ^ »^ 8a AALM # AFTA» y: -: v®s ^ ik aam, when the pharmaceutically «ys®rdsKei eg inadmissible # alkahaasés carrier for oral administration of the composition tinny dbzistbrma!.

Other vonaíközósbkbaa is found («äs« blymi myths vossatkoxi, which contains a plethora of combinations of a second chemical stack selected by the next group: toposzotnssiz bb sib, MB & U2 bditbdösy iobíbsbsi, pmkazbazím dakarbazd, ipttélabm, kapeeitablm to d> d «provides: tssdl taxotere,:... WÉgp ^^ ílpgnsnm, didíőkíkatkamíd, eitaeabm, eiklojksztamid, ííbsziamid, nte ^ Äsmidok, sisíplálla, ktirbeplaisy ttikonnoitt, daksrhazm, píokarbizts, étgpozid teoipozid kampateelsek hteonbetn feoritbschg iíbtjmbiela, daonóRíbielíg daktimhiem, fdikamtÄ, nnkmastetg L aszparagmáz, doxorubicin, deaciaxes pklfexek, mkwl, icvamizel iriööfe »y« ^ te »sgKtl« i efepöxfcfc.nitm-iglbbbdpabk, PCÍPO, käAmsÄ, itanusxio, vitibiasssok viakmxtm, vinorelbib, cisxpiaiîn: karfeoplatm, bxalipiatak: Imaiinib mÆÆ &amp; iamam <kmaz yiyipitord, typhosatine, herbiímcln A, yokebit, erfesimtittitt ,; tataRMs * giaíitmmer-ae etudes mteríPxm & £ * £ $ interferon fcéíaPfe, tiatallsumab and iavëttdusPm A; thehighlightingbeaccessofthecompetitionofprimation. '1 vegpPbaz Avastin in the second aspect. Λ invention and fi) formula! buy &amp; cle or croissants; sbikm applies P13K ~ va! related disorder) 1 mTÖR! in the treatment of capsaic reflexology, the use of RbteneS-Mara, where the order of PBK-related or mTOR-thiid-related disorder is retestiosis, atcmsclerosis, chenotic disorders, arthritis, diabetic retiosis, pseudosclerosis, prostate kiper writer, allergycluriasis, Inflammation, angiogenesis, lummnolögM meadelettys, h®asyâteiHgy * fyu1îàd8ss kidney-Ixegus and cancer kdzíSl. a method of treating a mammalian mammal with a )T) formula is administered by a KSKAvtd; tumble-in. disorder plöyabbi aspects related reszíettózis PBÍsvvat g, atherosclerosis, knot disorders, arthritis, diabetes * rsílnopátla, pszoriáxis, jónididatáprosztaía bipertrófla, ateroszklerázss, gytdladás, angiogenesis, mmtanologsííl réndsiiéííssségék, ttasnyálinirtgy-gyulMas, vesebetsgség and Maki cancer selected. For further yonatsuic aBB K-related renlbl &amp; nazi.

Further Yosútikozasokhan s cancer is selected from the following group: Isukémù, skin cancer. haemorrhoids, breast cancer *, alveolar cancer, pet lymph nodes, lung cancer, lung cancer * iron larvae, stomach ulcers, vosker, stomach and brain. further discloses a method for initiating a mTOR-ml related disorder, atoelyovk interpretations *; an ophthalmic agent (0) is added to a mammalian mammal in an effective amount for treating mTOR-related dysfunction.

TransfersDefinition $ m. A mTOR related disorder. resztemSzn. osteosarcosis, bone disorders, arthritis, dctb &amp; rcts, pNerase, benign ptoslafta htpprepta, athletic-sclerosis, cerebral palsy, Anglogenesis, immunological tendencies, pancreatic (transmission, kidney disease and cancer around the body). TnTÖR is a capillary disorder of cancer.

Additional line cassette clips are selected from the group: leukemia, skin cancer, bladder cancer, breast cancer, mumps, pel: asthma, prostate cancer, lung cancer, y &amp; scar cancer :, "h &amp;ng; y'MMGo. ^ my contact: treating an abnormality that can be affected by .. »* sm smt: For a mammal, we add a compound of formula 03 · :: into a kSMG-I'gycl-related verbose: e2« : cataract lîseimyssêglîen, 'In addition, in relation to hSMö * l-r-rhythm itessibbdgiis; arteriosclerosis, inflammation, hyperglycemia,: Mtatt%% iat ft ég ft ^ s ég ég ég::: 4 4 4::::::::::::::::::::::::::::: ik ik ik ik ik.

In further aspects, alSMOs ^ al'connection rmulethighity site

For more information on cancer, follow the following group # I ^ Ât:% »yummy skin cancer, bladder cancer, breast cancer, uterine cancer, ovarian cancer, pmsatata ^^ iÂîmsteg bleeding, stomach cancer and bedbugs. we also knew the procedure for the manual engraving of the Ephesian tree, in the sense of which "a nailer of a price is giving a formula" formula in a quantity effective for the karein beam. we describe the root of the action, the activity of the active agent ^ H ^ tiiiSl ^ iatls ^ Slow amoebe is an arm weave * to a mammal. ^ ÂÂ # Âi; à «2éiésêre, in which a mammal of the formula <RTIgt; (?) </RTI> is added to treat an acute malignant melanoma at an effective dose, further disclosing the use of Ságyszőv. or bone-sarcoma kexe, in which a formula (I) of a mammal in need of it injects a compound in the tissue tissue of the stomach, in addition, to a start-up of egppoitbdS ya-stained cancer: a scarlet skin, m ~ tysgtáky breast cancer, uterine cancer, scabies cancer , brooches, lung cancer, colon cancer, pancreatic cancer, kidney cancer, pediatric and cerebrovascular disease, atnelynsk in the mammary gland, a mammalian syrup adds a composition such as: (a compound of formula (j)) is used as a topazisomer; 1 inhibitor, MME 1/2 inhibitor, HSP9Ô Inhibitor, procarbazm, dakafbazine,

gemcnshm, capeiiabin, fork: | actax taxotene mercaptopurine, tlogeaeio, hydroxycarbamycryl arabic lactoophosphate, Ifbsafcmnd, ßliröxäftäiakhk. eisplatin, carboplatin, mylomlin «dacarbazl, procarbizm, gtopoac k-yipozide, k-uTipsaeciris; bleondcln. doxorubicin, clantbinein, davnorabicin, daktsnonticin, pancake, ndtoxaoixon. I-Asparagine, Doxorubicin, Echinacilli, 5-Younguradl, Docetaxel, Pakiitaxel Lenkovorm, YevaouoÈ, Srinoickan, Estrampartm, Estropeane, Mtuncan Gel Clamps, BCNU, Lanterntin, Lormtsin, Vinblastion, Vinclstin, Vinorelbm, Etssft &amp; , Natinsb jnezylate, avastin (bevacizamabk.xamettitpelamine, topotecan, dmgxcloid inhibffM, iirfosrtktok, berfeim »ein A, geniszteio« ethsztslm and l &amp; veadusain valamint; pond carries an effective amount to treat cancer?).

We also describe a method for inhibiting niTöR as one of which * is an integer with am (i) xKOkllb having one (I) image! vogyülete? Inhibition of mTOR is administered in the form of an effective amount of scorpion.

Also disclosed is a method for inhibiting an FOK in an intact individual, "according to which the inhibition of a nasal sxorpho W3K is S2e &amp;

In addition, a method for inhibiting hSMG-S in an individual is disclosed, according to which the inhibition of hSMG by a dermatologist is "â" mpobtjàb6Â ^^ :: gàé »now8 ^) en. it is also a method for combining mTOR, P1.3K and hSMG in one individual. in which a healthy father is treated with a compound of formula (I), which is: 0), 133¾ RDK. and bSMQ-1 inhibition of Skeospontjáííb in Ménnysus.

Supplying more food to a compound of formula (I) during the course of an evaluation procedure:;

the preparation of kbvetkesb cadmium dcorcratex * compound

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HI III t s I «? 111 nmi ll £ 5iï s I I I I I I! i 8 | sf If> ΐ · -i Sà r * ο ": Ρ? - · g S '<?>? so we got vbgyfâfs (4) and (8).  € *t arm *! 5am | tkâÂniïÂ4kiiâ'kà & kunduJ &amp; anyagok tt tt | Many of the yssiMetyl urea derivatives have been reacted with silicone in the form of (41 or (8) in the form of stone (s). ^: «I ^ g ^ l ^: ^ & ^ úú ^ .primer smis- ·: * mlmù &amp; ^lm ^^ vhli :: a» a ^ ttott <...; â: '' mëg #  .; Ott m M ï ^ ï ï ^ f ^ ott p 4 hogy 4 4 4 4 4 4 4 4 4 4 4 4 4 ott ott ott ott ott ott ott ott ott 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 ott ott ott ott ott ott ott ott ott ott ott ott ott ott ott ott or a txeteroaril. ss: s ón ón. An aliquot of a catalyzed equivalent <r. Ishvyi; ioáh vjoii-fto ^ Mnxads can be introduced into the (novel diatomaceous compound). l ^ $ p ^ spelling;: vgp ': p ^ | g'egy AlkKigket bed could be built on it; that s Cb) an imaging agent in a presence on a plane and; FdCOb or m «gt« t | uk. Iseviü alfetbt and i ^ g®ftletí! Sí: '; to date ^ * ie2bk # ká, so brake bridgehouse alcohol and mm ·, nest * M ali | &Amp; Raskekíváaist V.'íí

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Ca> I «kv <morph« iîn / Bi? N / scetôri / vfz ^ 2Ô <iC; (b) {Phs P ^ Pd, DME, NαaCO ;, reim *; (è) RNCO, CM:.: Ciî; sEh or (COCKk, RNB2, EtNN, CHC.U; K2 / Pd (b)

Invention sxermts vesyglaisket is a motion is shown on the 3rd Reactor.

4, Reaction * teM

(, 3) NHR'H "toluene; bb) H-vt'niwUoaS * jMH & Rd.

Mogje &amp; Yr.eS: Hs R 'vsgy' ·· H or nucleophilic aromas to Boc-ssıs ai aiikí. The last removal of the dormitory is the last one. l »rf> your« iMrFeRs5Di8LiLaNe ^ ': v8iSiS: night * · ^ ν <* Ρ'®- In this game you can find M, 4-dfemm rostrums, 44l »orn! f: fobenxo! bóí and? î $ The new version of this article has been modified. § $ R $ $ kr

(aj ROH / NaR / toilíoi; fb) SwellingOperator * plipmm * et &amp; acetate>. o ^ eimroL. Him R eukleoSi amimkolslrays, then dig &amp; «Omí Boe-ssafemazéMi aiLiKiKiKi * *, water group sFaPeOf uFeRiMeMeRiCe: The ultimate goal is to make the A-Calkoxljsml: ® cosmicide target d-fkÍOntimsbeOoolioI and Ã? (4Ä (: m0döm <x .HeafcçÈévàxiai

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also NHITR " EöM, CH; &lt; / RTI &gt; E tf &gt; H palladium-carbon palladium, microcellular methanol.

Note: If you are Rt or Rj nucleophile! what it contains, it was transformed into the amine Boc · ». Removal of the protecting group is by mrdvö. urea-formation step after h &amp;amp; The (d-aminofáailXplperazsnvh}]) 5nstanöa fireflies were made of 4 * akrd1> e &amp; lj.

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MFLÄtöK jí taîâlia &amp; ry »» kul kul kul kul kul kul kul kul kul sak sak sak sak kul sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak sak MF Λ Spectacular !! C> -C, "speaks in the stkm group, and there are white borders. One,: CV € .ç joïâ ^ sOàeji ^ J ^ ës ^ ôfeia ^ te ^ ^ • In Ikbnídek IkisssiÄ sjÈenëfemsÂ: êthe »Älfe &amp;« «s sénénàppâtalisation iems, but wm Ihglaf and in itself the carbon atoms of stdrkmms, as an example of i sb ss« s Ä unless otherwise indicated. we get the name of the functional group from left to right, and then the adjacent functional group to the linking pmu lee haho << poklát «ns ssLohnod smloz ma ns (0 * <Φκ«) ti * ,, οΑ'Ί O í O) csovrO signify :, terms defined by bt aunty reporting?

Ag "acíE" kMÃégÂÃóÂóÃó¶à â‚à â‚â „ott ott ott éni éni:: éni éni éni éni éni éni éni éni éni éni éni éni éni éni éni éni éni éni éni éni éni éni ó ó ó ó ó ó ó ó ó ó ó ó ó ó ó ó ó ó ó ó ó ágy ágy ágy ágy Functional groups are attached to a bark, such drips may be either abutted or filled, ab woody or aromatic, and charcoal or heterocyclic. Examples of a CrCsaelksopor include. steel 11 ··, benzene I, right of iniiig pmpjoniln Ikilbwirtf, poplar and the like. The short-word aeil is a dash of ad! denoting which are e. sMtMfÄi. can be doped with $ ztity.tafian or one or more of the following groups: more geo, H; N-, (OrC6 &amp; p> ammo <CrO;,; dkii} ammo, à £ r € ftaj .x} C (0} N | € rC, elementary} · -, (CrCsiaikïi> karhoslanddo-, liCÍOjNH-, H ^ OtOá-, fCrCVaJkn> NHaO> -. -¾ irtdroxtk%> C ,, alpha ~, Cr € i, alkii ", Bf.EO- (CrC.udkoxi} ka (bomi ··, (OrO;, alkyl) € (ö> (CV C," atϋ ~ 5 Cr € -, hey: sroa? th or C ;: - Cycloalkyl · A: z "alkyl" means a hydrocarbon, an3cly may be: a straight chain or branched carbon atom and a carbon atom having the label, e.g. Examples of the 0 t-Q> subspecies are bluffs, but not exclusively & iodine, ebi, prop !!, jacks, penlil bexyl, flavors of isobufil, cabinet, t <0 ft. ## STR11 ## ## STR8 ## ## STR8 ## The CVC salt is, but is not limited to, tnyl, prop, pcttf, hexif, heptyl, Smietihexyl -, 2,3 - d methylene-2-yl, 3- [eblpent-1-yl, octyl, 2-ethyl] hept-2-yl, 2,3-diotctillfex · 1 t -friote! .tSpet5f.-1-11. An aldele group has become a suffix-dreamer with one or Ü &amp; s dumbbell sxtbszthu as follows: Balogen, # îs | Gr ^ Í «| p«; CCrCl2 / xClCl2 / ib) N-, -N (CrG2kylQOXCrC4alkH), PÖC (κCr% l-kilj, VNHC (0) K, d3PjNkk, ((Ollkffgkg),, C (V}) H (Gr. kti) {Cr (: «atíí), ÆNébitoxi, CrQalkMg C -.- Ckaikfi, --0 (0) 01-1, - € <0) 0 (0rGédktl), € (0) (0 r0px! i) . f.VC ,, aryl. C 1 -C 10 azoalkyl: C 1 -C 10 acioalkyl C-Cmaloalk 11, OrO,:, aoxmoalkyl. -OC (O) {0VA) (yi), CrC <5>, xx> xiaoudoyl: k and -btOj,

The term ^ IkaSnF stands for egpnp or branched unsaturated hydrocarbons containing more than two hatching bonds: taltnaz: and their bartenders in E or Z contaminated plants. , A! 34-C, and batches of bots for dowels, but not exclusively for b '; a-i, 3 - <; íc: tti, bufa-2,:> - dienll, isttprentk ftettta -1,3-client! and pt'2,4 '· prize-2-ll.

The term "bargain! Bt !!" refers to a straight or duplex chain of unsaturated disruption, which means two barrows iartabna.z. G ^ -C ,, and pt. -f, 3-tlünll, silly - 2,3 '“dllati, penta-!, 3 -0115¾¾ péöta - 24-di): t5S !, Αχ" îikeAP Mfsjhxès egpateé -Vis®? efâgaxd Ihnen saturated · «àsênhÂgéaesoponof Jetem, asneîy at least one% eH ^ binder» ». ^ tent or ^ a | j'A £ ktmlpmtäclhbsn,> ', ak <n \ t the baker! te t> hbak about dark Is .mm: jdxktdlag; ax style: pmpllép :, lÄidsb, 'ÄKiten, teobudlénj, «xeMtetîlén. l-pettrPtg Ibpeníé η, l ^ pestéb, tefeëtp Jdxtpe, steexpe, íxdxíx | f! s IxhepÉo, 2 »heptene» Itebeptëte teopett, 2r.ok.yt, Ibukîèn es 4 ^ l #? Cï ^: ÂÂesôpôîtrà Examples , dp pern t-fesaillile 2 - huilten, ixoIxtilMih ex-teblién, tepemèh., 2rpmt4nf teöpsnftte ,. l-hexet lEhsixesp 3 ~ h «xêo es Istehs. Examples of C 1 -C 6 alkenitespporbte include, but are not limited to, propylene, 1 ml, 2-naphthalene, tebabene, hexafluoride, 1-pellet: 2rpedten, isopesthetic, n-hexyl, .2-ltex, 3-hex. <%., body, k-heft., Ibheptéix bdiepten, doc, J-tht 3-th and s-4. Examples of 3-C4 alkenyl naphtha powders include but are not limited to, but are not limited to pmp.sub.2, .beta.-en.sub.b, .beta.-2. and hexkAsnl1, A Pylen group may be substituted by a "orifice" or a plurality of the following: to a purple -vM% (€: r €) of Nyl. -N «'rC, aildl} C {0} (C; €;; a ikil}, -NMC: (0) (CrC # lky: k-ΝΙ €; ο} Η, - € {01ΝΜ2, : -CiO) NH (Cr - € <0) N (05-ClslklllPrCsPlk: »CK, hMtoxü, Cr € ^ lte.l: s CrQ.sub.-QiOjOH, -C (0} Epr -C $ aM || : ~ € {0) {C (<gtiikilk ClisrC ;; j.sprik and CrCselktealkll, but "alchemy" miniature straight: or splattered unsaturated sxénhtdtogthsí jetem, which contains at least one pile of bits: ik - (. 'GsÍkli3: bésöpeíáPki' a: examples include kpxhtí, but not exclusively ax: acetylene, ptophg. vbtíktk: 2-bt, Ikpbuíss, saek-bptlp, t-pop ^ .. 2tpßBtla5.teopenit: I “hexte, Itebsxltg telxedn and Ixóhsxla,%> -Q.alkinite_5 examples include among others psn ptxipAbiml, httiEEknl, bat-tin-tell, peoHkl and bex ^ S-JC: rC »examples of aliases include Mxte but only ptxip , MkSdölI, btiE24sll, panidnick bex-Edml, bpgtrainsil, 2: 'tethylex-4 ~ ip: ii, ogddatk and S-meiilbept-S-MI, so it can be sxob sixtaslaslasy or one or till # is the group of halts, halogen, kffik, addedJMR (Cr-C, alkyl; KCrC, 8lkylM ^ -N (C, Ό3ΙΙcycloxoxCrC * a Ikil), -NHC (OXCr te | : -MC {ÖR; > CCPPHpÄaMl>. -CCP?

CrQalkoxi Gi-Ckslfell, - Oli -ClCljOfCrC-Alkyl), e * -Cuank &amp;

Cv C $ etk.k> aiktk

The "alkod" R-0 group is an Idea, where R is a timer defined below:, sotx: <n. C = - ;, examples of slkexiesopplets bites kPxöö, deatem ktxafs the self etiquette e * five »puxí, I -prstpoxi, ta-botox, and t •> b «|: esl. ^ y a epa A het het can do sxubsgSitpälatlas or with one or more groups sxuhsxtltttelt the followingxchol: balogen, btdroxl, CrCa; ko> k, kkM-. } aíni80 · 'di (G |' Ct, ali} atnmo- ;; (CrCbalkilJCCOJMpr '• Cyclics (Ct ~ C <> alkyl) carb <! NC (0; p, {C 1 -C (> alkyl) NMC {0} -, dc C 1-6 alkyl (NC) -; MCE, C, '<. Calkoxt-, HCbC-, {CrC;, alkoxy) ksrb <> ntk (CrCl3 DCCO) -, Styl, CrC1, beleroayl, kCKMalkalkyl, C1-Qbaloalkyl, amideChCl3, CrQcarboxananthalkyl or ethanol, ! falkex!) kai'beml "," alkyl-0-C (0J · esopofiol. Examples of Cj-CpyxIJkafbottomolpots include, but are not limited to, meloxl, etoxt, a-propaxg Ι-ρίβροχί, e-betoxi and. -btdoxi Eg y (alkxt) carboml ”esopoft lebet sxubstituted or with a desire for more esopmt vibsxtlated the postcode kdxäk balbgétp htdroxtl, (CrQ.alktláamsno-, di: t'C: A. € (O) NClCiquic) -, (CrCialkyl) - Carboxtatido-, IIC (0} NH-, I-NCOCO} -, {C 1 -C 12 alkylpHCCOK diCC: -C., Alkyl) NC (α} ··, NO) · CrQalkoxy-, HOvC- (C; -Calcol Ikartxm II-, (CrQalkii) CfO) -: CVC ,, aryl ~,% C * bsieroanK CrC «clkíoalkíl ·, credo · ·, antbío (C, - {. Ka: kd} ·, (CrQaíkil}) carboxib, C: AkAarboxtatr} Idoalkl- or Ojbi ··. Λ / "« JkiOenfek- "punching a - ^ iO} ffll ->: cs» pQttotors ^ mè & m ν * &amp; ι # χ &amp; νφ * Μφ m * * ifcs Mrnm C, -C * alkik ::: i> | Kidh (5 «connected. iCr &amp; äikii} amidoesopom ·« illustrative examples include kft · sML <you are not M &amp; tag: «C ((^ MeO% s -GCO ^ iedllll, íO} NHCH> CeCe ^ - € ppHiafcÂCHÂC%, ^ | D} NH € Í €} 3 € 3 MP IGCIE, i '(0) Mk Hx M * * Ç UHOH'ïlb b'tl <'ll, - € {(h} NeX ^ Gtb,) s iis-aO) NHCi {2C <CHiJ-5. A / "(alc> amyl <w«: An example of an "NH group" is defined as follows: "is defined as a group", A (Examples exemplified for GrC1 to CH3), but not CH3 CH2 CHK CH1 NHH · CH, CH * CH > CH> N1K CH7CH :: CH2CH2NH% CCT1HClTNH-, (CH2bCHCH4N1I *, CH1O6GlICCH2NH- and K.llX: CMK One (bb) kil) anhnocsopori can be s * ihs: ztituáisdlao: either one or more: with groups sy.ub.vzi «oá It says: halogs%, ΙΙΥΝ-, ^ Cb-CäälkUJiäitbiio · ', * 11 (4; 5-bow ^ aíkl 1> anaino íGr-Gsihkő) hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh I would not be happy; Ai% $?>. HCfcP * (G: rCsslct) carbonyl-v: βGpGaKiIiIlIiIiGs'-GiiSiLiCi; -

The term "alpha-alkylalkyl" is defined as an alkyl group in one of the foregoing, wherein one or more hydrogen atoms of the alkyl group are -HH: «optionally substituted by one or both of the <RTIgt; SKböszötneasset,: the "alkíikarboxil-" kiíejezfis a olyeo fcotiekltsd, őeiihalfíalkliesoportöípíesg which the &amp; xerkeaethex carboxylate in an IC (OKk- heíkciíínaiitá} &amp; exigénatoapán kgícsgtöi kapesólédlk ^^^ J ^ k aáteUesopönokTa. examples among plural azaseioxt, peptsmöxi ,, pröpitkisrbokl digs impeatiikarbosd.

It is known that the carbon atom of the group is a fetal carbon at 0: -¾ for alkydopopl: is attached, Examples (exemplary of ex-C 1-6 alkyl) include: but mm only -NUa} CH: î, -NH € (0} CH: CH2 CH-CHCl3) CH, CH;> Ctk, -Nf] C (O) a, € H> CH2CH; 0} € H3CH: JClb Cil.Cik, ~ ΝΗ € (0} € Η € € tbCH (CH: S)>, - NH Cí 0> C i I (CI Î,) C 2 H H s, -NItC (0> C: {Cll:}} and -NH € (0} CHj (CH;)? ·

The term "amylene", AsfcsÄn'1 ancestor "Vikifen czŐsck," âÂJéenen, -aalält àÂ, alktmib and: almite groups, which have a spherical attachment within the structure of the sfkő. Similarly, examples of Gene ^ Cs alkenlteneopoyl octane are 32 etsylene and ptopenylene.

The aril cybercrime is an ardnst sdtthldftigdasaeportot jsleat. examples include, but are not limited to, tbnlk í d d ft d d ds í,, J,,,,,,,,, ab ab ab blfemi and oatmeal arsenic An aryl powder powder is a tetracid stearic or four or more cylinders substituted with yMM: Cr-Cpdkit. halo, h-axatl, bydoxic tbdröstlfG; - € gSíkíl nt-f ,. ímddoalkl? -. di-alkynyl-, -COOi -C1O8Cr-Csaikii), - OCCOKCr-Cyttkli}, N-alclamidoo - € (0} Ν1Ε (€; -C (.a: kl) anbdö- or -NO?). M "(sïti ïfeîît ^ fííííá ii Äifesopöri ileMnt, and» the aMfesopott is a ydmgéai of a desire »t ^tlé ^ Â.dèSNàK arifcsop ö rÃ? R ?: ssn fee ^ eössiíve. Lí ^^^ a ^ l ^ Mte &amp; t : js js · · · ák ák ák ák között között ik ik ik ik ik ik ik ik ik ik ik ik ik ik ik ik ik ik ik ik ik ik ik M M M között között között · Ms $ wm * * Z »hs« »uahu is the following: halogen, H; j% j i i i i ^ ^ ^ ^« ^ ^ f f € € 4 4 4 4 6 6 6 6 6 a vC! alk: il) ~ i (CrCpkiiboxboxlainld--, HUQpM-r ».iip ^ Qjb- (i. p.» felipBk '{UK iH {CVQalkΠ> NC <OK NC-, hufoval t.YtVkoxk Crr; ! alkyl. · HO.C. Irish <4featkoxnkan> onlb ;; (CrCoak MïÿMfri fecnik Ci-Cahi ^ áíiy Ck4 :: # Äkii «dki | -? £ rC% WöatóÜK amino (V? ^ k% PP) no | C x, C <-Akarbox S &amp; m ideafed · or 0; N ·,

The term ** (aril) aml "i>" is an integer of {aril} -NHk k ^ &amp; h1 ', where aryl is iMieies de® »·" (aril kosi "means Ar-D, The meaning of "fess" in a vineyards is "fess". The term "foxhole!" Can be an oeovaroma, a moone, a bicyclist, or a poheikfesOS: a carbon ring ring, anxiety, illustrates examples of, among others, "&amp;« om quintuple, propyl, dRlopehHK eifcloheptd, eskmktype dehabldrermlinsinY 4 | okkhydryl * * H * thym ~ &amp; ibeldro &lt; / RTI &gt; Examples include, but are not limited to, the following examples are exemplary examples such as, e. , but: no: a: elktoptqpll eiklotad, .slfclopesitk elklöhekii eiktöhepítl, eikleekti l ék ab ab ab ab 41 41 41 41 41 41 41 41 41,,,,,,,,,,,,,,,,,, 41, 41 41 lehet 41 41 41 41 41 41 41 41 41 41 41 41 41 41 41 41 41 41::::::::::::::::::::::::::::::::::::::::::::::::::. following: halogen, -441½ prC # ifcsljm PrCsalkdX € rCpilílip ^ -. «C (0} (é.r 44Μχθ) Η, ~ QOp% -C <0) m {(CrCp &amp;% P (© PilrC« ÄÄr ^ lfcil), ~ € N, bidrosit, € rC # koxi, € re #? Mb -C {Gpp0 (0) ^ 0rCfiaikO}, -CPXCrSyslky},% ^ # ri | -O ^ h ^ yarH , P: stoilyl, C 1-4 cycloalkyl, KA, iC: <OKCrC * avaly Crßffeaiboxlamldalkyl- and -MCE This klM at the same carbon atom of the corborphic weed can be substituted by one of the two hydrogen atoms. oxo (::: 0) coughs uens; formed by the term "elk el &amp; enii" is an amoose, feldthe, otonoeiklosns, himhhtss or pofs &amp; shosmgmg gytefit, which has a twofold twist of two gangs: connected Cj «Oseskloalkenyokm my eye-catching, among other things, not only the eucalyptus, eikiobéénén, 4,4a ~ octaim4> 41 and: eiklöokenifesopoit can be» záhsxtitoálailsrt or one or more groups behold, the following are the halogens of the following, ~ NH>, (CrCytlkilpll, (CrCXalkllXC.-CMälkllp-, -NtCy ^ aiky} C (0} (Crpalkíp · 44ΗΕß | ρΡνΡΡΜχ «· ΙΟU) H, · Ο0) ΝΗ *. fe: (t)} NU (C 1 -C 6), aXO) NiCY AX.alkyl) (C; -Cf.alkyl), -CN, hdroxyl, CrPaCl2, CrCl3. -CtOiOH, -CtOltKCr-Valkyl), .C (OH <. ', - C »alk). Cr &lt; 4nnl1, C1-Cyheferoaryl and p &lt; / RTI > These stones are the hermitiy of two carbohydrates, which can be a two-dimensional one: an oxlgéoatnmmai m &amp; pk>) as a sculptor, the term "dstaikiljstatnoii" has the following meaning: two groups of ïini delïhfelÔ: kspesolod. -NsCl bow).,. -MtCHjCH,! (CH: <), .NtCHICY ··) ?. -Htt.'H .-. O f-OI Γη>,.-NtO-liCHsO hUh> -, Ni < BiCHu :); ·, · Ρ0Η ((:: Η0 :: '4ΕΙ · Ι :;}; Ns nv Bfe Π,) OBg Έ) -N {C {CiE) Bn -N (CtO-bh} iO ;,) and NCflîygClI.C.tb), the two groups of alcohols on the nitrogen atoms with the narrative nucleus), which is a 3 to 7 carbon atoms in which the hydrophilic species has no more than one carbon atoms; -71 (¾ «^ PrQailfcUH * ^ C3. ^ P: Cu-C? (Cr sterile} -,? ) K - ~ ^ h. SSy ,, · -! ($ $ - or: --8 (0¾ pre-play. A: "hal®" or "yoke" · | ·, -Cl, -Br and -I s Amot jéSeot, A '' Î (yC'fi Imlosiklb "is a CVC * defined above): 0, -0 ,, alkifesopmf is a yagy iöbfe:: kldf®g <i®3ien || s is up« -f »-be up, -: Br or ({with some of my branches as some snuffs! Examples include, but are not limited to, -F, - € j,: -Bt- or -I, Examples of examples are as follows. but not exclusively - € B, P. -Chh, -CP1, ClfClF1, -CtiîCL -CH; CH, 8r. -01001 (...: 1, -CiCHCH.CH.F, -OHAl-CH2-Ck -OSF-CH3 / CH2Cl2CH1RH-U-CHCHCBA / IOCHc-Br, -CHX: H? CH2 Cl2 Cl? -C? 2CH (Br) CH}, O-0.CH (CS) CH1 O1; -CH {F) CH * CH j and 'C (iiyAH; a> A. "hetemarlfe term mö) ^ M« s «^' '. bfelk1usos or pe {esp®ShAt :: Amy :: <Ye> <Shell # {: You are at least one of the atoms of the ringtone iMa, Oxygen, Sulfur, and Oirogre: Meioalomok. rC> Heleröáfilesopofihkmi Examples of Ahbs between feras® Bolha, insAl runners oxazines, isozymes, araldiasis, IraldazRl, bmiedlRridases, psampldr, pmtm, pyrrole, B-ais {llp | parts, 1,7, AMmsï {5: i-snerA1, fe, 4 ~ Hazel:: 1 H-tetrazole, I iselellol, bezzodzhzepezole, beosofersßenzxixazole, heasimiphole b-mAilbeRznlazole, azaeRzimidazole, lodazole, iinazoline, quinolium and iapklnolef CfeCC ^OOhoas include groups, aote, a phenyl, pyrite, pintnidia, or plidazole gytM an olyoR S or P-Og &amp; moaocyte keleroarllyl murine coadensall, wherein the gyifeilhen is one or kei oHi-ogbaaiPm, a bltnogiaaioRi and either an exigeas Am or a youth, or an oxygen or kPa-inducing belamase. Moruxákhisos CrCj Imteroaril groups for pike, including 2iMeírazoí, 38 * · Ι, 2,4-; Γ! Ίί2θΐ. ferrate, doles ·, oxazxsl, hozol, kmrazoi, izoazazi, imidazole and pyrite. Substitutes of one or more of your groups will be posted on a réero-aryl group by CVCyalkíi, Iniío, bsioalkii ··, refreshing, mmmCvCumny. Ali, ytoMmton * <&amp; ms -Céaikli), N * Älsms «lo-, -Ct'üiNlb (O.-CmlkiOamfeo- or -NQ2. wherein one or more of the bidixigemomers of the aliphatic group are replaced by a hysteroaryophora according to the above-mentioned formula (Examples: C, beta, mi) Examples of Abbey include 2-pyridazinyl, z-alkenyl 3-pyridylpropyl, 2-kmohsnylmyl, ; t4 «dpMU. #: ÂMotorbone One (iseferoarnjaikslesoporl lebet saobs) Unsolicited or one or more groups of compounds is as follows: - balogen, 11> 8, bidtostl, (C: -C .; alkyl) a; <ii (CrC;, alchemy> -. (€; - • ^ 8! kjlXXO) N <C, -C: a! kilh iCrQ.aikil} kaffevdamkbv, HC (0} NH-, ibfeCiOK (OrQalkHINKCCOb, tli (C , -ApIkiDNfiOn NC-, hldrog),. Fr € # act CrClkki, HO> C-, (CrC «a! Koxi) cartons> iK (€ rQa! Kil) C (OK CV-Cf tard-, c, ~ L belemani- fe '.- Qmkíoaikil-, (VC; h.do <plane annaotr.-lhafeii;. I (rfe .oík'Jikafeovi-. T> - CAarbosdamid oaikil vsgy (>; N. The astroglyphy or ospreeaaAas means "bAeroexperience" "heteroeiklii" refers to moooc &amp; feieiltSRs and polysilicos esoporls; f: h ^ ro8l0it ». Partially, he shook his half-hearted brick. Examples of CvCy Ile-conesxipoOs include, but are not limited to, aziridine, oxirane, oxirene, thiufa, pyrrole, plroidite, cyldrofaran, cytrahydrolate. dihydrotisden, tetrahydro-thiophene, dilioia, pelpersHn, 82,3,6-thi-thiMdlrudl, »im: hp |?« razbi, oxaz », 5.6- <3ih« ïro-4i - {-? 2,5MsÄÄ-----------sssssssss:::::::s:::::::::::::::::: 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3: i ö i ö k k k k: :. m / z 2,8 ' s &lt; RTI ID = 0.0 &gt; &lt; / RTI &gt; iJ &lt; / RTI > oxa-5-azabjíddo {2.2.2) »cache (, tsI-dfPx & ÄÄleik ·· iS.S.joca., 3-ya. & oz! cll <o -» pt »n 'o .> Uko <2 ppbbt hd Jnu 2 <rabu> ip2.2f> Äi,: i, S- <lyo-3-yas3biCiLiPiPiI, k-€> Kai3-aii: ik-if3. 2.1] bktsj; -341s 2-ttret: S> 2,3-dla [1, 3, 3, 3-imidazol-2-yl] -3H-indole-8 "azahic3MQP2J; ! -3-djazabikio [3Jj: | i3onän-9-y, 9A> xzy3 «azabsik · -: io [3,3, l.} NonatKYK 3 ~ ÖW $ * azabldkPJ, { .peeMH4 * 3: s: - dsxx "9-aZab5Iiop> 3.1jnof3a3-9-ii>: 8-alpha-3j4 - pentoxone K2H-J, 4-bs xo-xo [f4] pure, m.p. , Room A kerbő bstsfociklbsox jgÿôfgk craving for bovine systems at least 3 megapixel bonds, for example, a € (hetero-acyl group moiety but not excluded), and ibazibyl, cyprocyclylcylformate including, but not limited to, spatiblkk »XÄÜ and dtaxeödmii. C, among those heserodicileoposl among others, but tient kizét ^ lai'bz azeStatblybetrablätökmöliiu! andbibboywallowbuttonsofthebottomobacterialworldsofthefollowing orthefollowinggroupsoftheswitchesCalculus halo * Mlöalktb * M &amp; pk * MároxaíCrCplMlK - * '% aiK «ktlämfeöv'CWÄ CpKKCrC ^! kn), - © GéÖ) -CaAaLiLi, N- [alpha] *, - € <Ö) NM2, TVC.XalkíOamklo · Desire -Nt 1>.

The "betenxííklílíaikllk" denotes a kllbjozös íbötlekbeii dehmäti blkttesöpöttöí, aieiia the alkyl group one or Tolba bldtógessíöutiá lel are according hoteroeikkiesogorttaL belongs b 2 piridilmsttl The "beleaictkUKCrÄlktU-eiöpTOk between pipebsztniletii-i, 4-bteíMsbbpfopy 6 - pfperazMIhexll and other haseulök, Thus, it was found that they had [Ciykil] eb3]; lebet szttbsädtPkbiaö or one or more of the following are subordinated to the following: known, HsbK CcRG <ieíki0am3pö ^ di (€ rCy, alklt) amlno-, Ã £ r

• »(Palkino0) N <<. YC> aKKK pf ^ nd th e r,, MC (OJNH-, M:> NC (OK (CrC4alkyl} NHC <OK« KV> C (, tdkii) NC {Ö) , cyano I, CrC.ailkoxi, CrQlkk HO.C-, iCrC; alkoxy) carbonic acid, aryl, C, CV, heteroan, or Cvcadylalkyl. an example of a fused-to-fused alkyl group to which an alkyl radical is substituted with one or more hydrogen atoms. Examples of &amp; CdCdhdroxIkdkik • groups include

· αι; οπ, -CH'Cii'cdk -Ch ci <'ii: α-CHbkKomahOH, -au ~ i cinci -CH (ee e higher H e homologues. A.' 'ronocyclic m? the ring is a bit higher than that

•: «gytk ring atom heteroatom. It is possible to use the following examples: but not limited to, but not limited to, asbestos, extrane, oxylb * k, pipettes, ptobttibic dihydrofuran tetrachloride, aldehydroylphenyl, phthalidone, pfperidtn. , 1,2,3,6-bst-starboxylamine-11, transhydropyrate, plane, lane, needle, piperazine, bacilli, α, 6'dl <: lro-4lk 1 J-oxazm-M, 4'-phosphate "3s4 ' -dlbydro-2M-k4-benzoxazine -? -; k tlazin, dithiaa and diocab, The cells of the stomach arresting into the dislocation have at least 3 widening. Thus, for example, a C. heterocyclic group can be, but is not limited to, ttxazilran, dtazbldlbll, and diazluteril, C? helerocyclestone stone # ^ oz »oh the other, d # betb zippered in the thoughts of the oxttanH and dia / ettdtntk C'jheterocycloophores Were filled with more than one, but it is possible to have one of them or one or more of its subgroups has submerged the stones of the stone! CrO.-aML halo, haloalkyl, hsdroxik hydraulics (C: - 'C'fîtà îk í î> -, ammoalki! -, dÄtaass ^ * phi © Æ (0} D- (Cr € si1ïik> 0 «> XCr Aaîksl ^? Ymikii »io, 4D (Ô) M &amp;, (0f-CXaIiIiI & & înkiî> - or -NO>.;; or more îluorntmnot tannin · »/ (: (> jx> d torn b: · * imports« dp * M, among others, s Ci "ntd i, (*> C'i, é B <Cy,) ,.

Bgy Ha? Any ethniSs. examples are man, mouse, rat, -ororirosic, dog, maeateg, etc. | cow, pig v &amp; ye lambs, cowboy, so exemplary ,; chimp pivlâtlvagy gon? Who

Aa '^ tloa ssutbeiv sxubsKiíík "Míszjé is a good thing; it was supposed that at least ^ it was worthwhile, at least: s ^ lk'free &amp; landing« 1 »οΚ.λ» μ: υο sau dormitories * N1K-NlbC (Aasktb, -NrrdalkalkylOr AAalktl), -NCrCl3alkyl.) C (O) Cr; - <: ;; dkSO, -'NHC (OKCrC;, <RTI ID = 0.0> yl)} -NHCCOH, -C (O) NHH. -Calkin * A {(>} N (Cr (:; alkynyl: <RTI ID = 0.0> cyclohexyl). </RTI> hydtoxt. Cre <RTI ID = 0.0> (CuOx, </RTI> CrAalkyl. -C {OX> H. -C {OXKCr Xlgälkll), -CXOfCVQalkdk from CVCtriri, C1-C14betaferonyl or CyCKcyclototyl.

Typical "pharmacologically acceptable salts" include, but are not limited to, examples of vfsaklhst and sdkbú oldhaiut, such as acctat, ahmboinm. Amazon or ^ -djaraiuosztiH »« ^^ '* •> dtszsö.fbnaf) szzz <.Μ ^ ίΐ-ΐ0β3Βδΐβ ^ ΐ1 «ίΐΜϊΐ« Ιbönzoát ,: biärögeo-carbonyl blxtntst bp szsslílk öiiartaráí borane bromide, bttttrái, kgfi '^ misie ^^ ádiilrkamxzHáj ffcároft> rszsdfoaát>, carbonate, kiorírk kídits, eíMh klavtiferiáh dÄsoiaiftiss dihidroklosid, tàïimzld% individuals at , edlszlJás ikárofotxzsdíbnát} esztlák Cétfeztdlbaátk éítléntiánbss, astnädi, gltseeglát :: (gíükphsjJtönáí) giüjnStilí, | ikbröbdk glutamate boxaduorföszlát :, hyslirékeídhíák Íbdíobamm XïdfXïfemmtdj hidrokfedds hidroxinaítoát i * # paitóát hydrocodone, AhidtttxiA-mdkAt, iodide, izotlonát C2dndroxie1iosxtihbnát}: lactate, iaíoíbsoidid: 1 antique latMeoBlueBlum, ffiapédütnn, maya, maist, mandoia, mfegl umin: CI'ddKokkl · 'Xyatiamino} -i> - gllcit tnplii meti-broodd, meti-trim, methylstdkit .tnuk, sunflower, nitrate, N ~ -mstUglökstuih mtm $ yurm $$ x φΜ% öxä, pills, panto {4,4 '- mat.ildftbis-i'hydroxy'2> oafo # leaning phthalate), pantolentl, fo ^^ sfis #., Pilplet-ondk potassium * propionate, p-toluenesulphonate, acylate, sodium, staplers sxubacesa, s2W. ^ Ä.mlÄb.l ^ lifeiÄß8P * my dad, tanná *. tetrachloride (hA) -hydro-dihydro-β-methylmethyl-1H-punn-2-dkm s, tert-iodide, s2-anniKi-2- (nfdixiximethyl> t-propanhole), valcrate and ions, salts. "An effective term for snanoytsel is a quantity of brain detoxifying agent of the invention that is effective in inhibiting nVT'OR or POK in a subject.

Certain combinations of the invention include brain or multiple chiral centers, and the ányéb «« «tttttttttttt ttttttázázázázázázázáz? yatytdct is a melting pot, and oaiannttt is also a mixture of tmatdlomerck. Where there is more than one chiral centerpiece in the thesaurus, it comes into play, the guerrillas include the xoindsian binary bosses, they have been swirled, the form of a structure is chiral .. dtftoreomer or racer form. Unless otherwise indicated as a particular stereo la i or isomer 1'On the art, it is well-known to prepare optically active forms, such as synthesis of active substances starting from the thesaurus of the rhino ion or from their optics,, i. activity nutUiiu and therefore can be used for such an abnormal cell growth. atn. Thus, the potassium chemical Peti is effective in the treatment of disorders such as: atnelyekke! the mTÜR order; brain growth is associated with abdominal distension like peidlwl, steriosclerosis, rash abnormalities, $$ rMs, dyspepsia, psoriasis, and prostate hypertrophy. compassion. artglpgsltsizis, Immunology; abnormalities, diarrhea ·· * óg ?gggäs ladäsäs x x x xesesíesesíesesíógógógógógóg i i i # # # # # # # # # # # # # · · · · · · · · töintiintiintiintiintiintiintiintiintiintiintiintiintiinti. verbs have mesh grids and are effective cancer. iRílndm type »solid <lap0ií«: 4s. iifíife Míbnönen iMkIiIi, Mtxax heat shrubs, breast cancer, uterus # ;, psss encephalitis, pssssatarac, lung cancer, eagle * tagworm, bass thymus gland. kidneys, coryorrhea, brain tumor, advanced yocytic carcinoma, slut dyslipideae léidcémi », malnutrition roelanóRKu in the treatment of sphincter or esonium, etc., etc. According to the lollipop! Compounds <RTI ID = 0.0> PB </RTI> looks like bdnburor activity and isxBEffect to inhibit an abnormal cell growth in which PB looks play a role. Thus, according to the invention; desire belts are effective in raising »hb« dé! Íe.fté. ^ pfc. smmiyehk a * Pl? kinases have an effect on abnormal cell growth, "mini example) restenosis, atkszierierzfè, · Äht rehdehenessègek, arlrtmz, diabetes au« topba, psrr / a, jörodoia, prostate iupertrőfne au erud. ·, yradiadas aogiogenezk; inflammation, kidney disease, cancer, etc. In particular, the present invention has excellent anti-cancer cell growth inhibitory activity and has been shown to disintegrate. they are effective in the treatment of cancer, e! especially leukemia, with poison ·;, vaginal cancer, breast cancer, uterine cancer, ovarian cancer, prostate cancer, lung cancer, colon. honeymooners, «walking, gyrretree trees, agydsganat, advanced« kidney disease, and binfoblast leukemia. elongatedCheap) meiano, crooked or esoteric. etc hand-Mass juice.

Formula II for Medication! yasm &amp; coio-active active ingredients are usually fake-in-the-pocketed Jtay, which is a basic vapor-bed liner such as a solid. or liquid pharmaceutically acceptable bait &amp;amp; &quot; and, optionally, pharmaceutically acceptable auxiliaries and carriers, using standard and conventional techniques. The pharmaceutical compositions of the present invention include oral, parenteral (including subcutaneous, Imronexicidal, Positive, and Intravenous), or nasal orthodox. Thus, as a solid carrier, the composition can be placed in a hard gelatin capsule in the form of a tablet, powder or peilet, or in the form of a drug gel or pastilles. Λ a solid support may include conventional excipients, mini-grade binders, fillers, tabiale flakes, disintegrating agents, wetting agents, and so on. If desired a liquid carrier is used, the preparation may be a suppository, soft gelatin capsule, i. e. In the case of a stomach with water, the administration is carried out by the administration of the present invention, as well as conventional &amp; native materials, waxing agents, ointments. non-aqueous vehicles (including, but not limited to, oily oils), fatty acids, and / or silicones: and / or screens. For paroherapy, it is usually sterile water, with a mixture of salt, salt, succulent, glycosidic acid: similar to spearmint, andthepieces, where the usual suspenders may be used. Ordinary retardants, putty pellets, and similar pellets were also added to the paretal dosage regimen. Particularly useful is the direct administration of a compound of formula (ti) in parenteral cysts. Λ pharmaceutical preparations; we use the usual ingredient, i.e. the active ingredient, i.e., according to the formula (I) »combine appropriate amounts of hiving ready-to-use &amp; m) ánsd example * Semmgftm; The Ssien «®; mwl Pm $% ® of

Phmmap · M. 1¼¾ Miteux -MD: Upptmon Error &amp; amp &amp; WsikmspÖÖö), Μ 0) injected with chemotherapy effect. ip: iWiA Inputmmmm 1mm> $ MA Chaotic Esmoma Activation Activation Snon Set; the; the particular compound used by the user is the particular disorder or sbetee in question. Azrm ii ^ mméWk tÄfbk, leaves; treatment and reflection of the given combinator * | Ózi # t tbtMtbk unitgame and the relative level of activity and relative activity level of the activity -iç © ôfe3F ^ Î: -: d <* ^ - su. ái $ Μΐ f ^ Él MÉM8 «âay * wtfn &amp; Âskfét to the circumstances: höZzéliAt the following: kt et ïesilptation of the life of food

Ep i) take pictures? or a suitable dosage form of a pharmaceutical composition thereof is one; :: «work ^ ;: tä &amp; tt ^. ^ T« ^ # g ^ iÍiÍ'M # Skiing «is suffering from a condition or a reality: i wb &amp; gp% M mg / slit .10 mucosa For intraperitoneal administration, the dose may be a) 04 to a wide range of 1 mg / kg body weight for intravenous administration. For fkm lis fvados, the dose may be one dose e) | avg% Weight kg. $ mgdistributor in kg range The active ingredient is dosing the same dose, but it is usually given here, and 8 doses are gradually increased until the patient is treated with the optimal dose.

However, it is self-evident that the amount of chemotherapy administered by the octopus is determined by the disease in question, the selected compound to be administered, the frame of administration, the age of the avion patient, the body weight and the weight of the patient. ·· with winter. The chemical or pharmacists of the present invention have an amount of acceptable salt of Heg. which inhibits active mTOR or FOK in a subject. These stones have an Armpm or M Carrier Water Label and a Label to Determine the Optimal Dose Range The exact dose to be used may also depend on the type of administration to be treated, and how much to be treated? kÄpilie Physical Injection and Non-Liposuction Surgery: Based on Meaning, Equivalent Dose Rate »beadbatmtfe: kilidnbdze in the intervening period, but not exclusively for about 2 hours mmiep AiräphÄ about &amp; Örágkétsí. about 12 hours per hour Mntep M per hour, about 36 Hourly, up to 41 hours, about 72 hours, we «l # ^ eh5hkÔÇ: Âegyikéfc0rié ^ Pnee every three weeks, minipep tern: Also nintt ^ y two-month spy, Dose number and frequency for a complete treatment course the opinion of a health dwarf is decisive. The effective dosage amounts described herein are consistent with the total amount administered, i.e., several of the compounds of the invention or pharmaceutical compositions acceptable to Midiik. the effective dose> # quantity refers to the total amount to be administered.

In one embodiment, the tailhole serine compound: yap pepper mixing salt is administered together with another active ingredient,

In one embodiment, headlmUmk is an effective amount of a compound of the invention and a pharmaceutically acceptable adjuvant, and is intended for use in the present invention. The effective amount of the sky in additional active ingredients is well known to those skilled in the art. Vv.to is a specialist • m ^ iat # oÂî: ».; ^ Â: Plastic: -« ptipàijs. :: fe ^ iôS-meônyt.? Skyen: mAbmigyir. A compound of the formula "or a herbicide" is an acceptable salt <RTI ID = 0.0> ofthe </RTI> syllabic effect of Sycha additive or a npgvaidxMst modAzgtsi azmoigiks. mtm abhadM case type mSm a: other active ingredient mm tidjilk he> In this case, we should be able to bind any of the above substances, it is believed that the chemical or medicament according to the invention is a "ii" g &amp;; dlsat6 salt and the other hystoeapig synergistic effect

To (1); The following examples and rederene examples illustrate the processes useful for the production of Ci chips, <n 1 - ¾ mv.kcimazHrho; <k Otsaosm: 1, Reaction to frame:

In the specialty? fhHsw; erk :: b «g) · j-T Reaction Schemes for Imacid Glycol &amp; Time (s) according to the present invention: 0) DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS.

The following hhtij: Ä $ Ä'hitsztiSfjuk; and c c c c c kel kel N N N ések N N N N N N N AC N N N N N N N N N N AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD Dimethimimmhidate, DMF well-being KhN-dnethylmoramide, OME-F &gt; M &lt; + > The PovvihetmW is a mixture of CdH1O and dleniboxide (CtsH2O) '. Ikmthemri ** is the trademark of ôow-'ôomtng'CàsfSQS ^ ïoa. -hydrosytePt-β-piptazinetdns ;; ulib; nav, GMT means Civeg. Huoig base means dhzupmpsbetylsolir, HPLC is sggyeyosndsCi liquid chromosography, LPS is lipopolysaccharide, MeElbl is acetonitrile MeCM is methanol. MS spell 'tnmopspcUu'metní ·, M u ^ elemese triedkamln. NMR type magnetic resonance; PBS stands for ptJÍ &amp; salt solution tpH-7.4 !, RPM! O is a paw (Stgnm-ARSrieh Cotp. St. Louis, MO. OSA), ADS means dodecyl sulfate jp. Lnrnsd}, SRi is Sufforhodeam 1 ;, TBSCt is tetc-bnaidmdddd-kforide, TCA is represented by Ädrecetsasy TFA is triththoretic acid , THF signaling teMbjdtbtbmk 'TtG means thin layer chromatography: and TRik stands for Eisjbidrexi-methyl) annnormalate

OF MATURITY

The ali3bí; e | games are a combination of the images of tj) and the eloquence of the examples of spoofs. The following examples and examples are exemplified: &lt; tb &gt; and mm% itÄfeHfoy · Serve to limit its scope.

1. RgÉreProof; t-f4H4A-dlosnrfoliss-4-ht 0, d-trfazin-2-yl) -d »-3-pirtdi * È ~ drtlkarfeantsd Step 1: Y-clerO ^ d-O-mnldlh YoursAlternatIonLiLiLiIlIlIlIlIlIl

OamsAklorld! (Ifoig, îômmnlj peton with Tidd mlj and glacial ice, a mixture of triethyl annu (30.0 g of a small amount) and morphine of Cl7.4? -C-un. After the addition, the reaction mixture was washed with water and 50 µl of white sardine and white water. Waiting to dry the solids and leave. Teas and TsiillO yEs of the raw teep &amp; tes y o f ^ fel fel fel fel fel fel fel fel fel fel fel fel fel fel fel 87% '(Ml-Hi 280.7 1 Step: «lia 2-fetrrt4. - dM« ^ (M-g, 4.9 mmed), catalytic amount of scintillation · · · · · · · · · · · · · · · · · · · · · · . «« (Fi) (? Mg, OM 1 mmol),% M n-carbonate-octyl (3 mL), A-atom, bonmic acid - pSmd <ol and: &gt; 1.6 g, 73 tmmtm PMI É0Ö m!) throw it back through the cooler 24 of ours. The% %ίρ | βΙ% of azdid% z ίρ | Λ Szetieti vfezéi (200 mi) mdaSrik and its organic layer: oiapezium-ssSfattstS szárfostok. 1st filtered and the solvent was removed by evaporation, and the mixture was mixed with si .. ic öä fer iat fer fer .. t ö ä ä .. .. Ä t t t si si si si si eet eet á á á. There was obtained amorphous solid as 4-fluoromethyl-4- (3-yl) -5- (5'-pyrrolidin-2-yl) pyridine. {> 1 * 11} 343, 3. Lèp &amp; K i4H * y * M *È4--È Mr Mr Mrikmkmkmkmkm44444444444444KKKKK: in in in 4 4::, ,34343434343434343434 (((.. .. 20 20 20 g) ) made with methylene clone (80 ml) Oö € ~ ert (nibszgén: ίβ ^ Μ ing. 0.04 ai («of> · #Mimeîïammt (3 0 ?! adsunk, the edges of 20 edges - (mm mixed, and -Aromapimine (0.10 g of 0.8 :) mmd) was added to the reaction mixture and an additional 2 median was stirred at room temperature. The solvent was evaporated and the residue was subjected to HPLC using seesmfoTij / TFA as a mobile phase, 90 mg (303). Yield: <RTIgt; 444-6ylimide: </RTI> <RTI ID = 0.0> b0n-4,4,4,3,5-mazin-2-yl}; </RTI> <RTIgt; Method A: Preparation of Carbarnides Using Aryl Exoxylates: 4- {4 / 4I> Ireactive (OAO Imiml) Amount of MiaMkus: Dimethyltin glycine (DMAP) Foil Chloride For 100 (ml) of Mixed Solution in a small excess of aryl. (0,6) sostra): The reaction of the reaction mixture The mixture was shaken for 44 hours. The RsakefedsS: the original, volume was filled with diatomaceous earth and ten mashes were collected by filtration and washed with: methanol (IS srdf, then dfedl-unefrei). In rare cases, the hoe is a crude walnut strip with a crown-like toothpick on the back of the solvents, depending on the polarity of the products.

Here are the following:

2, Rdorendapékia; i ^ 4 ^ 4 | he ^ ls »orfoll« "44bfvJ, S4flsstítt; * 2" 8> fesi || í | yÍ! | | Dimethylquinol-4-yl, 3,5-triazm-O-Syrazinyl (0.08 g of 0.23 mmol) and 3 µl of dsddzodanate (30 mg, 0.25 mmol) in dm: your serial mixture was added as a white solid. The product was subjected to silica gel column chromatography, eluting with 1030 MeOH: ethyl acetate, Yield: 00 mg (50301; M -: - 11) - 403.5.

4th-4th anniversary of the "-44SHA5 - H mzm-2SS) 0min ^ fenllksrbS)" i0 4 (4.6 - l> imMMr "4'-11-l, 3,> - sr! Azin Starting from (d2) saniline (40mg, 0.40nmd) and fattyMododate (? 2: tng, δl, rolol), according to: dm, was precipitated with a white solid, the products of which were purified by silica gel column chromatography eluting with ethyl acetate. Yield: 0.128 g (68 *) M-1- (1) - 462.3 4. Reference Example: ~ ~ f4 ~ (4 * 6-45 »Kmilm-4-sf-1,3A - S -2.'Il) aryl | -3-strain - 2 ^ Teflon sdd at 355 [mu] mMgg $ $ Ii ($ 6 (5mg, 0mmol) and JdiciHydro mg, 0 * 14 «» «1) khmkifea; the title of the title is different as gray solid silicon sulfate # teomatoblasts:« Ä 5% etM- & cet (yi »et« 6l!; * i «curve Yield: 2 wg <i4% ^ (M · · Η>" · 4? 0, 6, Refereeciapea: 1 '[4' (4,6 '<Haa rfoÜ «-4-yl- 1 '(2'-yl) pentyl-3' - (4'-methyl) -1H-1H-4 '(4,6', dm, dhv4HM, 3) .Smi &amp; zim-2-41) anilmhöi (0. 1 <30 g 0.40 mmole) and: <RTI ID = 0.0> llffft! </RTI> supernatant C7Smg, 0.56mmol) the sgeOots compound of the plunger was separated <0 white matter matter. Yield 65 mg (33%) 470.4 6 Eeifer «ocfap $ 4a: yyyy *

The oil is 4444 µl of imiol-4-β [β, β] xss-20]) (0.140 g of 0.40 mmol) and 4 α-morpholinyl (S3 mg, 0 oC) of crmduha t (α). 'yield' is the title * veæyuietet Mlcntictum: ell or white stardard material * (MH i) · 480, 3?. Elephrate (434 µmFik3 *444 (ife (4ÍÍmmfe |888HHH k k ^á 44 444444444444444444444444444) (0:, 140 g, 0.40 gauze) and aif: xt iso i iso ema ema ema ema 2.4 2.4 2.4 2.4 2.4 2.4 2.4 ái ái 2.4 2.4 ái ái ái ái 2.4 ái ái 2.4 2.4 ai ai ai ai ai ai ai ai ai ai ai ai ai ai ai ai ai ai ai ai ai 52> · · · 522.4 &amp; rafferfilter HC4 ^ kiOrfeail> 3-f4 <4fed8in6rf »UB-4 ^ sb150, S &quot; iH8 &lt; 15 &gt;

Aging 4-f4,6-DtmorfWm »4-lh 1A $ ~ triaz @ 2dl) antimN> 5 (0440 g 0.40 mmole) and 4.kUk4enlir (Zdsia # b0i (04 rags 0.61 mmole)) Yield: 60 mg (30%); <> * H) 406.3 9, Reference: [4 »(4» 6> dimorre! in> 4 <-iM) Preparation of 3t5-> tricycl-2 * ii) Feyl <RTI ID = 0.0> vv (1'-dotifene) </RTI> kdrhemld; 44 µl Horforphol-4'-1 · 3, S-iri zm-2 * iigtntienhöi (0.140 g 0.40 mnml} and 4 mciolytfernz z oo (s) (01 dig, Ö; 0: 3: mmoi) The title is SzcriuO: kcgyhisiéí What imite »ok: el ya # solid amp! (ΜΦΗ) ~ 402.3!,, M m lai lai lai>>> id id &:: lai ((((((((((((tm tm tm tm tm tm tm tm tm tm -Hloroine "401" f> 54rzfn-2 [mu] l: anisole <0.140 g 0 * 40 mmol) and 4-chloro [alpha] 1-ol (94: mg, 0.01: mmol) of the title $ Zeri »E« fs: IOÂiedll and white solid (6096); (VfeHV ···· 496.3 11 * Sm Example: (2,4-dichlorophenyl) -3- [4- (4H-trifluoromethyl) -4- (4-fluorophenyl) -4- (4-fluorophenyl) -4,4-n-5- (4-ol); ), starting with 0.30 mmol) and 2,4-dichlorophenylisectanate (7 mg, 0.45 mmol) from the title compound of 40 mg (27%); (M a · H) - 498.6 12 - Reimmmdnpekhr: · Calculation of H4- {4,6H-quin4c4m-ndM-15-thiazine-2-yl) -fefdl-3-eidarfeamM Jp, 13: 0 g Oifmmo )) é% etH ^ iasieiaaâtbéî ^ 't ^ wgj. - a surplus?> en veil volume} read the same thing: kOlfto &amp; dItök et white s yi, jfeysgfeiifi Bozamt 38 tsg (.25¾¾ (MW) - 414,4 13, Refergsreispêlita; tia'e ~ H5t {t ~ 3 ^ f | 4 ^ 4- | {(4 in 4rfe «ut> Uar5; the <4M" Ski »ihsu} above0P '? 'tt »' ^ I ^ S-trfexiH ^ - 'iliLiMeXiEtIoFeFeItItIon 1, Step: L4-4sy â - m <irfoîâsâ-' -ii- '| t, 3,5] ir:

Garyú-klorki (18.4 gm of lemmmoi) acetotirud (100 ml) and crushed ice (300 g) was prepared by mixing with truffle &amp;amp; (30.0 g, excess) and morphine <8Jg, 10 min? } a mixture of GOFE'-or .4 · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · • • • • • • • • • • • • • • • • • • • • • llozamt;} $ .g *.? W &amp;> (PAH) 234.4 2, Step fere-b «íSL3- <4- k-fetiorCollio - L3 , 5'Fin8Ki {t-'2 ~ 2 ”llamtito} as« tldíi »Archive« rhosifet 18-21 ^ (23¾ líkmínöí) scefönsai (50 Pi): #s road ice) k ^? Ölt '.' K. Ä Ä c if - ä:: - - - -] bo bo bo e e (((((((an an e e an an an an an an an an an an an an an an an an an an an an an an an szilárd szilárd szilárd k. The product) ^ àfftôîÂês.-itfít -'- 'ftèl- · kdlMiÄ40väb |: alto ^ tosß. l-fezain: Opg: (8: iéi | y (M ^ fe) 373 3> Step fere ~ Dilution of L3-LL (4'-4sylsubstylacetyl-L3s-lfktn-4'-l35nin «} acrylonyl-Lkarl5XXiide

Tetefe - 3 (4: 1: 1: 3f: S ~ lysit5-β3-β-amino-3-carboxylic acid; iodine (Wfenitfine) (0) xylene (78 mg., 0841 mmol), 2M (3 mL), β-siribipefyl butyric acid (8,97 g, 4). , 5mmol), DML (180ml) is added to the back of the back of the dorsal fins, 24 hours ago The oyster is evaporated and the remainder of the dehydration is carried out by CelherM crosses! (208 od) was washed with magmazifm-silk-trees, plowed, filtered and the solvent was evaporated, the residue on a silica gel column using ethyl acetate / hexanes (1 µl) in elaensen, thus yielding 0.86 g, 161158 yield). -3-4 - (4 - [- 1-am) nofc] [alpha] -6- • Ttforfollro 1, 3,: 3 «8i'aäm} ~ lÄmlao) azetifcl- arboxiMtöt g. (Mr.H> 428. 4th step ttU'e.'btitíl-3 ~ {14- (4 ~ (l (4-i1 «old_leaf}) kzr8aí! -Horfolíu - 4 - ll ~ L33 -triazfff * 2 '· * H | ammn} 3zeiidm-l ~ é {aé &amp; ft5

Tert-butylG- (Ρ 'ρ ~ 3®Ηίο &amp; 8ΐ1 | -8 ~ ®0ϊΐο8ο-4- · Ι1 "1,3,5-Triazm-2-} l] ammo} azeOdio ~ l-ki« nxoxane (100 mg , 8.25 mmol), 4-fluoro-1-isoeyanate (63 shirts, 8.44 mmol) and DMAP (5 mg) were stirred at room temperature for 24 h. At the end, the reaction mixture was purified by ACI / vtz and Gilson HPLC. White PA, Yield: 48 mg (38%); (M Hl) 545.6, 14. Yield: tert-43-l-3-yl-trifluorobenzyl-4α- (4- | ) ai5iiufíífe5Síl} - L3, á ~ trsa7ÍS "• -2> 'S?) 8m roulelelfi H gr gr ^ ^ ^ ^ list list list list | ása ása ása ása ása ása ása gy t t))))))))))))))))))) 8 ', 3' nylase-2'-4l:] amo) octyl-5 '-carboxylate, 40 shirts, 0.32 romol), phenyl / ocisane (58 shirts, 0.40 smnoi) and DMAP (S mg) was eluted with &lt; 5 > -THE. at the end of the day, you can use the following: Glyon HFLL: Refill with AGN / vlz and ΑΓΡΑ Apply Baker # Solid: Material; l-lotion .40 rag i G AO. (VI-vii) 54 A4 $ Ê> <'WÊÎkvmsi% pèlàm.> 0 # *! Ό ~ ΐΜΙ} η Msp | ^ iiyi8 ^ S "í ^^ feéxiy · F [4 - {4-am »lbrn! • »j j j j 4 4-----3,5 3,5 3,5 3,5 3,5 3,5 3,5 3,5 3,5 3,5 3,5 ho ho ho 49 49 49 49 49 49 karb----karb karb 49 49 49 49 49 49 49 49 1449 (70 mg, 0.58 mmol) and? MAF? L (5 mg) kmnhdv. Λ end) &amp; Reactivities are:! ^^^^ pumpkin and iÇîiht! «. f $? li £ AV #: È: i'Oi ^ firewall Using € H / vig and: 3: EA. Breaking solid nail; Meme-M'.sg 123%); (MtH} 548.7, for cint) vegvnkrtel tertiary> ui3 ~ {4- (4'Sininof '))) A-nirr <i>) - 4-ii ·.! ..: kS.tr! ax; ti'2-kj; iti) i; s; o} ;: tsstit. (130¾ 0.2? Trstnol); (40 mg, 0.30 mam) and DM A P 3 5 mg) were stirred at room temperature for 24 meals. The End) The Reaction Thing Is Awesome ·· Is Iák And Güsm? tPt € is also an officer for ACN water and IFA Aikaktzäsävai. White solid; Yield: 85 mg, 4, - <0, AH II) I7i Iinferencing gel::.!: ~ | 4 ^ 4> (8 ^ t ^ 8> 3> i3aigí $ 6jN ^^ M ^^ 3 ^^ 5 > tr ^ »^ i || f ^ 3} |> <^ & á á urea dieting 3'era-btí (t03-ft4-íS) orfbsíti-4-) Oen ^ Í44 (see? 1ká ^ m 3a.n5Si30SiIi, 3iAnaNm2 @ 2 [alpha] [alpha] 2 [alpha] ([alpha] H5 -kk-Höffooxifen 30 mg (0.955 rmmoh DCM-med pOml)] prepared as follows: , 5¾)}} were added safesulfite-brine and mixed for 24 hours to end A)) the reaction mixture was concentrated and Chlson HPLC &amp; sOOkj AGN / batch IFA. Yield: 20 (333): (Μ · ß · Η) 447, 10) I? 1 '- {4- [4- (8k &lt; 1 &gt; 10Si] &lt; / RTI &gt; 54ktsstmo} -O-5-yl-4-yl] -L-5'-14isia-2-olis-O-3'-othlkl , -!) u'fl-> S) t '. ii t. (4 '| tg «rJ)«' s vrhammrsmmík'iknsl 5 .'Λ4τ38ζ?: «- 2- •• ADartífKtlüxetsíH» *;! - fcartmxOat 30 ms (0.05S mm »!) OCM * mel (20 mi): blended temperature of T01 (1.5 ml) for Bdmrt:; · and for 24 hours (for each end with a Foam and GiisonFIPLC board, using ACM, 'water TFA' Yield "M% h | M · H> 448 .. 10) ^ iffereadapekts; 3 '' | 4 »| 4 ^ Ca ^ (i0! As54 | k) s) 5) 3ta) r0'-mii 1ib! L« '4'4! ~ 1 »3» 5Ai4sit * -2 "0 | (e» j |} ~ 3 #! "I!« Er '·:! Eol!

Ibre-íntt 11 -3 | <RTI ID = 0.0> 4'orormin-A-1-O- {4 - [(4 &lt; / RTI &gt; -4,3,5-yuan) -2 ·, "lO3Si: t) opz | dtt) -1-bösiM! 30mg (0.053mm!) Of DCM! (20 ml) was added TFA 4 (i, 5 ml) at room temperature and stirred for 24 h. The reaction mixture was tbménvik-ttOk and Gilson HO!, (1 with AON / water ancestral IFA. 33%); (M i II) 465.1 20, Reelerel; I "| 4v | 4v (rt» immís »F6-mt> rm>! M» 4-lFee3j5 »lr! Azja-2HI | fen! Preparation of 340 µl acetylhydroxide

Ieax'4) ti'3i '(4-t) mrfo! In-4') 1-6 '{4 -! (4-n) e4il4enlikat4> &amp; moil) an) ino]! Bn) U 'l, 3,5'trlazine.'2' · - ii); 30 tng; (0p3 mmo!) PGMmm! (20 ml) was added to a solution of TFA4P, 5 un. At the end, they had their seaknlOeiefyei and their Giison HPLC! swimming pools? gardens using AGN / water and TFA Yield; 40 (..>?%); (M iH, t 461.5. 2L Refercaciaptdt ««; »Γ» -0η0! ^ Ν || ^ 8ß0ΓΜΐ8 «4-) Ι ~ (Α | 4" | (ηΙι ·) 4ί «^ Η1ί0ίί0» ΐ »ο 1) η) ηΙηί)] 1όη1!) '!, 3,5 ~ Shut downp2 -0 .05mM (0.4mol) of carboxylic acid (0.4mM) DCALmei (100ml) ; keyed sldaÄoz ÿ%> m triipsggdti: (300 «* g);: #. tripitLmmni ·: (3 ml) is added slowly. The reactivity is 15 grams of yolk thistle and 4-amtnopmdia (200 mg, 2.1 sotettl} ab) p «k Irnzza, the reaction mixture was bubbled through 24 volts and concentrated at room temperature with cold water: quartz crystal; and: m. 100mg (40%); (MtB) 548.6 -4Attar5 «« l elMliSee ΐ%! Π ^ ΜΪ ^ || (4 ^ »Γί0Η» 4 * ΙΗ * ίΦί (ΐ> ^ 1η · 4 · -ί1Ιί ^) 8ß »0ΐ1) ®Κϊ®ό3 &amp; ηΙΪ | -ΙΛ5> ΐ3Εω« * 2 ·· 4i) amyl] azeolinium srboxiate 40 tog <0.073 tmmol) mixed diodextract (20 ml) made of DOM atc (20 ml) ) mk room temperature Os os 24 ek végén végén végén végén végén végén végén végén végén végén végén végén végén ils ils ils ils km ils ils ils ils ils ils ils ils ils ils ils ils ils ils ils ils ils ils ils ils ils ils ils 26 (81%); (M * H) 448.5, 23, P, <* fer <ïîîcis | 3e purple l ~ f4-β4 ^ ® <they441, 0- (8-thiocyclopropyl, 2Lact ^ HHLAS4silase-3 *) '41jten II) -3-fers) Preparation of Echo Bridge L Step; 3 ^ 4 ^ 16? Preparation of? 1? S? Tr? 1?? 2?? U?? -? 8? 3? 5? > 4-yl- (!, 3,5) tzzb (1.5 g, 6.3 mmol) in a mixture of wetm / zâwfà ice · prepared for mixed suspension «• Oxs-S-azabidkiol 3.2.} $ #« ((5 * 80 «% t | S tntnol) and liiti-stmistl ome) adOatk and; at room temperature for 6 hours. Λ at the end of the non-volatilization: &amp; ytigot: styrofoam and: with water tsiöstofe, A ιψΜ product enough they were found to be clean for further mammals, Mozmn: 2 <og (99%); op, (Hk (M-HH aiOil 3- Step: 4 '| 4' '} warff> bo * 4-S'6 «(8 'Osta-3-azabiei {ftl3.2.1 | οΜ ·· 341) ···, 1.3, $ * zzie ~ 2nnam} }M (sasa (((((K3'' (4 4 4 4 4 4 4 4'-(4-K3 -'6''mvrfoHn'4-yl) 3,5'4TÍa? T «» 2 '> l) "8-e> sa ·? ~ AzabiciPiIlJOK (2.0g, 6.4mmol), I have made (irii'et6itosilrä) palitalkite (0) ) catalytic mcunyicitye (090 mg), 2 M sodium atoms, 5 Logs (5 tol}, 4 »· 3Μΐ6ρ (εί; ί10θΓυο ^ ίϊΥ- · ρΟκί1οΐ04ϊΖΐοΓ <Î, 5 g 0.4) · · DM5) (200 mi) blends back into lmt6: I am scaring &amp; ou · we've been burning for 24 hours. The solvent is evaporated and the ataradéM.MmMMt ^ Mixture: MoidotOsk and CditeT ** - eo ; water (200 ml), washed and cagpasic sulphate was washed and the solvent was evaporated. On the silica gel column of the silica gel, we have obtained mycites (up to 1.4 g, 59% yield), m.p. 154 (Me H) 369.4. 4'-4'-fluorophenyl-4,4-aza- (8r-oxa-α5-azabibib-3,2H) oxy-3-yl) -1 ', 3,5-yl] azole (120mg, 9.32) mmol); A04 / water and., White solid, mp: 242, yield 35 mg (288 ·), (MH) 488.56 M, ReferanteBelts Í44-l8t> rhead) -3 »j4>) 4'Htrphol> '4 ^ 1Mb (SKtxa ~ 3-azttbleíidö | 3,2, lji> k034))' »» L3,0'4: ríazín -2'lljte «llll4i) ij b3mk! The final size of the title is. 4 - 4 - mortb {m - 4 - HAL ({| - - ^ ^ <- - ^ ^} - 1) 3y $ 4ria &amp; im2j - blast mg, 0.37 ruins) * dvilapt (ηi | i: 8delg6at (50 mg, 0.36 matte): «S DMAlAisdl (5mg) kimdmvtylspr t Oresyl and their Gilson HFL? -sulfates, acrylics of ACN / ViA and LFA, white sieve; op: 248; Hbdtmt: 86 mg (86%); (M + H) 506.4

RefereselapStóa; IJokLldÖO- «(, 3 * 54 Hrd« £ ~ ttj l »p} kar bsiaid dOklÄs» The title SKCsMi can be combined 4- Í4.nκírfoiir ^ 4 sinSgBmjia-Iv-sxabkiklorj.S. I lokt-3 ·· !! ) -! , 3.5mw. «V2- -fl ^ pgfcbèl (100mg) lightweight, room temperature.« 24 hours a day! stirred. At the end, the reaction mixture was subdivided into aliquots of the ACE / VFZ and the TFA mfcdmtesav 1¾¾ sgard appg 'op 228: Yield 80 mg (80%); (M ~ H) 502.4 Demonstration of the 25th Rder of the Beast? · process; following these 26-32. relkmnskpéîdâkbaîvlsmerte- · ïclkvëisôieteksî?:. §2. RefercKdapêkla; I '; 4' (4.S <1: rIl-ox3-3--3xablcík> | 3, .2, i | s> ki-3-! Lß »S ~ lmKl8-2} fea! lj-3 “äSK4! l · ka Hm mid (M dl) 452,53 27. Rddeisdspériîiî 2 ^ hldk8xlel: li '| 4« (4 ^ Ss »8 *« sa »3 ^ a ^ k | ^ (44ds ^ 3 * * 24i> é .d ij ij ij át át át át át át (((M M M d d d d d d d d d d d d d d d d d d d d d d 0 [alpha] -phenylacetate (k 1 -H) 612.8 29. Example of Refems; iApp *? D? D? 3? A &amp; &lt; / RTI > ((ephemera), pp ~ ~ 34AA4, SmPiPova-3m; «bidkkÍ5.2 <1 pskt-J-iddidrisHn-S'- | l} kHOIfesdms IMi -M: H) 478.55 3 | Í ") 4 - {4,6" [alpha] = 8o: m ~ 3 -Other €) kIi3,2J (<k6'3-4k ^ 1, 3,34r8: rl: »- 2-0) 6; HO] -3 - pjrSdÍK ·· -4-ilkarbsmid (M vH) 515 32 »Re covered ela púid a: i" | 4 - (4, S-0i ~ 8 "<ma ~ 3-'ai: ai0rsk 18 δ 3.2, δ6-13--43, S-Irish (α-′-2-yl) α (β-β-β-β- (η 3 -Syl) imyl) pyridine (Μ) ; Η) 344,6 33 »EcfëresdaiklSâî 4 ^ | 4-s« or0simiF> iF643 »fs> # is ^ 0Idktep ^» llö kk ^ l ^ IJ, g-'fdsÄ22 >> 0 | 8slm production T. Step; 4 ~ (4, S ”<HkO) rdv3.5 ~ s4ads» 24h18t8rS4i &amp;

Clsleclon (2.5 g, 13:, 5 mmol) (ί14ρ | -Λ®: 1 (160 ml) Mfi? Sldakhsm esespsßkcnt morfblM (1.14 s, 13.5 mmol) was added after -28 ^? Et! Nt (3.0 mi, 21.6 mm!) Transmitters week. The shabby rcc: -? 8;> € <m was mixed for 20 min, diluted with mslclclfree. The organ phase with water and sddd and MgSCV? The solvent was vacuum dried on a plaster, so when it came to shedding, it was given a crystal of Siberia crystals (5.027; § * 9385 yields ^ 2; Step; 0- (Ρ ^ Μρ-6-ρ0Γ6> ΐ8 «δ-1) , 3 ^ 043κΐ8-2Ο | (»3-0Χ8-8-ρ ^ 0ΜΜ {3» 2 »Ϊ: | 0! Ϊ́ΡΗ szsatédsc 444,6-0 liste1 .3, $ - irishin-2 ~ yl) moriblm (2 , 34 g, 10 each) to a solution of CHjCO-smi (100 mL) in 3 parts - 8? 8? 3N «t (4.2 columns, 30 mmol) was added. The reaction mixture (room temperature Mea was mixed with a slurry &amp;amp; amp., The reaction mixture was boiled and salted, and MgSs6 | (-im dried). ptotmk »so get the dm compound to get styphthyptagkdet (3.0 g; 96% yield MSi!). 5, Step; 4: <4-morphopyrrole-4-yl-1 (3 &quot; 8 > a > 0-8K80k! KI (3,2,1) oxy 4od) &lt; 1 &gt; y: -lOtskes - () 0láb8: Fépin »ÍiJk ik .i> Í4kléí ^ S *» «Km (O: ILN»> L3, SAria2m''2'iL «3'UNa" Sa "3Ínc} k? o [3.2.1dilyl] O (3 :( :) mg, 1.0mmd), 4-oo-neofontorbic acid t328mg, 1.5mg) P <i (PPhj) 4'158mg, 5 mol%> .JM-Dimethoxy (DME, 2.5 ml) and 2M Nal: <vim solution 0.5 ml) The resulting blends are VM0 - «; î heated in Mimiig microwave oven. <. «) Bah6hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh. mgt'ttdeliot undergoes MFUj-y rivals, so that it has ephe xsthytefiltercapitalisation »xyllabelheaver {288mg, 789¾ Imsat«}. MS (.BS.O ro / x 399.2. 34 <Hide exemplary 3 ~ k ^! 4- ' SHirfoifS'-4'Si '&amp;' | 3 '<ïxsi-S ~ i3 «Abschik> K5-2 <l |«> kt "8-il) - · 1.3x S-trksa: iR-2'-5i | ~ Îs- ^ il ^ piddiâ ^ lïl ^^ aiiâ idi 4 »p-kÎëaiOiiM'îi" 6 "{à ^ ôSa '^ âïâfeicjkioi'3.2.1] oct'8A0OO , 5 µl (22 mg, mm6mmol) of Synthesis &amp;amp; Et, <RTI ID = 0.0> &lt; / RTI &gt; N @ 05 05, 0.13 mmol) and in &lt; RTI ID = 0.0 &gt; &lt; / RTI &gt; reâkâiéêk ^ i ^ "3â: obâhâi ^% ékïa 6n Í S pemig mix and d-ambi ^ pftÄÄM3? today. OJS romol »to / from A ?, albg ^ ers ^ #) ^ ^ | Wat« «« «« ük ük ük y y y Az szert szert szert szert szert szert szert szert szert szert szert λ λ λ Fi Fi Fi Fi Fi Fi Fi Fi Fi Fi Fi Fi Fi ís ís ís ís ís ís ís ís ís ís Dimensional yiiiiiii s liAteBiAte rEsTe sTeS of 1TFA. s », 8.8 mg, 245¾ yield). MS (ESI) tsO 489.3. 35, Rhythm Deaf: 4, [0444-ya> rfii3iV'4-4l'-A '(3- «s: a-4 ~ shi3.2.i | akOi4i | y> 033" ei'mdm2 "ii | * & g il j carba romi) we have the following methods described in Example 34, as described in the following examples: - 4 "Α-8Α5 ~ οχ» - '8 ^^ «9ίοίΟοΓ3, 2.? | I> kt-K> -1.3.5-Arkädn-24ijäm ii in (22 mg, e.o. mnmi) for tritos »(O mg, 0 # 6: * nmel> and Aramroobenzaroid (23 m (¾) by reacting thrombi j with the title vinegar as a dirty white solid (10.6 mg 3.1% hoyapt). MSpSt) m / x53l J, 34. Mefereneia example: I., | 4 '| Í'ísi (> rA4ia) 4 ', 4', d '(A' x: aNka: arad: n44kii3.2, pp) kR8'4i} -O3 '- (rhyla-2-4i (, phenyl) -3-pi? Sd ß «-3- ii ka r ha sashaiMiifi digest of the method described in the 34th thesis 4, 3 J * mazin ~ 2dl) amlin 02 mg, 0.06 romol), tritosene 08 mg, 0.06 ruol) and 3-ro: smoltsite (i? * og, (i, 1, 1 mmolI reacts with the cim s corn vOgyObet SMfgpr ^ | ^ p ^ ^ ii: Ma; yi. 14.8 mg * 4) \ t M S (ESI) m / x 489.5 37. Eeephenolipid f, (4, f4aXyl), 3-J4, j4 '' KaiolljX-4-4-6 - '(3'-tys-8- sm; abialyl3,2.i.-yl-k-yl • t, 3,5'-trialyl-2-4? 0Snyl | cis> aRisd coupling The process described in reference 34 is a compound of the formula (III). 22 mg, 0.06 mmol), trifbgene (18 mg, 0.06 romol) and α-fkotanil; 09 mg. 0,] 0 minutes) reaction time. $ m sxsrroo compound (14.8 mg, 499¾ irosani), MS (ESI) m.:.r. 506.5, 38. Eefei'ePsiapllda H'Mbidroxi »» elii le8dj 3 ~ (4- j4 "m) Preparation of? 8? Bn? 9 -I? 6? (3? And? 8??? Pp,? 2? I? -8?) Preparation of 4,3,5 ~ tmvist-2-yl? based on 4-β-methyl-1 H-β-β-3-oxy-η 5 -beta-cyclo 13.33, i) oct-8-yl) -1,5,5-iriazyl-2 'yl] (2.3 mg) , 0.06mmo!), IrishGrgO (18mg. 0.0 {> mmo!) And d-autinohenzT &amp; alcohol <22mg, 0.18 ruin, and beating teenager! 9.6 mg 3P <. IsoKats) .N4S; t Sl) n ',> 618.5. 39. Refereaeiapéidat' l-4i'2-lifd5msitil) fsadj'3-j4 'j4' mo54bit5-4 ^ ii Preparation of -6 ^ (3-ya-8-a-pbii) p (3.2.Jltifet: * -8-0) -1,3,5-triada-2-Hi-ethidium carbamide The process described in pfcmnâ? Γ Γ θΓ: 4 4; ^:: ί 3: 4 4::::::::: 4. 4. 4.: 4.::: · Ξ- mg 22 mg, 0.06 mmol / l triphosene (38 mg, 0.06 mm) ol) and 4-amoolenol-0i-alcohol (24 0¾ (pi 5O0l): Ma ^ 0> Oasavsf as the 3-alpha azerepropylic acid (30.6 mg, 33)) % to give Sfp.SI) m / z 5> 2.5, 40, Rel. '| ^ ÍNil3mmo') iíH ^^ | ^ | d ^^ tfoli »^^ (3'« iX »« 8'8 * aiM «lkh> | 3.2.lipíí» ®'tí> * · «I A5 'tfla * i «~ 2 * H | fenO} arAlMls® · The 34th rs. <Mhaá I ^  ^:. # Pfàà'âi [appè 4- | 4> 4íöfi0ln% Al' S - { 3 ~ yxS'-8 ~ 8 ^ bykio [3.2, 3 ytp% 13,54riazine-2ril] (22 mg, 0.00 pad}, trippe - # $ 6: 5 »- # 4s pmksferyfckbrtd ($ 0 tp * 0.3 4 nmP) were obtained by reacting the dm compounds as a white solid (HAH,6HA, 6.14.6 mg, 33% MSiBSli m / z3.6 AL Hefempppri ri ^^ βΐ ^ 11) ^ { ^ | 4 ' «! Ρΐο 1» ^ * ^ 3 ~ || · δ · οχΡ8 < «ΐ88ί> 1ίΙΪίΙο {' ^ Λ 3] ^ ί ΐ48" 1ί> -

rijpmazmO - ΠI e ί ί ap M ί ítás ítás ítás ítás ap 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34 alapján alapján alapján alapján i- i- i- i- i- i- i- i- i- i- i- i- alapján alapján 2 2)) 3 s S-Iir i i i i i 2 i îí Ãîl tΠi> <22 Irish, O'6 miSii | triplet (M r% IoOmmoj) and pAoksMm <20 mg, 0.38 mam) were obtained by the title yttpj vegpjpa tôtüpüla Mliára mtyagPal (0.2 mg, 33% draft), MS (FS1) np 302.3, 42, j ^ Pmhexa ;: ÍA4Pa: á «lbsii! L5AP% moiPli * 4d3.-6A3mxa4Faza3> yk3öP, 2iF | 6kt >> 54 (F -1,3,5-t rt» * 10-2-131 juice é ö ása ása ása ása ása Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ Λ rtn-2-yl] αHn (22mg .06mmoh, irifosgim (18mg, 03) 6mmol) and 4-ammonobenzene (21mg, 0, iSn, n-d). as a solid (14.3 mg, 46% yield), MS (ESI) Pz5: 3, 1, 43, m.p.: 4g4 nm nm3pipemKi3 'sOi &amp; tri1j'-A' (4 '| 4 ^ m4rfelbt-Pti ~ 6'-0 '- «sa-8» • azal ieiki «| 3,2J |« kb8 "(k3g3prikÎ8ZâSi" 2 "i! Fe40jkuî'hit4rid In the 34th refreshment ippjemti strawberry spices (44440ti) ? 4 »SA:% í ~» - 643yx <^ SMK; ih, <nkit) í33Í.riokt-k · --- livin, 3, S-Irina-2-ii] Ppppp: 0.06 opd), (rhizp (iSmg, OjöOmiPY) and βmmrilgprstbbAl · dfkPItn (54 mg, 0, i 4 ir 0 ii seri vppkfd ksptnk pjpér solid solid) 2 TFA, 5.2 mg, 7% yield, MS (ESI) m / z 586.6. 44, &amp;epms3afpp; Trastn-1-ylfluoroethylacetate A 34, ptyl, ethylene, i.e., bis orthiol, z | 448loi4o.p # 44i-6 ^ 3-ω.K8'4-azûhsctkini34- | | p | ^ * $  di) A, 3, β-methyl (22 mg, 0.06 mmol). by reaction of fibrin / gene (10 mg, Opi mmoj) and isoprupamine <3 i mg (pi amp) to give the dye according to dm as a white solid (0.6 mg, 5036: yield): MS (ESI) m% 454.S 45; RdbrencipéMaí 142 ~ bä <leöxie (tp5 ~ (44 {4 ~ morPin ^ 4 "tiPp4> sa" 5 "SKal> tgfkiö | 3,2,3jok" S''li> '' According to the method of RAP 34, 4 ′ 4 4 4 mm β1% 4 β (3-oxa-5-azahydro (3.2 µl) β-8 · η 3 I) η J-triastn-2-41] aniline (22 mg, 0.04 mmol), tritosgene (1 k mg, 0.06 mmol) and esmolamine (13 mg, γJ 8 mtntd): ippliat% αya | , 532¾ yield) .MILOS) m / z 456.5, 46, Reifes'eep, yyyy, MS (KS ·) S13.62 (Μ1! I) + 4f *:. '^ 6fé.r «» « &amp; PM »5 l-4 ~ |: | ^^ ö? 1« Ils-4-H-4 »(^ - spas'3-si ^ afe | c | ldí) | 3.2.1] ok ^ | Γ1-β1-η1-5HK5í-2 * jjfj | | ^ ^ |iäiaia 3 3 3 3 II II IIr6illli^^^^ MS MS MS((((((: S .Sl mit mit 4 4§§§§§§§ mit(( 4 4 4 4

M1 {f £ 8ilfe3 "piHd8K-44ÍksF6smld í4§4IMbis &amp; fe 258 * 0; MS (ESI) m / κ 489 (3).

Ajs h îçfersneispélôa 3,) 4p4 ^ fee »: l8mf ^ áa:« ^ áSí »{^ yi» kefeikss »ypgpfefefcei alSotitik live with 4% Reffers Award: mîd MS sHS! im / z 471.3. 56, Refreshment Example: 3 *} 4 ^ 4ρ4} »ι« ΐ ^ ΙΪ0 ^! ^ ^ # | »^» «2 ^ Ι) ^ ΪΙ | * Ρ | # (2 * 8Ι # ^ Ι« Ι ' Η) ί ΐ ΐ%% ^% id id id á á á MS (((((((((((((((((((((((((((((((((((((( 1-4 [mu] m-d] [alpha] 18 [alpha] -M-1, 3 [mu] l -add-2-yl] phenyl] -3-44 * (N, N-1H5atyl) [alpha] Aryl '' spindles, S3, Rkifermciapeitfa : I ~ | 4 ~ (4 (6-dIm <> fMía ^ 44i-ip, S ^ writing ^ Ii ^ ii) ifeö5íÍS33 (4 ^ (Íi »merchant {) í4a8i} Iia} '« · bam id VIS Ii Si / 4 (> 6, .î S3, iRefereidia: 1- {4- (4H-4Iinoryl} -isyl) -S4Eda-4a [alpha] [alpha] 4-thi [alpha] 4-thiolefin ESÍ) nv> 530.2 54 Reflection example; Ι-) 4ί (4.0 ^ ι ^ »Γ? ΟΗ8 ~ 4ν0 ~ Μ, 5-ηΐ8 ^ 8ί'245) ϊϊ» ΐ | ~ 3 ^ (4 ^ 0 ^ «Ϊχ (^ 8ίΙ) Ϊ54Γΐ> 8ρΐΙίΙ MS (ESI} m; / 47B.: .S .SeemiebipeliitaI" | 4 ^ {4i6 "pentimilyl" 4'-yl], 3i ^ [alpha] 1a 48Sr241} S888i | ¹HpapapapaO) )8884Í8888 ^ ^ijaaff MS MS MSESESESESES z z,5 ,303030 55303030isi30í30303030303030 4 4 4 4 4 4 4 - - 4 -! -! !rif3030rif303030303030. ¹³L) δ-3 - (4- {2- [2- (2'-5'-yl) -or-1-hydroxy] - (1'-pyridyl: [alpha] 8a83? Yl}) | m / z 62!, 54.5? Mèfëireadapêldaî “[[4- (4, 5-dimorpsphenyl) [alpha], 3.54 [mu] l] 501 [deg.] C. 311. 318808 ^^ 5 ^ 11)) 1 ^ 13011488 --- toi'M (ESI) m / *: 506.3 58. ReiêraaelapékÎÂï :: iMi! £ é ^ {f4 - {il (<ÍfeÍi! {Ft $: YMMBMMi (ESI) m.fe $ 20.3. 56 lithium diatomaceous acid α-4α4a8 <srlöll88-4'-1E6 "i) ethylene 2l4pyr4iE44iO: s)" í3 # lbia * m - 2 - yl} phthalyl) "3- [pi] aldia-4-yl) pyrrolidone 1, Mjafe: NaH p0% pt. ? mb! fee> -2) 4pMa-; 4> 'iIi (Í, .Ö2 g, IJ.D moss), fessa «sáííbahSiöérsékfeíe«. Meanwhile, we've got the following: «SO-peMg lightweight and 2.4 --- d (k6r-6-8acAtíar 44i # 3) IPIA {: (2:, 35g, 10, iami) Mikink boasa. slowly; KHE-béa (56 sM). the. 48 48 pt pt oh oh oh oh 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 essa 48 essa essa essa essa essa essa essa essa essa 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 you take afeptisa «: .just, and viærasBtes MigSOfe. SxiMiCe: íbatdn ^ ksblík ,: and: a: 2-kl # -4-ä «otS) 3l8n-, 4..ÃkSi ({etching« -2H "p8'à« 4-i: lôX!) - ' 1, 3:, 5'b'iaiaia, diatomaceous acrylic oil, oil purification, 405 gib - gçefekbsjfen efeggpi steâiwa ,: festaa «:: M g, 30%; Mhët silam Mittag ;; pp; OlSSMS (ESÍ) mpIO1 $% 2; training: all 8¾: I, iPEbct example 2, step by step «2-4 {yf4 + müríolm-4 | -64tetrahidro42Hi> iran ~ Mkr iMA5-4rzz!" (], 5g, 4 (0 <RTI ID = 0.0> &lt; / RTI &gt; &lt; / RTI &gt; Mpds: b | 4-) 4Mtorfedk I »iliédo '4 p ι ï h nA Mm«' ù 'rt | 1 ν' »si * bäoddöi âilkotmok; tz 1. rcfoencfepdda 3. Mpésélxm describes edikshtad, 4- | 4 "; yörföläS'-4 ^ 4i-6- (eh * grayling · '' 3Ε- |) Μβ · 4 · 4Ιοχ5 ^ 43,54Γΐδϊΐη'2'4Γ | ίαΜ; Ιη ^ όΙ (212 mg. 0.59 ntmol) ktn-didva iwttig &amp; oasa «6 &amp;?%) vegterofe - ketone compounds as white solid, mp 238 ° C, MS iRSi.s m / z 478.3 * 66, Refer * odspimenstt 1- (4- | Mm-lM-pîedoMydoxfp · t <3y $) id43mS "£ dIffeo ιί) Μ ~" cover 1 carbyside euyl "" 4 ".) 4. Morohn-4'yl-6- {tetfahlro-2H'pk4tiM-dod.S 'I, 3,. [alpha] -O-phenyl; -3-fcdikarfeafedra dinomin din d d 4-f4-fSK} rolliTi-4 * {í »6 * {leirahidro * 2H * piran-4« slo.} * 153 »5-tn82:» v2-il { astHa and téegfdel * · »PhenizociaoE ReactIoNs gt gt lik lik lik lik lik PL lt lt MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS s MS s' '' '' s | rfelm-4'4Ífe4fe1rölddm'2E''pirja «.4.d« xi) -4AS'4 »46xi6 4 4 | fePilfe3 <· -pirklín ~ 3 - kkarbsímid's lyrics 1 ·· {4 ~ i4-orfolin 4-yl * 6 ' (tetrahydro-2H-tartrate &lt; / RTI &gt; xiV}, 3 &lt; / RTI &gt; orro4ie-4.4E64tetn: h í;??? 5 5 5 - -! '' '' í iso iso ”” k '' '' 'í í iso iso iso iso]]] > oaaath6 {starting with. Λ product <3 at a time with IJPI.C. MS (ESO m / z 477.53. 62, Msfefeue | fei% !: Ie4 "(| RtirOsie5e61) fepyE4 ^ l4}} 4-6-kernel ~ iRfe: (tetrshRlro ^ 2: Í4kpfe6» M-jio.sí0 -! , 2,5 'ï Monthly «-241) phenyl) corn chelate -R | feai1> -c8rl> S) p | iitHi ilMitotype; live-a! .. refeactionpeace S. A ter» rpskéi Gilson MPECSvd cleaners , MS (ESI) m / z $ 06 $; 63, Refersesfsplidtrt fe (2''ee10 µl Rf 4'-H) -O ') 4> »| 4-S? Pî # Isa> # iyfe- (tetr &amp;; lùdr <^ 2 ^ pfeàp-4-i | pxl> - L3J-tri8gi «'' 2 ~ s lfeaii) 4sr imkl dMlmMeL- (2 - M 'k! pkkjin'4 - II) O' ( 444 ~ aHr4dlh> 4 - y ~ 6'-Electrhirir0'-2H - pkfiM - ü (> xs) 'l.:SS'-trladí!-24I] fe! 4l) k «!' - dapdddt the reference k is 3, step by step, and the coins have been purged, the coins have been cleaned, and 11Pl £% was cleaned. MS Í '(: S} m / z 491.5. 64, References Ι * | Μ ^ 0 ^ ΐΗό) δΐ #) 4 -444441 ^ Λ8 «φ8 ^ ^ ΐΐΛΜϊ | | {|» ρ1 ^ * 44 | 6 ^ 1,3; 5-008zm »241}; Oifösxgéoes procedure The products were: Gilsoa EPLC purified MS (ÍS1) m / z 457.54.55, Rofe mt de ρέ ki: I'-tkl-aretylfeadl-d-1k) -05550 ^ 4011 ^ - ^ .6--64 tetr'alúdrmlfl'psrésí -Sdfexs) - !, 3,5 - * r (colorGMl) feoilRardam timeframe l- (3mö | l: fe6lE43'-i4-i4 - m0efeHa »44k6 ' (tetrahydrofuran-4-yl) -4- [4'-morpholin-4-yl] -4-hydroxy-2H-pyrrole-4'-oxo-4,3,5-tria-2'-yl] anhydride) and \ t to react with dOGLP isodane. This is Gilson HPLC. MS (ESI) m / z 516.58. 46, Refenmdapdds *; b | 4> (d} t «et} l8« »aolfeail | -4i'd4- | 4 ~ ai <fxfoii» .4-4l-6 »({tertiary» <i''Hí'gÍrtl8: 44> 'dloxi ) »T, 3.5 ~ dad« -24lf feasijkylid Hid production *! '(4-oxime iii: nono} fsmilj-3 -) 4- (4-010: iobo-' t-i! -Ft '(fem -halo pyran-H-pyran-4-yloxy, 3.5.0 hvm-G-dlln-1-n-carboxylic acid is added to a solution of 14-β-morphoho-4dR641e-Δrldro-2H-p-r6o-4-Hoxi). > 3. $ 'Trio. &Gt; * 2-Ujamlm. &Quot; Suitable for 4- (N, N-dm-phthalimid-2-yl) (Reaction to its compounds). ESI mM mM 516.61: Methyl <RTI ID = 0.0> {3 &lt; 4 &gt; 4,6 < / RTI > , 2, pmmoi), THF Cl0 ml;), VfeOH (ml ml) α H 2 O 2, r rm) kevcn k $ * l l '' '50 50 50 50 50 3 3 3 & n &amp; 80, «Bjkdeloads * i ^ and lssÄtpike hypaikakoassásávat - boiled for 8 hours' BkoénylteftOk and 11204 (5 ml) adtmt, map 2N HCl .ld acid (stitches. Árd solid: material skSfíllk, Μ2 <> Μθ Μθ rnostfttfc and szárlM ;, lg * ski tsrmekm ksp &amp; sk r m sams sdliM as i i <3 g 96? ”yield); .MS (EM) ov'a 506.3 68, Refesumée examples ^ ps {d) m80l8iöfH «)« M |) -442 "C4" p »6 ~ yOuOiO" l, 3,6-tem462S>)) | &amp; iM ) {) »It m0o) femmi ml in the last 4-f 3 -î4 - <(4,6» t> smorfo) so> 1,3,5krísgln “2'y) l | m | vi88 | oh | b« This is a mixed solution of HBTU (563 mg, 1.455 mmol) in 2 ml of NMP-vd for 1 hour. sèktefen, and bfeM »dimeti (no), (130 d, 1.1 si umm!) sdmttk added to it, map: sgy overnight ÇH.» CI-rî (40 ml) aduink added and full of NaHGOI- md and H2Pval mosquitoes, IilineaISIS and sdlikngele chromosome-crystallizing methods CIBlCMMOHOHTiFiIiOi &amp; vl MeOlil (10: 1: 0.22), so that the product gates as white plums as anpg (9Smg, 5730mg); - 526.4 0 $, ierlier08d0 | 8 8 i 2 yk 2 2 2 2 2 2 2 2 2 2 rek rek rek rek én én én én én 72 én én én én én én én én 72 72 72 72 72 72 72 72 and 3 á The silam was mixed

sdÿâ | ot skltoOk and 8 yEs # t k white white silyl material (73 mg, Mozum ™ 953-¾ MS (ESI) m / i-57: 6:, 4. 4% References HeadPlda; 1kÄuffelmm1,3, Sdrimife ^ -yl) phenyl »l5) ~ S- (# i" m "* iipperadts.'i teiss-« Il) phenyl |) lmr1> sm? id-ktroclorting production 4µ), (4 - (4.6-Dnnorphum · 1; 3j5-triurides30l) feotl) acetone) 0ersg8essv (550mg; 0.297mmol), Mamphade (30.3 pl, |,? SJ mrm.O) . HBTU <563 mg, <.405 vesicles) A solution of 2 ml of NMP »vd phenvene prepared according to the OferÄesde example iv-medipSpetadm-al (132 µl, I, li8 mmol); lg) · 'p4' - (4.0 * <limot10i? l ?, 3,5-tnaKm'-3-yl) Vensl) '-., 3- (4 - ;; cisphobyl) kni) cyrophenylpypophosphate as a white solid (9Smg, 54?); MS (ESI) m / z MS: 4. 1- [4- (4-Dihydroquino [5-trin-2-yl] -phenyl) -3 - (4 '' (4 -) '; D) fearbgnvid {70 mg, O, i 19 mmol) and MeOE (I mL) were mixed with 4MISCi in sdfe (iott), 3 guides. The solids were filtered and washed with yeast, yielding a white solid, m.p. mg, Hozama 0036), 70. RefemKiepőitia; 4 <.p. (4 »(4P» ÄörfeB8iö-l, ^ aid »ái () tree :: 44s .. ^ 4 .. (4! He-.C) ínKnk) Iino» k3.5oU3Zfe-2 »ii ) feayl) oridoide) 5-ene-3V (ISOmg; 0.297tmol), Btmig base 1> 03 til, Í; 7i2 mmol), HBTU 0®'im tnmoi) 2 ml ÄB ^ Iskds ^ lll-ev? Reaction with Ammonium (594 µl of 2M solution in THF) to give the product as a white solid (118 mg, 7736 yield); M $ (ESI) m 519.3,

T-Meferendapethorn B »<2 ^ d8mdltóü8tmBeid) M <#“ C4 ^ t8racking ”» - 9 »matlIhen8amtó-'Mdrnktór8d 'Soul 4- (3- (4- (4,6-Dimorfbimo-I,?, 5» tríazm) 2d1-phenyl) nreidepyrene8S3v (130mg, 0.297mmol), Hmtgb? 3? N? Id, 182mg? 1? I? ^ reference to the sample at km at the reference at example 68.vCK ^^ à ^ - ^ môïfÂo ^ lJ ^ trii ^ ma ^ llife ^ ^ iâ ^^ mtttttto »^^ white solid pp $ fe # d8 m &amp; M% ifamm &amp;: ΜΒ.φΜ} Μ ^ ·: 5Mß (55mg, 0J27mm) and MeQH (1ml) 4N HCl · · added to dioxane (Iml) and 3M M mixed, Λ solid: imysgot Äik, and Washes so w &amp; m &gt; copixe (70mg, sHosam ^ 88%), "9%" " femielajjélőss -tesrl &lt; / RTI > feul) &lt; / RTI > Eanig Buttons, | 1: He3 $$> · Θχ5 ^ 4 :: 01 {βο |% iHBl'fâ- (f $ 8 mg) 0.495 mmssl)! blend solution with densitron NMP; Example 68: Example: Wednesday reacted with 4 µl / ml of β 4 µl / µmylphenyl (67 mg, 0.396 mmol). The solvent was evaporated and the solvent was distilled to give the product (40.1 mg). 62%: bez; n} (M5: (£ Si) mt. ::: 658.7 73> Predictive; 4- (3- (4- (hmrxsmldExploitation 4Hp- | 4- (4 ^ Dib Α- {5.Ômg; 0: 099 atmol), Hosslbase (1? 3: p | 9,594 mole), 1I8TU (188 mg, 0.495: mmol} 2: 0l? : example seri-sage sSrSnk mini-sM-sMs (76mg, .OJMtmm!!, ssdp efpämle Ä is Ä L ti ti ti ti ti SS SS SS SS SS SS SS SS SS SS SS SS SS SS így SS így így így így így így így 7.4 7.4 7.4 7.4 7.4 7.4 7.4 7.4 7.4 7.4 7.4 7.4 7.4 7.4 S S / «:: ssíi®: 14.7

4-Fluoro-methyl-4 '- [4,6,6-morpholin-4-yl] -4- (4-thiazol-2-yl) phenyl] - (4- (4-pyridin-5-yl) -piperidin-4-yl] pyrrolidine) lg9} capi [alpha] 4-d] (4,444'4,6'-naphthalophenyl, 3,5-b4azm-241} yl) urea} 13-benzoic acid (50mg; 0.099nm), Hus-base P03 pL 0; 5Ski mole}, M: BTO (SOS mg; 0; 495 mosol) A mixed solution of 2mM 14MF was prepared as described in Example 68 for 4 ~ [1-pyrimidyl] -piperidine R8 (6i mg, 0.396 srmsoi). solvent evaporated and HPLC to give the title compound as a white solid (37 mg, 58% yield), MS (ESI) m / z 692.7 75, hexane 644 (1,4'-Ρί | 6ρ «Γΐ4ί» -Γ-Ιν «^ 0} Γίκ όο> ίί} · 3 · '(4 ·· (4,6' 4ΐοί0 · {·? οΙί« θ ''), 3.5 -ί548Ζί · ' " 2 · 'dt) &amp; i) ksr Pham16 eletotiO dig 4: {; p (4 (4 ^ .. DinK «subtitles; k5-trfaz: tr-2í-! reido) herbic acid (50 mg; 0.099 romol), Homg base (103 µl, J J94 ososol), 448 µl (188 mg, 0.493 mol) in 2 ml of BW4M. rt; Ä8äät &amp; reágáltóttük in Example 68, mfereoeia i '# ilppetfidi * «« Ei fé.7 mg, 0.496 mmol). The ε46 was added to the white solid (59 members, 60% yield): MS (ESI) ovz ~ 656.8. 76, Example; fe (4-4-54o4thef; Soo} piperidine-lh: {irh <mH} PoSiK4-i; 4 - '(4,6-diSulff {> l5a «-" L3, S " Preparation of rationale 4-p- (4- (4,6-llmolylidene) 36 mg, 0.099 mmol), lithium (103 μΐ, 0.594 moles), HBTU (88 mg) , 0.495 mmol) of a solution of 2 mL of MM in water was reacted as in Example 68 with HN-di-ethylpiperidin-d-ninyl (51 mg, 0.396 mmol), the solvent was evaporated and with BPLC. you get the product (30.6 sag, 52% yield), MS (OSI) m / z ~ 616. 77, ttolfere example: Ι · 4 ^ 4 ^ -6ßΐ «0Γ0} Ιίοο-ϊρ}, 5ΑΓί8 * όχ-2 -ίί}% όΜΡΑΐ (45 (ρΐρ§08Α-Ι-ίχ®6ί »ίΙ} ^ Ρϊί}) Cardinal Soul 4, (3 (50 mg; 0.099 mmol), Mmbgd> Ugi <J 03yd, 6.594 mmol), TO φΜmg, 8.49S mmol) of 2 ml of MMP in a solution of $MM * «ncja péidfe was digested with gJg S SÃÎnâïsi (34 0.396 mmole). the product was obtained (: i ?, 2 mg, 30% yield? MS (OSI) m / &amp; ~ 573.6 Tg, EeferesdapMs; &quot; Production &quot; 4-d3 &gt; (4, (4,643im «fMim &quot;, 3, S'3 : ni: ÄSö''291) fOiT0) umid) ö ö ö ö ö ö ö:: 2: ö: ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö ö 03) 99 mtsmi), Ihssngdsfeis (: 1: 03 yk 0..594 mmol), HPP3 (PS sng, 0.498 «stnoi} 2 ml NMP ~ velMsx8! L: mixed pldaias 60s and example Sgept stmgáhísmsk pyridîi-2 -îimethanamf «pil $ 11mg, 0.396 mmol. ; Cold Solvent Carbonated and HFU? -V * $ usaOiIiOi,% y; s products capts (9 s «g ,: $$% fee); MS (BSi) m / z 596:, 6. } «Ktá« «IMHITUS» ($ 8tn »$ 9lor (2.08¾ (8,85 snsnsh) azdonsstsl. (20ml) and water; (lo. Ml) ready to read on ÖX (3.3: v / v / vkk / k) δ (1.46 g, 9.76 sq. m of aqueous Na (CO'3 ~ .maI (25 mL) and acetone (25 m!)) ready to go out with a tidagoletOle &amp; spy 15 pess diait The swallowtail OX-nn 2 Hour 46 keyertilk, sngjdsgtók! The following compounds were obtained: (30:70 EthylPaestanes: hexanes) to give 4ffesin-1M-8-oxa- 3-azabietko {3.2. I} octane, 35 g) as a white solid; (4-mer • (sxvfbs / .uminated amino} -i, 3, S-trlot-2 * yl> 8? 03i-a-aaaMdkfep, 2 (joktan: 3 · ' · 54) όΓ ·· i.: K54fi; bind'2dh - k'oxa'5 'SKal> personaSdp.2.1] octane: (8.085 g, 0.33 mosol) and βffS: (0.041 g, 0.39) ssutsöl) «cetophtml ((we) and water (o o il) I am ready for his solution «Mann's 'amint': (0; 36 mffiöi}, solution 55Xo« jmelegiisitäfe and 2 awards: ir keyssyttik, mafdbsípáí'oituk, so be lucky ssnlRoAriázistí ksipmstk, indirectly! use it for cleaning. Following this procedure, the following vermietek is a warm-up prize. ld4Aier-α-Pyridyl 4i} s3.5es;) rapid4a-ox; iA-aKdncik! S) p.2.i] (310.5, M; H) i-td-Cl (i63i, t-bus.-2- (4; 8th part'3 - ;; Zfibiesk! o [3.2, iioktósv3 - il } -6-C 1-6 J, 54r (axat 2 -methyl) -4-carboxamide (385.3, Mi H) 244-t 8-oxa-3-axahk; oki; jtî'-3-ii) -6-chloro-3,5-tria-en-2-ylol-etafiol (386.3, M; H) 448oSxadmzabic {3.2. diphthysic:, mnxxzk-T-smun (32t, 3: MW> 4K8axar3 [beta]) [beta] 4 [alpha] [alpha] 4 [mu] m @ 4 H @ +. H) t -buhkl - {<M SrgxmSmzahioikiOfl.ddsktlmadlHlCldJ ^ (397, .5,

Ohmic 4 (4, 4-oxo-β-phthalic acid, 1, 2, 3, 1, 3-y) - 6 (sxsb <; zt: it: ss; iit: -m- sulcosyl-3,6-trifluoroethyl-46-si};

Bis &amp; Iner O-m &amp; zdoddd (0.33 nuno!) With Kduo (2 mL), EtSilyl (2 mL), and 2M aqueous Na 2 CO 3 p, '? 88: m% tfeMlt:' ^ 8 ^ «Xlo ^; € ^ mÁÁ8Í« «« ::aaaaaaaaióió »» »»......: ^ ^ ^ ^: ^ 4: ^ 35 ^ ^ ^. Through 5 perceo kzsxïsïÂ. PdÇBfô3) A - gt (0.021 µm · ss 8.0: 18 mmol) and 4 µl ©> 0wic acid at 58.094mg, 0.43 µl) at <8anfcbbz, and IMIi Isadij and X3: We have filtered through 0 ^ vàBînekg ^ p1fei - Aæ: «fei3fêtMi8uuk es, t> 11x0 *** '» «. Is the rbkpéoykPlb &amp; Cetal? Washed linters were washed, dried and concrete> o «o> lcc 0k. The crude product was obtained by HPir supernatants (Waters system, 5 ~% CH3CN H20 νν 140, 140 NI 1405iv. Iiï> &amp; z aryl substituent dazine compounds). 4 "{4- (8Aisa-3-M3.2.1] octane--» 't-Hmpendsp-1-8) -1, 3, -5-tn «vn-2ollo <367.4, Me Η) 4-0 -P-: part-3 -: &amp; ed «edkfep.2.l | eclipse: 3" l; 6 &quot; 6 &apos; : a? lré'2-4Í) i5Alln G53,3: ,, MfB) 2- (4- | 4: - smiley! ïl: l) -Brush-eKs-3 azabickio 1? .. 5 joktan 3'1) 1, 1 ', 5'-o-2-Hair, ethanol: p43:, 31;

4-O-Skiafoleoyl) -6- (8- [α] 3-Fluoro-cyclopropyl} -1H-acyl-O} -N-thene; 1-JpArisPiB2 * 8pie (375.3, APH)

4- (4-Sm5E-yl-nyl) -A- (E-oxa-3-α2-thiophenyl) - (M1A-1H-phenyl) -1-phytyl-3-0- (4-amylol) j-8- {δ- α1-Biphenyl, 2ePtane-3-4p) 3pAri &amp;z8p-ylamylphthalam-1-carboxylate; (454.4, Mf H).

Procedure 1 - (4-pAE-oxg-3-yl) [3.2.1 | Ectene-3-yl] -A- (sx «bstapl-asnmo) -1.3.5-trtam-2Af) phemi} ~ 3 '- 4pMdl4-d} carbarmd: '' A solution of triphosgene (0.034 mg, 9, 114 n-rBB in CH-Olj (1 mL) was prepared. The excipient was tannin-idlyl (0.23 mmol) ClBCE. solution (1 ntí) and îdefij-ginini: (0.095 M, Ööoun) adpnk 00¾¾¾., and -concepts: saobahedrialheart IS for minutes'. Bzuíao 4-iU5uööpne (1 ^ 43: 0¾ in Opbdopojkï'tik) 1 µl of solution dissolved in aslSk lye, and βP ss is scabiesed on a dish of yeast, steamed and insulated with HBLC-veS (Waters, 5-70% C113CN in B20, 4k05H NH40111 so l- (4'-4- (C-oxo-3-yl) zablclcloP. 2-octane-3-yl) - A- (sfesulfylated asnino-1? -P-rnazine-S-ylphenyl) Pyridin-A-yl-carboxylic acid derivatives were prepared using the following chemical formulas: 79, Example Example; - <4- (4- (8-tm-é «z5sb <dki"> | 3.2.1 yl) íeidl) -3 ~ ípírkíl t 4 - ír.íkar.b8míil előállMsa;? 487.2, M; 80. Hepha-1-ol-1- (404-P-3-3-aza-methyl) -3,2.11-solvate-4-yl] -6- (1-pyrrolidin-4-yl) -M, 5-4-yl-amino-2- -4Ijfei50) -3- (pírí <Hsí-4 ~ dkkaibaibai «d ásaásaása ásaásaásaásaása ásaásaásaása ásaása;;;;;;;;; 474.2. M = 11.8: 1. , 3.540-135-3.0.0) .delta. 1-3-14- (1 - h5loxMiS) 1% 550 µl of ethyl acetate, 1- [4-, di- (di-) methyl] -1-yl-1.3, 34: fiazol-2-O) 3-yl <0.140, 0.40 mole) of a mixture of n-ethylene chloride with a silica gel OAikon triphosodium 25 0.25, 8.54 mmol): and EON (3 mL) admixture. OAA was stirred for 21 min. Then, 1-Cyanoethylene is added to 50.10 g, 0.73 nmol, to give the title compound, which is stirred at room temperature for 10 hours. The solvent is eMol. The remainder - AdoMifttuk BMSY-feEe and MEME-tIiCiLiCiTiTiLiTiTiTiTiTi so Aktiig P, 5 "líl8d8-2s-- - ï Ï> ieo 11 i 1 -S 4f4 (t> Fluent itst 11> tes 11 jfea rfeami ) 508.4, M2. Preparation of RefemtdapiMat m? D {§ $ 4% 0ÿ48mmol) and 2 ~ m? D) 1 "4 ~ sminc ^ yälftb {i {(IO sec. 0.73 mnip)" followed by the ethanol enriched in the rdarene sp. - 4 - (4i - ylhr: -> f1b [ki "4-yl · · - 1 ', 3', J '4r87 {n-2'! 0jfS: ti} '- V5i-m (' ti1p5sf 'Miij * 4' {|} fe ^ awicio {we want to clean up with ËPLC}; Yield: OOmg, smKtSíHSi «« ^ ··· '*: ^^, | 3. Réka'éádáflNlll 144d4, d'dhs <! rfolm "4-'Skli34" tld8Kls> 'S ^ | ^ & ski | "á-M- {hklí () Slow? 5etd) í« «Il | rf «jm-4 - i from W ^» iris ··· · ddamlin (0.140, mmol) and 1-smithm feudmeizpap (starting from 0.8 µlPfnol?). -0 (1 * 4uKa-S> 1 · ind · 4Mj, 3, $ -mastn-2-yl) in <RTI ID = 0.0> IFcm-l4-f4- </RTI> <RTI ID = 0.0> {Hydroximettf} -yl} </RTI> RPLC-S Yield 58 mg, 26% MS (δ 81) m / z 492.) 84, R6Meuciaphthalate 1-dd -dporporin-1'-1H-sS-dHaxal-1-dllphene Preparation of 11'-lddroslfedlJcarbsmsM 4 '(4i.6 ~ Diit9Oltt-4 "i | 1,3,5-tna«? ·?; - iilanitine (OJÄ' 0.40 mmol) and l-sminPeidae (80) mg, 0.81 mmol), and g 81 reference loops for the reference period 1-04- (4.6-0000 ^ 51 ^ -4-51--1.5.5 -. ^ rs8 ^ iis-2- yl) above, followed by purification by HPLC. Yield: 62 mg, 16%; MS (ESH nvz ~ 478.2. 85, Ellefereaelapllda: 1 ~ {4-ß4.6 ^ Ι ^ * 00 # »-4» -4-Ιί "

ImntM ≤Ltd 4444.6 - Dimorfol; n-4-S, 1,3,5-triav (n-2'-yl'-3'-yl) (0.140, 0.40 t-unol) and from 4-trifmonoethylamlin fi00mg, 0.02mmol) and in the 81th rhythm of follow-up, following biting i - = 4 - (4.6 - dinmd61in-4. dl ~ L33-ln £ ii ! feRjl'jkáf ^ É ^ IiIi is the first thing to do with HPUCI iisatMkssl. Roza; 25 mg, 13%; MS (RSR m / z - 430.2, 86, Reteriod Examples ¹R^^RRRRR ÖW W W ^ia l l l ^ ^l ii ii ii^^^^etieti ^ ^ ^ ^láííííí (trsnuorn8el (1) e01ife.) Preparation of 5 ll of 444.6 "Dimcol tert-methyl-4-yl] -1H2H2O-libi (0.140, 0.40 moles) and 4-triethyldiethylHlidyl" (Ί40 mg) , Ö .- 'IO mmol) based on the method described in Example 81, the process described above, "f444, he" dtmofftdllHl * -41-1:), V "iriazin'2 - yl) alkylaryl - 3" <RTI ID = 0.0> iS-N- (trifluoromethyl) -1-furf-1-yl (lithium </RTI> methyl) yl) feml), clone aldehyde lives HPLR crystallization. Yield: 40 mg, 1 ovo: MS (ESI &quot; nvz &quot; 628.3 &lt; 0 &gt; 0 Refebesample; &lt; 4 &gt; 4-f4.6 &lt; / RTI &gt; dimorphide-4M35S-tR

Preparation of adhesive fracture bridge at 4 - ('4.6 - Oimorfdin-4 - i - 1, 3, S4! -Diiii - 3dl) (0.160, 0.4? Mmol) and at buyer (100mg, 0.61 mmol) and the procedure shown in the relational batch 84: C H H 4 * {4,6-dimorphol-4-IM J, S-triazit-2-yl) ^ &amp; ij | v3- [5 '< trifl «onthefree <1ίη-2-? 1 urea is excreted:« 1 RPLC purity Yield; 10 mg, 4.156; MS (ESI) m &amp; - S31.3, 88. Í »{4Hf4 he li8t ^^ ^ tt-4-8« Í) 3.5; 'fe'iazí »T3l6tt) féBtif | (a-p ^ i .--, WőíröxletH) f« »8ife» ri · Hsunk! eSMlRasa d-ddHDinKnfiliumHyribi J ^ j- ^ azip ^ delimit (Ö, 160, 0.4? mtrt!) and t - (3-AminoOlePlease (Time mg, 0.73 anmol) starting year 81 following the procedure described: - [af-ko-dimot 10110-4- · '*> i .XS ^ ria / hiO-ttwfeHjfl · H? -0 k «h - · Μ · η m some carbohydrate kdltfnucttct« 1 H PLC * MS: 4 mg, 4 µl, MS sSvSis uVz - 531.5 W. Reimmcomplex: 1 - (4-fluorophenylmethylphenyl-1H-imidazol-1-yl) -1H-methyl-1H-NMRl Preparation of PhenylM 2 (R) -Bamfd Step (2) - 1 - (4 - {(38) -3-Methylmorb] m-4'41 | -6''molole-4-yl-1,3,5 Trisazine: î, 3.5-Fisyl kCi-chloro-monoHufo-thiophenate (2.0 g, S, 5 mmol) 2 (prepared with 50 µl of methylene chloride in a stirred solution of 3S orf 3-methylmorpholir g (0.85 g. , S mmol »was added with two equivalents of carbon monoxide, then added to the reaction mixture at room temperature for 3 hours and stirred with water. Wash thoroughly with water: dry over anhydrous MgSO 4 and filter. The solvent was triturated with diatomaceous earth and the residue was triturated with 1: hexane: 1: 1 and filtered. Λ Solid was used without further purification. (1.0 g, 40% H a), M + H 357.3, • 2. Step 2 * Kîôr! 4 ^ f (3S-h3! 'Xnet> lms> rfoh ^ 4 ^ ii; | 4> * m0rfç »lln:« 4sll> <î »3» 5 * tr1 || i.Â' 11 26, 4.2 mmol), sodium carbonate (2M, 2 mL). (Mixture of arg (catalytic amount) and 4-aroxynenyl-1H-clonic acid "pomol ester (1537-g; -6.3 mmol) in DME (KM) ml)) He goes back to Hiri Asknssisáya through Sarrah · needles 24. The solvent was evaporated, a, ttmt ^ (| ^ Lf ^ Í: kyohii (ih> $ ÍÍ: ^. ^ T solubilized and Cehí # * f-eh filed), filtered off. The solvent was evaporated and the residue on silica gel eluted first. eluting with hexanes / diethyl ether, then increasing to 1/1 hexaramethyl acetate to give 4-yl] -6-modblm-4-yl] -phenyl. "2-Illamoline (71% yield) was obtained. ivk-B 557.2 3, Step 1 - (4- (4 - ((35) -3 rhythmic-la-11) - 6-Morhdy -4--11- L3.5-4r «azm-2" H -) - k - ptriáiii ~ 4 - Ilka ríme »mid s Idá Ifit: 4s | .4 - '((3S: KI - ^! ld! liliJt> CdlSM: 4 | l4feiÈÂÉ1iift ^ -' ii4» 3ÂîteZip -> - 2: '' tl | anillpMÎ (0J60,% 44mmol) and 4-mmmopyridine starting from 100mg 1.06mmol and following the procedure of Example 1 Retereaction 1-4-4->: 4 ' f (5Sy5-novaiK) Rír !jjj ';; ;bibibiiiiiiiii 5 1,5 [5'Srtzh'-2'-yl; fnylH-pyrid-d-ylcarbamate Yield: 125 mg of ftU; MS (ESO m / z 477.5.00. Retereumpekho t) (4- {2 -lïïdroHetihfeail {- 4- {4- {4 - j (3S) -3 ~ H} <dÎlinorfoliw-4-yl |. ~ -e i8orfoÎMi-4-yl - 4,3,54rmzh) - 2- iljfe «Ijjksft'hí! -5 - M'ethylmorphol * 4 [mu] 4 [alpha] M m / l R-4-a * 1,3,5-triazm-1-yl) aniline (0 (100, 0.44 rnolol) and 441 -diethyroxyl}). mg- 1 tntnol) ktntdulvs and dl. in IP thermostats with hesstylation: following the procedure 1- {4 - (2-dioxyryl}}) di-5 - (- t {44i3S) - 3-nietryrofurf> γ-4-i] fot) orphon-4-ii-L3454riazin4 ^!}} fcuil): I am going to give you an extra charge of 1101 .. (5 - ¾ of cleaning. Yield: 125 mg-603 «: MS (LSI) m / z 519.6 01, ReterepKt? Ddn;} - | 4 '- (2-H1-fryxisyl) d5-3- (4- (4-K3S) -3'-methyl) orfolin-4-ill-6'-soro / aryl; Production of 4 '(l - 1,3,6- · (Γΐίίζή5-2 ·· ί1} Κΐο1) ηζΐ'1> ίΐ! Ί) 8ί1 4-i4-LY3S> - 3-Meiyocytes: fli> iifi-4 ~ j! | _5,5χ-ίθΐΓο1ίη - I-yl-1 -3-5-4: 4 ^ 4-4-2-41 [mu] l (0.160, 0.44 mmol and 4- [nminophenylmethane] (0.1) «) G ;, KO 1 mtodi) clindrl and SL <RTI ID = 0.0> ss </RTI> 1-H-2-hydrosinyl) nylon" 3 '(4- (4' | (5S} M - nietylfhthn - a - yl) 6-morSdinM- 'ss-L-3,5-2- {í ~ triazíp emiÍlarba || " iuidci was isolated by HPLC purification. Hözaótí 55, MS (ESI, vtri / z 506.3, 92, Reference; l ~ (4-i4-f (3S) ~ 3-mice! drOds! 3 ^ 4) Preparation of -fluoro-6-trifluorobenz-4-yl-L3, S-trfazfn-2-yl} -phimyl-3K2-methylpyrrolidin-4-yl> kitba-4-14 -} (3S> »3). Metiimotfol 41.3 * n, $ - trtazi ". d-tlf anil i m / o 0 (44 mmol) £ * '% · -Melib-Kmnnoplclc él U 0 g, 0.9; mmol), and 81, refereasla [alpha] 1 to {4H44 (; '' S-0-n-mortol5n'4n1? -6-monomerHn-4'-S; : aa ^ ink) -is} ieniru342 "m8ty |> yidm'-4 ^ äl) hand: b8midi was colonized by HPLC, l-paint <RTI ID = 0.0> 1, </RTI> <RTIgt; i, 3 -1, 3, S-tnaäm4ki | fesssl) Happening the Idp 4 * 14 - | (3Sh3-Metdmor! Bhn ~ M!} ~ 6-nîorP> ïiη-Ί ~ îî-1,3,5.tti / in-2-SI | astlnbil (0, .1¾¾ <Ü: ÏK4 * • * âî «iiiiofeillyanol ( 126rag, 0.92mmol) and in the example of SL, l> #m «lalol: yt # t'competent H% (14udroxiet: yl); benzyl M4sH4 '[(3S) -3-methyl Imorphol-d-ii] -ti-.morföKß-44l · I .XS-Irishl-S- il) Kodí)! we have separated HPL ('with purification. MS f ESI) measuring 5194¾ 94, Reference Example: IpIi Preparation 1 »Step: Propanol 1250 mg, 4 I nur.nl> s.?Heat THF (50 mi) mixed! N-bmilliutnet (2.0 nd, 1.6 mole solution) was added to a solution of -78 %% 6ty. The re-stirring mixture was stirred for 30 minutes and the solution was mixed with: i-iikh%% -morlblm-4-i. (1,3,5) triazm (1.00 * ·., 4.25 mmc # THE-M prepared: The solution of the cowboy quadruple pigeon was made for the first time for 24 hours, and with water Kveoe $ Ætoi: # ÂMéitél.MÂit «off We took the kaptpl: svets product without the ÎâSÂilîàs to the next step.% Step: (raw '· 4 * ( Chloro-64zopropo. d-1,2..Ltatahyl SjiSpell (2,91 g, 11,2 µmol), 4 * & m. , 4 mami), tetfakisa-paikklionn-lrifetùlfosxfîo (120 mg catalytic menis · 0 0 eg · · · vu J J ι>> 'ora bora.-oidJ 1? M lob s'egset v <sv? Dm., M> il no ika'ina'i- .. '' di) Vl Lm (100 mb over 24 veins. Removal of solvent up to Is also remainder of the solvent in a meteorite plate was filtered and filtered by a € jewel &amp; SM). ®! And the remainder of the parent gel .chromatic chromosome is first eluted with 26: 4 lysane: ethylene and then! increased hexane / iodine by 0.6.5 g (added J%% d. ^ fooptopcn & year - motSLhno!): ism-d-ManUm! htpUmU Μ H Μ <'3'! up, - 4 (l'izoproposi-o-moditlini 155 0 u do N n d Î Ô Ô () (0.140. 1) .44: mmo!) and 4-atninn ·· mg 100 mg. l, starting with "<$)" and the example of §1, "following the procedure described in 1-44 - (4-bisoprop: l-6'mor! olm <Ml« l <3, $ 4rlaz> n “2) ten! l}“ 3 »ptldlm4.4! cleaning ski! Yield t ^ mg? · "<> MS il S '> rn / 4) 6> 95, Refenmelapéida; metik-4 - ((4 - (4-yan |> ropov-u-tinphin! Tendon-4-- L3.5-tn8sin-2'-bibe-1-yl] benzyl} benzyl) 4H4O-4-oxybis-1-yl] thioimide; (15 g. 4 »): ® $ 8, $ 4, mm Cl od) and 4. • ikaípomeidenxbfe ^ mg, SOM) 4S Rated: and their vase arsenal and time-weight IMstik,% organic layer drywallen whey extracellularfilterthefiltrationofthecleanthefiltrationof 1.0% ethanol, and subsequently 40% ethylAlylidene-styrene. | 4 - '(!?. 4' opt'Ofmsi "6'mrmfe ln * 4! 'l ~ tt ~ L3iS azsn !! ^ 2HI) fea ~ ll 3k (j 4 ^ (4 ^ RâéÎs | HPE! -Imyln-4-yl) liide) iudlfAm !!} carbatnide

Methyl - + - ((['1- (4-isopropyl-6-morophenyl-4'S-L', 5'-pyridin-2-yl ')) bvttzoe &amp; avbóí (i60sng, 0.33 mmoles) and - mctllpj in the example of 7 kCacrU following bcomtatonic passage • 80 mg (44% w / w) of the compound according to cint as a white solid admixture MS (ESI): m / m z; 261:, 2 ~ s ^ -CÃ £ Â «îîîñ <| 34irídfeïï ^ -îï> îï

Meth · 4 <{(4 · (4 ··! ^ I'opΓopox δ ·· HOrfo ^! ^ Mil ls3,5 ARHI-iC ^ ^ · 2 · yl) phenyl) · III) k3.îb «nκHi) âmini>} b (5Γi ^ oes3yMI (200 mg, 0.42 mmel) and; -: 4'aÂo * i ”? 3S8ti | s | ^ ÂSSïôi following the L Sosérieu following the hemutaix procedure 65 mg; ») S (m sxermO A pseudo-white is a white solid. MS (BSI) m / 2 $ 74.08. $ 9. Rectodecap: (04- (Oa ^ O (morphoOf'440L3.0-4r1-3i: 2 - 2 OI} FeOH ~ 3- (0- [xxlppi> r * yl] yl''4-41} radicals 444.6 ~ D] mor (b0s ^ 4014 J55-4riax> (i -2-5l) } <RTI ID = 0.0> (I) </RTI> (= 40 mg 0:40 mmoles) and 4-mn-1-phenylsulfyl; nhOS (70 mg, 0.02 mtno) and in step 3 of Example Ib followed by bsmulamb procedure 20 mg (1% yield) as a solid d solid MS (ESI) Honey 403.4 §0 Retamethyl (R) (4yf4f {; §3: H3 * éblmerMmM ^ 4- | 4 - [(3S) } 4-oxo-eco-4 - [;] - 6-oxo-4-oxo, 3,5-diazafin-2-yl] yihih () (0, (40, 0.30mol) and 4-smlno-iodide. 70 The procedure described in (d) is as follows: The method described above is prepared by treating the title compound with the title product and purification by HPLC. Effect »: 120 mg, 40%; 497.4. 100, Rheumatic Example h:) - {4- | 4-R, -Ilol-1-yl-2H- [1- (4-fluoro) -4- (4-yl) -4- (5-fluorophenyl) -4-oxo-1,3,5] r (axl o-2-O-O 0 (-M-Sulfn-d-Lkarbaodd), Step 3; 2 K10r-40: 3.0-dsl00rft-2d-psr? M4 (&gt; 0-omr (b0- Preparation of 44IH I A5 | 4razm

One of the Klem nvaMi Lomfeikhtmn mnmmmmmmmmmm (610mg, 2.6: smnot), sriibiyylazilOpimoilysisation (1.43g,: 3tpmmol, 1.3eq) and (PlgP) PMCiDi (SUMMER 0.2 (Pt. vfemerskis dioxaebaft (S; S) Ä ef; ef ef közben közben közben közben közben közben közben közben közben közben közben közben közben közben s s s s s í él él él él áb áb u u u u u u u u s thus leaving the beads on the bead gel adsorbed on the column. The plugs of the ethylene gel were placed on one column and the mixture was subjected to a flash chromate spacing step (10; I) to remove solvent such as solids (343; mgm: 4% yield); MS (ESI) sn / z 281. 2. (Step 4 ~ | 4e (3 (η3-yl (η-21 bpb (α-4-d) -moryl> 1M-4-11- | 1, 3, Production of Slirlazsîï'lnifeiHhiïtîiu:

In a smkmlmMm, the hybrids are dtroethedene (4 ad), smart NaXO 3 (2 moles) (I m, 2 mmol, 2 ECU); p% pijPd (401 mg, 0.088 mmol), 4-yRin> bo'mnic acid? mgg. 3 »*> mmol. 1.5 ECU) and 2-chloro-4H-methyl-6-dihydro-2H-4H-x-4-d) -6'-mor (lead ~ 4 [mu] l] 3.5 [triazole] | 76 mami) and the vessel were sealed. The four faces i40M) Am: JO: warmed up to the melt The solvents were removed and the crude products of the crude product were chromatographed with epsbs: purifying € K.Clj''eri! -Fn.eta. (Ht: I) and later i. H1Cl1 / MeOH-NH.); 20; t: Ö * 1) was obtained as an off-white solid ($ 20 mg, 87% yield); MS (FS!) NF? 340.2. Step 3; 1 {~ · 4ρ4> {3.64> Ι ΐν} ^ Ε · · · 2ί ρίηΐ »ΙΙ} -4 ·· ·· · 6 Μ» ΓίοΙΙ »·· 44ΜΙχ3.5] ίΓ}» »^ · ίο ΐ | · -4 »« ΰ} · * 3 · ρ * Γΐόί »-4 · ·1Ι - urea production; brine {140 mg. 0.47 ruins of ClECk-vci (6 ml) made of decoction solution 4 | ·) ·) .3,6Μίη! Θιο-7.ΙΙ '> p! Ru'4'í! Ed "mo! 4,1,4,4,5] tri; iso-2dlH-ene (200 mg, 0.59 mmOd was added at 2 ° C. Zeilene blend was mixed for 1 minute and Amtbinöpiridlnt: , 7? Mmol) and i $ δtrt (8li: 001:, 19nm) 11); mfi: kbk for heat and; for rejection (for an additional 4 hours: mixed. Solvents; solvent formulations and: a; Mixture: semi-parativative HPiCMte was selected from the group consisting of 11'-FHH-1 (i.e., 5mg, 22% yield); m / z 460 δ T 1 4 4 s 4 4 4 -Mor6 h 1 -Hi-4-sA6A5 * ihííOOíí ~ ~ ^ ^ M55 1 1> ~>>>} 5 ^ 1 | | '-ees5ÍI |' 3 '· -pmíSímM4bkaf basuki eld &amp; I 1 *. | 4 «| , 3,5] tria / in «2-t j-fcoi! ) - S-ptridmM-tl-cadmium · (δmg, 0 28 bibid)} and kd-Ot (1%, wet) (113 n <g) were suspended in melat-TlIF / CU? C? 1} (30% by weight of junk food (I sat rhythmic) 3 »yan after the reaction was completed and by katahzatorl: i.'eliteÏM: filtering offs and removing: sludge pellets in vacuum, so that the raw product is scrubbed, which is dehydrated) Thus, on HELC (ΊΤΑ-phthidstte) tolyolytic (32: mg? 203? Wheat *}? - (tefluyl and trifluoro-yl-yl-yl-lianyl-1'-phenylphenyl-1'-pyridine-1-yl) 11-Hafbain-dl; MS (ESI) m / z 462: IM, Retee example: 3- ^ 4- | bï4 ^ ¾k1o | 3 * | ^ * 1 | «kt ~ 3'Sli> KI> ^^ n> i >; rfí? jiiíS '' <í ~ í ^ '| i ^^ Sffï'ïsîâs ^ - îI i s ps s i s i s -! -m «rföHo-4kibn ^ | tri» z | »~ 2“ t1i> *? | K # - »» eöl-8 * a ^ ÄI ^ (34 * Jl! »^»: * ^ oh ^ * sa;

In a three-byte flask equipped with stirring under nitrogen atmosphere fcxrpinr Π g. 4.24 mmol) Soyapentates: (water-free in TlfF (15 mL). Mixture; -7 S? Cm Hithium and 8ul, 1: 1 (2M TiE) (5.53 mL; 1.2 eq.) to;) and the mixture was allowed to stir at 25 ° C for> 0 min. To the reaction mixture 2, -1, -dichloro-6-nmrfolln-4 ~ li 1.3.5) trs3Z $! $ <99Ü tag, 4.24, mntol) We have given years one night's edge mixed style; The organic layer was washed with water and washed with water (20 ml) and the tops of MgSOt were dried, filtered and ^ Âiï # bà © st #. Thus, with a further purification using a further purification using ptunE OyMkmtaatop &amp; tt áv? €? €? /; ΜοΟΗ / ΝΗ3 (15; 1: 6.1), it was obtained as a white solid (600 mg, 42% yield) ; MS (ESI) Honey 340% Step 4vi4 - ($ vMmiÉ8 ~ UM Buttons> P <2,! Show *:

Dimethoxyacetate (4 mL) was added to a UFO tube. aqueous Na 2 CO 3 (2 mol) (1 mL, 2 µmol, 2 eq.), (Ph.n'!) 4 Pd (85 vol., 0.074 mmol), 4 - 4,4,4,5,5-tetra : <RTI ID = 0.0> (ethyl) (ivE2; </RTI> <RTI ID = 0.0> ii; </RTI> <RTI ID = 0.0> [alpha]: &lt; / RTI &gt; 10? 4 -5? 0d'H-4-d- {1: J <$ Jpjazm; 2-tloxyl} -8-methyl-8-aza-bictyo | 3.2 Hokink (500 mg, 1.47 mol) The mixture was fed at 60 ° C for 60 minutes. The solvents of the mixture evaporated and the crude product was cryopreserved; 1} to give the product as an off-white solid (300 mg, $ 1? Ízizatn): MS (ESI) m / z 369, 3, Step-Piperidin-11-carbamyl:

To a slurry of TLC (60 mg, 0.20 mmol) in OLC1 (3 µl) was added 4-tert-4-hydroxyethyl-3-bicyclo [3.2.1 oct-34-oxy-1H-morphodithi-4-yl] 4J, 51-triazine. 2-it} -ememim (100 mg, 0.25 mmol) $ 2 C ~ m. The aliquot was mixed with 1J proton and 4-ampsilone 0.75 imol) and NO (346 g of 2.5 mol) were added and the zeel mixture was stirred for an additional 1 h. The shoulder strap is made by a bitterness and the following is called: pizbmtOik mH3-bleed) so}} {'4- (4- (8-rng ^^ «··" -bike43; iodine} -6- (m) rroxy-4-yl] -1,3,5-triazolidinyl] -1H-pyrrolidin-1-yl] amide amide, 28 mg, 22% yield; MS (ESI) m / 517. m> yerlauehtpéma: 4 ^ lM4 - (^ Metií # «ipa-bldfe {o | 3.2 1! ^! S * | ^ 8l ^« Íi | ^ ia ^ á0) ifbeRMWW «Malthy68;

To a solution of tntosgene (20 mg, 0.40 nsmel) prepared with C 1 LCIv (1 mL) in 4-β 4 - (S-us "8-aza-4:>; cyclo [3.2. 6-fm> rfbitm4-'li4î (200 raf, 0.5 ï «» i) added 25 * 0 * 00. Λ the reaction mixture was stirred for 15 minutes and 4 ^. βλ * Φ> and NO (692, uk 5 hedgehogs) added and etc reacted over, mixed with solvents, diluted solvents and crude mixture with Mgmgs ({PLOb (MB3 &amp; édaægr)). , such as 4- (3- [4- (4-Smsettkyl) cyclopropyl] (ΐ> 3.5] ίΓί &amp;.<; Γ! - · 2- ;; ß -; ^; Ι} '0Γ0! 0 (χΗ> νηζδΐϊ · {ίΚί; kaptosh: (42 mg, 15% hoxam). MS (ESO m / x 559. 144, alphanumeric: 3- {í4 "AfofA4iss4 ^ 4'5 - {4-43-gi;" «Jbi'4'4-wrt0do} ~: &amp; n4] '{L3 (S | Sííí! 2í; v - 2'ibi «b · 'ftö) * ?; mile} ^ 5? 2etMu; -4 ^ i ^ äfl5« Rice-l &amp; r € ^ | fer eMbtisa 1, Lépési 3 ^ ((4 ^ iCi4t ^ 6 "mörfclis» 44k0 ^ | Preparation of d3n-Lkat'boic acid tert -bisAl ester: 3 µm? *? 0? td? p? 4? and a solution of NIL p6img, 8.48 µmol) in THF (mass) at 2.4 ° C to 4 ° - (or, tblm-4-4- (t, 3, Striazine p9H), m.p. 4.24 µm!): S4uSpOf: I was added (PC, A renketdei added; I; We pressed the press (PMou: and we'd like it) and 1 * 4 hours &amp;% mixed, pulp g reaction on chop, 4, add one more, and add solvent to the product. On top of a column, it was placed on top of a column and applied rapidly using CHiOL -MeDH / NItS · {20: 1: 0I) as eluent. à after fractionation and evaporation of the solvent (? 50 mg, # g% of product: yellow solid, MS ŒS1) ro / z 315% Step 3 (j4- (4-4t of α)) < Aliquotylmethylthiophenyl) phthalimylmethylthiophenylmercuryl (1 ml), so that thiocylethylamine is added to a solution of dimethoxyethane (IS ml), aqueous Na2CO3 (m / m) (4 mL, 8 mmol, 2 eq) , (fi3F) 48α (317 mg, 0.55 mmol), 444.4.5, · ··; ^ ^ »νϊ; 14Ε3.2] ]ίοχ8Ροΐ · οΙό? ν ~ 2'ίί) 4όηίΙ ~ οπΡβΐ pji g, 8.30 mmol, i, S eq); and 3 - [(4-chlorobutylphenyl] -4,4I {: 1,3,5]; rrazm "2dlamiao; pmethyl azetidinylcryl: bos5 acid • tertiaryuryl (1,3 g, 5.53 mmol) and fesMuk. The mixture was heated to 14 (PO) for 60 min. The solvents were removed and the crude product was purified by silica gel chromatography eluting with CHAllyl et al. 1: 1 / MeOH / Nl 13 (15: 1: 0.1), so that the products were obtained as unstable solid asymmetric spy (Ug, 53% yield). MS (ESI) - 442 Step 3: 3 - ({4 «M«) PhoM * il "6 ^ | 4 ^» ptrhltuM-4MrrgMP) - «teKiiL (3APP ^ s ^ **" 2dis5mjnoFmetilp · -it Idss * · LkarbunsaYAent-h «!

Trtfdszgéo (269 mg,: 0,9o mmoi) with CMpi (5 r # jf6sà »% ®detailed» Id & Emotion: 3- (144 (4 - amtnotefin) 16-anornal n-4d [1J] 5jtrasine-2-dam: mt3j-mmlil-azotsdm'S-'''Ponsay-tersthylether (§00 tog, 1.13mmol) 2: 5 € ~ o; The mix was stirred for 15 minutes and 4-ammoptddt> rt (319 mg, 3 µmofof) and NEbA {Lód,? 1.3 mmole) admixtures were added and the macelo mixtures were added for an additional 1 h. The solvents were removed by rotary evaporation and the crude mixture was purified by BFLC. fTFA-medij ?, so 3 - ({4 ~ sne; lo; π id-γ-Μ * r M x ut x x ut ut ut ut dot dot dot dot dot dot dot nd nd coated acid-4 µg / ml mg, S tP aw ans h (1 * 1 m z 2 S L. & R &amp; mmm β-pmMnMM-IMm-CminM compound 34; p-Morphim-4 ~ ilkS ~ p- C3-6 -6m-4dM5-imi-carboxylic acid Cs-budiol (λmax, 0.18 mm i), U> io «. It was stirred for 16 hours at 2 ° C The solvents were reduced by pressure distillation and the oulmite was treated with aeonium, 1 / MeOH (1: 1) (2 mL) to give a white solid which was filtered. The product was obtained as a bis-TFA salt, 46% yield). MSIES m / z 462. Rffet-eutyric acid: 1) <RTI ID = 0.0> 0- </RTI> ^ 1 '- (2'-4'-) - (4- (6-O-8-3-8? 06 ^ .181013,2.11081651-3-11) -6 - (4- (3 ^ 2, 1618-4 tspp / ml) tobftsMt was eluted with <RTI ID = 0.0> CH2 Cl2-yl-lys-R6-ylpiperazine-1-kanJoMe </RTI> as described in Löwik, et al., CR Ear, LËlrg. SLisem. , 2823-2838, p. (I) P-moiety of Pis-moiety, Chi-341-b, chlorine-1,3,5-1 risdo-1-ylpiperazbide carboxylate: 8-Oxa-azi-ene-yl-3.2.1] carbonylthio (8s4: i) g, 3.3 'mmol) of vatf <($ 8). "Needle spinylbis bovine chloride chlorobutyl] -bis-bisal-S-lilipyrimobutylbenzoate (1.0 µm to 3.0 molesSlaemostna (mlot 16 ml):. The rmmpmax xtöpimssm ssfcYermttílk, while sÄrä'-iÄöö ^ fesi ^ oMtt (O (VHLg, · ö, ymmol: adiank liozzâi singles tësxleî., AK tslsgysl 2 rays mixed with xiiiMi ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^) Miaiaii The sweat of the sweat is cool, the dm dizzying sS: ssfirusés eMvoliiiiife, vizzsi: we are dying and pfamm sgiMtiveate MS (Elf j 411.0, 41.3p pb! H) - 2, Step 4: β-4i. Ilokane ~ 3-yl):: L3, .5-lr! Aria-2 ~ -planxMxkmdmx liât

Tert-butyl 4 - (4-P-oxo-3-azabicyclo [3,2-th] -anthan-3-yl-6-chloro-3, 3,5m-xxin-2-yl) piperazine · carboxylate (1 , 0 g, 2.4 mmol), 4-ammonium methyl acid, pmafobester (0.69 g, 3.2 mmol) and methylene chloride (0.28 g, 0.24 mmol) in aqueous 3M odirine-xmonol 1: 1 The slurry of ethanol / isoacid (12 nil) was irradiated with micrein-Hamm for Î 2 € * € ··· οη for 1 hour, cooled to three times with ethyl acetate. anhydrous magnesium sulphate was dried, filtered and evaporated to dryness under reduced pressure to give the title compound: MS (LSr) 468.1 (M: -B.); 3, Step: TLC: 1b4; ^ 4 »II OSA 3-8za6kliÍöp.2vÍjokP8" 34Í) -6> 44 to (3-pyr {Pi 'iE ~ -4 iÍareÍ66) «{i) - {, 3iS-4Pis £ {hL241p pera * m- Leiman IFAX:

Crude t-batib4'- (4-arnyl <4eV4; rm - (: L <sxa-3xz; 5I: 4 <: bow (: L2.1 ject-3-41) · 1.3.5- -505000-241)}) ^ ¾¾ ^^ ¾ ^) ^ -1-Carboxylate! Cmin 1.4 mmol} was dissolved in tetrahydrofuran (20 nd> and then sequentially with Sibelg (0.38: gr LO mmbi) and trimethylfluoroethylene (2 mL), treated with a solution of aminopyridine (üp3 g, 5.6 mmol) in tetrabdrohrane. The mixture was reduced under reduced pressure to give crude 4e [mu] M - (4- (S-oxa <3- ^ b {eik1of.L2.13IaaP48P ^ 4i (3 ^ Mdfe4 * i {t ^^) M | p: p, N, N, N, O-ylpiperazine-carboxylic acid, one of which was purified by HPLC to give pure solid, m.p. = 388.2 (MrH) s-107; 1i: 4- (4 - (^ 'ösaa''irí; iii> ícík o | 3 <2iri «kíá8 ^ ~ - l) -I' - (|> spef" xm "I ^ l> -L33-! -file <Elix ~. 2 ^!> réíu0 ^^ pn1dísv4 ^) fosrhasúá cIMOMss

Raw fSîïXi-but [3.2. ! strikeM4iHF {4 <3> ^, 3, S-tr! y • • 2 · illiquidity · carb »?; ilate is added to 1.4 omro!} Hvé iiérme &amp; fc 0 m! and fcifiaoree acid (3 ml). The deck is reduced by the pressure id; «? betüraCnyltettük. Mamdèkhoæ dieîii-éier; you give. so dm wednesday is a mixture of sddd di-tfa for many years by filtering dkídbiiitoUön and home vacuum m & ixmmmMB (!; $; -> 4%; F | M «4 # -f» Referendapddm ^ (444A4-meii! piperazisdAi> As - (^ <> s «d-safes43J / i: lok? 'A4i} eh53 <5 ·· j,. (4 * (4« M3x80mtoíbicikfo [3.2.i] okayahi}} H ^ | ppíaz ^ k »rbami <b2TPÄH (I F5 clot) 98% in the mixture of »succinic acid and: Π ·> ν, ··· · · IbtmsHo i: i | Ami) 7TM melted» for 70 minutes and then dried by evaporation and HPLC usdhot titk, such as the iη drug!:!: i FA «FA FA FA FA Mb Mb) {{{B $ $ 50 * 50 2 2 ef 2 (MH MH MH MH MH ¾ ¾ ¾ ¾ ¾ ¾ ¾ ¾ ef ef ef ef ap ap ap::::::: te te te oz »« 4 »^ | r« »li}. Te te-4.flkarba!» Id eidâlHiss ^ Î4 ^ <t4 # çgÂtclktepJJjokfâpsMf | 4 ^ pÿàiW54§xU33 ^ «Ât * ll ig ig) 4 ^ iiNàiR? 4ÿ | i) «Carboxide-2TFA (<RTI ID = 0.0> 3-dipyridylacetate </RTI> <4 ml) and Ttiotl atainbaB (0 .10 ml) ixmzaiddddde (0.10 µl) (treated with pffigt, A * di &amp; and HFF £ 4v tlszÄtodi, so «'the compound of the title was worn through my TFA salt salt; M $ {ES · *) 57 ^ 3 (Mdfi -v 110. Kefereecisp &amp; da ~ 44 ~ i4- {8-os8-3 - azahkfktopP || ekF3dlk6- | 44ptrMta ^ ílmdll} psperazí8- - LdH, 3b «riazm ~ 241jferotK3 ~ p! rsdsn-44lkarba« nd dictation 1 ye! s, 0 Ovi) vrbíuk'ol! 'linkem 1 Ah φ pu. <m Fé; 1 td «iWi», Fd) tmmil> Lp'.rid «4" d) carbanddvTFA Π50 mg; dlldóroitnanlmn {4 mii and iridibammhan iö.12 m!) 3 • pinninkttrbovddeidddei (Ο, ml). then nanumdHaceioMhorohydride i80mg). The "fly is dried by couples # y $ Η £ -« iá "!", So they get the ctm seri tht:''F'HkA: sópAO «; MS (HS-H 5773 (M * H) · HL RefeeeacbipéMs; M ^ ^ 4raedlpl | K; rad8 &lt; 14 > II) &lt; 4 &gt; S-ox8 &lt; 3 > Í ^Í Í; ^ 3 *aí * * FSisis IraallllííFS-pirk pirk-is--ilkikiirirlalaidid ««aaa« «- - - - 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 pip pip pip? -: ΙΊ 4 || * 1,3 f -2> í í) fb «1ΙΊ» 3 "^ {bíídösn ^^ ip 'karhamidOTPA i 1230 Ing) dikinmteiäÄtt (4 mii and trieOFammhan (IrsalJiiegitFkkii'id treated). steamed and steamed: PLC> tdzdiottidF% y à h  iti iti iti iti iti FA FA FA FA FA FA FA FA 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. 2. | | | | | > eraziätk | dib ^ (^ dkdÄiZ8blelkiöPi2.? | <ikt '' '341VL3P' li'iazir'-241} reisiKLpyridine-4'forbitoid l * (4a4-t8-Oxa-3- &amp;amp; tbi <iktof 3 2 1 | octave 341) ^ 4pt ^ r8ZÎt> llHiI, S "Piaàiii * l4i) femîjh34pirûbü-44î)" · Karhamld-ΠΤΆ-! 164 mg) in dsk10rmethane (4m) and trilyl andnbatt (I · «! } we started with diatomolithioaceo-clotdd ddochioriddd (100 mg) The hills are a snowball, warm, mysterious, and then bulleted and HPI-G-szt Fistitotik,; g> a cin; mytholytic gate, TFA, TFA, MS (FSO 57), M + 41) *.

H3, Referaiteiapéíds; 44-14-44-4zolide thio-β-α-thiyl-6,6-oxa-3-α-cyclopropyl-3H-2H-3b-1-tert-2-yl-24-yl-tyl} -3> {> iridium »4 llkarb8flp.ÄöMm (100; Slg $ Ä1 $ t * 88 $ bfcäft (4: ïî-il) &amp; iriëiülà © n pà £ à £  ° à £  «pÄM4ÜöridM <ί # ίΐ% we started}, The dice dry: pâMlitsk Fs EPLCko (M &amp; onek, l | ya-rhyme; suffix: get>>; 1'bA swan; MS (ES *) 593.1: (Mkt) * 114; Eelbrooda example; {d-dCprktln-d-ltka ftekmmW ~ · »gotRelltenöl -1 ^ jMÄÄ'S-iilijlpjirs ^ ä-i-isarlJösiMt pt {<t .. (4 {g4 '.) xa'3 ^ u? abiciM'3: 2J) í.4aAlík44p43eí <t ?; »' ' E1-16ESES-Tria / IR-SE10e11sES-ipklin-1-yl} · -Rarbamk24 FA-r (75mg} dichromodetahba tetrol} <transformation (2: ml); &amp; ), the mixture was evaporated to dryness: and purified by RE-HlEX, so as to precipitate the precipitate as a wearable FPA salt. MS (ES '<) 540.3 (M t-Hj s-U 5, EdbFePSsoft;; t44A4 ~ (S-ax8-3 " 8xal4a§klö (3v2.1jöfeMií-34f | "I- (4-ököpípékidbí" l "H) -, E3, E» MAAM -2 * s ~ ^ f «ü!) -3- {f} srííiínM- H) &amp; srbas «expedition L Step: I · <4,4ΜίΡ65Γ3,3,54ηκζ03-24 (> ρ || 5θζΐίΙ1η ~ 4 ~ οο: MiesneNese« mix · «to ice-vb degyi (72iai} add to cianuHdoriti ( 2.2 years 12 mmd) oedtmod | 4 $ rni). then piperS <lna-uu:> aolkdT # lvkbö: fefefMöt: (IJ g, Î2 mmol). Mstmml- {Mimi} and water <16 inl> were added to the dendritic Ac additive to add rtfiumAlgrogdit-Aarbooat (2.2 g, Í4ina). visas! (25 mi) SauSipesAbja on the cake. The mixture was stirred at 0'4> for 2 hours, and the dm according to dm was filtered off with dichloromethane, vbæel otOsOtk and vacuum.

Ml (ES-·;) M $ M (Mt-Hjf 2, Exit; stÄllbb · mare; 8 * Ö, xa-3-a2 »blcikksP.J 1 jsAldodoreclorfd: (6b nil): vis: oMâtsi Add 144J ^ Primer 1, 3 * 5 * b4 [alpha] 2 * i [p] <RTI ID = 0.0> (R, R, R, 4-thio </RTI> (2.7 g, U romol) acetone (48 mL) is prepared as a F suspension. The degyhex is a solid nickname: (3.5g, 24mmol): adjunct, Λ suspender W * O ~ m 2 Ara; ksvsrtök, map is left roomSoSurface, we have the compound according to dm by filtration: dehydrating, waxing and drying under vacuum : MS Ibid-) 324.4 (Mdl): · 3, Step; 1y (4- (4 "amisôté« îîEsAp-ossi-3 ^ azabicyclone, 2J | octaîï -3 "ilk-îdi ^ -ii '! RxiR" 2 "i!) Pip» ddÎ8'4- .p4 .. (g..O>; a-sm; sabiciki «13.2J | oktàn'3-yl) '6-kîèr'4,3,5 u1ttzia'-2'lî) pip8ndi« ~ 4'Oo (t, 0g, 3.1 mmol), 4- (n-n-dinophenyl) pteryl (1, 0 g, 4,?: mmol) and tobacis (: ferric: ifbszAn) » Palladium (δ, 2 17 g, 8.17 tnmoi) in aqueous 3 M aqueous solution (3 m és and 1: 1 ebuCoal oil (12 ml) was used to irradiate the lozenges. After cooling, the two blends are blended three times with ethyl acetate. -t) - 38i, b (M * H) f 4, Step; 4 "p- (4-thaxaP * azsbk | 3,2.i) 8EtatfdlLS '" ppmpiperidyl} 41i * L353,3Pyrazbt-2- • ylthio > -34 | «RklmMdl> Karharyid denial:

Yeast E (4444 µl> 9) - 6-4S: a> Sird-azabolfe-1, 2, l-octaph-A4-1, 3,5-triazole-2'-piperyl: ym-4: (mole 3,1 mmp) §: and triétibootm (flies of 4 microns of meta-meta-aliquot <3m ml4): trilium gonorrhea, g.

Yekmmol} followed by 4 µmopirir (KSSs, 19 mmol) içtrahidrotnssmml pb milMsxSi MMa- râvM, Ax S Ssock »5t t U pressure - saMmera was evaporated and msm. &amp; etrn compound obtained as TFA salt.-MS (ES -) 501.2 (Mdîr IM) »sisií ;á í d d d 5 d ^ f4 * (4 ^ hkiroj3f> ipe! rtdt) * Preparation of pyridazolecarbamyl (4-oxobutyl-3H-4-oxo-3-yl-HS '- (4-oxo-naphth-1-yl) - yl) -; iK8? fi? 2? 1? 1 ?,? -? 3 - (Pyrrole? -tikarbum? d-TFAA (5S n? g) was added:)? 0 * C ~ ou «atrium ·· dKrokfdrid (H) ÎÔfttânhg.the room temperature ..« * -eï gy gy #: bd áthefrequency ,, · · residue, which mbsjiiPFLC-Yettiszbiobank, tay a dm szsäints cholesterol iH; ®i'A: -s® | ^^ MS (ES * ·) 503.0 PHH) 117. References &amp; î t ~ | 4 ^ | ^ fbs «kl! amsHO> p {peiridie · 1 «^ ^ ilNlri here ^^ ^ Fetti hprldin. '^ Hkerhsse Preparation of 4d (4 * (0'Oss3: ~ [d] d) [3.2] Thiol 6 [(4-osopiperaphtho-1; d] F] 4-Alimyl-241) 1bnyl] -3 "Mdl" -M-dWarbrnnidTFA (BSmg) in dichloromethane (Sml) and brine (3ml) is charged with 1-amine (0.030 nd). then with ice cream ÍO.O j.6- 8 # and «here'H ^ j ^ a> Ä> xiböFohidri« l # Jl p £ '. «^; 3kÄ) i®J $ i. The reaction mixture was treated with methanol, and the mixture was evaporated to dryness. The residue was purified by tlPLC to give the eb γ-sulfide compound as d> -TFA MS (ES ') 502.3f.M-4-I. Reference example: 1d4 "t4- | 44aatdsaj« H>) tdpemd} S ^ ïdliyO "(SAssa * 3 * a * a (show: ibp2Jf <> kt''3AÎ) ·· ~ l, 3> 5-4niizlndM1) ieroi} -3-piddm - Preparation of m.p. 1 - (4 (4d8A) aa: kasabicska3; 2.1 | cAtane "3" li} -6 "i'4 - osopiperldyl" -Ii) - 1, 3, SdxiaKlnAb1} ll3dpkd <mF 4 -carbarbdd-TFA (50mg) teirahydrofuran (5nd) metmatmnn &amp; l (2.0M okku udraindrnfm'asbai, 0.16ml), ni <tjd glacial acetic acid ( What was and what do you think of the end-of-life u-thne &amp; nohiiii and the ìjjjig sabirtKj'a pdrQlmk. feisip | jÍÉ :: # ^ i ^ »Aj áfeéib); MS; pS-1) 51 0.3 (M +) ·); | ^ (4- | 4 ^ j4 - (étb «ï bíö) piperiddv-l'ii] '6A8: a' 3'-aKabteiklukk2.1 jokt-3-Hk" U3 «> trj8ïJ8 ~ 2 "èl} feail) -3-pindi« -4-illuireaides 1 * (4'k (4 ^ i8 ^ Xi44a * {{b! how much? d1 ^ É3 ^ il | j4Ss | i4> 4 ^ 4> ^ iArM # ^ îj ^ Ü5i-3. * (Plrifte »- 4-i |} carbamyl · 1 FA <50 mg) · tefraHydrefuräfthan (S ml) with ethylamine (2.0 M solution · in the thirst for thyme) , 0.16 ml), ice crystals to.oOO mit and · immune tracetox hmohydnd * {<11 mg) were treated with methanol after addition of the reaction fluid, and the mixture was evaporated to dryness. Thus, the title compound is obtained as the di-TfA salt of MS (ES ^) 530.3 (Μ "· Η! '13Ö. References example»:: ís'4 ~ | 4 "(4» {[2 ~ {dtmeíHamíu <0 ^ Oi) aíSHnsí) pjtHnidl »* l * Ill-i ^ ya? -Arabidid · I <d3.2, M« kt-3-10-1,3, S-rria «ist" 2 ~ iiSf «syl- 3 ~ pirldi £ i'4 ”Slksrbíkíkíkık We have set the« .lm saurine compound in the reference example 118 «as« &amp; * (4K * $ ^ ~ Bcl

• azabíesktojS.?.! | Okjdn ~ .3 "yl) -6" i4 ~ o \ opiperldm ": i4: l) s i3,54na7ln-2dl) phenyl) 0" ip; ridijo4.jt) t: {|) gm: isf2rFA ROmpt N, K-dknctd-ctlJéndiarmnTi3i (0.Y. 26): Reaction Paths and iSi.C-vef tftfiotmk and trl-TFA as a TIt. 'Ha ^ »-' 2 'H | fc«> l} -3' plrldie-4-Hk8ri) ï s s s s 1 1 1 - - - (4 4 4 4 4 4 4 4 - »îV6" {4 O ". 'Spspi:; dm- î-dV î -.) - 4 s fern IV' -tpiridîn ii ii) that r r TF SO; SO mg) 1 - {4 -anthnoe "Ripirroi sd i-mri (0.0) 9 mh resonance beam and à; s s, kísérieu in the example" nistet; decomposition of the compound according to eins as a TFA salt; MS (FS <) '4) 4.4 (Md-Bj) -122 <Metmei> &amp;amp;Pst; Piperidyl <RTI ID = 0.0> yl} t, </RTI> 3,5-tert-4-yl, in''2'-iphenyl) ~ 3 '(pyrinyl-5' '') xrbainhydro ; i. {4. · (4 '<8' <> ^ «'4ϊ-aKifv4eikks | jt, 2 î joki n ^ di VíH ^ KíXöpsperindin'41} ·' i ^^. - t-iliknibamtd-TFA (40mg) and 1-methylpyrazraz (O.Ö5Öml) and in the 18th reflux period, following the procedure of the title compound after purification by HPLC; MS :: {ES-ä-} 5S5,9fMiH * * 123, Ile-i4-t4 "(8-ea> 3-'schools> i3,2, M St St Ö??)) '6' (4 '{2'Illitials.com}) * eridiS' i ~ H) "ï, 3,? Ktrlaïi8 ~ 2'il) fe H) -3-4 |> IHtHîï 4kM) karf »the« îtd dssHiiásaásaásaása fa fa fa fa fa fa-fa fa----Osa Osa---i-azabscikkif? 5 -> heptane-4 01-6- (4 owing, s î> 0 ', 1Λ nsaest-3-thiophenyl> -T-Mom · 4-yl) urea · 50 shirts «nnoiabdnh (0) 920 mi} Mmdtdvs and Π-8. í'öietvamapáMfert following hemuMMt sweeping &amp; Ät at &amp; gyntetee -dfcTEA as a soy ÜîfLCks ilM &amp; in. : Β P:: 34 (1.3 (M-1'-l)) · i 24, Re &amp; Δ4 ~ (4- (IFeyarih-8jhiei), 3,2,1: pi |> eridylS'-I-yl) '- K3> 5 ~ Irish iazine ~ 2'-Ipepis)' - 3 '' (plyídm''40Í ) PrhamIl 1 - 44- (4 (8O3) 3'-zabicyclo [α] -1-octane-3'-yl] h ((α-trifluoropyridin-4-yl) i) kaf ( ) aínii.i '] ï A-month (S0mg> ès and H2- $ mm «ptii) morpholine1 (0.03 Î ml) Idi ^ blVp - ^^ - Jiitví reno ^ léidá' itati demonstration« followed by the Pine chemicals for example, MS (ES *> ft) 5.9 (MtH> i-3S, teeSeesOpdep: loktàn -Sksk ^^^ pvptridisM-'ÎInresi) ífe8i '' ^, SvtPmzsi-2 ^ tl ) Piperonine-4-yl-Psol) Setaacetylation of 1 Se > 3-thiol: abylcyclo [1] octat-1-yl-3 '- (- 4-ox "| 5S-5-pyridyl) -1'-oxide <355 tricyclo ^ xm-2-y) i «ethylphenyl ^ -3 - '(pí3Fíáíí3-

• 4'ii) Carhainid · 1''F'el (50 mg) and glycine-methyl-cyst-hydroxytrid (20 mg) and Peti-amethyl Π0 drops) following the procedure described in the retention example: kdonites do not dl - TFA salts »by HPLC. after cleaning; MS (13 yrs. 574.8 (M: H} m & n &gt; r &rt; n &#39; C ' C ' C &lt; / RTI &gt; C &lt; / RTI &gt; ^ ^ if if ei ei ei ei »» »le» , Pt (4 µg / L) Sa &lt; gb &gt; sbisicipip-2-ynane, 3'l) &quot; 6 &apos; (4 &apos; Syiazine-'SdOtenlIVS 'diclofi'-yl-ijprpranil'TFA (59mg) and glycipamid-hydropipipridbdi (ISmg) and tricyclic amine (10 drops), followed by the press shown in the formula I, according to dm. Compound Xi dctIKA pEdEiPiPiPE jctIt t p m MS MS fc s t 559.8 (Mte!) ·: ·

Wh Referendum example r 4 | aretdô) ife8tl) '- îPj3' trâP '2'Iii) ptperMin''4dIsis} pô) i * ®îëëll 4l>! 3, S4daxiîj.'2'-i!) ^ Sl) -3Kps ? 'îâsn- «4-Si ^ &amp; fb ^ 5M'TFÄ'-lsö :: pà © ssg) and (33mg) çSrie0kamio2} (18 ps)

kmPtiv &amp; and: || ϊΙλ 'i ^ fem Ä g g irm irm irm st st ots eti a eti eti et et et et et et et et et et et et et et et et et et et et et et (St MB 128: RéíerííPeispimens 2- (i-f4- (8-o ~ ~ ~ ~ ~ ~ ssa ί Ι (3 3 3 3 3 3 3 3) 4 · it «m (k0Fe» iii - 1PS-insM a -2-11) pij> erid ln-4 ila ín mo) eeeisaví é l é é a a a T T * * * * - - ““ ““ (( 4'-S-oxa-3-α-α-β-β-β-β-β-pyridine-4Blureido) femyl i, 3, $ Rna2i «-2-> tl) plperk-isomaltoneMiol (28mg) in dtl. ml) ftinypgsretsav Π ml), and its stems -k. dash :, S'FA salt of the desired g gpilslëbfeapfek, MS (£ $: ·) 560.2 (MiH) t 228, rafer example: 4 ”} 4" (2,4-di xs-8-8 * spiro (4,5} dtH> IMi) -6-morphol-4-Ui, 3, S-H »iPBb '-ïljnîâdm prepared by MS (HS · ·} 288.47 (M * H) + 2: 3¾ Mefepodapetda; 4 - | 4 »| 4 ^ l, 4 - <}«> sa "a" asplro | 4,5 | d8C "8 * 0H | d «0t, föli« '4''ll> -13> 5-trS8z »H-2“ ^ Iiljf0 ^ fri ^ |} irldlri ^ iiket2> nmid retrograde; MS (ES *) 519.58 (M B2V · 23: 1 :, Refereodapéid 4 ~ j4-> j4 -> (4i ~ (Hi> sa "8"). fl) &quot; β > 4 > H &lt; 4 &gt; 4 ' -dl, 3, 5 < / RTI &gt; MS (ES4) 519.58 ß'Μ II); 233, Hefspnil Example 2 - (4-14- (L4-dis> o &quot; a &lt; 5 &gt; sspln5j4.5) dee " 8Bl) " 6-morph < 8 &gt; -Il-1, 3,5- [¾]% ^ ““ | | | |eeillillillillillillásaásaása 3 3 3 3 3 3 3 3 ((((((MS; ES) 518.59 (Mt H) -. ':: i-j4 - (tollim ««) Íemii - 3 ·· (4- (4- (E4 »dkiS8-S-aMasptf« j4,5jd «c-MI>' 45 '·.-morMln- MS (ES +) 561.66 M-BI) -; -. 234, MepcegeiagpSd; 1 (4 ~ rf8K »fe 1 ll) -3 · (4 - (4 - (2, 4-dsix> 8--8 * aspira) 4,3 (d x x8-} 2> 66-mfelrfeljp ^ 2k 4,3,5-t5'li5 ^ ki -2'lijien4i | carlsamide feeder &amp; MS (HS> ·) 54 3.60 (M -: - H) &gt; 135, ftferenemethers * 2 - (4- (4- (ΐ ^ Ιοχβ - ^^^ ρΙιτοΙ ^ Ιάΰη-ΦΙΙΙΐΦ- ^ ί ^ ΙΙΜ ^^ Φ-Μ ^^ ΜΗη ^ '#: Production of JJ-tbmdilpiridsn-B-dfJkadmmid MS (ESB ·) 533.6 i (MB-I) -! 35, 'RefereKdap & da: 1 - (2-fd3nmiMaiïîi! Îo) gtîlj | 3' {4- (4- (- ii> s> rP> li3-4-it-1,3,5-iptei) - 2-Mjf α2 | M ^ 6ldldldldld:::::: MS 2 ES-M 313-62: (Μ5Μ) s 237, Rdemid Í-l4- (4-fiK) 'Mvtk6-'k <> knM ^ M * l, 3,5'tria ^ m - 2-d) Rm} ij-5- |> iridm-- 4 - dk8r- · bamM deâdstsVsa WRMS: C2 & H.MM8D2 + IP Spam # ® Calculated, 595.20838; pip pSI, "prtfl4 megliggdt), 595.2898; BRMS: O8H24N802 ·; · · · · · ·, 885.20939; found (BSi, [M Bt]; sMmoi), 595.2895; erythromycin 2 - (d81 "orallyl - (4,6-dt-8H) xa-3-a" abt-tolyl-3'-yl-3-9-yl, 3'-8'-tert-2-i-2 '- one; feepdm is a ddImItIon

Clamt-kjoiM (922 mg, 3 times) scalöpsk! (8 ml) was added to ice. A solution of aza-trans-α-oxa-3-pentylcyclopropyl, i.p. (750 mg, 5 mmol) in methyl acetate (2.1 mL, 23 omipl) was obtained. After 28 passes, the precipitate was collected in vacuo, yielding 2.8 g (nocturnal pores, 3- (4.6-Mt &amp;amp; 1, 3: 1S-Bac5a-2,4-P2: kS-c > a-3-aa) &lt; / RTI > tlk2op: .2, i] octane: and 3,3 '- (6-chloro-1,3,3,5-triazm-2,4-du i) {8-oxy-3-azahalkyl (3.2). It had a 7: 3 cardiac mixture of Joktao. Its mixtures (490 mg) were 2 '(di-methyl);' li H-benKofd]; roasting (Ί46 mg, 8; 87 titm) and K 2 CO 3 ( 987 mg, 7 mmol) DME-Pa (2.5 m2) was treated for 1: 8 guard, tipd S-part *, so 1; MgglleltdMlJMM ^

^ 4Ke | '4:] lr ^ id8® <g' '^ 4: t5' il.,> v ^ - &amp; il! -! 2 a 4> * nb »</ (&amp; <' V5 'U <g3 2 1' »Hdan> 4 chunk HPLC-« iissEiM Ä *. 475, # &amp; IMMnescIepeida: set &amp; 3 <4 # 0; fe1 # ~ í, 3i54 {ia «in-2 ^ VAT (S <s 3 3?>?> O o o o o t t t t t t t t t 2. 2. 2.) 2.) ek M g 2. 10 ek ek 2. 2. 2. 2. 2. 2. 2. 2. 2.. ) sdmnfe, rê # smekgÿe Me-Temperatures 3 <Mn 41 mixes, Aa-segregation saslkM anvagoi ssc &amp; t-ting 6s vteel washes, The exaggerated nvers are: lissm voll: ès iisatlt &amp; s ÂÉ: lavISb: - m kômtkmo .Probe. éket mixture (270 n; g: imnyl; 2- ^ ifiwoapsvetii ^ -M for $ 46mg, 0.87mmol and: MSCOo # 67 to .7: mm «l) :: kexeli8k: I> ME ~ öfen: (2.6 mii for 18 hours: pass g ^ .2 ^ ui> »~ ~ ~ f4> nK> rfoi ^ 4lí ^ # Ks> í» "l-'áé8 |! klkk (P'i; 3ii'i-iS-1: Si-13,2 ?, R 1 -Sib-> -12i: Ii::: Í Hlsbenzyl lysidyl) ddS!! <($> Referralscard; 144 ^ 4> this is what ^ me ^ €) (â ~ 4i-3l ~ 3 ^, 5iil ^rli3M2 »(l) ifeeill ^ |» lr1.d3 »~ 4» t3l ^ ré 'ImreM rIllIiIlI op> 2! 2® €; MSffêS-f) m (g 433.3: I <| I, referendum;); íg ^ ^ iks po po · sm sm sm sm sm sm sm sm sm sm sm sm sm sm sm sm 2 l: i: ≤ 2; MS: pSI | s &amp; &amp;4902-142;i; -: | 4v (4kko | tï ^ jSôs3 »6 ^ m« rO> lln-4-lüt ^^ "ΐΓΐ82: ίη- · 2--0} 6ϊηΗ) Μ” (4 ”| (4 · -8 } «11Ι" plpergælo-1 -ilJIM fiion 11 ffend) production of rliam id; MS (ES!) Ta / àt 561:, 6, 343. Referenehfiáldália '' meillpltiedd! Η · '421)!> 8ηροηίΕ déálíMsá MSPSÍ) mM ; S7 $, 6 344. «Krn8p» jréMsi k | 4y34dMssa63 ”aaaldelklöjj 3.2.1 | okk | hsÍ3« .M | 2 * |> lpefldsn * 1 ~ lÍeloxljsÍí3, S '·

-ό1ηΜ «'2 ~ 13JleMl} - * 3ip3rldl8-4sl3k8rl> Recovering &amp; MS MS (ES!) m / a 531J 146. Relay Modeling for You tleelfeklil ^ ## - <öx8M-8: A8L »idkk (P, 2.3 | 6kí" 3 "FL3-l, 3, Mtm2íB-3-yl} metal ion) karMimdt« LMI ltágs; MS (ESI) mM 650.7146. IMIllenic acid 1-elclc1H4 (4 ^ 14vl4 ^ ({| 4 ^ (4) CH2Cl2 [mu] mi) MsMi8 [alpha] 1] <RTI ID = 0.0>> yi> </RTI> (M 1: 3? 8? -hydryl? (3.2.1? E? 3? 8?> 13; S-td8? K-24?) lphenyl) k? Pamide? Y? O? (ESI / δ 7S, δ147.? y as ab »» és s s s s s s s s s s s-4 4 (((4 4 4 4 4 4 4 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 4- (4-ylpyropyrene; <RTI ID = 0.0> rssi </RTI> ~ lll) fe8lll-3 ~ {4 »| 4 '(8 ~ ovaM-a25Mielklft | 3.2.1 ll ~ 34l) ~ 6-o | 4 ^ | (p? rdddd4 4dbdbd 8s04eMeH ^ ^! ^ P, 3 "tn8gls-2" lli (s) (shielding MS (ESI) m / 2 712,8 (49 Jkéférénclairrés: K4 ^ 4sl {2 "sramoethyl) aral j ^ 8 ^ xaM * 8æableifcloj32. I ll ^ iHP »^ Ruling 14RMS: Œ1Î23SI002 and seeing this page ^ ..- ^ I« ^: «^ I # $ (Mother (ESI, IMMÍH · megigydt), 4632388. ISO. ¹H sineHHnenerararara aabieelelelelelelelje ^ ^ ^ ^ieiklelelelelelllff)) ^ ^ HR ^ ^ ^ MS MS MSllff)))) * HR HR MS MS MS: C: CH26NN80O2 t · H; eSe sMnMoit 495.22515; found (ESI, | M4lî} v observed), • 4952240.116, ~ plp «? ^ m-4-" ïfeii ïsëï8S £ âisîli Millyla MS (ESI): ») / 2 Μ $ Α HEMS ; C $114ÍM $ $ :4: + H + for Formula / Phenyl, $ 16.33543; tufa (ES), | MS: Hj + WtMMM, 416 (524 ?; HRMS; £, 32114 IE 994 · + H- &lt; · · Total Glucleotide Calculated, 616.33543; Found (ESI, (ΜΗΠ; Calculated), 6) 6,3354; 152, IMferpiExample; H4 ^ 4,6Hahli ^ orfoll6 ^ IM! Ll? »« - 3't!) Fe8lt {- ^ {# | i @ lines> 4 ^ 1 ^ teellïi «· Preparation of the fatty amide MS (ESI): m / z 573.3; HEMS; C28B34N805 6 31 ·) · IshecleantMtBlBeB, 375,27341)) (ESE [MMi] -; - msg% * S | 373,3722; HRMS: C28K34WSÖS »mm $ Mplam« MtSiftett, 5? S, 32M $ IÄ (ESI, [M H]; - s.), 373.3725> 153, rhythmic matrix: δ - '(4 -1414 | p "R) 4i> <) xs <4ll) ai) 44S-ÜxssM * s5) b5eik | 3.2J | ecn3 -) IE) J) 3 "· Infiltration -It is produced by the preparation of MS (ESI) m / z 463.5, 1: 54, M ethod: 1 - {4 * .mu.l ^ (set 8M5 | dlf) -> 6 · (S - xa - 3 - aza bld kb> p.2.1) ok ¢ -3 - M R1.3 , 5-4 [mu] S [delta] [beta] - [alpha] [alpha] 3 - |) s: FklB5-3 "[delta] rbssmsdfel6pIMsa; MS (ESI) m / z 474.5 151, Relbr« «; β4-β-Sstsrlbbs) #### STR6 ## ## STR8 ## ## STR6 ## ## STR2 ## ## STR6 ## ## STR4 ## ## STR11 ## Preparation of 1'-methyl-1-pyrrolidine-3-fluorophenyl) Ib S (ESI) tn / t 533.6, 166, Ile fersadla exemplary: l- (4-i-4-p-3-trifluoromethyl) ^ m ": |?" 6- (S 0S8-3MKSEE] k) oi3,2, l] s ', MJL) -lm 5-ΗΓΐ ζΙΐ ^ ^ ^ Ρ-'ΙΙΙΙ οΙΙί-'Β-ΐΐΙΐ' Ιίίΐίΐ - ^ '- ΙΙΕδί'Ιϊ Preparation of MS (ESI) m / z 476.5.167, iRetylation-1-id-P-Ed-e-cycloalkylpiperazin-1-yllambml-bH-β-P-β-melting -341) -1 J-5-lyisyl) - 2'41) fe5iE) -5-pl53i] i5)> 3 ”) H> siä siä siä siä M M M M M M M M M M MS (ESI) mfz 571.3 168, Reib mtola III; 1- (4'-{4'l-41 | 7isyl) "3-p) 6-naphth-4-carboxyl-8Si5Si-MS-SS) s ns / z 462.53168, ReRa'eatdapéídi {4-I4: Kiprop« xsfeMMyxsM ~ tbp2JiOf3-4i} np3dHs: »e ~ 2 '~ i1 jiffe il ppersxl« -i »Preparation of Il 1 lis ç-fessSE? 16, Eefmmeiapâkls *; -plrmdmMHikarfcaaml; MS (ESI) m / z 438.8 161, Preparation of Refereoapiae: MS (ESI) r / z 381.5 162, Répée) Preparation of aisolate, MS (ESI 1m V 448.2, 163, Éefereneiapeta; l- (4 ") [4H32 ^ 4sbk) from 2IEp ~) i-a " '4-b) Fei-i« <H4óIl «* 4n) -l, 3-s) n« Zi »- 2-41] &amp; nb] -3- [4- (4 [mu] m [delta] iprazb-1-yl) crb-1-yl-trifluoro [6β] moiety; MS (ESI) rate 584.7 164; 4- (| [44 (4-Carbo-6-recrystalline) 8- (4-dl) -3- (4-fluorophenyl) -2H-ll] N-1 - (1-methoxy-4H-4H-f0b "zamsd) ; MS (ESI); 530.61, 165, Éëprëîi «Iap4ki &amp; SS ~ S2» ElsM &lt; tb &gt; 5i &lt; 6 > 6 (E) (((4- (4 &gt; 3.6 ~ 5: rIa * sife -241) 16alI | &amp; arb8í »Míl aHi) Eenz8mile &quot; MI (ESI) m / z 5 &lt; tb &gt; 8.6 166 < 1 &gt; -> 6-S3? 6Mis? M? IE?? 3, S-frlazm-2H {) 16? M. | M? | 4 - {(4-K) et) Example 1- (4 ~ pEd) aielylamine [alpha] [alpha] [alpha] [alpha] <1> R <1> -O] k4rf * 1Hl «ali} -3" | 4 ~ (4,6-6bft () r6SiIi-4 <- Preparation of 1, 3,6, 4r) α) n-24IeEefylaIdMiMiSv 01'IfN904 ΐ: ft-; Example 602.3? G)? G: pyr), 602.3193; ÎM, MefereoekqxTda; ^ I ^ ({^ | l, H [disßet_support «u} etiS} piper8Kin ~! 'U) trotting {9ii) f ^ Ui'5- $ 4 ~ (4 ^: 4Ïd8îdrf <sIm4» liPp $ 4 ^^ dtamil; -5RMS: 05U-54N5Ö04 *! L · ö.wvgkOplete szôteîoU:, 643,364985 ode (ESI; IM dip: set: 6gyeh), 645.36 55: 169, Reflected'Iapetdaas: |: ~ {4''f4 "P'iöxs-55 - ^ I> kSklo | 3,2J | t5! I6'345) - 64 {pi | 96? 36555 ~ 4 ^ 55x4gii! | SmslHs> | -> • '3.33 - ß'ϊΐίiSi - ^ - il |! ^ sSí3'ξ> ΐî'ï <|: sϊ> ^ - 3-4ilssärl> link «I elösäI ^ MS UiSbtn / x 5 55,6 Ft.: Hebrew« » »Î '* i | ^ Mri» îs «^ rft | fè» ll ^ pr »3 ^ k8rl> aœiiâ: 5 ^ Sàilità8a; MS (ESI rmfä $ %% $$'. 4-p "Oetyl88S3 · dl @ 1M @ 3a [beta] 3 [beta] @ 1 S @ 3 → 3 [beta] 2 [beta] 3,2,1 | Preparation of ¹SSi ii ''îî |îîîill 45 45 45 45 45hhhllhhhhhhhhhlll MS MS MS (MSI) m m / z 482: 5 5 72. Rsdai'etielapOIds : i "{i |. | <| .v (-5" 8ietsM "is: i5sidropirj5» idiii-5f2H) "i5> -6-p - s> x &amp; '- 3-'8« ii6c6y- · | Β-2-3! <; 5s; 5: 3 * 4 [mu] l [alpha] 58 &lt; 1 &gt; 18 &lt; 3 > 3 &gt; 5l | Pi4l | p5p4 &lt; 3 &gt; mid-year-old MS (ESJ) '; SO i .6 ITS, Rel. example; I »P3 | 43 ^ 0MM ~ sæsb5 € ikIo | 3,2JlôkîP ~ 5 | ^ 6 ^ 5 | 4 | ï; 5 |) ? -558iftX1) -?: 533? -F'HKjn? 1IPIPS1? '- pyridylmethylcyclopropylamineSssH MS (IM)? 530.6 174; 5} okî'3-j3) «IJp <1> xxSS-S ^ dlPryl ^ S'pIrsdlft ^ ilkssrOsssId«; MS fFSÎ) mfe 521.58: ITS, RPI &Fee:; | vp |, | 4, | 2m <4fisi-'I '{mi54 «x5m (4: sl; H! L: ox5 |" {6-oxy "3'8:« 8k5i.5kio {55.2.I! <$ 5xi. * 53'-5! H '»| ^^^^ ín ^ iSll <p ^^ {4 ^ p ^ m £ t51pp &amp; ^^ to 1SU 3jI} ^ j ^ r ^^ ^^ I ^ idí'SÍő4M 5'MS 'SS £ {}' 'm / K6íRt ?,

176i Rafetmeiapéída: 2-} 8âdrôxsei5H4rH “i ^ ~ 8> 9pxk?> F8x« toxk »* td} eî» Sâj-6 ^ S-part ^ 3 -'àà: 6fe ^ M lopPI | ekI ~ 3 ~ tpIp * Mrí8 «Out ~ 2p | &amp; s8Í535iIar6íi!« Áí e56áIEIdss | MS (ESI) m / z 439.53. HERE. ene ei ene ene ene ene ene | | M M M I I 4 4 4 4 4 '4 4 4} 2 2 se x - <E {3l- «x £ Sp ** pEkí« ífeI «í3.2.I: | 5> 3 * 85) -« j'P ^ trteadÄrl ^ lllfäa ^^ aißlllliÄrbä ^ P stumbling:? MS (KSI) nvz 458.52, ITS, Rheumatic Example: 1-dichloro-propdSS-1-fluoro-isopropyl-isopropyl-5- (8'-yl) oxy-6 - (> Soxys-3 ') δ 8: 8 8 í 8: 5k · ·PP <î) 0kt '3-i3> SiS ^ td »æi8 ^ I5) Phenyl) 5i8r &amp; S5? MS (ESI) tea 484, .50. ITS, Reference Example: Ip4- (4? 6M8SterRdin-4-4kí 3, S ^ tnspd52 ») I) fe« II | PsP ^ {(4 ^ pkOOM ^ p4l ^ d> ptptMdin-34I> ksi '&amp; ksrOss® «) Production MS fßSV) tfk 042.4; (f) RMS t 34tM3M9ÉI4 ^ Ml Molecular Formula SammiteP, 642.33) 0µ Bowls (ESi-4'5 MS, IM> Π) δ 9,642,3495; 150, Raprete Example: lp4-d4- # Mxap * .áxah8eikIöf3.2.1 | oki ~ 3 ~ 5ÍK64pípeéIdm-S "Ilpiaps:} | í-Ií3íS · '4rkiK5? 8'-2 ^ i5 | pi55 | M-> |> irkI5i8« 3'i5kärfe »8n5d eeal prize for MS (ESI) 516, 6 5 151, RepreaseSpeate: l «{4 * j4 ^ 4 ~ aaHBeEutoxl> ~ 6-48-ex &amp; -3-8- * 8hfcjkk> p, 2.5 | oct-3 ~ y) -MP-tr5a * in- 3 ··· Il | lsm51) -3 ^ plrid? 5 "3-ife8rfea885i.l recovery; MS- (ESI.) Tn-z 490.57 182 ·; llafereoeiapsess l-f4" {4 ~ p - '£ £ S'3'axsbie5kkï | 3,2J | okî'-3-d) -6- (2-pppp1l ~ ~ 4-derte8) -I, 3, S-Hs ?, ?????? â ^ iiliiïrlïisfïïUI Eclipse; MS (ESI) m / ss 530.63 5 S3, Rate nn <RTIgt; c1 </RTI> Example 5 - fd-iP-oxo-S-axa 5> idkl «13.2.1 [mu] m-3-i5) '6 - (p 5,5'4'-yl 'x: i) -', 3, S '> 8r? 5a-24} Li? 5? 15? -pyrchi? MS (ESI) m / z 516.61 5S4, Referme «* p: · East: 4 - ((14- (4-0 ^ 111-6- ^ 08101881-4-51-5,3,54ds? J8 ~ 2-d > fe »8l | ksí'b8moiIanantatao) * besixoessv; MS í &amp; Si) nrz 476,3.3 185. Ν ^^ ί0ΐΐ5ΐΐ; ΐ5ΐ8Μίη« ^ «ßΠ | '4 (| Ρ ·' (<Ι ~ ί ^ ρΡ0 | ΐβχΚ5- ^ 0 ?? <> Ιΐ8 »4" 'ϊ§ "ϊ 3.5 · ίΓϊ8ίΐ38-2- Si ^ ^^ SPI: lííSrl3i3íSSí> í: ífíSí6lpí <í} ~ - ^> vj5fgK; ís§! MSI ESI m / x: 552.6 186.] Refer »« c «» j> é: m4 * i- * 4> atil-4 «m0r íftl» a * 4 »il- 1 Preparation of 545-1 [mu] 4 [alpha] 4 [alpha] - (4-ol), 4 (MS), MS (ESO; t>.): 452.5 187. Refm'ttdapidae : N- {2 - (dichloro-8H-NHR ") [alpha] 4 - ({14- {4M-opioxy-6" 8-morpholin-3-yl} -1,3> S-tertilyl> 40 · ~!!). Preparation of Efs? 31sololxxmsms MS (ESI.) p 548.67 ISO, Rdemteiapéida: metR4 -. {{j4- (4.b5 <tif.6 »merfotln-4 ~ H.3, S ~ (rlaMn-2) -H) f j ff $ $ $ $ Í Í Í - 5 5 5 fee fee fee fee «« «« SIS SIS SIS SIS SIS SIS SIS SIS SIS SIS SIS SIS SIS SIS SIS 0 9. 9. 9. 9. 9. 9. 9. 9. 9. rfoOtt-4-sl-8-ffl S, 4Sp2 ~ ox »'8 ~ s5: í805t * iU0) | 2.2.1 Ihept ^ S-Hj-1.3.5 * ~ triixS5" 2'Ef fe «il) - i- '| |> kidÍ5! -' 4-0.l ha arhaí 'time is calculated for the sum of H.RMS: C24I'06N803 * · H · · ^ 475,22006; production (ESI, MBB}, observer, 475.2201. 41jfattii * * 3nptrktin * 3-dlka? 0 &amp; $ $; MS (ESI) tk% 432> 49.19 L Ratio-based; Ι “{4 * ρ - {«4Η5ΐ®1ίκ0χ6- (8 <· 0Χ8 ^ 8 ^ Ι? 8ΡΜο13,2,1 | ό ^ ί-3 ~ 1Ι) -ί, 3.5" Ρ {82Ϊΐ {^ ^ H | fe «H} M ~ plrkl0x-> 3'-llkar0af «(exhibit; MS- (1-.50 m / 446Λ '192, R d ^::::::::::: »^ M ^^" · produced by (ESO î5Ez446,52, 193, Refmmdapse: 014- | 4 - (! «ÎpKsp! Ls3mmM-M (8th: m ~ x03ï8t> idk! 3,2,! J0kO3 1: 3, 3, 3-oxo-3β-2-IIIRmll) 3 - psnO4 '3'-Rhamk; MS (ESO m / z 460.54 194, Rderdaptikfa; 1- {4 - [4 - (diethyl3,333n8) - (8 * oxa-3-axabldkkH3.2.1 fofc (SMiH: 3, Mrs8as4 £). • Η | f «ß k) MS (ESO mV 47-1,57 195, Reference &amp; D? .EiJ (4 ~ (~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~>> i> rfikm »4 ~ 0» l, 3sS ^ (rs8? Ä2 # | Pkiljk3rbameil0 amiatOhenzeessw; op. 204-Ό, MS (ESO mx 4? 6.2; 196, ReEl. 011- (4-8 ^ (10585,010 (0 ^^ 65-14105-011-1,3,5-048 ^ 8 ^ 201) 16601 ^ 14--1 (4-88 ^ 11-- plperada-Mi ) fearboniijfe3ili} karham3d t'loáiiídsa; ορ ΓΌΟ 'Μν (050} mz R5S.2197, iRe-dslcl 4? - ({14 ~ (4 ~ 8xel115-1-yl-6 ~ [delta]}} 1-4-M1, 35 [mu] l] X8n-2-sl ) pnll) kari> amo5I> .8: iSilss <1) 'N ~ j2 ~ (dk6? tl? 5? 86) dLi-N-meHll568 «» Ethification of 385d MS (ESI) nv ?. 280.7; 19 &amp; Example 1 Reflux Example ¹HÉÉ ·? «O ^îîî 199 199......él::: 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ^^^^îîiiliiliil |''3 | |ll5ïï ^ 4MPMPMPMP ka ka ka bi88838385555 MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES (ES!). 200. Reflux esidapddysil {4-β-p-88el5> s (e (8SiO6-.s88rPlm- # 10I3Str8 «k5-2-80P {5 {103-pl3'k {» v4-.5k carhatoids produced MRMS: Calculated for C22H2SN704-11; N-Asp. 452.20408; -Alley (ESI. | M. Kj; Yu): 452.2047; 201. Refei et al.: O (&lt; tb > l | k8r!). )? 3 H) M- (14-P-385-yl-15-4-i-6-p-oxa-8-aza-5? 5 (3,3,2 <l {oj | k4-- dl)? ll? $ 46l6z28 ^ 11ir6 » d | s: ^ irlÍ5 6ll IIT ^ i «ö) | i) r ^ di» ^ i! 'eiői ^ M ^. MRMS; C30OB8N9O4 -; - IR -; - osszegkèpiei m oo, 589J119 ?, killail (ESI. (MOI) ·; ·.;, 589,3036; 302. Refemvctp: ^ tt | f <i'í0> 3 * piH <m ^ MS (ES?) m / x 460.34, 303. Reflux Plp-Cs (d6) .delta. frlasI «^ AâtlÉMs; MS (ES?) ta / * 474.17. Ü4 <i (s | ere8« kpÄIe 1- (4- (4- (P-Mdros? -? ^ bldroxilst ^ ll ^ illaffite ^ CS ') &amp; xs ^ it ^ bkik «$ 9 {j? .2» $ jlc = pJ ^ ®M) »iMs8i MS (ESI) ro / κ 492.54 30S <! 1« RrmcM5p6? d8 | 4 »| bss ^ * ~? I? <TeK? É0I) aa» «0B§48 * ö48» 3-8 * 8b? «Ikli> | 3,2,»? Hc «2SnH |« ii} f4isit> »S» flri0 (?) <- $ »i || i (ji08SRid« IMIklÄ; MS (ES?) «5/7. 506.5?

2Ö6 <Rb (8rbn «l8 |? I # S: 1- (4- (4 - ((5S4SB2jS» äl8MM ??? | 2,2,)} | gp (»3 - ?? {- 6-p» <5X8 ^ * 8Kii?> FciM lo | i.t. yl-3-H} MS (ES?) Mfz 407.53 207. RefftrenclapOds: 1 · {4> (^ ||; 4 ^ 4 > β »0Ι | β1ρίΐ ^ η44Ι1) ß ^ Ιß | 0> ß} 4% κ!> Ι ^ 0» lop2, i | okr-3-li)? 3 <§ -?) Ia5 (? 0-2-il) fei50} * 3> | 0 (Ι || 0Φ00κ «τ0ΜΙΜ001} 00 ^ ι (MS (ES?) MM 592,”).

303; 1- (4- (4-t8-β5-β5,5-Si-5blbtc> j3.2S MS (ES?) Mfz 573.68, 3 () 9, (((((ss) Example 1- (4- (4886 (0) - ^ (1506)) () 1) ^ 4) 1 -), 3,5 '? Risx | si-24)) fe8llJi3i? 8'4i! ; MS (ES))? V? 4) 9,406 2-reflexes; 1-1d-H-nirfBS1n-d-? -ClClSsdS? -In-S-azsMdlkfepp? Jh8 | 5? -SM) i-1? ) rbzl55 ~ 2-l) fe06f) ~ 3- (4 ~ {(4-p (n'5ïl DI8 lp-l- (5erHlÎ55-l-?!) i) Ksar> i58il | fe) I5L}? k8î MS (IS?) m / z 654.3; HRMS: calcd for C35 H4 3X904 Ht, 654J510S; salt (ESI-FTMS, ΜΜ?)? ·; ·}, 654.38120; 21t, Et2O)) 655? 5β4Mi53 f88 (0-4 (| 4- (4- (3-0loxy)??; YM) -6-0? 5 ??? 4-ii ?, 3jS4? 8ZÎ0-2-5l ) (e «5?)“ líá 6? îs 85611) 55 tendons ΐ «<ί! bpdzoáí d6â 1? (Iad): HRMS: C25H23N6O6? H? O? 212 ΙΪ6 (ΐΓΐΓΐΓ 55 «58« 58 58 58 58 (((((((((6. 3-8 ^ 55015) 5141013.2,115) ^ - 3-51) - with a time interval of *; MS (BSD 555/2: 39-7.4 $, .313, 1ïel8r855C58p; 1 - «Äkk) p) ^ p:}? ~ 3- (4- {4 ~ f (1 ~ 5» 8î5?)) bï) Î850) 8d | H6 - ($ ^ i> M-33888)> iiïlkÏ6P> 2.1 yi) k (-3--1 ^ -: 1,3,3-1658 ^ 50-2-) 11188i) ) k8rb8555) t? MdilIííOss; MS {BS?} 10M 423.52. 214, fefer60 «? 8p8; ? - (2-chloro-4,6-yl) -3- (4 - {4 - ((1- (6-fluorophenyl) -4-fluorophenyl) -1H-pyrimidazol-2-yl; ES?) 01/2 427p): 213, Eei8re0 «58p6Îd8; ï- (4- | 4 ~ || lm «l5l8i5l) 850l80) ~ 6 - ($ - ss8-3-sxsfeli5kl0P> 2J) 0ki '^ - sl) -l, 3xS- -1) í5xs0-2-í? (íl0SÍÍ) -3-5iír? d80 "4-5lk85rb55í55sí? í4öí Il l??? t s8; MS (BS?)) 55 / ¾ 4Mkf4. Example 216; 1- (4- [4- [1-5] 8? 5? 5?) 8mm0) -6-p-0S8-3 - »* 0B1e5kl8p, 2, 1k1SM1) -1,3 S-t5d8zl5f ~ 34) l? Fe5 ??)) - 3- (6-P-n50 (? L | s) p0r88? Ss? -??) | Spldl? -3-5? | K0rl> 805? 48lg6?)? {B: 81 | &amp;460; S6. .217, lieRmaps); 1- (4-? 4- || í6588l5? 8ill) 858) 80 | -6 - ($ - 0S8-3-8 «8hl« 5col, 2, 1 joktSll} -1.3 * 5- "15cc ? (? t AI5) -2- l "3- {4- (4-5X 5FP 6?) () 65'8S) 55 'I-5):? íív0) ?: jll5) 5'> 5s.05ld dieselil; MS (ES?) M / z 557.70. 218. Rdfemsclapëkb; ? - (4- | í2,2-íll05 «l ?? bp5: 0zí5) p) kí5rfei) 555l | l« 8 1) -yl ~ (4-4- | () - 5neí5tel5l) S0i í5o |? -? 5) '- (8- ~ d3f8-3-a2afeklk? Ol3,2J jok5-3-? L) -l, 3.S- {ria «Í55,2 ^? L | Íf8? Dlk8r? 50í»? »; MSu $ l) «Wed $ 45.61, 219. 4 -)) (4) 4 - ((1 ^ 9 ^ 1 ^ 11) 8.501015) -0- (8 ^ 01515-3-824101051 (10) 3.2.1) 0 ^ -3-515-1 ^ 333-? <P1) [delta] [alpha] 1) [alpha] <1>, <RTI ID = 0.0> 11 </RTI> pp6 | 1) k611 «<t1>> i-pl5 $? Dl9-1 ^) 1080 [mu] l; MS (ESI) m / r 8?], 69. 226. R «f« m (d »pdda '. ^» Meíltlop.2.1] Oct' J'il '-ï »555" Waaa »-2-H} f« «}!;> Fea>, l)» MS (ESI) w> 546.68 221, flEcferend &amp; péidx: I -14- (hsdr <s sJ m «ï) f« -s il | -3- (4-14- | ll-} « fiHk'tll) awí »o | - ^ {^! £ 84 ^^ iiy.Í ^ 'l«! 3,2, Í | okí * 3-H) ~ l3vS-lrï & xift'2 «U | fcnîl) ksr (production of ïs 8iiU «; MS (ES!?« vz 489.58 222, Rfiterewd: l ~ {4- (2'fe «imxlsiâ | fMÎÏ | ^^ 4- {4» {(Î "« îoUkîsï ^î8ôô | 1 ^ $ H3i ^ i?; 3-8ÎSîl> insert '| si | 3/2 ^ | <> kl' "3" ll) ~ Í ^ sS, | ns; ya ~ 2 ^ U | fasil} ksrEsm3l MS (ES! Ï ïí * 503,61, 223 * (Md'eovssspdiEsi 1> <14-14- (I -hlïir ^ xlelll) ^ fojfo? Ïîorfolm-Ί-11 -1 Mrm ^ îîï -2-î11ïïï? <RTI ID = 0.0> 3-Pyrrolidium </RTI> (1), Okhsmddd (M.P., ESD m / z @ 2, 46, 224, fplossmds, Example 1 &lt; 1 > 4- (4.6 &quot; d &lt; 3 > .2 I} Oct-8 ~ il-135i-ΐΗΐ (2ΐ · · 2 ~ Η> ß 3 «} ··· · MS (FSls mt 5 HEB * 223 * 12 * fer« «dapeMa; BietllM- {y4 - {4-eliE6, íaorf <4 (a ^ 4 ÍEE3 ~ S ~ tr Azia-2 "(r)" i5: !! | k.s5'Ss (IIS «Esi»! »«) ·! 'bensroat dessert MS (FS !; m? 463.5! 226 * IPOiroodoo * 8 »etiq'4 - {({4, | 4 * (3.6 * d (hldr (» - 2R, |> lrá »« 4fe ) i} V ^) ^ Clo-dl-44l-1,3x5> IHa> 4 »* 2 · '-date, MS (KSi) m / z516.55, 222 * I2el6r» «; 4> | ((4> 14> (3,6'6íhldr6'-2H> pifa »'4-IIF6> m6lf6likÍ4 ^ Hs {^^> H» zi »-2 ~ iil! Fe« K | l-ll the ls> s) MS: (ESI) m / 502.53 226. Brush »* d <RTI ID = 0.0> (8b) </RTI> 1 ^ 14-5 ^ 1000-4- (06-12 - (^ (^ 0 ^ (- 4418 ^ 51110) ^ 01-1,3,5-1 ^^ ^ ^ - 2-41) 1) 5 ^ 0) -3-> sipir | sl: í3ft ^ 4 “í4ká ^ b ^ * γ1-δ t41i1: digested by BRMS: C26B / 27N902 SW on the image, 408.23605; found (EM, [MM # - n »egfigyeU), 406.2383; 22¾ lîsfereiâeiapêiâaî Í« P; 3; 1 F1 <3β-α: «H H 1 H oi pho | oxo-molar BRS: C3B-B0N9O3 · HH 6 6S8? .e« k pl pl 6 6 6 6 6 6 586.32486; , 586.3245; 230. ReRæssïdâpéîdkî1-14H-5e-5'5'-yl) -3- (4- [4- (5'-yl) -4- (3-oxy-8-ol) -i (? (? (C 1 -C (? 3,2J | oEE-S-4) -? -? p, 3-triazm-2-yl) production of &lt; / RTI &gt; HRMS: C28M3IN704 + H 530,25103; (FSE [M-MIE-sour], 530.2508; MS (ESI) m / z 546.676. 232. «í> rfo0R-4-0-1,3-S (r ( Si-2 - [alpha] @ 0E3- {4i (4-thiol3-β5-yl} «- MS (ESI) m / z 550.4, 233. Msformiemp &amp; mmmsm emMMsm MS (ESI) ) m / y448.483 234. Esfere (5? p6f? a? 1 ?actH-3- (4-14-i8; sM-as5Ob (? ik? 3; 3? | :)? kfe3-E? 6) - (0-η 2 S ′ .E ^ -4bz; 56k (ll-lof 3.3.1) t (os-3 - 0) - (, 3,5-dasimylphenyl) atoms of 1660 ( HR HRMS; MinONRV »4- H -; - ösvegU plate uaniitoti. 467.25136 mk-jt (ES !, p (- H) 4, iN, 467,2525. 23S * ftafemtelapéida: | «p.3.1 j {}« Hr8 ^ âS> -î, 3,5 "îrÎ55ÂiS '' 3! -ÂS] r «iîll} '3'5iirkiià ^ Mk®f" fe8i <l eSMIIRâss .HILMS:: (737143 IOSCO -; - H * ôssaegkèplet; #: -asdM & main, $ 36,226226; found (ESI , {MM-fj-i-awpflgyek), 130,263 S; 236, IsfaraaeSapât «:

«Ii> Preparation of SiÎ5î'feôsî: | i | rjfefïî 1} lsrlímixi; M3 (1-S1) mil 23 LL 232, ileferaeaSapéida: N- [2- (dlr8elllamoo) «UI | - 4H! J @% etll4 * t» o. Hi ^ 2 ^ i) !? T «nslfksrbsmôî i | s mistOktmKamid Preparation 238, Reference Example; {J ~ H 4-HDL «? * Elliamlhe) pipendia-I-4l] karfeoail {fe" yl) '3' (4> 44 »eti06 - m» r was> 8: v ·

Preparation of 4-yl-L3,3-trifluoro: sK "2-5§1-yl] alkyl"; M3 (ESI) mfz 538.71 I 238, i-4- (44i tll'6 ") α-α-dHH-4H: 1W: sSS-yfásdásdB * 2-0) feaii - 3- (4-¾MdOthylthiol, ó MS, MS (ESO m / z 462.534,: 248, &lt; + &gt; -03 1 H-1 (N, 8-tetrachloro-2'-pyrazol-4-yl), 6-trifluoromethyl, 6 '- 4-fluorophenyl, 4-fluorophenyl (i, k8 * E8). 8ml8oj * -N- {2 "(d1-methyl5By) etiSj-N-metflbe8:" ISâlMtàsa; MS (BSO m /? 536. 53.

Ili, If &amp; Example Example: Ok4 - '(4 ~ lL06- £ ÄK5rf «lm-4-iI-l3, S-tmKifE34i) ie8il |' -3 ^ (4 ~ | (44d» «nM« sskpL Í> MS (EShin / z: 586,741. 342, ILgíbmseSpec; Ν ~ Γ2 .- (3ί ^^ 4ΐ6ΐΠ3ίί5θ) «ίίΪ044 {ί4" (4 ^ «4ß06 ^ ί888ίόθ8 ^ 44Ν ^ 3,5-ίΗ4κΜ ^ -2,41) Ι «? Ϊ́ΙΪ | ^ k83 ^ äS0älLu8i84) Production of mSit4sMK'8SÄS8kl; MS (ESI) m'st 533.649 243. Example: NH2> 4djmetitemla)) ii | '44 | t4 ^ l-.ia «<Plâ« 4-ÂiÉôIla «4-II * '' l3 # 'tÂÉÎfei; l« I | ^' fi8011k8s4ïa858 (tkâî408: E * -N ”£ 8» tllke, 8xa? DESCRIPTION OF SIDID; MStf'St)! '' / 544,62 244, Referenceselage *: ^; j3'-Pimeyla8 «86) et Hj-4''i | [4 - '<4-'metexk6» m8rkk} en "4 -lL! 3, S-3 ^ 4 ~)> - f88! Come on? ¹H!! <<88::: 8 «36Il 68a * α-jpKl: 6-chloromethyl: MS (iSO nt / x 520.68.346, Eefereddape: δ 14- (4 ^ 58 ^ 0 ^ 06----) 816 ^ 6810--4--0 ^ 1.3 ^ 1638 ^ 642-11) 188003--1 Preparation of 4-1 (4-818 (11- ppiperyl-1, 5: 1, 41) carboxylic acid), (d); MS (ESI) nms 532.60, 247, fefe'68d6: O Preparation of {4-L3,3 ~ d] ppipyr "88xm-1-yl] -8-chlorobenzyl] -L1- [4- (4-586-thiol-6-yl] -6M8" 4'-ll4j3-ls483; ki-2-k) [alpha] 8; MS (ESI) nv'z 346.63, 348, Eaferaaeîaplldat 4- <|} 4K4 ~ mat6si ^ m «ifidiar4 ^ 8f <l; Preparation of 4- {2- [alpha] d] [alpha] [alpha] <1> D [alpha] [alpha] <8> B8 -88]; MS (ESI) m / x 560.66. 240, Ilalerii; L (4'-tert-8-ylphenyl-3 '- 4' [4 - J8orkdh5-4-k-k-1-8 -I-8-yl] -M8f3.2. J1f | kS-H> O, S-4alkyl). MS <ES1) m / s $ 14.3;

ORMS :: C34H3IN7O3 · H-> Calc'd, 514.25611; found (ESI, [M- H] - · Observer, 514,236 L 2S0 «Ibferei example: i - '(4'K4-me01 | kpar8« 8 - l'-U) me (k | k'} diL- 3 '? 4-' | 4-> ptorf4Í! P'4 ^ Í'4k (4 ~ asa * 8 ^ 848-1> sdkkd3.2, l jeki-H) -1 dddH &amp; skK.OdffeidOkai1> 8 : Generating Btid: HEMS: C32H41N0O3 Total ^ Formula # .- ^ 15 ^ 3 ^ 10 ^ 15 lllale (¾¾ | pLf || ·: · îkégkfÿk, i'OO, '405. 2SL Ilheferel Example: 44Π4 · 44Η! ΊΙΙ * 6 ^ 8ß ^ 0 &amp;ΦΐΜ3; Μ ^ * ί «^ 2 ~« 1) Γ «} Ι1 | ^ 8Γθ8» ^ Ϊ) ß | # ΐ »6) * 'Ν ~ | -'il) fe? d? 8? a8sid; MS (ESI) m / 621.77. 252. Rfcfere «ci» pétóH pHi} smIrMiTiT) fo8i1} kririí &amp; 8tk? «Exhibition; MS tESh mJz 532.7 !. 253. Rcfcs't'BClapêlriac 4-H H> "* Äíî" *> "îsît * rf <> ïsn-4 ~ ll-IS ^ l" lm> ls | niiii> i | tër8 *; «- t'U) fettU {he"% âmhi «exhibition; MS (ESI) ov; · 649, §2, 254. Refmaciap &amp; dat | {. Η ^« ΗΙ- ^ «Ι« ΓίοΙΙ «* 4-Η * ΙΛ5-ίΓΐΐκ # ϊ ^ Ι1:> Ι« »Ι || 5 ^ '| 4 - ^ (4> ΐ9 *« ίΗ |> ^ ΐΙί »χ ^ Η'“ ~ 141) mii tii] feaii jkarhamid etoalkt, MS (ESI) nvz, 544,733 255. Reference example: 1 ~ [4 ~ {4 ~ t> «ti! -6-8K> rft> ii8 ~ 4-yl · 1, 3.5'-triayJ í 2-s |) | | 3 3 3 3 3 3 3 3 4 4 4 S S S l l l l essi))))) 55 55 55 mid mid mid (ESI) m / z 461.2. tert-1M-1R-4R) -5- (4-fluorophenyl) -1,3,3-trbxm-2-yl] -2vS4Pi-4R4i3k3f2,2, l {hept85? -2 ”!« A5 # í} 5s; MM: t ása ása ása ap ap ap ap m ap ap ap à ap 62 62 62 62 62 62 62 62 62 62 43 43 43 43 43 43 43 43 43 43 43 414) -5- [4- (4-F (β-chlorophenyl-4-yl-1H) -2,2,4-fluorophenyl] phenyl] S.2.1) phosphorus-2 ) Mole: 8 | about 303µl Ml (ESI) m / z 615.3: 258, Ratfelekesapée: l- (4) ~ {4 '[(2-mek5XíelfS) amalgam [- 6 - (8- <sxs35 A2A) Si «5E (' [3: 3, í; | s (~ sI-3) -l, 33 ' Preparation of 3'-pyrrolidin-3-yl-1'-trifluoromethyl, MS (ESI) m / s 476.54 250. 1- (4- | 4 - {[(1Ε> 2 · «^ {άΓθ» 1-1-3 »« 1) Κ'1 $ 11 »ι»} Ιηο> Φ (^ Ηΰ> χ ^^ - ^ 8 3ί (3ιθ! | Μ »ΐ: | <) ίΜ ^ - ~ (l) -135 | 6-4j4isï: îH - 2 - IFNH3 - 3 - pyrid3 - 3 - carbamate *; ESI) m / z -176.54 260. Re &amp; retma example; H 4- [-M j (IR) -2-hc &lt; 1 > -1-iHSHlfilS [int. x53 <l-azakkdkfePi2: í] ok (- 341) -1.3,> - lr6îsk3--2''îï || eô ||| P “plridd3-3 - Okarbadî3d Award, MS (ESI) m / s 476.M, 2e, <RTI ID = 0.0> Rt </RTI> at -11) / 1 <RTI ID = 0.0> yi-yl-xHH-2 &quot; ss &lt; / RTI > / z 460.57, 363 <Refef ^ «la (m / d) (4 ^ [4 ~ (d 6 -6) [d] 6] (0 -hydro-3-carboxylic acid [3.2.1 | okiyi -. (l) 41p, S-lr) axl «- 2 - dlffe8d ('3-p5rídl» -3 - Íka {bay oid before it? MS (ESI) moss 674.57. 263, R « lkr8 «e (8i> -i? d8l • 4 - ((| 4 <4> ^ lm« roles «- 4" in the case of "4pcs") »» » ) ^ ;,> - (|> r r {r r-2-ylidene) 6 ′ irs8mKl, mp 266-268µ MS (ESI) ον /: 260.6; HEMS / € 341133) 4704 · <· H. · "·· sum for example smmïtiM, 566.33383 ;; (ESI (supra) *), 596.2724; HEMS: € 31H33N604 -î-B-t-Oss / ægMplotre: 566.27283; found (ESI,? e? j: calculated), 566.2228. 264, Relteredplapildäi E [4- (4,6-di-3-esa-8-αKaI: Hcsk10 | 3> 3? 6? (4 - pipera / id-1'IIi-80) ksr6sMld 6I66fí (6th HEMS; € 321136) 4603 -t-Bt all the above, found 568.32-186, found t ESI, (M-rBB omgii), 568.3247 (for HEMS C32B36N603-β-H; Numeric Code, 598.72486: found · (ES), [M-Et], 568.32-16; 265, Rpflthe example: I '| 4 - ( 4.6 - di - 3 -? -? 2:? 16MdP? 2: | O08dE ?, 3,5eit48? H? -Il) || 0: 8? | -3 ~ | 4- (4? ) l mid ka mid mid mid mid mid mid l l l l l l l l l l l l l l l l l l l l kills 23402;

2§Ö. T ^ eTkreanapIda: l-ji-P-OO ^ stiOtIt &amp; sMI-'S '^ - l ^ ssf ^ ^ ^ eXs ^ s ^ fescäfc-! O | 3,23 | est ^ 41)' 0 3x5-í mg | 30 -30! | fi> s {| äj äj m m m ki s s il HR MS MS MS MS MS 80 138 MS 4 H-MS MS MS MS 138 138 138 138 138 138 138 138 138 138 138 138 138 138 138 138 138 138 138 138 138. * 308 »; MRMS: 00143819804 + ·· H4 - image number, 575,30888; Pati (ESI, (M> H) ·; · calculated) 575,3089 207. R ^ &amp; ¹Hââ -p55lsls ^ 43 43 43 43 43 43 43 43MSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMSMS 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48 48] HRMS: C2SH30N8O4 · * · H: Calc'd, 507.24628, found (ESI, M * Hj * Observed), 507.2471 269. Reference Example; - {4-42 ~ (dl6tM ^ best «« ¹HMMMM (ISi) atM 638.773.

279. Reférépetâpîbâï ~ | 4 * jpwbfcsæO | OpH81a-î4l) karfeô6 | lfe8il | '3-4444yfeôîsR6 ^ s8 * it'Rîlla' 4'ïl ~ -'l: 33-fs-laKáv2 "il} rtaslljksrbí (mtd dosbis; MS (ESI) tn / z 633 J2R 271. Reference column;> -t »λ £ Hplgk (sdi -4-ii) h« w <(mi (l dealbt &amp;a;MS; 1 SI) mz 511- '. 272 ReCeRs 4S (- ((4-14 ^ 6 ^ (1-6 ^ 01-16118 ^ 4-9-1.3 (64544 ^ 16 ^ 2--11) ^ 60 ^ 6 ^ 948961118 (^^ 9) ^^ - (1: - migtilplpendliMM-1Rbím / aokd dealter.kís; MS (1 SH)>> -MVk 273. R «f« reeeis; 3eftl: t; l "{4- (4- { 6-8k (r6xH5- «3X8-8 s3k805CíRI © * 13.2 l | oct-8-llE6 nt8rí6 ~ {Í8--4 -> {RE3; 8 · --tmxí (fe k2-4í {« ~ IIj MS (ESI) 8v2 5 (4.551.274. Reterenckiplda: 1 "(4" {4-f3- (dl6 (61st)) [delta] -1RRstkR9mp1E13; Preparation of (1- (4681) -3 · --Rssy | 0m-4-yl] -bide; MS (ESD nvx 463.56 27 |, IpR-decomposition: 1-i4- (4- {3 '! (l -8iee). (sHHlkHnl1 {R6-6-ft5rbb4-i; -E3.5 "trH2; m-2'-i) Preparation of R 1 (30 {-i ΐ ΐ 4 4 ^ ΐ li ar ar ar> sm i * 1; MS (ESI) mfz 476.59. 276, iPÉt'kitches; l- {4- (4-m »rR4ljï-4 - î | ~ 8 ^ pprr8l (: dlss - 1 ^ 0p» pb) '- K3.5-t6tel «- 2 ~ il | b? MlE3 · '6 | ^ Mtt ^ llk8rl6am10l' # ^ Í) Rtá »8? MS (ESD ov 488; 60 &lt;277; Preparation of RelayaplOR / MS (ßSJ: m / x 517.64, 278, Preparation of Reference Bakc: -2- {1 {6Ball} -3-pHdla-4 &quot; δE 505.63, 279, Refereimppeldsk "ISiaYMimide 6Siylation; MS (ESI) (64; 435.47. 286, i.e., silica; MS (ESI) nv = 433.47. 38 f, Ri-'î 'i.'î'i'î'îessâpeîdiïi: tgrC "Sati 13-7- <4-ili> í'> rfbíîîî-4- í (|> ss'isâîîî - 4 ~ sSÎ ^ trÎLï ^^ <sP> îïm | ïssi | f <iSï: ll | ^ Ï 4fc4 | 8i8-2 «iiV9-oxa-3J-dlay» bidk} o3.3, lIR08aft-3 »k8fbox« Éa1: elMHk HR.MS C 30M37Ï49O5 + Found: (1¾ fm HJ · * hanging Ogle}, 604,2993 ISI, Ilefo? ^ I5 «page« y »í 1« || ^ || “| 6, ^ Ιό * «# <^^ # ΐ6ΐΙ = ί; Μ | Ιί ^ ίΙ> ^ ιβΟ? ΊόΪΐ8φΙ ^ Μ ^ Μ» ^ Ι-4ilirSälI} ^ pirii »^ l ^ rbanr. ^^ iiiili (Ska. HR.MS C24H26NO4; H + Calc. «491.21498, found (ESI, fM + H} +), 491JIJ3, 243, Rddddd ^; 4-J4-43) 6 '· dïhklΓO' · 2H pR4i ^ 4'll) '4- · î î ír ír í í í 4- 4- · · · · ·>>.. 5 5 tm tm Preparation of the title compound (MS): MS (ESI) m / z 612.739. 284, U.S. Pat. No. 3 <Mda: 4 - ({{4- [4- (3,6'-dichloro-2H-pyrazol-4-yl) - 6-S] orMR-4- {thiol -4; f'8ay.Ri ~ 2'fRfeH) il}; MS (ESI) m / 4 5 / 2,694, Seat * Reteremic epithelium: k- 4- {4> 6'rfi-3 - (> s8 "8'SSK8pR9clo {3,2,1) / κ6-8'R --1,3,5 ~ í} 4s3; i5í'-2-0} teslp344 "- | <4-'IRiïîipipprd ^ y-'l'i ^ susRR ^ oMIRsrissSld« IS4IÍRás | MS (ESI) mte 625.78 i | 6, 6Η4- {43ΕίΙί-3-οχ8 ~ 8-ίΐ! Ζ8θΕ3ΐ (Ιο | 3.2.1 as k4 - ~ ^ ~ Säk> 1; ^ sS ~ 4 rice ^ ïs ^ SIS (ESI) mi2 506.61 ISI, iEefi'PRdisi / dowel, - {bcloxymethyl> f (? 8d) carboxylic acid, MS (ESO m; ·: 543.63) ,. · 288, Refo mic 58 baker a: - 1- (4- (4-fluoro-J-ox ^ -S'-ampolole, 1k> kH $ ^ M ^ 3> 3? S? T?) Preparation of y4d} * 2 ~ 0)? Rk3? -? 4? - || ttH9? 5ssRs6)? 4R? phenyl} carbide; MS <RTI ID = 0.0> i. </RTI> S1> ov2 556, / &gt; 289, Ref. (4 ^ (110--048 ^ 8 ^ 636 ^ 1013.2.1) okR§ »-5? -1.3,? 'Ϋ' i3ii »“ 24i) reî33fjk8rbâï »Time to create; MS (ESI) ηντ : 600.73 290, Ηο ^? Γθθβΐ8ρ6Ι68 ^ 4- | 45Ρ ^ ί803'6ΐ ^ 8-4 - ^ - 6- (9- (ϊ «- - 3.7 '(Η888Ρΐ ^ Εί6ί3.3ίί) βο »3ΐί | ρΐ53,3-4Γί8 * ί9 (· Preparation of 2-i (1-yl) -3-pyrrolidin-4-ylcarbonyl; MS (ESI) ns / z 503.57. 291, Reference Example) I- (4- (4- (7- (8 (toll-9 ~ (5Siw) /? ”)> Kikk5f3.3.1p505iH3" H> -6-mo5-fe> ltf5--44I 3.5 - ínaeí8-2-5Íjfe8l) - 3-plrktlii-4 «i MS (EMI = s / M7, tat 292, Rffereacyl: 1-4- (4-yl-55-acetyl-Eo88-3,7-d5acyl) -cyclo [3,3,1] (d) Preparation of 43-R} -6-8.6 -f5> k-4 - ik1s3sS; MS (ESO? 4'ζ. 545.81. 293, Referenodpolds; 1- (9? | 4- (7- (8? 50? 58? R58?) -? 9? Oit8-3? '? - dl8Z8? 5? Aci {3J, M5SO5 (s3-O-6-s88-phenyl-4-R ') -3,3'-5,555,8 (s-2-yl-50) -3- (Srl-8? 4-yl-pyridin-5 (yl) {R8s; -5; MS (ESI) ov2.58 i, 60 294, colorol8 [alpha] &lt; 5 > [alpha] &lt; 8 > 1- [4- (4- (80 &lt; -1 &gt; &gt; Preparation of 1-4-yl-6-prepy-13-β- (′ 8i-9-α-2-RIR: ¹¹¹¹)) carboxylic acid, MS U.S.I. 7.4, 295, RIY / fee: Ε44 · | 2 · ((1ίί586: ί1 »Ηΐ58; ΐ) οίΜχ5 | ίθί (! 0''3'Ρ1 '(4' - (40-6-5« θί'ί80.5> '4-0'1ί33- · 1: 5'ί88: (ΐ5-3 · - - ||| 1 (55) 1? 5? 5? 5? -Li? R? 8? MS (ESI) mM 492, 2, 296, R 8 -S-855 -Ii-4 - (4-trifluoro-8,8-yl) - (4-ii-1,3,5-MS (ESI)? S): 503. 297, Eofordscype example;! - | 4- (4-05 (judgments (5,8-8? 8 -1R) k'55il} -3 ~ i4- (2-r80lRp5a4psl) -6-588phtl (- 4-0) -'ik-l-iryl-1-îiiresdlHuârbamld el (k. ³ r Mis (ESfi / 530/0 (. 298, Reemic spatula i-4-β3,3-d5588) (8-R) k8r5 } O8 (η) 8 -3 | 4 (4 - (Δdd-6) η 3 Rf (η 4 -4-0-, 3,5-iri * R-2> H) fc »Mjkarbae "Wi production; MS (ESI) sn."> 544,684. $ 29, Ref6W5 »piapÍld4? Preparation of '-yl-silylhexyl' -J 'O' isohexazine in MS (ES; î ov. 5; 7.3; MS (ESI) to z = 239.2; MO, Refemu Example; 't' «M. <4«} C 4 4 ~ 4 4-C ni «« «i mor mor mor mor mor mor moraaaaaaaaaaaaaaaaaaaaa «a «« «« «« «« «« «« «« «« ««aaaaaaaaaaaaaaaaa ES ES ES ES ES (ESI) t? 9 / 7,3.

What, Refereo Example 4d (| 4 «| #« Heading «| * ^« «hourdan ^ 0 ^ 1 J, ^ ds ^ ^ ^ r 8 8 8 8 8 he he he he he he he he he he he he Preparation of MS (ES3) avz4 &amp; 3.3: M2, MeMresilicaldaldi [beta] -butyl [1] -CH2- [1] -NH-1-fluorophenyl] -cyclohexyl-thiol-1-ol. : 1 ^ 4iOiFolMM ~ i3 ^ ii: 5Si8E2 ^ dLi'2iS ^ H3asbfe} kl (d2.2J} f} (; |> MR, -2 ': lyophilic 8Yi: time to MS (ESI) tmz 63 ?, 4th MM SefereaeiapéMa? 3-f4 ~ (4-æ6 (| lpipea3X) «- Î43> fe« ii | M ~ {4 ~ | 4 - '(^ ô * K ^ aKabse8fe8o33.2J | Â'S4IE6> Preparation of <RTI ID = 0.0> F1- (4aMz3 </RTI> 3M3> <RTI ID = 0.0> Vs3v1 | 5,2. </RTI> ll. ESL [M + H] + observed, S 2,3402, HRMS: C33H41N9034HCl Calc'd, 612.34051, found (ESI, [M: B] 4 calc.), 6] 2,3405,304; M 4-14M se se í í í í st st ~ ~ ~ 4- 4- 4- 4- is is is is ^ ^ ^ is is is is is is is is is is is ß '| pl | ^ or36-1 «^ |! 4ti ^ 6ll || É1l3a | 1 ^^ 4» MS (ESI) mfz 544.66, 305, Rf = 1, N-2Bdlamdmino3d3Mj ({4- | 4 - (1'-yl; ethyl ester ^ 3t89Eb5lloMBi "@ 3 H-theta). Preparation of 2'41 µl / ll lityl iodine) bu3idd MS (ESI) mp 532.65. 303), Releaser; Nd2Bdiosf408? 1? 1? -N ~? 8? YlMi (4? 4? (? 1? S? 4? 3 ethyl)? 6? Mi? S? Preparation of 2dlf p 1 µmol or «sl )oo::> 3essidzididid MS MS MS MS MS MS MS ((MS ((MS (ES ES ES ES ES ES ES ES ES ES ES ES ES ox6r 8 ox ,r )66 * 86 30 * ES 30 ES ES ES ES ES ES ES ES 54666666666tttttttt il il. II> -4 ~ | << 4b ~ l4 ~ Cl "! M4jlelil>" he-; m> Mlm ~ 4dl · ', 3,5-3raMt'2 * «0 || ^ nli} carb $ 3lt <dfl ) ii ^ iiáia1'b66'á »: tb $ d'Pl§áfö # H> t MS (ESI) tn / z 530.63 306, Rée et al., l" (4- '|| 4 "(dlsíe3H8mmo) ) pli3erldis »Í ~ llfkar35ood) C6idí) M * (4 ^ (# (download)) -6 ^ ~?« orfollK'-43! -1,3, S "3: rlazí; 5-2'433E'f4i MS (ESI) 0: 3-: 572.72, 309., supra, 4-6, &lt; / RTI &gt; , 5-3mxln-? 2dii3sM3) kafbatsH) il} á ír Q a l l MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS (((((((ESI) nov 538.63 319. RElwdPfetspéklaí 4 ~ ((| 4- | 4 '( 1-n80 tert-1) 6-morphol-4dE: 3.3 [mu] m; m / m] 241] 3eol31; ESI) m;? 538.6 3. 3Π. RelVreoelapéida? N'eil.: 3o3); itU'4 '' | (f-t44 '(3oo) tl3: tert-3,8'4'-Mf5f5'tr! azla-'2'-Hl? MS f'SSI m; z. S, 15.62. 312. RELIABILITY I-{4 »{4,6 ~ dH1> MS) '2> 6xa-'5-azabidlo {2.2« l | h «pt-5« il "13,5« triazlB * 2 «i! * | Ópll} '' 3'- | 4 '(4 "SsmlSp! pei'aí.lsí-3" Sl) 3estyikar3) shirring; MS (ESI), ca. 583.70. 313. Rel'e re;; s; s example; 1 (4-14,661-11 S, 4S) -1)): aS -; izah »dk6ir2,2,1 & piS4l- i 3,50 Ida / iá-2 4l · - f6PíÍ} -3 ~ (4-µmtm-1-11: e: sd33-karl) pmld; MS (ESI) ro'x 569.6 ?. .7 7 * «, * ZZ- w» 53 Φ * 22? * ££ · COU £. Ο Lake · λ> λ £ «. £ 23 CC3 J * W Lake ft4 Lake * w »Ui # - £ · ~> 7 t» W W Lake *. lake·. 7 ψ ψ z. Z. &amp; % Ψ c · «4> £ v g * -> * >> ££ $ t a. . · "* · /.> W /. •• .s *" · '· · w · / 1' 7s' · '*, .JW, Lake, ν',..,,,>> W / »», Wifi -., 'É X / X X..;'? Ν f f f f >> >> >> ^ ^ tó tó tó 37 37 37 37>>>> γ * / "Λ 0 # sA * WV v." "* ΝΟ * ν" '3SV 7 3-y U // W' '-ν' y <yS> fivv, * «fi / y. ν "'/ v * W ^ 2' ^ Μ î- · * w 4 · ^ W 4 s ^ ^ ί'ί« · Μ V fc-g · »· · '' · ··· '' · 7 ' fc4 "J. Φ?: <} V, yw. Λ VW, / y,> W, ÍA mm mm / y; MÄ: V * Τ '2 ^ 7 p ·' '^ φ ·' Lake · ··· ß Lake Lake ^ ^ g * Lake T ^ ^ Aa- 7 * «. p ^ ji? 3; O ív ',, 7. 7. 7. 7. 7. 7. 7. 7. 7. 55 55 55 aw aw aw aw aw aw aw aw aw aw aw aw aw aw aw aw aw w w w w w «« «« «« « «Ív ív: j j oc o CP $ $ ív>,, oc g g $ g g,, oc g g v> wi WW Ο-ΐ X «X% • 'T' / 5v? if "*!» · ^ ÿ ÿ  TS f M »~ ~ S S * SF SF SF SF SF SF SF SF.... £ g g ?? ?? ??» A A £ g ?? ?? A A w w w ® ® ® ® ® 2 »^ a ^ i ^ ^ ß ^ Λ <$ · ä :: 333> ry V ^ ^ Φ &amp; y 'V $%

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filtered with ethanol. You filter the filtered stalk, so according to the title; they were given "raw oil chips, msd ^ iössKS ià ^ ol à ë à ë re à gs à ë à gs à ë à gs à gs  gs gs gs gs gs gs gs? MS (ES) - 332.3MM: 2 »44>} klôr # :( 4 # ftrôf ^ Vi 3,54'fiaa« (2.2 g / ^ ^ sr-mol) aceioismyl HO nils k # s35Ilîszsososate : jtog ~ «rain» feverietstt; | add to water (60 mi). mix (2S.5R jdm- ^ jS ^ iötetänH- InOisfW <ä: (.}. ^ 0gg, - 6> ö mmtâ) scettoAto (20 ml, 3 :: I): k # Fried oldrtov &amp; ï. * 0 g, 12 mmol) (12 ml} knife! S * psp * i | â «0 fce: z $ # ik Ü ^ Oto * 20 pc ^ ^ ^ ^ ^ ^ ^ ^ ^ «« «s áb áb M M M M M ((((-p -p -p -p ÎÎÎ ÎÎÎ ÎÎÎ ÎÎÎ ï i i i ï ^ ç ï ï i i is i i ï ï ï ^ ): in water (3 ml), -pf3 &amp; tentotogene- • fluorescence (0.35 g) in water (S ml;); $ a $ § $ pen «$ a in 4Í ^ ákÉPÉ: &amp; j # 8o> * baa. «zóW * 6-mAtArActIon This is not the way or the story Blietogr-astontoef kExcludedOk gk etei stostak and homemade vacuum pushed seMMttto The chemical iSmegsgekfm« ®ti # s' s {{2S, 5R> I d ^ you &amp; C ^ nittotfeU) * i, 3 ^ 5- ^ 8¾ ^ veit morfod »» »!:« anolba »; MS (ES) = -417.2 (M @ morioin - Cl) | (2SvSKH ^ ^ I ^ δx ^ ^ I ^ IWoill ^ 4i | 6 ^ i6> 4'l!;) ^ 4-aRîîM6 » IJ} ^ l ^ # ^ a5j »» 2 ^ pirr8lhitei «2 <S 'vlälKlimetanoi <4M Vaccination (t25,5R) · iMdMÉfvSiJiIiRoffenHVI ^ l.é-íTissie'S-il.ipíjrmlidie -ií.S-díi? Tdimeuutol ( 0.9! g, 2.5 tntnoí), 3 »^> ® -8 '^ ai» E-mail "hliÉ6klond <0,3? g * 2.5 mrao) at &amp; noM (Id) was treated with α-ethylstylate (I ml) and in a microwave reactor for 20 minutes at 13GT * qo mdegtk'HOk. {«Egyetfoegyet a a a a »» »t · · · · ·ntntntáltáltáltáltáltáltáltntnt (((((((((((((((((((((((((((((((((((((((((met met met met met met met met met metukuk cím cím cím cím cím címssssssssssssssssssssJJJJJJJ tend tend tend tend tend tend tend tend tend tend ((((((((((((((((((((((((((((ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES SR> '2 <5 Birr (t «to» 6u: ttlál »et8s * IMI <Ix) BaeHI) pyrrole« t «l * n« iíJV> 6i (4 »6Ítr6ÍÍ8» II) -' |: ^^ ETRI »2i» «(fofoSRH '{4-D - osn'-foaz» bic! Kloj3,5.phocyania - to!> - 6A4Motrolen!) To3, S -' »- í ^^^ ditnaistöö} (about 2 *? quality) dsklórmetátwtá} (IS Mi) was prepared with a tánmás »tán tefofotmifoknettd -kii6r8 ^ Äft # :( 3íO; g *: 6ii" ï «m« l and ftodazolia (0.55 g, foi mtnol). k ^^ Äaafep ^ k.They '· nights over, we were mixed with maid water «e. $ efoäk. A. wet | Izi $ t dichloromethane # was extracted three times. The combined etho-actives were anhydrous: n» * gmlzmm> color ( ett ^ ok ok ok ^ ^ ^ ^ ^ s s ág ág ág ág ok ok ok ok ok ok ok ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati ati you need to do a need for a mix of MS needles: MS: (BS '):; 671.4 · bw ti | <1 to eöiM! tlogi) aratlDp writes general tol 4]) - 1 * 3,5-tr btxí «* 24 |) atd Ma eföá litosa

Sahahprdazi palladium t 10%, 50mg) and 8- (4 - <(2S .5 S - bi &amp; »<(í.«! Rc-feetiíl íineti tlsar. 3 '> 3Artazi »- 2 - Iin3 - <: ixa - k -;} Z3Y3 Cyclone' 3.2.loctane (0.54 g, .1 * 2 annal) tetrtoidfoAirânnpi ( we) bladdled the blend of mdtrigenbatfoil in a blend of yoghurt. The «blend: '. kO «»> $ r * S ') 04' 4 (Ht 347 * lieiet-eaeiaisáMn: NH '| 4 * Í (3l (,? S> »255-bis (lÉrdrdktd5)): pÍ <RTI ID = 0.0>? -Yl "yl" -d "P" &lt; / RTI &gt; lrldie >> 4TITLE: iiiiiii: ^ iSlifta $ a • 4 * (4H (34Âα ^ * S ^ ^ [3,,, fenfenfen'S * ii) ^6 t t {2S * 5R) -2.S -blsz ((ter <: ·· • 'butlMtoeti.tóttoiJsa ^ TRY ^ iífólldW ^ KJ ^ · tria7i »-2-ii janiit« íO, 16 sennd »prize-winning (4 drinks):: oidá ^ t -: brain« ^ Sai You have been treated with a torso (24 wide, 0.00 President) of 6 mm% 210 and four dtklonecdsmtnl sOO pi. With 5 family plots, the bird is the solution of 4njnnnopsnditv (45pgj 0.4k nttnol) to sitnihiÄßjpjjfi in the hands I á: TC &amp; tnrôœtätà à Sa à à k à w à ra â‚                                              The raw residue was treated with the saturated ijydrogenschloride xidium. The dyslexia was prepared by evaporation and evaporated to a high-efficiency (melt-in-the-wall) process using a Pheiyouxx Prodigy ossdope and a gradient of 5M aedx »titrile / 9S% D.? 25 <RTI ID = 0.0> y. </RTI> of the title compound was obtained as trifinoreceixo buoy (iäS mg) MS (BS '} - ·' 133 # (M-HI) v 34 $, Eeierenmpetda: eMaltMsa 4 ~ ( 443'Xi ^ 8-azabicyclo [3.2., I.e. S'S-> ii} -> 6 - {(2Si3R) '. ) si) nteiÍÍ; pin'olj (; !! ud-il) d, 3, S4TÍazín ~ 24i) &amp; in! <0 ^ -16mmol) dt-chloromethane! i4ml)! (1 ^ immok 2 (0 pl) and one dictation! (5 # μΙ) prepared with a solution (24 mg, 0.0 $) of the solution, after 5 min the β-4- (4-liposylate peroximylamine) 61mg, 0.32mol) handed, tritotted with 1 ont, tritotted with methanol and evaporated to dryness. listen

for the sake of lucidity in the process of fluid trapping. ... P1-6 '-MM-atoms. MyiSil also has a radical live 5% acetonitrile / 9%% 0J3an. Water per liter 25 minutes. After purification, the ethanol was collected as the salt of intestinal acid (see). MS CBS ') iS 630.4 (MithT 349. Relational Examples 14 *' Cliral Pyridyl 3-r 1) - 3B 4 - (4-methyl-4-fluorophenyl) -4- (8'-yl) -cyclopropyl, 2? ^^ S-trsazjs-Srjljysiilïlisrlïaatâil: production. MRMS; C25B27CIH803> I? > Calculated, 523.19674; found (ESI, vMvBp ipcgö ^ ell),: 523, lom 350. This example was added; B (-B1-4) (di-diethylamino) p-toluyl (4'-methyl-5'-4'-yl) (tetrakydro-2H) Preparation of "4" tl) "L3, S-tithia? R &lt; 2 &gt; ii] phthalate, MS (ESI) rn / z 614.¾ ISl. '-ainin «lei> si} -5-j4- (4a!!! i-dii« í> rfol «- 4'U" l, 3,5- rs8ZÍK-, 2 "i jietdljkar> Art» Kl .piÖSlItlSs MS t £ SI) m / z 477.1, 3 $ 2, Reference example; N "f4" ({j4 "(4.6" dl "R'Oaa" vkazabieikloj3.2.l jokt -3 ~ il "1,3-triazine-2'-|:) fc» 11j ~ liStrirattKiilkaiaolfullaill-N'BNSnIImeölglkmainirl Preparation of 4 - 4, o-di "8" Oxa-3-azi-dibide (3.2. -ii, 3,5-iT3-n-2-yl) aniline (50mg, 0.127mmol) (dissolved in Chloroemnne (1.5ml) and inert (0.120ml) and triphosgene (17mg) dichloromethane (0.5 ml) was prepared to give 5 eggs, then K <4 which was N> tenLtlV.Tsi2, <<lnne {tlgkr.int «Sido | ·: · (27 mg, Ojíd ntmol) Cysteone EPLC is used to lubricate its compounds according to ctm TI · As salt: 31 , S mg (35%) (M-H) ni z 614.3, 353. Reference sheet; N- 4-ff 14- <4, β ~ ^ Η ^^^^ ?! ί! Β ^ Ι? Ϊ́ €: ΙΙί. ^ | ^^ *: ßΪ | ΐ0ί ^ ΐ? # Ι ^? Ϊί ^^ Ηΐΐ * ϊ «^^« · 3ί- · Μ> ^ ϊΙ * Ι || "arm | Ossnos8} aiiti3o) phenyl Preparation of '2 ~ p3i-m? S' ilaectanil A 4 (4,6-31-8-0301 - ^ 'OzahicAiof.?.3. ! tert-butyl (3.5-2.0-octane (56 mg, 0-, 127 mmol) in dichloromethane (1.5 µl and trieylaniline (0.120 mL) and udosgene (17 mg) ) was added to a solution of dichloromethane (8.5 mL), stirred for 5 min and then added to N- (4-aminofetul t-2-pttryldehyde) (3 mg, 0.14 µg). - c üs U üs U vegy imi ict így így így így így így így így így így így így így így így így így így így így így így így így így így így így így így így így így így így így így ,1 »·· 3, · ίίΖίϊ0ίϊ: ί! ίΙο | 5,2,1 loci * '3-IIV-6 ~ (4> (pt (ter8« té ^ 1 * 11) ténÉiKitPla <t) ~ sB3, S- Triazm'-2'o) Prepare!) Preparation of '3-Methylcarbamate A * L m ^ ddsAgiak® bmalfête mOdc® Formulations' for the ter6'buiO-4 · # ^ &amp; ÉIé ^ ÎIé ^ Item 'ItemfÄ, so &amp; ëfo *. «rmi * vsgyido | d. (M-Hf-I) 516.3. 355« Reference Example? IIM> M »3b» a $ bislk1o | 3, '2 * I Aí) £ femía mlp6 b

As Y. redcddv &amp; ddon bernddfet in athletic equipments ati ß ^ ß ^ ά ^^ ΐ6φί (^. -Áí ^: bofefiU) pipera iiv ~ í-ksrboxiMí ·. cf. :: s second nucleofd aromatic susceptible step. Λ 'dlbpfop'ilrSBste? &Amp; the {m82sav8 {done: carbamséEnglish after the Eyes of the Eagle Tree! Thus, s is S2 <tb> <sep> to give 1, (Md-1) 542.3:. $ 3 & MeibréíSompéidir: '1,3,5-tr! 8 «| i ^' S'di) fêiï:! Î) N.H2'Ûm5r« îiÎ | mocha-llcdddddd dc ^ | kididlm. ®: s! Ksi! Sz vai vai :ferferferferferferferferferferferferferferferferferferferferferferferferferferferferfer::::: ó:: :óóó óite :: :: :: :: ::FA :: :: :: :: :: :: :: :: TFAFAFAFAFAFAFAFAFAokokokokokokokvvvvvvvvvvvvvviiiiiiiiiiiiiiiiiiiiiiii88888888888888 548.3. nylamnb) <RTI ID = 0.0> 1-14 </RTI> <RTI ID = 0.0> W1 * 1'-2'-yl) -1'-ylhydroxy-1-thiazolylacetate. zeakdévázíat® incubation®:: Âftotà © là kom comsk &amp; Äw traffic: fttf: 8 43 43 43 43 43 43 43 43 43 43 43 43 43 43 43 ml ml ml ml ml ml ml 43 43 43 43 43 ml ml ml α: áv íts áv áv második második:::::::::: ával ával ával ával ával ával ával ával ával ával ával ával ával ával ával ával ával ával ával ával oc oc oc oc oc oc oc oc oc oc oc oc oc oc oc oc oc oc oc oc oc ö «m m m m m« m tak tak. 3. 3S &amp; Mfeformmopopo »; 4- <3 ~ (é” (4 »(S ~ öx« * 3ra ^ ® | 34J] ok * ^ »^ !!) ^ - <4 ^ piperaÄ * i-0j4dt ^ Preparation of 1,3,5-trifluoro-2- (4-fluorophenyl) -1,2,5-oxybisone: A / 1, rachocyclic &lt; / RTI > 4 '(4'-Niofofe) H | |> ism ismyyy::> >ávalávalávalávalávalávalávalávalávalávalávalávalávalávalávalávalávalávalávalávalávalávalávalávalával második második második második második második második második második második második második második második második második második másodikmismisiviviviviviviviviviviviv®®®®®®®®®®®® ^ | gftbdfottÄ6k »li. ': ke? dA You get the desire of the dm (MAH) 621.3.350, Relatestiae: l44id- (8 - oxÄ'3omabk äldo | 3.2vi | okiiss3 »ll) r6d; 4- (piper8» m * lrllii (! Kailg8tmö) - production »

Reaction 1 of the Reaction Form 1: Pipe Chambers A (its ^ ^ k? Ba:? 1? T? T-femyl??)? lmrbaoíklkópgSS: Oián a'Boc-ptpemxia Intermediate TkÁ-vsl keagliki, so ayimsznHdi chemical, (ΜΗ!) 378.3 360. e: y & dmdOF «i%; 1 -44> - (4 -PmssHmz; dddkfo | 3.2 J: j Oiddddidl) "main (pip ddmHA! AóÉmM, 3.5-4! 4xxm - 2-d) ikail | p> e: i: 0karl3Sany production Âz L? î ere 8 T T T T ii ii ô ô ô ô ô ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható ható î második î cf.beta.beta.beta.beta.-cf.p.b., cf.the.beta.sub.sub.sub.t., was obtained as (m + H) 453.6. 'eísí &amp;! srbss3íií i> ^ 5állIfeisa

The first one is a sniffing teaspoon of the teaser, and it has been described in the eighth stage of taste. (M + M) 6I4J. Make sure you have the following: «'; , 4 * $ &amp; »ήη in Reaction 4 of the 4th Revolutionary» Mefferenentpóldm I - (4 ~ i4 ~ i3H »S'-8-s / .al> îçsklôkl2. $ LoygR-b-dVé'Cp ^ eryis-d'-shímlso ^ AáxS-AfiaÄ ~ 2'ii} fe» sl) 43 ”Stä1ksrbss8ld

Preparations of 1, mkcMvââaton. 'TemdaiÂ'méd »have been prepared for the production of potassium sprays (^ 11-14). We have set the right 4 Ounro rhombus and the right aram in a sloppy way. 363 «Reference Examples t '<4' <4 '<3 -« »a-8 -» * ®tl> icik! Oi3 »2» I To produce it

ReactionalMeFeFlFiFiCt modified by IoIiI <(2mcto'CÍedl) J) CB?> {- 1, 4GiMaTaMe * ^ J:% | llbIiWk4p ^ 1: ij% lsb®n, (M + H) i 5§? 3 NM NM 4 ak őv őv őv áz áz áz ors ors ors ors ors 64 64 64 64 64 64 4 ak ak 64 64 64 64 64 64 64 ΐ 64 ΐ 64 64 4 4 4 4 4 4 4 4 4 4 4 4 4 8- &amp;. ζ »Ι> Ι« ιΙίΙο | 3.2 »Ι1βίΐ <« η-8-ΙΙ >> 6 »> (ρΙ |» »η Ι ^» <ΦΙΙ®ι «^ Η8 Μ> 3» 3 &#39; s ~ ks ~ 2''d) comb ~ '3': llksrfess3i: |

In the Reaction Criteria I have the following: 5 - ('4-4 Ca3ofdsya3aaA} ®s8dl alpha-fetaxa in the urea formation step, (Μ-Μ-Ι): V. * 8o) dA3OnDeRiLiCe The reaction shown in Reaction Scheme 4 was made of 4 dlanni: oi and the bridgehead. 365 Reference Metals | «{4A4« {3Af4 ^ Í ^ MNb8kib | 3> I> l | dfeí4s ^ H | ^ {pipоrk3Í3 »<'4 - y8« 3l »o) »£ m ~ 34i} ífebí ^ Í) rfi®í | i | k4fbo iáid * i ||

The first line was produced in an indelible manner by means of N-α (i * .meHlp} pmdi? M-4Uben2ol · 1,4-dlarmn ab crystallization in the roundabout formation step, malii pl pad # iib ^ malii pl pad # iib ^ 4 ~ U} bk 1, 4 ~ d stsld Bldidy: The reaction box 4 was exposed in a brazed manner from 4d1aorizinobe and the corresponding product. Retorting time: 4î; 44 | 4 # ^ H3 ^ îsa ^ 4 # blttklft | 3,2.î {«ki» H'4bii) -l> 3, {bíria * i «» 2 »H) ft '» 3KB {4! Weasel Weasel

The ó ó emm emm emm emm emm emm emm emm emm emm emm emm emm emm emm c c c c c c c c 4 4 4 4 4 4 4 4 4 4 m m m sp with the use of cardio training in steps. Chamomile »Ian started with self-pyperidine coxutoric TPA, so I would get the compounds of i dm særmb. +M + -H} oki, 4, 3b '?. Retourddddn k4444,6'aib; .b'Osa ~ 8 “8i8bá, okki>: s | 3.e.lb:> kb.bS''S" ÍO'b3í5Afbszóo '? - d} leoíf> -3. {4 - · a; bá »Oiniiaa3irí *) oioni) b: oi: S) production of carbs« id

The i. You can set up a reactor in the commercially available 4-carbas bridge formation step. (M * H) 4? 1.3. 3¾ lfefer «âS | MR« iaî] »kMR -% - 5l> '-'IjJ ^ S' ^ isxii ^ S-iJissSilksrfikum A & S

In the L Reaction Schedule Ixaysmotted nxxk, the commercially available IVa'gaiombaa commercially available t-batiM-> amrnoljet tetrachloride · ailstm3.2M. # B4lJ; | # j3, 3¾¾ Attempt example; | .. {4 .- (4- (3- ^ æ {&amp; xs ~ 8 ~ A® &amp; b Cíkkd3k3J | wiser ^ 'd'-yl} -1 ^ 343'3: riax' ~ 3 '! -y} fessd) Creating "3 '' {3 ~ • kpk'i ftlk) xl'3lxx3: i§) feu!) * 2. 1. voakeibyMsM InteCtIoCeDiMeCeMaCeS x * skcdeUni forpte% sn Available 4 '{girtolidirK * l · lkod ft) snf $ r slka hriazMvat in kaMmidi lipaab. {kH By · $ ΨΙβ. 37 (1 References); (4- (4 / ^ dk3-sub-k) 3xabk> f3-3J | ö33 ~ d - i (} * l53.5 ”(f'äg« («- 3 3 - (3 '- (3' - [(2 '- (4'-yl) (1'-yl) (2'-yl) carbonyl]

As 1s s-æskçiôvâslaîsH Í3emu (aioft isAdoa was set to 3db 4 <: í34- «x7i? Pipörazin'ib!) TXoxi) s« ib'a! carbamite training! step. {M - fi) 656.4. The resulting 4-idhydroxy intermediates were prepared by reaction with the following compounds in a bematatite manner. 37 L Retename; A4A4,6-ia3 <> »” ”k'azabikeiki> | 3AJ) kk) -7 <3i5-'tfiaaift-2'.5l} fe8Õb3 ~ (4 '> PKpi m> ltd 1« - Ü - tl} et »x RR- $} ü) fc% rh8m out of dinner

You would be throwing me in the carbaryide imaging step, v. ^ V. ^ Yi, (MHI) 027.3. From 4-Fíuomitrobertzö and the "reglbling alcho", we drew $ $ MákdövMstötí béöíptpWt piötö «<3? 3. UmbrellaS (4A4A "dk: k-yyyy?) (Kk.A3JJ | ok (and ~ S4l} ~ d3,3A: rlszj ~ ~ 34i) Sbftil} - 3A4 · (2 · b or 'ixx sx i) feí 1 l) production of digs

1 rtsskdóvMstoa Ixsmutstotí: in the way we dd: 74y ~ &amp; fsja {> jb «oxi) e! A5tö! atelatgÄbuk wasted in a "judgmental step", (Maht} 574.3. 2 * {4-a ta 1 note ao srijet am> l; 4-Fb.Kxaksö!> old; the 5, wakd # # re »'bet» ^^ l.:p5dá^.

373. RMreoeiaparticle 3S ^ 2 ^ 4H4O4H3O3H4O4H4O1O3H3O4O4O4O4O4: rJl @ ^ ^ Ixj Fe I l) x zed o) (e «4} -2 ~ (# 8d (s)) ac« ta sbd

The Reaction skeleton kit was prepared as described in the commercially available 14- (4-alpha-thiophenyl) -2-thiadiazole-3-triethylate step (34 + H) 614.3 374, Reaction Example; N-bH3-i4-t43> - <ll (3-ftxa-ka * abldkio | 3.2J l «kt4.« - k'll> 1 J, 54> 'la2: hi-2 ~ ll} - ftxytt5i »X'ídot &amp; ayi) - 2 ~ ( 4 íMeííb «£ p-Asl r8jls} aeí4amídelŐálbíása

The L m &amp; ksiMMm Mmmm-ili-ll is a live knife in the cut-offs of my belts 14 # * · •• -awïhîôfeRÎO ^ m ^ H ^ p ^^ MÎJpÂmiditltelftlâ ^ âiÂal in the arm; in time formation. (M-H4)-37 é 3 3 3 Κ Κ Κ 3 3 3 3 3 3 3 3 3 ((((((((((((( F'Ι. | Ss ^: iFeSl> tIiTiDiDiFi) 2-t'-P'-4,4-phthalophenylmethylene: digestion

Reaction I, Reaction I, is presented on the basis of the use of alkaloids of 344-giooylenyl) -2 '(pla-malyln''-illaostanfld: alkali in the tubal formation step, MH-1) 040 * 3, ·: $? $. 3. $ 4 * Nintendo * ~ Mi> l &amp; 8 il .Kl-lpirldm-S-iOkarbam Time Output Ακ k osirkdóvádd bén ^ inasdé mililibilter k ^ skiMidli ^ || ii ^ M &amp; &amp; kaphsaô '] ^ tid ^ ~ 3 ^ inia: in step of formation of uranyl., {M * H} 4 <·> ί, 2. 377. ReferencesHeaver; H44 ^ S ^ xa * $ <&amp; ^ Neik $ e ^ 3x2.l | oklil i ilHHIZ6 | * iSiiiBa $ IM |!:, iÍ3 # ti $! l # zl8 * -2'le} i «filt> '3' (Pyrite 's' 4'ii) * Reaction Fluorescence I was set up on a bidiid-beam mode d® fegidsMetsni: fómnlpnibsift; ^ adkain · x ^ rwd vnxadxininCopA '' .. Upis <1Ή> 4M, '378. Rsfereneiapéf &amp; tr l - - (4- (4'i ^ «) 33: Preparation of α-β-ssbicyclo [33] [alpha] [alpha] - [3] - [alpha] - [alpha] - [3] -Mz2 [beta] - d] IlliyltyldAddd-methylpiperazine-MOfeidlarbadate A: «Reaction Scheme I sion is presented in the present invention in the following manner: Käphdd 4- (4-.d8 ^^ | ^ (t ^^ | 41) í «5iIiItItIfItIfItIe: the / kA« i »iIs image 24s. step. <M * H) 5583 *: t? S, Rçferèoeiapéîda:: 44 ^ 1Illii) «$« (4 ^ (44M (Íipl | É> ya ^ 4ii ^^ (l1} ^% $ ^ bamid A® i cf.fm # b «midkdpz« si sts. »MMd) 511 $ .. -2- U) feaüKH4-l p <}> ^ ^^ ^ 4M ^ P ^ Ii Ii) We have produced the carbamate step-by-step solution using the i'-sobenidylpyp &amp; ithcarboxylate in Reaction Reaction I / iaon bcmniaJoH. ' 'A-v &amp; I started, bed with dm chemical (M + H) $ SS, S $ 3 L Rdemtciapék 144- (4 ”(v3 * nxa-8-8 * 8l> kikt« | 3, 2,1 | »small-'8 ~)) '' n '(feopropilnnii» oH3 # t5'saxi «-da2rd) fextd) -3' {4-í {dime <iiando«} isedi) dddliiáxa A.? Reaction Scheme b! we have died in a deliberate manner using a commercially available bip: available &amp; d 'dinnetic (antin') mefd) aniline in a knrhamid formation step. {Mdl} 517.1.

Eeíeranciapélda; 4-iH-3'-1H-dddioxy-3,2-p-xyl '- 841' - {{isopropyl-8-methyl-3,5-trifluoro-2'-yl} phenyl) -3 ”(4-AmylaoneHnilK« n * l) carb8mid «YMM

The i. teaKdos is given in a bmusatical manner available in dd commercial lysol: using a botlk4-dmlnobenzylcharine at the kaxbamklata stage of your catbamide image: # &amp; p ^^ lbikÉÉili'bP-like with 71';; cup (Μ; H? 4 B 9.3 553, Rdemídapék: 1-i4- <4- (3-part "8" »« d »eikln | 3.2.1 dd» 3-0) -0- (sopsopylmin) - Preparation of 1 <3, $ 4ría $ iii “• 2-ii) fi] n-3-yl; 4-pyrrolidinyl] methylene chloride

The i. i *>> ν.Λ in '' no, i.iît à uk  ban ban ban do ban do do do ““ ““ ““ ““ ““ ““ ““ ““ ““ ““ ““ ““ ““ ““ ο ο ο ο d d ob ob ob ο ο ο d d d ob ob ob ob ob t t t t t t step. (M-dk) 543.3. 334. Edrogenia diphthalene d-Mtd 3-xa-8-az.a de a k 13.2, i p> kr-8 dl-en-Cisopropylansso) -! Preparation of d, <RTI ID = 0.0> S, </RTI> m / 8 * 4 * d) xyl} -3- (4'12- (phrolidin-1-yl) eu) enyl] carboxylamine.

The action was performed in a bammamti manner in the form of <M,?. (M-t-H) 573.3. 388. Reference Example: H4 ~ (4- (3-a | i # -a «abic * * 3,2, i | kià« "8-îlHt4ixôpr <> piî # if8iiio> - i, 3 <5 ~ triarizia ~ 2-i 1) fe ail ï-3 ~ <4-42-idmsed Iss m isn) etox S) fenii $ fear ham id lunch nuts

The reaction mode shown in the L Reaction Schedule was êt $ -ft in a training session. (M; H) §47.3'-l'HiMhyLeMiTiMy &amp; «I-Ruornitrohcnzolbóí and the full * alk> hoibos âHüottt &amp; <$ K '* æ 5 ya ^ ͧváx] atm! Fee * ö« vexxo ^ 386. Refereiscapap; ? - {4- (4 - <^ -> -8-ax8bkilífftP <% Í] yi ~ S> U> ^ &amp; main> main>>> l3ß4täM &amp;## «H" feililil) ~ 3 "(6- (4-methylpiperazin-3-yl) carbonyl-3-yl) urea

The L Reaction Decreased Methods »Prohibited killing #commercially available in 3-44 - mefdpipa! -n) Pyrite-3-amka alkazazaza in the Cyclone formation process. (Μ · ί · Η) 53P3 387, Refmmmapéida; -24i) fenHV ^ 4- (piperazî «-l'sl) ÎenlS) ti» rbanùd eDelete A? i. mmkiP presented in the React is stacked with a tube-butyM-td available in the tube, with the use of: - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - ) We got our hands, î <i. P! V-unti ve &amp; ydknet, (M * B) 344.3 386, Referemdopelda:! - (4 ~ (4- (3-nga) ~ 8-azabt íkloi3.2.S Jokesau-SH ^ b-fixaprt ^ lIamPdj ^ l ^^ &amp; gaspe -2-4)! 7a5H> -3 "(4 - (4- (dsaH? 4uiai« o) Production of p3 (> aruna ~ kd) iea4) carbaa3d The modo shown in the first batch of motifs »

• Mountainworms in the armrest training. (Μ · *: Η) 5 &amp; 6A 389. Refereodaphim «; 1- (4- (4- (3-9saP ~ azaMPikíöp2.Ílaktáa-Si)> P-px «pröpsla (: 8se (ÍÍ) assits«) - íj3, S '-ârîaals-2-H> (> ad) d44- (4-ma (8pîperuïks-i-ii) fe »iIJksrMnît8 8ÎM! SMsa

As shown in Reaction I, air (<4 was obtained with five # kefçskialebstï fetsafumrams using 4- (4-methylpiperazin-1-U xuhhn in the catechol formation process. (MM3) §7233. 390. Rheidodapet; - (3-o: œi3'az8bî <àkIô | 3.2, I joki-Skit-S-tlxoprsp ^ meisRatshta ^ i ^ S- • 8'ta: íia ~ 2-H} taatb'3 '(4 - (HtÍ8ieíi!)! Ho} mIiIi) to produce k3i1> a «ICT

In the Fifth Diagram I Reaction Schedule I, we prepared 4-({dhoediaminomy · yimHin aliquotationofcapitalisationcontinuation, (M + H) .431.3, 391.) Throne: H4- (4- (3-0m # 8) ^ bl9lfcl9Í3J «.t -irÍ8ZÍí''-2-jud} I-3- (4- (2- (dam (U«} ethoxy) fes5l) before the arm

The 4 (2 '(using methylamethyl) mdlh; as described in the KufbisH'iUking procedure. (M: H) 361.3. 392. References; i- (4 * (4-09 * s ~)) 8-α2-κα-decyl-1,2-oct-1-ηt-3H-methyl-3 '- (3'-t398? J8-2 -)) -3- (β-pyrrolidin-3-yl) carbamide idosii? step: 8r (4-tert-6- (4-fluorophenyl) p, 6-tria-2 &gt; I > -3-aza-8- 4,3,5 [mu] Kbybel ({, 2Sg, 4p4 trun} in acetone #Smt) and a solution of ice water (20 [mu] l). - 'Hydrochloride (9, (555 g, 4.38 ram «# and urethral dehydrogenate (25 g, 9; 2 µl · acetone mfl') with water (t § ml). (fC «m.2 ripple, rnnfdÄozato-plane; let us let the temperature drop to room temperature 18 (Mo over the fish) The crude product was subjected to a rotary evaporation, eluting with Pt, 5% methanol in methylene chloride, so 8 ~ {4 ~ h> 4M4> mu> phenyl) »t, 3.5-ΐΓϊ» Ρρ # 2-ΙΙ) -3'θΧ8-8-8Ζ3Ε! Θ! ^ Δί'3> 2> 11οκΐό8ί (Ö “89 g, 56%” was obtained as a solid material. (M; -i f) 348.1. 2s Step: Woody: ij ”P“ ^ lé ~ ~ 6 '' (4 * ïS5tr0fer: }l} - i Jt®''o '* í! Í * s ^ 3: -9) - ^ - asK :: v $ > as Íieik ^! o [3.2. i} bktánbé | (0.450 g,.!, 29 mspolica * ions (5 mL) and elite (solution was prepared. For this purpose, the &amp; rbonate (U 2? Ag, 2.59 mmol), matrix): (0.134 (3.42 nvrool) was added. The captain was "rusted with a rusty sludge spheroid; bOX-tac 2.5" was recycled. 4- (4-'nit OLED @ r6 "tsomör &amp; Ilim - LI3, o-fdíiZ i -: i-III - si iv:; s - i / aisicÍKÍrii'12.l | Oktávia?! (0.455 g, 81%), dye, white solid, tlRMS 4 3.9, 546 (M · I: I, calculated) 4 15-3 $ 26 i> KH, y 3, Step 3: g ^ 4 ^ 4. ^ foi «« i}) * 64w ^ orphan «K» -L2, S ^ na * ift * 2! 'Ô) -2 ^ s * $ * gïibÎ! É} ktep.2.1] o | 0.418: ¾ L0Î mmeil ptndmfeen (3 mi) and DMfobop (ml.lPPzPtz dipstick, then <sntit> klm5dAlrfodmtot (viShhg, 2J2mmoi) added and the white-white suspension was added to the crude layer: juice dm ' and the "zuspussia vkosgair MdL" We have been doing ssexpezzhhAhk, mMaplm, and we have done so. LCMs indicated that the reaction was complete with sera meat. Â The raw product in DMF {<> mi) and reddish: pmi) was added and further mnlDAkid-dlMdrat0S $$% IJAmnml was added to the solution at room temperature (§ hour fceverteid. {«Aid pierced. washed with methanol and m.p. 12-13 (m-3,3> 5driazio - 2ct); mifet. (0.195®, SsM) was obtained as a yellow, solid material, (MH4) 383.3.4, Step ^, S'-Hazm - 2'-âl)})) (- ipi tidbî * 3-- (() kst rbatald ddddd sa í í it it it it it it it it eti eti eti eti eti eti eti eti eti eti eti eti eti eti eti eti eti lor lor lor lor lor lor lor lor lor lor lor lor lor lor lor lor lor lor lor lor lor lor lor S-4Ä: ae «bHÄ'i | ÿizbeo in 20 minutes, 0.05%« p «iTet. W-ners Atlantis pod) l - '(4 * (4 * (3'-o: za ~ 8' ' azabioík: io: P <Állokláa-> | -: ili; 6 - tioua> rib too - 3Ji5'triazi " '2 - d) foni;) - 3-fpiHds5: 3- *'! 11) k3n-bstpid (0.032, g, 63%) resulted in tibial silyl. (M-iffj # 05.2.). 393. Betéeeuesapetda: Í- (4- (4- <3'-oxa ~ 8 "Stzaiddid« j3.2, t! Οί <ΐ4η - 8 · -.ΐΙ) -ό - (. 4ΐηΗΐΓΐοΙ? Ϊο> · 33 <5 ·· tria¾in'2 · -fl) fiuήl) - 3 ·· (longest ^ 4 ')) We have produced the commercial mode described in Reaction Scheme 6: pGdlo-4 ~ amtt with flat snapshots of damage &amp; antimagemy *, H; m; 28 mg (54%); &lt; / RTI &gt; 505.2. 394. Rellreoeia example; | (4 .- (4 - '(3 - os5íA''ax8t> ic d d 3,, á á á á d d d 'L 3 3 »er á - i i' '' L 3 3 er er er i i i in in in 3 in 3 © --ii) fouiî) feaéb8mâdelôâi (âàsa A é re &amp; kamovdztaron: inôdoo pseudoEu walnut commercially available 4A <L • -metlpmeoiztUrd AiMiMiI) for boobyamming tbooze; 392: Reflection example: I- (4A4 - i (3 * <A: av8-azabtetkfop, 3.1 -it) feuiI) - 3 * P ”(): dtmetllnmsno with« tiS) tbftil: iii eidatitity a 6, leakoibvázialoo jxiomtafob on the media commercially available: <RTI ID = 0.0> 4Ki'-lithium-1-yl] 3-ylmethyl-5-yl-alpha </RTI> in the caffeamide formation step, DölmE: IS mg (3454) ((ΜΆΙ) 301: (2, 365 * Eeferenéfopébisï L (4 »C ^ s (4-ss: 3'-Sm« ab: leskio | 3,2, i) okîàn ^ foii) ^ b'-tfo? « Preparation of 3, S-iis ("- 2" - dl) phosyl) - 3A4A1 - [(a)) - (iii) (a) carbide production 6, in a pseudonymous way, with a pseudonymous &amp; : .H »rbiXfei <file> and step. Yield; 35 mg (59%); M + H) 59t> 3i 397. Ueferenefapótdat - (4- <4> {í »ttls« ({^ h3-me'ttíit «? viiiVf ^ S'trla ^ tt ^^ fedilHáHtfl ^ t am id a fortune, &amp; κ Ί. (we have been using this mode as presented in this article. It is available in Italian.) $ Mdm ~ 4-atttkt almdsnazasav &amp; la carbaηκ kon 's » , Λ1 ü'4fe '398 »ReleObeRpds;!:> (4H4 $ fe-bi.s% {(HK ^ metlH <orfotlno> ~ U3> $> trii} zin ^ Hit> ^ ntt ^ N (piH4in ^ ê ^ Production of r 'carfeamide was prepared as described in Example 1, and commercially available in the form of pyridylurea of the following formula: carboxylic acid, yield, 96 mg (79%), (lMl) 991.3. Xietferenciagéidm i> (4 * | 4 »6> bitz ({RV'3 <'hereethyliporfolim> t ~ l3s5driaaiu-2di) fêai ^^^ PmeUl' ': p | pern £ m ~ iii) fb« ii} kad> amid előállítás® ··

Prepared in the manner described in Example L, commercially available fergalmnfegn, using 4-> 4Pittmtlte> 1? -Bityl) annihine in the carbamyl styrene step. Yield; 81 ϊκο (81%) 1 (1 H) H 588.3, R Rafeylpyria: S 1 -C 4 bh x 1 F 1 -J-methyl merfluoroacetic acid, trifluoromethylphosphate. (i-pfidia-3-yl) carbamate

The iJí. as described in Macroscopy, a commercially available Throttle Names stealing S- (4- S k # 1 in the following image> Yield; 56; mg (79%); 589.3. 481, Reference Example: Ammo) methyl) <RTIgt; 1 * 1 reactivation as described in the commercially available 4- [4- (pimyl) Hammol-4-yl] carbamate step, Yield> 28 mg (43%); CVAE) 547.3. 482, Referendum: i ^ d ^ Cd ^ b ^ CRH ^ iR ^ tlliaoiltotlno ^ lJl ^ ll ^ ^ ^ ^ ti SK SK SK SK SK SK SK SK SK SK SK SK SK SK SK SK SK SK SK ása ása ása ása ása ása ása ása ä ä ä ä ä ä ä ä módon módon ásával ásával ásával ket ket ket ket ket ket ket ket ket ket ket K K K K K application in the KMmmiokepzes: shroud. Yield; > 0 mg <72 ° * 9, (M * S * 7 A '48 #> ReRreasePalidium αMHi} e! Ed)?

The reaction mixture was purified by flash chromatography, eluting with 9l- (2-pyrrole (3-ylmethyl) ethoxy] 38i) 3: alpha.max. kttebamidpicture3 ^ ATTENTION. 1-Iosane 1. mg (57%); (M * H) 683.3. 484, Mëîerédeiapéidn; N4 ~ (4 ~ (3 * o «a ^^ sattklkfo {3.2.1 | β ^ β ^ ΙΙ ^ * ί§ ^ 5 ^ ΐδ18 | * ^ $ βτ'Ρίό.» - 4ί1Ι) * ^^ 4 ^% Preparation of N, N, N-tert-3-yl) -methyl] -hydrazin-1-yl) C7. reactéiováziaí} 1, Lépes; 8ip * spin ^^ s8trofe3i8) ~ 8 »3J ^ trkw« ^ si) 65'OS8''8i'8 * 8blesl <! «Preparation of the 3,2,41 training course. ret? em, example 1, step 1, according to ssmsrtéfetíófe 2 »13κρέ»? 8- (4-pyran ^ pdl0ds8idrO'2H '~ 4' '{l) ~ ~ 6AS 53ltr «ífe8M)" "LT3" S-4rlazin "2UL) 3 ^ & amp ösá'8'-azá8ieíl?; Preparation of i, p, 2.1.

A microwave (in the haemlonus 8 '{44dór # 4) i-m! Troíemí) H, 3, S%! Yields, 140 g,? mm? h? 6? (6 ml) of the label to give the side nitrogen through to 18 passes, 1 ml (0.088 g, 0.076 mmol) and tribmil (3.6- dfhdr (v2H-pyrid-1-yl) ((0J6g, JImMoOn jdttmk). Dolonamamtk and 160A3 ”om40: minutes were heated by micro-luühhn altmlnntzässvu ;, More tnbuí 0 {3,6 ~ dihydm-7II» p} Târ> ”441) siÂsnà8i | Ô, 283g, 0.76mmol) and 0, plS mstxd) were added to self-dye, and staple-clover; The product was washed under vacuum, and the product was purified by silica gel using silica gel as eluent: 8 g ; 0 ~ 2% for arsenic / methylene chloride, such as S- (4kv (r-diSudroAH-pyrrole), Ak4oOSroicn; -Laq-v2A!) - 3 -Oxa'k. α] octane (0.430 g, 861µ) was obtained vi as a fluffy yellow solid: flRMS 390.1660 (M-M, calc.) 396, 068 (M-H, on lake). Step 3: 4- (4-P-oxa-8-aza-η 3 -L-oxo-8-yl) -6 (3.0-yl-L'-2H-pyrrole-4-yl) -3.5 Preparation of trilium β-2-ω) SILY: 3 (KIIPI (0, Ö7; Í: g, L2f ihinolj eedtsávvai .iegyét of $ 5 * C).

Mm {2. ml) was added and the obpllc was turned off, 84 (4 ^ 3,

4disive2-) l) -3-i> sa4t-nzisblciki »[3.2.l | okanyan (0.100 g, 6.263: mmoi) is an antipathy box! (2 ml) was prepared for the first 5 minutes, then we were protected for 5 minutes, and then for 10 minutes. The mixture; Yields of the UKlfithi (4 times) is a yaAaAlAlbAlcT, which contains: aqueous nabhmx-carbonate Not applicable The: one-organic organic extracts with water, washed with water, dried, and: batch-hyite, so 4 - (4 - (3-oxazol #bicycle <> P 10,060 g, 74%): kagbmk, sponge-teaspoon-leaning: the next step 360.4, 4, step ïvp> .p-pi <} xs 8 * &amp; zebie8ktúpi2v 1 ¹H ~ í í í666 '- - (3j6 dlhi4e &amp; 2 2Lpdd * - 44ll, 4: 0-α) αaaa ^ ^ ^ ^ ^ ^ ^ ^ ^esesesliA ^épéptilsilsils---ítítarbfifiid «« «ása trif using triedl-urntn metl: isnrklut; tdb <m end-point for mafcy-lattice scaffolds using carbamyl formation and commercial pMÉft-4-amine commercially available as a bleaching agent for blFLC purification (5-93% in aionitrile in water 20) under 0.0536 FA Puifc, Waters Atlantia Column) i ~ (4 '(4- (3-Part'-azubicyclo [3 S, 1] octane-k41) -6 ~ p, 0--6thldmkSH-pM8 " 44iAi, 3íOstd8zt " '' 2 α-d}: η 1 - (t) - β 3 -4 -pyridir-4-yl) katbami4s (0.034 g, 703 # as a yellowish solid solid in the formula, (MfH) 486.2, 4S. References example: i - '(4' | 4 # 3 ~ part'-8-tailoring kl0Pi: 2, Í: jektáaeScpLO ~ (.3jk'dibid>, ö "2li-pyran'-4 - fí) · '• Î ^ Ya-tazm ^ ad ad ad d S d d ett d ett ett ett ett ett ett ett ett ett ett il il il J J ea????? {{{{{{{{{{{{{{{{{{{{{{{{ 44 members (32%); {MH} 583.3, 406, iteíferenelsp contextb: - (444- (3i ~ 8 ~ 8t? MsklbP> 2, <RTIgt;? Oct8'-S41) -0 - '(t &lt; / RTI &gt; 2-pyran-4 '- β) ~ -tP, S4ríazlri-24t) fe8tl)' - 3 '(distillate 4 4-0) kttrbatakl: The 7, unpublished presentations tttddsm a! 1 have been judged »; the following is described below: O-iA-ipjO-Dlbidw ^^ epirsmd-i'A ^ 'Pitfo ^ adLl J: J: ~ szdmm-5PÍ) - ^' Oíta'8''azabictk: ío | .3; 2 (Example 6 05Re51 As described in IcgxL) (0.260g, 0.658mmol) and EtOAc iS nd), οκ4; ν in nap (5ml) and reflux (8ml) Due to the solubility of 8M EA / MeHiDi: added) Oidate was added and 10% oxide-borne palladium (0.07Sg, 30% by weight) was added. The flask is mixed with 014 rg, á; - rd rbaîkm) and pt-to? To 6 6 6 6 át át át További További További További További További További További További További További További További További További További További További További és és és és és és a a a a a a a a a a a a a a : You're going through 3 meals. Lomblköthtdrogángteal tlsztlfotfok # more! 1? mixing thoroughly. Cosphorus C'ehte ™ »- search! filtered and. &Amp; I want to eat a fur coat, and then I get the hairpin. Thus 4- (4- (3-fluorophenyl) -1-biphenyl] -1H-P1-iodo-bromide ("IP") was added to give the title compound as a residue. HRMS 368.2080 ( M + H, calculated), 368.2085; M-H.}}.} ~ {4 ~ bis-3-oxa-8 "a« abicIkSftü, áJ! totr8bsdm'2íÍ''p! onto «4 ^ iÍ ^! í3jSA?!!!!» !: n-> 2'-sl) behold) '3' · * (g * Möp-4 ~ d) chamber! Preparation; The thiophage was used for a $ 4 &amp; l &lt; / RTI &gt; &lt; / RTI &gt; &lt; / RTI > &lt; / RTI > &lt; / RTI > carboxylation process using commercially available piddin-4-amine as, -About. HPLC purification (5- 95¾¾ of my steel in water under 20 families. 9.05% IFA buffer, Wtders Atlantis column):. {4. {4. (3..oxa-k-azab) article93acl ^ 8dl) "6 - (!: drahidrok> lb'p yttrium-4-yl) -1H-3-olaziryl-2-yl) -1H-thiopyridin-4-yl) urea (0.046, 82%) was obtained as a solid solid ( Mt M> 488.2 487. Reference sample: The% ee skeleton profile was produced as shown by the addition of -4 <p ~ - • mehlpspcrazsn-I-dmbim available in the carbs formation step in kgmsisedeitni, "54 mg (79%); H) S8S.3491. Riderenapolite S ~ (d- (4A3 ^ 9 * a-8-a ^ fetolkfo {3x2, î | nkÂ4bï!) - d- (fotrabldrô-2 (l “p! SAs * 4- l ^ - I "3.5-4 rb: to" 2-yl) top> -3A9 • (2At ^ mt4: i! smfop) efo4r) («8u!> liarbamld elMMMsa? atntt nfodtm was established by the 4-pAdtfoeiifamln {A «action) <t9dns afoaimagata) in the liAbthPidisation steps. Yield; 49 mg (73%); (M-t-H) 572.3. 403. Saphenyl algae; 1 - (4 - ([beta] oxo-8-oxo-3-oxo [3 '- (2-pyrrolidin-2-yl) -2 (1-pyrrolidin-4-yl); fond) -dA9A (dlmetjl8a5toö) a5ett) toósip &amp;! fbamld "IMI !! Sása; THE %. Reaction Schemes of the Reaction Scheme are commercially available in the commercially available 4 - A (din; et) 14rn | Rp) 1Rd). I bring; 21 mg (33%); (M-H1) 544.3. 4ÎÜ, «« «» »» pêldsî 1- (4 (4 - ((1 SsdSipS-osst -S-aziahfolklolS.Sdlbeptan -fosD-α-KRJ-S-amtnoffo-lino)) Preparation of dentifluoroethylcyclopropylacetate

The roakdéváxlatoo I was produced on a commercially available pimey-4 ~ smm application in a step-by-step process. Hozman; 45 mg (70%); (MAH) 489:, 2, 411. Referring to the following references: "H" b3,5-tdazis-2-yl) phenyl) -3- (pbidin-3-yl) carbamate (s): .ELe8kbl ^ ^ h hdt thi thi t th i s commercially available commercially available promotional epootomy in the carbamide imaging step. 1 lozam; 60 mg (95%): (M-rH) 4S9.2: <412. 1- (4- (4 - $ (Ι3Α ^) "2 οχη 5-8ΚΡίΐΐ ^« ^ Ιο (2,2.Ι: ^ «^ $ ^ ρί4ρ ΙΙ) 4 ^ ((Η) -3-Ιΐ3! «(ΙΙΐΡθΓ (0-lia«) - !, 3,3-trfozia-2! L) fordl) -3 "í4" (4-met | (pip «fakln-li}) fo« i » :

The k-reactive Aemnaiste honey was found to be commercially available in the following forms: 4 (4 with 4-medlplerazin-14 lacquers: s in dorsal amidation. Yield) 69 broad (90%); (M-Al) 5M3. 413. Eefotsaesapêhlaî (- (4- (4 - ((1 ^ .όόρί-οχ ^ -ό-χχζκΙϊηόΙίόίΙ ^, ί ,,ίίρΙΙΐί-Ιόχ-Ιί-ζ ^ ζοοίΙΙίηοΓίο-haö), 3 # -Triazfo -2A!) Foaf!) D- (4 - ((4-sitetllp! | [TePadH-Ml) méií | föníi) feTeTeMsgf - & ns, rsSkelkase «» betttptot descodeB was produced in ksrssksdcmn âstgafdiP i # xg »Í «· L)« ni: ir ir ás áv ai ben ben ben ben ben ben ben ben ben ag ag ag ag ag ag ag ag ag ag ag ag ag ag ag ,3 ,3 ,3 600 ,3 ,3 ,3 ,3 ,3 ,3 ,3 ,3 ,3 ,3 600 ,3 600 600 ,3 600 600 600 600 600 600 600 «X» ~ 3- »i'sbkdkki | 2.2Jihept65 ^ Si? | -6 '(fk} ~ 3>' 1RbiltiTiRiIiMi" lT3S4rfa * lb * 2 "11} <RTIgt; 3'-OnHsH1) ethyl) crystalline;

Is that? * gsM &amp; skeleton.aam introduced into commercial use. Can be applied to 4 '{pbroildift *' l-immtilkailln! in ureacpr-Hi step. Yield; SS mg (7SPo); {Ms43 | :: | ”i.3 ·: 4! S, Eel's Avis'; I - {4- {4 - pH»: tsi-b-azamsil ) j3.2, lb> ki--8 ~ ÍiMH (^ - 5fmmtsÍ3mss'f »> imy> '1.3.5-4riaxi" 2 ~ li) E: n | Í)>' 3 '- {pirldi0-3- il) production of ks rhyme;

MyScreenShortcompletedItImAtItIon sActIoNs! »« »Kapbá! I: pyridoi - 3 -international jW.m'a ^ sáYkWfeari &amp; 44 mg (66%); (M-H1) 503.2. 416, Eefsrenciapék! S »: l ~ {4 ~ (4A3mEbb ~ Kzahidjklo (3.2, l | 0klá.» "L ^ {!)" Bow ((Eh3 ~ metilmdrE »| j« 0) - l, 3, S '· • -tn8: drn-2-í!) Ien - i) - 3' {pony! Si - li!} K3i baíi »jd celebrity»:

The present invention is described in the following description of the present invention, which is available in the process step of the step 4 of the invention. 33 mg (333a); (Mt-H) 503.2. 417, Eslsréns example;

You are going to get into mskéloyMaton: we have digged sk> ketesfcedsb «f in circulation 444- * pPSf» Ipipes ^ zot - Pi: í} anilial alkaline slices in the carbs imaging stage, Hö2ap>; $$ img (62%); (M-M +) 660.3. 41S, Ed &amp; Re &#39; s 1- (4- (4 - (3 - & - ss-8-aza > cyclof3.2J &lt; RTI ID = 0.0 &gt; yf: &lt; / RTI &gt; alpha-3-d) rb> l) i}} A3P '· 4m £ sm-Mi) &amp; «| E3y (#haze: uk i. Yield of 4mg (45%); {MMi} $ 85.5. 419. Reflection Í - '(4-i4-! 3' - «ixa '-b-azsíbitiklií43.2J | «Kia?' - '4-'5}' 'b'; ((i) '- 3 - t" random noise "H rlbyso!) -i, 3,5-! trimethylbis-2-d) pyrrolidin-3-yl (4 '- {24d (bis) [alpha]);

Reaction K for the reaction kit is based on the following: LifeStaffs and Ps: ^ ^ andbett, 'Hö28mp43 mg (4?%) T CM M i) 589 * 3, 420, Elefranranapètt »; (R) · 1 - <4 <4A3vmstylmoftoinE-SAtSpecifice [alpha] 1 - [1] - [1] - (1-pyridin-3-yl) -3- (pyridine-3-d) carboxylate. Horses: Λ d Λ Λ Λ Λ g g uk uk uk uk uk uk on on on on on ható ható ható ható ható ható ható ható ható ható ható ható ható ható 3 3 3 3 3 3 3 3 3 3 3 3 Hszatk, 4 | mg (77%); (M * i4) 476; 3, 42 L Referendum; Example 1- (4- (4- (3-Fluoro-methyl) -6-tetrahydro-2H-pyrrolidin-4-yl) -1,3,3-tricycl-2-M) -H1). '3' (4- (4 ^ «» <! D |> fpmszúii ~ MI) l «li8i) karl> oh (« out of my life We've put on the nose on the 7th skeleton, and my predators are! " -mstilpiparazio-i4!) amtt »r alias: às $ ^ | '.ikâE> 3m <dl> .êp / es) k-pefbeft Mozart»; 5) mg · (? $% &Amp; (M> H) 573.3.

422, EéfmiïïOsapêldt »; EbbA4A ^ E3 <0H4rm (oM »o) - 6" (thiol 3 H 3 3 <3 "trm 2 ~ 2 d") Ethyl PA4 "(pipsrasyl) phenyl bamld EMileástE A 7. mkeidÄÄ ^^ mataaÄMiIs o0itottüki.l! #; flax! # Âg # o ^ i ', juice ^! lnl6 sts> ^ nt »t-4 (4 * -a!« mOíbnl! | pspsra ^ ilri-l: «Kad5öxli; i áv áv ben ben ben ben ben ben Ets Ets Ets Ets Ets β β '' 'g g g ^ ^ W W:: ^ ^ g g> rug (90%); (Μ · Η Η) 559.3 Teftethelate Example 423: j - (4-44-0 RV ^ HBelRworfoMnoMWI 3.5drlaZiß-4 dl) α1MM4d {S3 ”3 ~ Methyltestyl 11) prepared in the manner described in Scheme 7 &amp; t &lt; t &gt; &lt; tb &gt; 1-dK4 ~ aa) inofesUKi < / RTI &gt; In Rtarhanndphexes, the Roc-plethrazh · kAtm'fermek H'kttd V oh,] iivi a seoi.ik * s.nuk t. î <H '"*> (S) -terC" thiol-4 "{4" Risofeayl) -3 "nylpyrrolidinylcarboxylate allegations A 4, reactive skeletal activity was obtained: AAfornítfrfeenzotbó and the elaborate mdihh 424. Reloreocyte example: i- (4- {4- (ti: yl) -3-meliltnorphol "o} '6-0etr8l}} | <tb> <tb> <tb> <sep> <1> <1> H-4 ~ 1S) -I3> Sf'ia3: <RTI ID = 0.0> m. </RTI> <RTI ID = 0.0> (d) 8eHl4H4d </RTI> {R3 "&amp; 8" Ethipiperazl "&lt; / RTI &gt; THE ?. Scheme 1 illustrates the use of ΔliStottoK (R) AerC'batiM - i4'ainiftolkidp3Anetslpip «r8zlteJ-- • caroxtel in the k arbtun training step. Raiharofci's pictures are the Boc-ptpetaZ &amp; m. Maâtemîékdi i'FA-Aäl tezellUk. Yield; 68 mg (90%); CM * J I) 573.5. Preparation of (R >m>> «íí'- (4'-ylophenyl) 3'-yl 'pyridyl-8-l-bis-phthalate) as described in Scheme 4, Cat. ®b «teöjb6l and the corresponding 'Ä araíőMíMítötok, 425. Reference, the mtdapéld; I - (4- (3 R.5S 63.5 i' d smeldpí GOS kite ^ t-yl} phenyl} -3 · l 1 (4 ~ (4 - ({RK ^ ~ aíéiym <srlöit o> é ~ (((it it ll ll ll ll ll ll ll ll ll ll 4 4 4 4 4 4 4 4 4 4%%%%%%%%%%%%%% ¾ ¾ ¾ > Yields of <RTI ID = 0.0> xM </RTI> alpha <RTI ID = 0.0> &amp;amp; &lt; / RTI &gt; in the ktu'butnide formation step were treated with TFA with Boc- * n ngemmm intermediate to obtain the desired compound. Yield: 67 mg · ψΊΫφί; '$ β &amp; Μ $ 587.3. p, S ¥ zAteee "b" t | |4- (4'amitipefil} -itornitrobenzoibo and the corresponding amitifol 426 <transferaseplate: ^ ^ d ^ oxa - ^ m ^ bridg Reaction Form 6i was adjusted in a tero-tactic manner by means of a «In. 4-blistering-1, 3,3-A8zinp-1 | : from 1-siphenyl urea ()), 020 g, 0, (133 mmol) aethonitzyl chloride <1.5 ad) and water. (0J m!), And agar (δ, 02 #: g, (1.0.33)) and the solution was stirred at room temperature for 46 hours. The suspension was diluted with ethyl acetate and saturated sodium bicarbonate. Solvent Washed The organic SAast was washed with brine, dried and evaporated and then purified by HP1-C (20% acetone in water, 20 µl, 0.05% TFA Putter. Waters Atrium) to give t (4Ad). · - ((3-ozP-azibylcyclof 3.2, trans. 1M-Pt-11p'O'l-1-yl) phenyl) carbamate Sodomate TFA salt (0.00.29 g, 14%) was obtained as a white solid. <"MmH) 618.4. 427i teefereoeiapáids: pt) v | - • (4 - (2- (dtn5« ttíarft {n &amp;) «io: ski) featl) - '3- ( 4Ad ^ me1ilmorföÍ8ö | -> 6 # etkS 'hklrtt-SH ^ pyran-wedge-1,3,6ArlaziiK2 - WikiWd |) Difficulty In the 7th Reality, a sketch of your sketch was made on 4- (2Ad5mpiÍátpino) mosi) aoilín in the process of maintenance, Yield: 34 mg: (Si%); δ-1 β 5?, 3, 428, β-β-β-β-α-4-yl β, β-3, β-1 β-β-1 β, β 3, S-1 β-β-β β β 8) A 7,. Reaction Schedule shown was set to ¢ 16 commercially available 4- (4 - Ethylm? azimicyclm at the carbamate formation step. Yield: 6b mg {6.1%}; 4 H4) 3873. 4¾¾ Rd'mmd example: {R> »i - (? '{' {- l, e |> roptipiper &amp; AI8> i 'i} f« »yl?) ~ 3- {4" (4 -' (4-ïtie5 {tm *> i'f ô | ô ô - i i i i i i i i a a a a a a a 7. 7. 7. 7. 7. 7. 7. 7. 7. 7. 7. 7. 7. 7. 7. ával ával 7. 7. 7. 7. 7. 7. 7. 7. 7. 7. 7. ával ával ával ával ával ával 7. 7. Yields> 6 mg (91% k (M <H1 ottl4 4 ^; 4M ^> p &lt; p &gt; p4p1 &quot; ras &quot; preparation of? 4 ?,? Reactive skeleton; live atoms from the appropriate atom> 430. Itd'e nme b example: {R) -4 ~ 4 - (4- {dinKttil8Hinino) pipt> ridia> l> i! $ feail> 344 ^ 4 ^ 3 ^ reiterite | : {îeîr &amp; hkir {^ 211i) 0 '^ ov44Γ ^ 0i3 <53rsa? i.; ^ îI feî »01i» yl> »Hîîd <0ôsHlinh8; and preparation of M4 amine Oiemn-N * N: Himeti piparkhO'-4-afntn &amp; carbam formation. Yield; 69mg (95%); ίΜ · ΗΊ 601..4. 431. Reflexography; <RTI ID = 0.0> (R) -L </RTI> <RTIgt; 4 </RTI> <4> <RTIgt; (3'-methyl </RTI> orthoHR <RTI ID = 0.0> H </RTI> tetrahydrofuran-2'-yl) pyridinyl] '- {4'-1H-4: yl | ip4-ns: [alpha] 4'-trifluoromethyl} fluoro; THE : ?. Reaction Schedule (4 ~ amimipup) (4 ~ metipipio <} crumble MBrntpätto «in the carbamate formation step. 1 lozam; 38 mg (52%); (MJ 0 6? 1J. i4-a> nmoteaifKp) petai: l '-1 *) l) »» Ethanized rocks are used for winter production. # 2; Refemtclapêîd »iRpl- (4 (44; iftpropilpijx; ra; tkt-O1: SiO1; R1VRO) A444443-nxet4« usbobio [beta] -6 '- (trifluoromethyl-2H-pyrazol-4-yl), 5 to azo-2! * ihfe ka; J J J J J J J J J J J J ával ával ával ával ával ával ával ával ával ával ával ával ával ával be ával be be be be be mg mg mg mg mg mg mg mg. ) 0¾¾¾. (4-aoth; ss> fo? Sl) (4-olefin <opkpiperstz: ifoswit; s ít «« ít ax ax ít ax ít ít ax 4 4 4 4 4 4 ök ök megfelelő megfelelő megfelelő megfelelő megfelelő megfelelő megfelelő megfelelő megfelelő megfelelő megfelelő megfelelő megfelelő megfelelő megfelelő megfelelő 443, Reference Dates (RVi-t4- <4 "(3" îïsebl «3" rSVsHiX3) "6dteinshi (iîs> s2E-pirāsiît-4di) -l3> S-4rM3zt« · # "Sl} Preparation of 6- (4-methylpiperazine, ml-1-ylm-4-yl) cadmium The method described in Reaction Scheme 7 was used to prepare commercial torgaiembi using the O-4 (4-methylpiperazin-1-yl) psridim k-stmit in the carbamation formation step. Yield: 69 mg (99? 3 (M * H) 574..3 444; id4-44-43 - om'8 "btklo [322] Ht> Matrix <RTI ID = 0.0> (tolmHydl). ) 4 - (4 - {4 '- Hpsp (: raitho' {"yl) phe}} alkyl]; Reaction Scheme 7 was prepared as described above using commercially available 4- {4 - etpiperaz.m-tfknilin in the carbate formation step. Yield: 62 hatch {439 *}; 5993. 445, myth example i * 44- {4- <3-oxa-8-azahktkloß, 2, Î '-1, 3,5-trtazit ~ 2'-li} fenji} «3' {'l' { The preparation of 4-isopropylpiperadn-1-yl] -naphthalen; As shown in Reaction Scheme 7, 444 * lzoprop% | pç ^ # t ^ 14l) 8t [beta]? Yield; 51 µg (66%); (M; St) 6! 3.4. 436, Array: H4- (4- {4- <ixa-8-az «bk4ktoß.2,1" l, 3? S "tdaz.5n.2"}} dt-d '(4'Í') Preparation of 4 "diphosphopropdispyperisationl" carbamyl carbamates: Λ 7. Proliferation is carried out at the shrinkage of the pond. "^ # Mm 11 mg (14%); (LH H) 6LL3. 4" >}> rpp5lpspm'8gfe-1 / yl) Preparation of the silicon: The reaction of the reaction mixture is quenched in a <RTI ID = 0.0> 8; Preparation of '-SJ, 5-SH'-CH4ttt} 3- 3- 3- <<<<4- 4- <4- 4- <e | «« «-fffff) )ánánán carbanilium: A'}. Prep. S - (: 4-Aoknoferó "N% N-Nifofi! Ipp-1n-4-s.iSg Mb $ albQa <? i $ àva.S: in step of step. Yield (36%); H) 6 Í 3.4, 43§, Roforeoslapéido: -153î5-irSgz; sï ^ 3-ïi} 8yj-3 ~ (4- (4'-mëtl | pSpëi-3zS »-l-booSS)) f] tslS) production of bafsltl: • As described in the? stomach (4 µmS of 8uSX4? m ^ p? pimam?-? 1) η>? ί8ηρο; $ * kaSsn soaking in the carbamation formation step Hasam 36-mg {46%) (LHH.) 613.3 . 439, ReSferenetapHda:! - (4- (4 »(3-03s # '8 * sbi« SkSop, 3, 1 | oktiS "8s ^ -S- (sulfuric acid-244-psran ~ 4-yl) - 1.3 Dissolution of 5-thien-5β-24S} phenoxy-3'-4 '- (4-bromo-propyloxy-5'-propan-1'-yl' -88-b8888) -phenyl) urea: The 7v teakovase seed was added to the i-4'-ammonofemil. ) (44zoprop8lpipera? -In-ll-lime) ««? «&Amp; carbam <tb> <tb> <tb> <tb> <sep> <tb> <sep> - {4- {4 - (3 - asS'3-'äÄ <cikSop.2J] 0S '^ n' <- 8-fi) '- 6' ((R) -3-MSTI {is6fisi5d6) - 1:, 3, S4H8zm * 3 '; "? S) feail> -34: vaifnid compounds of 441),, Rs ferenda example; 1 '(4- (4' {3; 3'-a'S'-ag8bflc (3J)} cyano-S41-6 - ((iR) r3''myllb8) P1-3a ~ -1614 ^ 1 ^^ 3- : 11) δ 811- [3- (4- (4- [4- (4-fluorophenyl) -1,15,50] Δ 1 -11]) 145111) 148845081514 o Shredded spade; -is> 1) d) 1r3,> Piss: 5; b-2'5l> -3-8) [alpha] 4: 11050S'folm; 3,4-nickel-1 '- (4- 1) ', J..V) razinh61 (1.23 g, 4.61 mmol) and olanum SndChemical carbonate 10.775 g, 9.22 mmol) in ucetone (20 mL) and ice-water (20 mL) (R) -3 x-xylenorpholm 10.466 g, 4.61 mmol) was prepared by flash chromatography over Mb6? -?,? 49? The resulting rust-proofs are O ^ 3 dpln and mixed. then h-sgymk will gradually warm up to room temperature kB in hours, A ä ä S S S S ök Thus, (R) 4- (4-chloro-O- (4-n-1-en-1-one-1,3-triazole-1-yl) -3'-roethylphoflot {1.40: g, 90%) m.p. l% 0 '| (li # a.: satíáfd material. HR.MS 336.98 $? 1M * H, calculated). 3.36,0845 1LHH, measures). P î î ^ ^ ^ ^ t t t a R imm imm imm imm imm imm imm)))))) R R imm imm imm imm imm)))))))) H H H H H H H IA · Bowl production; (R} .., - (4- (210) - 6- (4-) s strottm1Π-1v3, $ sn3zin'2-sl) - 3-methylmorpholobolic (0.94 g, 2, BO mmol) aveton A solution of (10 ml) in ice-water (10 ml) was added to LU dropwise over 10 min. S-oxa-B-azabk · .delta. 2.30 Kmol) and sodium bicarbonate (0.470 g, 5.60 mmol of atethodrine (10 mL) and water (10 mL)). The resulting rosin solution was mixed with 0'C-ou 2 tin). pxsjd gradually left at room temperature for 3 hours; over. The light brown suspension was filtered and washed with water. For example, 8 - (4-chloro-6- (4'-cyanophenyl) - {[alpha]] - 3,5-thiazole (n-2-yl) -3- [alpha] -B'-alpha. 0.964 g, B3%). HRMS 4) 3.193 i (M »tk calculated). 413.1936 (M + 1), found. Step X; d-α-p-psssyb-alpha-cyclone, 1 joktane-8-11), - 6-1 (R) · 3-raethyl; orödim:>) · r, 3J (: riiiæ: Hs-2- iI) -; oh6sï frontloading

ttp-uH) t'mesttmorfo) mo) -6- {4-dimensional í -) 1> 'tr.dzh -) - Λ-5-o ^ ab-az..b »' K: o3 0.95 g, 2.22 mmol) of ethyl acetate (10 mL), methanol (< 30 mL) and methylene chloride (3 female - SM BAAedmmlbsn Solubility of gpmge m / s and lW < * m &lt; / RTI &gt; $ * · ISlÉpnot (0.270 g, 3d40megoe; given at 7¾ 1hour «| :: ^ Ä ^ # ^! Aa |: #aH (at) tlmhottuk. ^ s ^ »! xjSt '-! ßgIft # ^« n kgrgxHil sdlpfk, gs ^ rélepésyj etiJ> we are going to hit the air, so we are going to get a lg ^ lsl ^ tóóásMnaaHln ^ O ^ S ^ i-é #' « ) (M4-H) 3§33- 4v Stepping Fiber} <jS ^ kÉ ^ (4 ^^ i: Èlpii> ëï'SÂm ^ I ^ âi> feïâii> kà ^ sïîfSidl dösklíAssí The Writer and the Forest «3 k &amp; b «a« and / or in rkkcklc, the L-peer-watcher has been pushed into a khk | vagyiOgík: AST, V bow | í, € -'S: iíss: Ó ^ él ko ko ko ko ko ko ko ko ko pere pere pere pere pere pere pere pere pere pere pere pere pere 0,0 0,0 0,0 0,0 0,0 0,0 0,0 e e ife ösadop l '(4 * (4 :-p>' öxa- k * ~i í í Í pp pp pp 2 2 al al al al al al á * ~ ~ k k k - (((((í 3 3 3 3>>> k 6 8- 8- 8- 54 -et.npmem / m- · il) i <mil} carbamK> l (0.0761 gs 95%) derived light yellow solid form.pvlldlPA, 441. Reference float 0- (4- (4 - (^^ 8-8-3 ^ 50 ^^ 1013.2,1101 ^. ^ 4 ^ -9-0) - ^ ((1 ^^ 3-8105 ^^^ 101050) - 1 ^, 5-- your production of 9 arched skeleton presented with akiden domsksk time 4- (4-k'.opmpdpipet & ida-Ill} antlía alkaliRaxing in the cowboy pace step. Bbzaop 12 mg (400µ¾)) (TEXT: oh3% 4v.)

442.ReReReMeReRs »» The 9th Ssakcíddklai · 'tesaiäkm we have been bluffing in the way- 4'4 (4' - «} kfep (^% ij ^ m> Kih“ Í * ü) 8n? Kh in the kmbamid training course. >? am; 92 shirts (39%); (Mdi) 626.3. 443. Reíereackjpéíááí l '- {4 -' (4 - '(3 ^ ö5! a' - ^ 8mhteíklö | 3,2ÁÍÖMkp # <ÍÍ) "A" ((Rk3 ^? A9timprfóHfio) ri, 3, S · "-lpiâ; kp2r | i | l« aPp3 - '(4 - (4 - (4îmmkmkââs ^ pipen (M8'-i - k) ³3Ri) amidamidPamid directlyHiGa: Reaction 0, hemmaUXf: «« ««--((((9 9 9 9 9 9 9 9 9 9 9 9 9 9 9 ax ax ai ax ai ai ben ben ben ben ben ben ben ben , Iklzsin; '77mg (939y); (62ί 628.4. 443. iReSareâïdapidae l: r <4 ^ 4 <3 ^ x'a ^ k% 40kikí | 3 ^ vi | ó ^ 6 ó ó Í Í Í Í Í Í Í Í Í ^ ^ ^) F F 4 4 kk kk 4kk2v | Í) leailp3 - <4 - (4pcsiiip3parads8l-karlmichi) teníí> xrhsmíd preparations 4-'metf! Ptp ^ 2ltt''1kd ^ m <^ ó ó ó c c c c c c c c c c c c c c c c in step t. Yield: 43 mg- (53%) (Μ.-1 · 1) 028.3, 445. Refereaekspéídaí 5 - (4- (4 - (3- <is «- '8-axacyclo << k43,2, l | ecra «'- he-0)' - oh - ((R.F3-iHerlkíiofíoHíio) - 'l> 4,0' ·« Sna2in-24t) fe »i KH4 (44« opropifplper Preparation of d? -Trylonyl)?? dö- (4- &amp; minofeilX44zop: ropflptperazi-l14ii) thiivs in the urea formation step. Bosatn; 72mg (84% fc (Ms-B) 656.4. 44b. Example 1: - (4 ^ 4-- (3 ^ 038-8-8868 [mu] 13.20 octoco-4k0> · - {(liK3 ~ methyl <RTI ID = 0.0> n> ffdim) -L3, </RTI> S ~ ~ tr] azl) -241} f ¢ »iiKHXX4 · "M ¢ l0fn; Hmad8-MliplrRlí" - '. 3 · 4t} tia: rt> sgtiid Effects We set the commercial kspbsté 0- (4-metiipi: pcmd »~ i-> ii) as shown on Reaction Formula. ) pmdia-3 - as in | kaïiP444 $ àvî * la in the carbide formation step. in terms of interest, the interest rate is 4- (4- • ίηρίρ-χ ^ ζϊπ-Ο-ΟΧηavalίavalη used in the carboxanate &amp; n step, Yield; 80 mg (99%); (M * H) 692.4. 448 »Éëlléî'efieîapêyiaî 1 plpm% in44l ) tei {) k &amp; rbai ^ N Hdalíba;

Bnmnisiîn n: mcknis on the i,! Makci6v4.-4a! 0 A-CA-lKppröpilpipm'äXia-i ^ -ii} ani nl: alkbteäÄävkf »karfsamid corrosion! step by step, Yield; 24 mg (88%); (64 -; - H) 616.4. 448, Réferéndapèida: í8 «) f« o} plpertám-1 -i? Resti!) Arm »time <466;

Reaction skeleton 1 was prepared as described by using 44- <(a: nyl4n1) -N.Nv <11mgtnp | psri4m-4-8? S0 mg (96%); Preparation of (MbH) 616.4, 458, Eefepgseläg61iia: ppstase3-fc?

The i. Reakelekäzlaißn, as described in Fig. 18 (4-alpha-inofenHX4-thiol), was added to give the featbamide formation step by step. Yield; 79 mg (95%); (M-rH) 616.3, 111 »Reference Example: plpers (ztO-H ~ fearb» pl§fem ^ ítása

I, • ffeakpijS ^ É ^ a.Ibèmntatôft. The idea of '' »was created (^^ l ^ ikßUX ^ lzop ^^ ijjS ^^ n ^ AS ^^» »in step 1 of maintenance time. Yield · 16 members (20%); (M # l) <> 44.4, 452, Reference Ticket: 4- (3- (4-14.6-hssx ((Rb3-mot3H5? RMlftn) - (3> 5 - triazole ^ 235? (Hsp no llljpnzs mén;

The mode shown in Scheme 1 «?? have you set it up with ^^ ipslilylcovering 4- ^ 00 # ^ - chip slip-on with dimaxazan in the arm? training step. 1 lottery; 43 mg (5%); (MH Ï i) 561.5. 463, Reference Example 1: 1- (4-14,6-bls: ', {(U) -3'nH: phenyl, nb> bno) -1,3,. > -3- (4- (Plrrolline-1-iime) (cml> small * 1> amkl):

Scheme I, Reaction &amp; demonstrators are provided for the use of commercially available 4- {pinolymm - i: lnethyl) aniHn. in the kmlxHmdTraining step. .Yield; 61 mg (7996); (M4-B? 3.3. 454, Reference Example; 4- (5- (4-14-β-o -8- azabfe-1-yl) 3 <2.1 lobe? -8 "II} -6- (1 <4: fab« I-21-t-p-4-O) - [1,3] S-thymine-2-1 l] ttyl) arad>) benz.nm 1 d etalal 1 Stage: A. 7th in the form of a visual display ·. ovidon dl botsukk in the market; available as 4-anilobenzamide for harbxmid formation. step. Hspgtm 23; pig (21%); (M-HH) 530.2. 455, Reference Example: 4 - (. ^ 4- {4-l3-ovu-b-az. Bkitits> j3.2 i] t> ktá - 8-ilXo-ti <4π? L} lffe2H- p} onto «-4-: ll] - ··· | 4 |; $ ($ - trta; ri8 · ^ 2« 4l) f «πí ^> uresdohN» N-dlmet! lb ^^ eíbsllMs; The 7th skeleton skeleton illustrated was produced using commercially available 4-amino-N, N-lmoti in commercial cubic acid in the carbonic acid / .esl step. Yield; 22 fi) g '$ Μ.β · 456, RcfemtchipsSa: 1-14- (4-13 - Part-6 - Sulfuric acid3,2, 1'-llkyl-9-yl; X644t4: r8bl8fr6-3li--) Pyrate-4-I) -> 4Í33A19azm “2- <1) Fe3) -3- (4- (premixture-8-thiol) <RTI ID = 0.0> kjgtrbamlsl </RTI> elaborated as shown by the present invention. (d-ammonofeKilXpMlld1I.XwtabOd in the aifcatylza-Kaa-carbamylation step. Yield: 41 mg. V>%); (M-H) 584.3 (4 ~ S-quinol); !)) S5) etafi <and reset: d-Híímbenzoil-clone and fem6ffete !04m! ^ Live: iittï £ 4t # live a §. preparation of the reaction shown in Scheme 1, "lï3iS" ïmæm -2 ~ ll) | ^ a9} 8 ^ i | 8 | - ^^ - kHmsîHsâî «îkwkâii) was prepared in a reactive manner: today &amp; ss <tml Mezam; Mmg (32%); (Ms-BílíH.3. 4, ino-NB &amp; pimeti l8m.ia) first) fe8R2ii ^^ -nbettosiblchloride and frightened amnesia was produced by the 8, refreshing spearminters on honey * 4§B <Relay «C spatula Ida; 4 ~ iM4 ~ (4 ^ $ * öm - 1 $ ~ ii sa bídk lo | 3.2.1) oct ^ ^ § 4 § 4 4 ets ets}}}}} t5 fa fa fa § § § § § t5 t5 t5 t5 t5 > 8ßΙΙ) ί> 88 ^: ^ Ιί | 1. · ^ ί | ^ ί | Ϊ ||| ^ |; <3hen: Kamsdö | wedge (H5: flat} "wristwatchStalkalaaalialaaa for the training of the kbbt.i." After the training of the Boa-amis káhi | 25 mg (22% g (M 4 H) 587.3 S: bean-2-{4 - [mmoS> e «zami: dö} elb (methyl) xrbamate): 4" lkkn> bfifizotkkiori; a corresponding dove was set up in the 8th jet plane: p. Beferesdepéldkí. 4- {3- {4 ~ {4- (3-part-I ~ aaaöíééelí3.2J | octar-S4Í "^ Ci ^ fs | i! 4i'í> '- 2M-pira'4 * 3% ~! , 3.5B: nrzm "2-tt} fefeS} mmidoVN- (2 ~ i'dimetdmmmBeBIhA ~ mettBm« zarald; the? .. reactor "is inserted: modified is composed of 4" amoPoMs "{2s (diméi: slassis}} til) 4k '<methylbss: a8: dd in slurry in the carbon black step. Yield: 10 sag (9%); (MSH) 415.3. 4 * »ra.lm) -NA2» -N'-metllt> «:« xat8HI production ?; 4 ~ NkmbeKS: íSi “k: archery bdl and â € œthe right thing ItmAtk live á 8. 4SI. ileferethefirstfloor- {4- {4 ”t3“ Osa-8-aaskí € Tisch [3.2.1 | oct-k-ylH5 '- {tetrahydro-2I'l - pyrazol-4-yl} -4, 5 --iria2t8 ^ ii} foHi0 * 3K4 ^ mftrlbHs ^ k8rfeo8îl fesM} kkk &amp; amsd START: A '7. rsskeidvasventingthefilteringthefilteredthefilteredthefilterofthecleaningthefollowingthefollowingthebit; Yield; 25 mg (21%); (1141111) 000.3. ## STR11 ## Preparation of <RTI ID = 0.0> mlR'Fesil </RTI> (m8fol) Meis; 4kNití0bssSBÍ141Red lining for mêglbleiôs andsMiglliettai live 4L RëîærsRpispéMaî 1k4 '<2-3sk8setiiamiH) yl) -3- (4- (4.b'-di (3-oxa-8-axafes')) 3.2. The preparation of α-II-1,3-5-triamam-2-yl) urea;

For example, we have developed a 1-inch bayonet-to-nickel nylon (2 ^ asvisil) for use in the kafbamid formation step. Bogain; x mg (*%); BRMS 57.2,309: 2 (MBl calculated i, 573.300¾ (M-kH, mrt). Dl Skin of the skin N? <2-3mi8 »food) besaní-1,4-leaching« Preparation 4 -l1peaker «bé4 ^ slídi and the up-and-coming binoculars» have been set. 4b2, Rslferéiíénééeí 44 {f4s (4- {4-j (fegtfÍkarttamfeífe?? ^ L L; fettM ^ 4s (4,4, fdfefeiratti®-15fe ^^ Mííí 444,4, $ ^ 4 ^^ ΒΜ: ^) 2 ^ Ι <«^ ί ^ · 2 * 1ß ^ 1Ιΐ« (25:, 0) (,: ti4 mmole) and girl (4 ml ml.57 mmoles of dry dlcoracethan p5Ö ml): 43 [mu] l: 14 <4 mm <4) was added dropwise to <RTI ID = 0.0> -RBCAm </RTI> for 30 min, and then the silica gel was eluted with 38 porcine pellets. The organic layer was dried over anhydrous N 2) and dried to give 3 crude products. Ezatlh is the crude stature in {15-ml} lystiether ether M-motifs and mins ultahtmggaJ pentane (30 ttsf) was digested. The resulting solid was washed with R &amp; Pentar so &amp; η1Μ · <4.4, S, 5 "tetramettl-1,3,2- 0Ιοχ» δ # κ> Ι «1η-2 ~ Η &gt; 88%). FINMR (300 MHz, CDCl3 δ 7.814 µl, 2H) 7.50 (d, 2H) .d (m, 211),?, 2 m, 3H), 7.9? , 1 B), 13ί%! 2U) Step 2: l ~ ouPiF3 - '(4 "C4,4,5, S-4« ira »isäü'l ^^' 'iilôSPiPjiyjtâP ^ -MVféfiOjkarfeiaùïit

Ferro 1-4 - (.4,4,5,5-tctrameil * î, 3,2'donahorolan-2 ^ H> feftlkf # km ^ (26 g "? $» <Ϊ́ type, · 2J M mgtil-- arma · '! HF; 265 yen * §30.mmoí) 150 mi of ïHF-ready mixture was mixed at room temperature »6 mud, map a« oítter ideslsgétiedesAilate to the rescuing; : an organic solvent: anhydrous Na5SO4, half slag, reduced pressure actuation, crude tetapletic silica gel, silica gel, and toluene using S-60% ethyl acetate in petroleum ether to give NneiF3- {4- ^ 1 .3.2 (22 g, 88% yield) was obtained as a white solid:; HNMR (300 MHz, CD € i, p δ?,? <d. 2H>, 7.2 (d. 2¾% ¾ 1H), 5.0 (s, 1H), 2.8 {α, JB. J, 2 (s, 12H). 3. Step 4 - (1 ', 1. "tf} a (b'2. 'yl) ~ * thio morph: etháíhíasa

Moriblm (9.3 µm 08 mam) was added to a cyanuric outlet (20 g, 108 mmol) and stirred at ~ 5X for 1 hour. Ke reake tas bird waits for their lilies, diklörmetáhnsl extsÄlföl :, AServes layers of anhydrous Na: S <. 5% «tllMcsääi alkaintazásával Jien-ierbeti eíuenském obtain 4- (4 / i-álklórN, 3,3nrlsxi t" 2-li?) niöBhiöt (10 g, 39% yield} kápiupks: Step 4: l ~ (4 ~ (4-mer-6-moi-fslsii> '<3 «S-rria35Ii3 ~ i-II) - fei) -3--85« tilkaehaa3y alive (4-, 4-alpha) ; uon-2-ii) iriOvtdo; 1 H) g, kV 'mmol). PpiPPhH * yd.-io ^, 3.1 mmol), F maki - (3 - i4.4.8, S-α-α5: α1- [i.3.2ji: ii-oxo-borane-2 'iiHenyl]] -carbanil {H, 7 g, 42 [mu] 4] and Na Na (CO 2 (168 ml, S6S nnnoil mixture in gas 1.2-cylethyl ethane (400 microns at 6M for hot water 8 at Nj slides). , its waters are diluted, extracted with nonylacetate and washed with water, saline, »water-dried, 804-dried, filtered and reduced pressure acacia Crude product of silicagel (100--200 nxish) with nickel crown; Using 60% EtOAc in pettokkerbeh: dasüiskée, so α- (4 * (4-chlorophen-6-morpholin-1, 1,3, S-tm2-2 * 3)) -R (1 → -3-n) ? etirKarhamid <4 (5.0 g, 34% yield): get * pad.

SH% MR (300 MHz, ÖMSO-d6) δ 9, -Isfbr. 1H> 8.2td 21U?, 6 (d 2H), 6.6 Urn 1H), 4.0 rm, 2; 3, 3, 6Ni, .MMy, 3IO Step 5: Preparation of 1- (4- (4- (4-dimethylphenyl) -R-trifluoro-1H-L3x5-triazm-2-yl) -phenyl) -3-methylxrbentide The title compounds of the title are described in step 4 of refeTeaNapeate 463 by means of a method (4- (4-kiôî-6-msîrfbliïto-i, 3,? ~ Triaa) 0-2'iljfei'.ith3-Tt} ir (> amkl and 4 - ('4,4,5,5-4' iraineyl, 3,3-diaxaborolan -> - d) - anitine, yield 2 g, 45% yield. Preparation of phenyl-4-carbamoylphenylcarbonate 4-Aminebem: m / m, m / m, (m), (i>, el <KH) ml 'knife - it

To its solution at -10'X, flask was lubricated (6.9 g to 44.1 mmol) per udnmk ci-epp, for -UPC-c for 30 minutes, then t'z'inh at the end for 30 minutes. The vials were washed with CFI.-CL and then with water (2 ml). Λ An organic layer of anhydrous Na ^SO * halves | and packed; Â Opté tons per ton of diethylene (15 mfi dissolved and treated with ultahartggai Ki fxoc. Trisjd pumice (30 txl) was added to the buoy. The resulting solid was filtered and # aMi; y> ostnks; (| y fëa0-4-kaybanioH (anilksîl3ajîîàtat 7.2m, 17% yield.) Stage 1 H ^ ^Cd ^ddd ass ass ass ass ass ass ^ ^ ^ ^ -ONON er er er er^^^^^^ mod mod mod mod b b b b b b b)))))) )enzaenza '(3- {1-4S-Amka:> R 1 -methylphenyl-L3tS' diacid-2'-yl) thienyl-3: Hithylcarb; (0.6 g, 1.5 mmol) and ipacanp (4 * 5 nri) stem: for PMP (i0 ml) on the prepared side, it is possible to use 4 * carbohydrates (~ 5 g, 4.3 mmol) at room temperature and 90 '' '. € - o? S Η) msfegirettOk ag fer fer fer... Lut lut lut lut lut lut lut lut lut lut>>> ék ék ék «ki ki ki ki eak eak eak eak eak eak eak eak eak eak szilárd szilárd szilárd szilárd szilárd szilárd szilárd szilárd szilárd szilárd szilárd szilárd szilárd szilárd szilárd szilárd szilárd szilárd : preparations * · MFL & Styles ^ tf> <4 - {# ·· • '|! r »<allkan> aoa> k} aMi: 0o]: | ^ é' -kíM> íffi4- (kk34“ dlksm-2-0} tonlinerbin p5 mg, 5.3% cosarb). 463. Reference Example: lP- | 4-p, Ssskfsgt (is5rkk »4 ~ M> -6-14 ~ | (JS« llksrtarsassíí> a «» «æk8il | -« íp # - irïkk * 2 "î?} - fotît? 3 3'rpsridit5-3 ~ Hksrbas itás ése ése ése ése ése ése ése ése ése ése ése ése ése ése ése 4. 4. 4. 4. 4. 4. 4. 4. 4. 4. 3,5 3,5 3,5 3,5 3,5. ása Λ * n n h ei h h h h h h h h h vegy vegy vegy h h h h h h h h vegy vegy vegy h h ie 1S% yield. 'MNMR (300 Milz, α> ΟΙ,): δ4.ύ ímo &amp;OB;5.6;;; (eg 2H) 2.8 (m, 2Η).; 2 {d6B) , 2, Step; ('(4- (4 * kibr4 «(3 <5'-01îsr8tlkotrrî61sookl, 3, ^ lnazki-' ~ ~ l?)» F3SlL3 'if8 «HkarbsmM is the name of a chemical« Example 462 Ref. 4, in steps By way of a procedure described: 4- {4; 6 * · • <kkU5r - i.3.5-tnazín - 5-0} - 3..3--4i: sK-; ? 3oribi: and bo; no-3-? 4 * (4 k5 <5 '; helix4k-4'l, 3.2 | dio>; aho> lan' -; c. · - ;; } * • fettu j-carbatnkf alcheming distance Yield: 1.15 g,; 6% yield, 3, Step:% Pd4 ' 'C4' S 3íls of8ííiS ^ 6 ~ (3d'-dbítt;??? ÍH''is orroib3 «ll, 3, S-'2 tr.sszb'i ~ II ~> '? Feist ^ 3>' 3t" êk8bkas3iid: production? Ad address soda égy égy ki «i i ® ®::::::::::::::::::::: lep lep lep lep lep lep lep lep lep lep lep lep lep lep lep lep lep lep lep sal sal sal sal sal sal sal Bl: k: ip5 * ;: β3J * aryl * 2-ylifeTH} -3 ′ SnetiCarbamate and d-IdDSSdbstylsbdb.sdloxs- | 3tas> l? 2-4l) anhydryl :: a) kaiza, a !. Bezant 2: g, 06% boa; »)). 4, Step 4: 4th, 4th>> 4! Kat'bamét «DOCUMENT The e: (m; yzepod: compound name: we were blessed with the care described in step 6 of Example 462: eck 3-airirpldiiktis: feni? Lk} d? Ä »Miätdli (» imat4sä ^ i .. Bö «anv? G 62%: yield 5, · step: arc | 4- (443.5 * dösetllmo? Vi5ifi> B ~ d) '' Sv (4''i) {soertÍkaébaaj «iii} as3íkíodtsíotlBL3, Sétpjazmv2's | * • 'tk? sidp-3-buykt» 3-bk: arbssmsd precursors The mind, spybtl compounds have been soaked by the procedure described in Ref. I s -ds si ít t 1 lrít> t t> e d> 3.5 dt isî: i?> - 2 - - H) * fetsi i) v3 * et41 kttr t: n id and: Smki > tridlo: v2> using 'Hkarbanes' Yield 77 mg, 6% yield. 464, ye! ya! 4 ya j4 j f f <| 4Hpuedikárhá ^ L Step 3 * Ρ »0κ1Ι®? ν125 * 3 · 4 ? 46Η84Μ1) ·· &amp; -ο ^? ~ 3 ^ «8ΐΜ According to the Sime! in the 4¾ step of the day, it goes off! MHtotiak. kobe dämm- · •• kbrid. and 8- »sn- ^ • azablcikirt | ':' n2. Î using a joke. Besam; 10 g, 47¾ bexs-and. Step 2; to produce mld The title saermt; orbleict is cured in step 4 of step 462 using a known process using 3 <4, {b] borolane-a-tlHemyl urea. Yield 5 g, 29µ yield. 3 “Step; 144444 ^ 4 ^ 1 »3 3 <41) - |, 3.3 - ^ 10 ^ 80-2.-4) - ^^ 9) -4- • 'mdifka r habt MéíSállitá Sä Λ nun s? ermti to combine; a -4> 2. reerenelapée 4; building # dad: Know your way with yapjap 1- {444χ - {H-ONa-3-azabk p; o [3.2.1 lok-tän ^ -iO-ö-klPr-1Λ? Ητΐ &amp; η-3-ίΙk The use of anhydride of <RTI ID = 0.0> W1-methyl </RTI> asbipolate and 444.4; 5.5-yl)> L; L4dk) is obtained. Hr> smn 2.6 g, 49¾ yield 4, Step 4: {{444-14 [mu] l) »ul: 11Lsrba: lis <> il} aPll» i> ll4? R6A-nsa-3- ' 8fe5b8computer4,2> j k kL341M> 3 # 4rzzm - 24! ása;;;;;; in the 462 referendum rounds? · fcmcrtcted spellbindingbit 1444: 4--4, <'<syl n, 6ib-vi ~ ^ s 4- iK o! "Ijoclime" -d> 1 'dn 1?' ΪΠ-Γϊ. Yield 9Q Pig, 133 «Yield, 465. Befenmempete:;: 3 - (({4- | 4-bL ({nickname} lbbi« bbu »béíbll'b - '(8'-part" 4 ~ íV?)? bie bie ir |,2,2,2ln,2nán,24,2 L L L44>>> 2----------adad444)))) )fffffffffffffffffff Live 111 The clip «xednb bluebell &amp; 462, mfm example 6, was produced by the Ismenei method by 3-simmobenzannd and vnll <RTIgt; ^ «» AOI rfefti ^ »^ io ^ iÂ6lïèuil) '~ ^^ x ^ 4 ^ a *« l> kîfelô0Aî | ôïétii4lHJ »beta-.

Ariad? I'2-4I I lepi | kp p bpa} kill) the? * and p. In step 4 of this article, the following examples are given: 14444- • (4; «nlnxnlnHl) 4 ;-( S ~ ox &amp; -.> - a /.; 4peildo [3.2.noUtan4V! rpL3,5-irl-: bil) - -ienb) v5 "using tneilic Tb3niid and helium - carhamoulol carbamate. Approximately 40 mg, 3% of lime. 466. Reference Example 3: 3. {f | 444 ~ 4 -; (mi4dkl} <RTIgt; HdS) </RTI> <RTIgt; .bv-2 · '4l) x | p6ll | kaébbf «» i! | 3ssipp) b «8 * 8 lilies Wss Chemical for the title; In step 7 of Example 462, relay was carried out using a known procedure for the preparation of 1- {444- (4-a; n-1H) -Il) -6- (1'-norphenol-1,3,3-trl). isbi-.lbil) fcni {) - using bin <: dlk3bb <imide and lithium HvarM Yield 51 mg, 4¾ yield, 467. Reference froth; 1-sne {d-344-p-; norkdbs-4-yl-{4-j (pb '{db8-3-dk; srba »i" d) ambly> | .4e6ll) - L3 , 54nazísí-241> production of ikmíij ka rbtunid The cbn is seried! Dry-Detel. 46 463 reieren example? step; According to the method described, 144- (4- {4-amyloxyl} -phenol-toluene-1,3,3,-yl-isopropyl-4-yl) -3-trifluoromethyl-pyridin-1-yl] pyridine was added. 3 aliquots with alfcaldtaza sauce. Yield 77 mg. 6% îwzah ;, 464, Relereneiapebi; J, 6-trladn-2-y) -fö6d {fesrbam! A, B is a compound of formula 442: refraction step 0, using a force-return path, using an iStype 4 * “animOplAilin and f &amp;amp; Ifos: he g> 534¾¾ Itogátkt - <ifepljfiotrh »tnki production The dm pæÉtiti Vgp $$ ë $ É s 461,« teaspoon #% go-to-the-go - (4 - (4-A4-m «! M> teniipb <morftdmo-i; ^ j ^^ jfj * 2 * | 1)» lyen) 75 mg, 3.9% hossm. 469 «jRefmweiapáklm -trlsmH-2 01 jfeatlj rl á l ® a a a a a a a 9 9 9 9 9 a a a a ld 1 1 1 1 1 1 2. 2. 2. 2. 2. 2. 2. 2. 40 40 40 40. - (4 - (4-as «ineleíHl) -0- (3,5-bi KgtHWí4öÍme) - !, 3,5 - f) óíÍKÍö - 2 '(t) - (EI> U) - 3-OieíOkatt-}; fe ïî t í - «> - k at Issíí« bow: »i î f« n 11-carbamate. Rosm 5b mg, 4.1% yield. 470 «Befôeesieiapligî 4 ~ | (i4 ~ | 4 - '(3« 5'-d »î: ls! Όrb> 0i ^ -4-'8l> -6-- | 4 - i (8» « 4kΓΓÄÄff i i 8 8 ^ 8 8l lí s sΓ Γ «: í> í>>« «« «« «« ««î« «L--3 3 3 3 3 3 }ikaikaΐ ^î omssssfefe ^ The title compound was prepared by the method described in step 7 of Example 402, using 1- (4- (4- and bb-4-carbamoyl) teamam, Rimam 70mg, 12.8% melt. Example 47L; -St33 "1 ^ 4 ^^ 5 * ~ 2 ~ llife8Ii | Production of chapel A. Sal. Finish end work with the method described in step 7 of raster regimen 462," s4-s5s>! Umfei ^ Í |} "(8) "05íá-5-skeleton3.2, í jôktàâr-3-iSAL3« 5- (rÎâeifi "2-ii) -îenijh3: iîkâtlïâS» Out and feA-pndI5v4-iiSrbana'stalkáíSpAa:> ávaL Yield 51: pig, 4% yield, 47t Reteeing (4-4 | 4 ~ (3, S-lymphaticprllH5-4-ll) -6- {4-d (mdi | i | ls-shi) -2-01Îefssîl-3-PLR et al-4--0karMmkl ileil in- ein was prepared according to the method described in step 7 of refractory section 462 1 - (4- (4- • '(4-amylonfonyl) -6-13.S - bimethicol 5) Yield: γ-2-iB'le-Pyl} -3 'with mmyl: arbam <1 and femi-pyridin-1-ylcarbsM, Yield 55 mg, 0.8% yield. 473 «Rderenelstpöld; Preparation of N '14' - (4'-biPKmn'-4-yl-13,5,5-yaxyl '- 1' - 1 '- 1' - 2 '- 2' - 4 'yl' orgoo 1 '; Step 4 «4, - (6 ~ kl6r-l, 3, Sl: rmz!« - 2.4 "dlBd! Merfi

A solution of morpholite (8.7 sg, -00 mmole) in 100 ml of methylene: danmolide (9.22 g, 50.0 dm) and dichloromethane (10.1 g. (raslml6eîe | ypî (stir for iSL-dï f for a few hours and slowly add to sapbebeil, cure for 1 hour in Szbábömeiísekiersa, weave a map mix). bp distillation plane: 4,4e (g..pp 1 J:, 5vtriazip-2,4tdsllplsnbrtbl | nt (14,2 g, | o0 yield) winter of our gates in Skali-coma. HPLC: Rt - 2: 4!> min; MS 286, 288 IM-RJ Step 2: Preparation of 4- (4,6-dmmolimid-1,3,5-irarbyl-2-yl) anilium. , 3.595 µm * 2.4-dn j) (δ, 4 g, 4.00 | | 4 ^ 44, δ 5? -TmmdM; (ip ^ k> xa. Botv4an ~ 2ri! Janiim (2 , 62 g, 1 µmol)) and iquacis' (tricalkisrin) 1041 (282 mg, α, 240 mmoles) aqueous 2M aldehyde xrbones (10 ml 20 µmol) s 40 ml of .RME ^: the prepared county is mixed at 80 o'clock for 2 hours. The reskclonal ^ 'lí ;: 300 write eiftfMSíSttai and the vse is washed ..--. ? -Stkjk (ISCO,? 2G g of SiHkagel column, slums -0-.118)% BtOAeOsexIpl ,, || y 4, - (4 ^).

rf-lUiI, 3> Siag: I I -2 ~ ϊϊϊM-40 40 40% at HFiLC: M® 2.09 mim MS 343 '| Ä $ fjK Step 3: N44 - P43> -dbTK »ib ^» - 4--044k5-4sia: «h ^': 2: 4 ^ fe8ïi || ~ 2.2 ^ ib4HiS} m * ët &amp; ii (production: 2.2d3flmtreeeîSay (20µg, 0.2µmro :: li8Tu pëmg, (p mttrdpie MBA (52 mg, tpötiaaci) |: erl 4> For a mixture of MF - I - {- {4,6-dimoriblm-1,3p> tria2m "24 | imi] m-4S: .beta. After a regimen of 6 µO for 16 hours, after the application of the sgobsb-stouple-punched stone-top and reverse-phase hmmandlefile process, 1 isotropic, fg 4- [4- {4.6-dimorph &amp; iin «4 * TITLE 1,3,3-tri &amp; / m ··:? - it) ferrets} «2,2-di8ue®s * -acetamide! (23mg, 46% on host; kapfonl · - .lPLC: Ht ' 2.16 mm, MS 42 [M -: - B | 424, &amp; efo (4mg | ia N ^ | 4 ^ 4 ^ 4i £ 09iChl: jl «4" H ·!, 3.6-1ria ^ u <.2rl ~ llb <1> H ~ 4p-4 [mu] -from-11: 1-yttle; 6a-2 - amine production ".4,6-4'tîf« 'y and' '. m * 2 «til <n (40 mg, 0.12 mmofk (» »lysizolulm at 16 pounds, 0.13 mmol) and mercury) Idodd (40 mg, 0.13 nsatoi) was mixed with 2 ml of DMI at 40 * -> n for 16 meals, and then the yeasts were mixed with soda ash and slamofen. This is the Hspamt and Reverse Degree Chromaticity Approach, so - 1 H-tmtJa.v62-aml * 4 dUf n »- ?? - fov, -u-; I receive. HPI..C: Rt - 1.74 min; : MS 411 (Méjj, 475, Preparation of Formula 1: Dimethylphenyl p, g-1-lrods Step 1: Preparation of 4 [beta] -Ltinyl Ht: Itto [4] (3 (3-teaspoons of 3 ~ 11 ib) ír ír ímím in step 4? 3:, :: î «ièît« telaf> elPr: 3, was set up by means of a scaling process, eíöá.á'-p ^ “chlor-l, 3.5.tria / in-2,4 '<lin) - Yield: 86 mg, 5% (1% of HPLC; Rl = 2.60 min; MS 353 [MtH], 2, Step-4-t 4 rt). 3tl) α α α (Preparation of 1? 123p-tris? L ?, 6-D, modoln? N '(call? Witn (11 mg. 84131 mmol), stlfoimnzzd (5.5 mg)) , 0.085 snmol) and iTyslfomin hclrfodd (6.0 mg, 0.0-43 mtnoh 2 ml DMFkMMtOt; 6 6 rh ath). were purified, such as 2.4-diniorioHn-'44] "6- [4- (2? 44e8'S / ol" 5 - '! l} fcnin "S.3.5-tnazldt ^ Aonk, Mösms 12mg, 97% hmmlhPlC Rt -2.09 it; k also 394 [M-1 476, Hferencephalic Example (4 - (4,6-Oin Kirhyln-d-ii · 1,3,5-O 1 Oi'-2-y]> 6idl | Mi ». irl> iäiakS Production Step 1; 1-> Methyl-3- (4 ^ (4j4jS, 5 ~ teirame (ll''Ps3P | 41ösaliöteldft4 | sil ^ l6nili - ksrfe8)

244-1®5c ianatol4nl | -4.4.5 (54ettamethyl-1, 3.2 - dlpxah0! '(7S8: m3i, 3 (86mol;; 3p: M: sgt-itm iti / 1) MF pi (4.68 ppm) was mixed with 50 ml of <RTI ID = 0.0> IHF </RTI> to give a mixture of 4 [mu] l of toluene and bp. , 54 µl / ll / PP:, 3dddd / 6iIiSi (2: '- 11l) &quot; i.e., 13 ^ Äm1 &amp;amp; 1, Yield 9033) Rt 2.21 min, 37? [Md-H .j.:;; Step; vim: vsgyilid in step 473 of the Syphilis example; a plated process bridge was produced 4 (4 - (6-duplex, 3,5-dazm-2,4fo) ) d: iinorphol; and 1-6-6-11-3 - (4: 44,4,5-540 ^ 5308111: 1,3,31410 ^ 4130 ^ 1 ^ - 2--01--100111- Yield: 13 mg, 1 l%: <RTIgt; gmgm; </RTI> HBLCk <RTI ID = 0.0> Rt, </RTI> 88 judgments (MMJ, 477, Beforenmapixac 2! ^ (; 4). <tb> <tb> <sep> <tb> <sep> <tb> <tb> <tb> <tb> <tb> <tb> <tb> <t> <tb> <tb> <tb> <t> <tb> <t> <tb> <tb> <t> <t> (: 11 ^^ 51 ^ Imagination 4f4 '~ ({b ^ iéy' (205 'mg. 1,8: mfeícd),' <! K) x; 1: 1, 2, 3, 2, 3, 2, 2, 2, 2, 5, 8, 5, 2, 2 (3 mi, 3 mmoh also with 20 ml DMB stone mixed with 80 * Ο * οη for 2 meals: recharged, then the shelterThe shelter by 58 trd-aeei and the IN NaÖÉ'-vs (Si mk ΜΜηΜζοί '} m &amp; · The unique ones are covered by water &amp;amp; An aqueous solution of ezane in this case was extracted with <RTI ID = 0.0> EtSaEeate </RTI> (58 m% three times). & £ unite serves as layers for Htett's «atrium-carbonate solution» and 6o Idaa bowl is dripping, Istrian for its organic layer vlzirsanfes: ir - Sidaid kd; Sikiputbik and bapaiajiia: So S ^ HP ^ te ,3 ,3 ,3 ,3 ,3 ,3 ,3 ,3 «« «« sa sa sa sa sa sa sa ill ill ill ill ill ill ill ill ill ill ill ill ill ill ill ill ill ill #LC: M "2.84m; MS 3 88 f MtBf. Λ dm series! The compound was prepared according to the procedure described in Example 473, Step 3, using 2- (4 (4,8-dimorbino-Î, 3,5-triazb> 241 Hex-1-yl and 3-ylethynylfit). Yield: HPI..C: Rt = 1.81 mm; MS 462 | M111] -dil) di-methanol ((I &lt; RTI ID = 0.0 &gt; ll.)) &lt; / RTI &gt; ) pirr6 (idmvf, 5-4111 jdimethane (1.8 g, 2.7 mmol), 8- "Oaaasasil> icikk) p.2,: i] oct?!" bidf <sii: lofs (8.51 g, 3 (4 nimol; et al. &Lt; 15 &gt; &lt; 15 &gt; molar &lt; 15 &gt; molar &lt; / RTI &gt; was started with trletinamide (1.35 mL, 10 mmol) and heated briefly with palladium on heating, with Reaction Reaction by automated calibration (Methane) ^ lj ^^ t ^) Oszilmpnj jjgy ëim longing for their peaches as hard peach-colored beans. MS í £ S'j ”· 443.2 (Mk-lif 3 líi Sk <(í:« r r '' ^ st <1 lel i «) í is ll is> ís «s íts íts fe fe>> 2- 2- íts íts íts fe fe fe fe 2- 2- 8 íts íts íts fe fe fe fe fe 8 8 production (pS, 5: E: j'-l ~ (4 ”(8 - axa-3: '- azsbio! k loí.2.2 í) octave - 3-! Í) - # (4- 1) D-Snazm-1-dichloromethane (1,5g, 3,4-dl) is made of diatomaceous earth (bulk); oMatate reciprocated with Th-butit-dlmethyl · -clOrlManal: (j, 3: g,, 8 (5: rám) and Irmd &amp; Zoom (0, (41 e. mmol) treated) The aqueous phase was freeze-dried three times with water. MS ') - 671.4 (MH) 4 - (4- (S-Oaa' 2-azabicyclo [3.2.1] octane-3'-type - ((2S, 5R1 ')'). 2, S - blues (space · «« «^ f f f xt € € tU tU)) r r r ld ld ld l l l i i::::::: 5 5 5 5 5 5 5 a a a a a

Szénbordoxos; palladium (18'Hi, 10mg) and crude 3- <4- (12S.S, SR) -2.5 - biitt? iî reííelí: u- 'l -11 niíroΓδΐΐt? 1,3,5 - (τ 1 lí> :, ùî -;?. Ί 1 í-8- <? Xu ~ 3 - maxiibi: Ik ïi> 15.2ΐ. 1 j «>: (max. 3 , 4: mmol) tôtÂidmfiàïàn »aï: (3ô'n: Q '. K4isa8it siposion was shaken over 8 psi under 30 psi Bsil was filtered through a layer of CeileÍSí feeder and reduced under reduced pressure to give the dm of the dm MS (BS) - 842.4 (Mfbí)! 663, Metereseia example 1 1 - - d d bMiMfIxakj-'azabklk-1013.2.1 jökts3-'| l ^, Mtrlazis - 2 ~ ii} Ι »ϊϊ3 |) - · 3'-ρ1γΜ bi-4 ^ i footboard: living habitat 4- (4Hg-oxa-3-azabtelko [3.2.-yoke-Ai |) -Aa (2St5 head, 5: dStsA: (space ^ bromide: 1-yl] pentyl} -1,1-yl) -1,3,5,4-aza-2-yl) anllm (8.24 g, Oddol) dichloromethane (5 µl) prepared with a solution of lead trieiife animas (588 µl): and tri-sine Grain (dye) in dichloromethane (1 µl) with 5 families of bovine (4 ft. t (Ätteal hands. f iththefrequest ofthefirstwarfsofthefilterthefilts.com and the ftpfe tÃâÂ'à ïftîftk. We treated. !> l; and <î «after the skilly-topping, the *« fly is sMilp, and s ms ^ dd is a large-bodied clique · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · >> % 0.1% of total trtlluoreceise acid to 50% acetonitrile 25 min. Evaporation Faith The title of the title was stolen by irifkm'scatmv salts &amp; km {75 mg}. MS (ßS :) ·· »3333 M &amp; t ^ fthefree 1 {4- | 4- | «2R, 5S> ~ 2 ^ bfe2 (hMro ^« «Öipfe ^ Ä # JJ ^ (^ xaS3k« 3 ^ yci | i: -lak5.2J | ekt-3 --k} k); i, S-IR (AVI '' - 2 ij | FEAD> S "| 4 '' {4'8 ^ 5; tdplpvraKïrî - l 'ai) from" d | ksrbsmid Preparation of 4 - ('4', 8 <) s; v-; bfts; tecikio | 32S] octane'5-11KvB2S, 5Ri - 23'b ^ ((S &amp; -teultím} etsk ssilsk} xl) îïîetH} -Ji!) - 1! 2 5-thtnn-2-O-lactyl (0.25 g, 039 (nmol) dtklbtTnetane (5 #t | made Olásfet successively tneuV-smuPui Λ00 id) es urdW'u ' n> 50 mg. Λ 08 mm) dA'-soybean oil, m | & ük,,,,, egyet egyet egyet egyet egyet egyet egyet egyet egyet egyet egyet egyet egyet egyet egyet egyet egyet egyet egyet egyet egyet ten ten ten ten et et et et et et teat teat et et et et Quaternite U evaporated to dryness The crude residue was treated with the applied iptette hydrogen hydrogen ddddd solution.5% &amp; cetomtril / 55% 0.1% aqueous trttlnotscstsic acid: 50% acetophenitrile under IS. BACKGROUND OF THE INVENTION The present invention is intended to be used as a somatomic salt (130 mg), Mb (ESA-03, 4 (MABy 823). Retemporary I · j444ted J3: json4Mi-U3? Te «^) (donetlIptpersxIn ^ l '-ttfenltlkasbansMs preceded by

Cyanide (0303 g. Itnmol) .div./div./div. Msasyll solution: 3.7-4losa ^ - ttaabktk-ibp.3. »ilGEkHM 0), 710 g, 43 mmol)» to follow this »: EtsH (# # 8 buy | 7 smtte) adomk hoard. Λ received a rejuvenating mixture over 24 veins, followed by CI-kCl.rvMbfgtetln. The s? $ M * «8? ** HM • •? Solution (3a) was washed and MgSO. Aa: vkköSÄM · "Ifevolitette" so 9 ^ 9- (0 · - &amp; 1όί-1,3,5 -) rhia «5-2,4-dii!" (3.7 "dIpka-0 -aabíeÍkiö (3: .3, l): We've got a Drifting solid (0.1 Si & 933¾ yield).

9.9 '- (α-d · · 1,3 1,3,5-trtazteS-1-dhObb S SJ-dtexa-Saetek) was added to a 10 ml beaker * Jop-S-chromate, mg, 0, 4,6mmol} 4-Sntyltiltersn-pinacol ester5 (133 mgi: (), $ 1 mmOJ), PdtMte} ^ (10mg), toluene (1mIX EfOH-4 (1ml) and 2M aqueous Τι »? The solution is exothermally heated with EtOAc and the axes are homogenized with MgSO4. The solvent is evaporated under reduced pressure (MgSO4). eitdtelltek: and mamddköt IIEÍ..CS Principle: Soul Fees :: Illyi 4 <4, -S-Elu---'^ ^ élt élt élt v ,1 ,1 ,1 ,1 ,1 ,1 ,1 ,1 9 , 5-ίΓΐηχ1η- · 2-Ι ^ was obtained as a white solid (120 mg), 44e, b-bt (3, 3-dl) si-9-axacyl {3.3J-thiazole-9-H) - 1, 3, 5-iranyl-2-yl) quinone (120 µl, 2 µmol): GlixOE with melting point of Efbte (0.237 µl, 1.09 mmol) and triphosgene (42 mg, 0.14). mmol ) adfesk, The reaction mixture was stirred to a mixture of x-ray &amp;amp; h.times.Fetep and 4- (4'-5'-ylpiperazm-1-yl) anilide (107 mg, 0.56 · mmole). You're going to have a raccoon mix on a saobatemite overnight. The solvent is priced <i1ik> and the amount of solvent in the IIFEG: the choice of the choice of the sucker so that the etm s «« mtl! «(!? S sb) was given MS (ESI) mfe 044,3300. (TeS) b b b te te te ft ft ft ft .2 .2 A A A é é é 8 .2 .2 .2 .2 .2 A A A A A 8 8 8 8 8 .2 épés épés épés épés épés épés épés épés épés épés épés épés épés épés:::: épés $ 855 «$ Í2Ö041 &amp; § é ^, and | : f: address-dlester hash '| 2 ^ il |:% t ^ «&amp; W *« í * 2, S * bls ^ liii ^^ StHjK2j ^ Md [»« «Illi" -pyrrel-1 "kurtKrsiMiíé ( ethanol (2R (5SiOr)) <RTI ID = 0.0> dv2,: </RTI> Rimethyl'H0H2O2.2.5 (2H, 5RHrfxoxy) <RTI ID = 0.0> (b, bg, 23ylmol) </RTI> <RTI ID = 0.0> ffMi </RTI> i. solution (2M THF, 34.7 mL, 69.4 mL) was added dropwise over 3 wells and then cooled back to <RTI ID = 0.0> O. </RTI> The reflux temperature was &lt; RTI ID = 0.0 &gt; &lt; / RTI &gt; 30 ml), and stirred for 10 min before being diluted with EtOAc. The organic spores were dried and the void phase was extracted with KtOAc. Single} «organic water with water and söi5.ids0jjí jnostnk andisaMmRufe (MgSO *). The organic product was evaporated in vacuo to give the crude product as a crude product by chromatography on silica gel using btOAc: Hex Met 4 (50: 50: io>) to give acisdiou (3.8 g, 72 «, 3, Step; <^ S <H ^ # ~ 295 ~ p'ei diluting $ z ((it'pó2 | ^ {Lidl e $ IMtlle $ §iRet1 ^ 2-dNl6Y4 ^ N1 ^ prrftMH · '-xximidylation of Λ us / ^ hoi <,> yi o o mmol) i) Mi ·; 15 ml) of okiaiaboze FBSt? * (5, 16g, 34.3 mmol = and imidazine? G, 46,? Ninol) was added? blend} SO-'C at 30 pounds microbes would appear in salt ((50 Watt) we made warm, cool to normal temperature and then mix (50 ά $) · &amp; layers were separated and the aqueous isl · EtuAc-la! eNdáháimk. The combined 32ser «# § · • was washed and dried (MgSO4, organ A was removed in solvent vacuum to give the crude product, which was chromium chromatographed on a slick gel EtOAcHex (10:90) slksl and so on the title hay: ·« gates (7,12 g, 98V> 4, Step: (2R'3Sk5R> come ~ feut3l-2,5-Piás ^ i'i>} ztlídtmethylzZ} Ilyloxy) a5etiI) ~ 3'hydro} psrroí! Synthesis of [alpha] -chrolexylsilane-Siiol (2R0S0Aercdului-2,5-bis ((1-thiopyridimidylsilyl) methn) "3'-dihydro-1-p-enylcarbosylate (4.8g, IRSmol) THFd &amp; 1 (SÖ-ml) .dissolved BBS PMSi solution (2M THF-bsm, 6.97 ml, 3.9mmol) was added at 0 ° C, A? and then refrigerate to 0 ° C, add NaïM solution (SM, 1: 2.6> L 63.2 mmoi), then e &amp; JæivçïôçtiJilOï »* (3.0%, 6.33 mk 62, We got it for the hour.) We mixed it with noel * «QOAo-ttd bigitott, A the organic layer was separated ::: # «% aqueous phase EtÖAe-ara. The combined organic phases were washed with water with brine and dried with iMgSO ·.). Throughout the oSddsáPR they were removed in vacuum, their raw products were obtained, which was spun into the nutspot with the use of pure soda ash by EiOAc: tk>: (30:70), ify got the ink (3.8 g, 7%), 5 , Step: trastis ^ alpha bot protection «í, 2R'.3SL3R'h} erC'butyl" 3.r4> isz <inetilV3-b «truN} p> rrobd» n «: l to a side of THF (50 mL) prepared with THF (50 mL) to give Nail-J (60%, 0.423 g, 0.66 mmol). , 8 g g, 6.3 mmol) and fBAR (0.105 g, OJ mmoi);

: (20 Μί) ί ^ Vákptimfea}) bepavoi and in m &amp;amp; water and ItOAe bap, the organic layer was annealed with yiySpyppf and mm. You can find out what you need to do, and so on, so that nym.t / m &amp;% · laîÎîtMki which 'gys' «te« 8i < ? gÄäÄ llsPMags:: 8 * gé% d: BOAbHex: (J; yiM> sltebmasebands so | 2R3k5iil * teéfeutll ~ Mbitte ^: OgA) kK | 5k.SSs: SKfefölg.íl: <> slider5t. lint; prw yd iíi) mt: m 2 'R 2 t 5R * ^ rc ^ fe «Kom3r (^ R ^ Mi ^ 2, SÄk ((tef» -W8d'im ^ ft.))% w / w ; oxi} ät {3.Ö g, 5J tnisoi) .SÄkle | i | S6. to sPkészSli's page Isssxrt TSAF page (1M mi> 2: J msto!} · adkmk í§ö € kí, the mix of your recipients? 1 d â mi mi î bas 5 5 ps ps olt ii ii ii ii ii ii b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b b bk 8 <k> kMal: »KS and FOrFlAlFlAlcAs The organic solvent removal vacuum extractor is a crude product as described by flash chromatography: purification on silica gel using EtOAc: MeOl. uk;, β S g, 42.53 »). % Step; pík ére térea ~ bdtkkd-pa &amp; rzflfekjocananalkcddd: synthesis with gp-lock t2S ', 2 S', 5R '} - tered> suiL: ¥ (; beissifoxi) b!' iz (] pd? ®SíP) eid | piíi ' iikisi'-1-carboxylate (I, 1, 5g, 3.4-xmm), 'FBF'kikpOitn!' : pB%,:, 4 í> g, IteSriatml): We've given you, Do you want your tea? laneMussi · 'leien; 30 pereig kavetiOk and ö:> C to HSOY. The quaternary was slowly added to THF (THF (solution of mpf), m.p. 3.4 mcol) with stirring, and the mixture was stirred for 12 hours and saturated MLO1; Vacuum evaporated and the residue with water and BiOAe. packed up. The organic layer was separated and the aqueous layer was extracted with iiOAc. Combined organic tlzls with water and sooldatislorostisk and dried leaves; MgiéAy The Organic Solvent? vacuum cleaners,% va crude products:: k «pMi..8iae. ^ .; i ^ ^ fi ms ^ ^ uk uk uk uk uk uk uk uk uk uk uk uk uk t t t t ok ok ok ok ok ok ok ok ok ok ok ok ok ok ) as a solid solid material

Take Table L in front of the slurry procedures. uU

SHMÄSAS

HUTNAMMER-FUELS [see TojæilÂrxs and passesSmi Blochern; B: hphp> lies. 24; 332 (ß): 304-Π: Ο: (2005 jEtnus)] ..watches fisatfi # action_image:: 96HytM 'temmfc «« |> 1LFIä m st st c « WgftjÄ (thM BEBES (pFEAA), 58 mil NaO, 50 nM p-glycolAliasia, 10 mM MtCI ?, <ρ?:; Ι »Μ .ΜΙ *: QßS mM tmlreeisOn &amp; Ε: and 180 mg / ml m | W »$ &amp; For all sexes: 32 μΐ (dilute the diluted enzyme for a short period of time 0.5 µl tea: i: haMoTo!): '2,5 uh ΛΊ Pt and Hué-SóK: Mrtúmzá stacking: test buffer for transmitters,' g -w: X / tMMiÊtëtÊ gtt> M plain 809 hg / mlELAEk CAPACITY, 100 mM .AiFE-l and LOS mM , HisO-SSK iarfelnuiz.The reaction plate is shaken with 2 rows (linear; 1-0 o'clock) of tissue fluid under gentle shaking, the reaction lead is slurried with 25 µl of Slop puff? -7d) 20mM EDTA 28mM BOTA; alkaSma? ^ WÄ À phosphorus iett (Ihr-389) Hls6 * S6K. OBERA mm tray is made on a stack of nozzle nozzles (T ^ 1 »p ~ 0Solar unticv, (1Λ5, (dl Stsnaitug) made by EumftemuNEITC (Eu) marked UO ^ Eu: |> cr stitkesí, FerkínEimer). The OBLIIA assay buffer and m. "PureinemehiF solution available from PerkinElmér The stopping kinase reacts up to 43 μ1-έ $ four MsxíSörp Semem (Nunc), which is 55 µl PBSAtaBdmaz, Λ I iís6-fe> K-2. they are washed and washed once with PBE. OUR FOUNDATION 180 PL OBCWiA YYESGHAM PULLED 40 NG / M-1 Ed ”Pi T380) -S6I8 ANTIBIELY The antibody bonding IA lyöRakaí is then lesgfdtik and 4maer messuk FBSs], which is OpSli TweenklBat (BBS?) For all Ipk 180: μ [DËLF1A Inlanenone Greenland and Jeraesek is a FoichinElmer Afleur teaser fleece blade, the resulting data is used to calculate IdfeHÓges mimicators for the enelstatic scaling tree and crystalline water in 20 mM HBPBA pH 7% 2 mM MgOI. 0.05% CHAPS; and 0.01% [added ifrissen]. The stop / deletion buffer is 100 mM HE F SS, pH ····, 3, 4 mM ED'f.A, 0.055µ CHAPS; ATF in 20 mM water; PIP2 (diCS, Echelon, Sait Lake City Utah Kai 4 P-4588) in 1 mM water (MW »856; 5. The ÖST-GRF was 1.75 mgfml or 1.4 mg. Ml) 1032 giicetln, The Red Detector (TAMRA) was 2.5 μΜ lioncenh &amp; olOfe, For PI3K testing. Black polypropylene fluorescent plates with Nunc 384-wells were tested by placing 5 µl of diluted enzyme per well. chemical (or 9.5 μΐ enzyme and then 0.5 µl yegyiSs; DMSO) was added and mixed, then it was added (supernatant was added to initiate the reaction. Samples were incubated for 30-60 minutes, then added). the reaction is solubilized by 20 µl, iop / detector mixture is diluted with λ PY3 &amp; 4 'tact buffer, for example 5 µl or A3 pl PE'Rt 630 µ! diluted active substance (eg 4 μΗΟΟ. The final DMSO ratio is 1% in the reactor). One alternative diluent can dilute the enzyme to 1215 μß. In this case, 9.8 jErf sdtstArlynkankem and 0.2 μΐ compound were added to DMSO-bah, for the production of I rnl substrate solution 955 µl of resin powder, 40 μ] ΡΪΡ24 and 2.3 μΐ of ATF-I. ; µ μ! ^ bs2fÄot: give: Any &%:% Mkte »i * eafeeM:.: eitndfiMhö ^. The StopState Bond Mix Case is prepared as 4 μß red dexter (Heti c c é--S 8 8 8-5 5 5 S F F ^ B ^ ^ ml ml ml ml ml ml ml ml ml ml ml 18 18 18 18 -GEP-ΐ. Λ Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι Ι mm mm mm mm mm mm mm mm mm mm mm mm mm mm mm : tm! 0ù: nsilla ari ^ Oiöfe siopididter blend adiSSe; à                                                                                                \ t Ok ok ok ok ok leh é é voit 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25 25. discs are read on devices equipped with filters in TA MR A-box. The unit is nfNi (i) evc, where $ j | | | î li li rol rol rol rol rol rol rol rol rol 3 3 3 3 3 3 ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ ÿ. The tëjpse »active prestigeresults: yours: p-IOÖïïïP-îxî esokketdel down 30 pen; ax rnP archbishops were increased to 1 in the direction of control, ie 120 to 50 n * P units. K it it it it it it oft oft oft oft oft oft oft oft oft oft---oft oft oft oft oft oft oft oft oft oft oft oft oft oft oft oft oft oft oft oft oft oft oft--- i Ntap tumor sepvona. Sheds were divided into% -yyakti ten-well plates at about 3 0 @ @ cell per well. One day after dispensing different concentrations of P13K bldblbt: given to EJMSÖ: end of cells with OM80 end of cell proliferation by 0.25µr blaTOtpiaRp ^^^ MiOn material et n y y es ^ ^ TR TR ax ^ nk, which is a well-established indicator; for in vitro cell sedimentation of cells: From the use of sets purchased from Fromega Corporation t Madison, WO2: ptotM «iÂl.pwt € Éofl, # 0 m-m-mm m« gk ^ lÄiMiTO. vi ^: *. &amp; &amp; &amp; &amp; baissât on cell proliferation: a treatment with some control scores ««: vtemyitvs determines the core, Ass is the drug concentration that &amp; was inhibited by 59%, KWA (μΜ) was determined. The brown SMG (hSMG-1) was screened for transient transfection of BHK.293 cells and a GST-p53 {(A? 0) from the p53? hS.MG-1 Protein nickel assay was performed in a 06-well formation as follows: Enzymes were pre-seeded in kinase assay (19 µl HOPES, ptb-7.4, 50 mM NaCl 0.2 tnMtfTT, mp-glt). "Etiquette: 9.5 μΜ mfeüíaztln IáÉ :, 1» M MnCI5) Mgltotmk For each iy «k |; a <RTI ID = 0.0> p. In the kinase kinase MM pathway kinase cytoplasmic suppository was started: which, ATP-f and γ vf pM t. et, 0.5 Mg GST-p53, 10 μΜ ATP, The reaction was performed at room temperature 1.0 Then, 25 µl stop solution solution was tested, then the MaxtSorp Surface beaker was effected on a Fluoreldunc plate (Núnc dd30954 was placed on a plate; sAjbabShould be leaning for 2 hours at: ú ^ ^ ^ f f f f f f f f f f f - ^ zubs ^ flil Teftétjje. - the history of # 'playfulness; before the night, the discs are suctioned «S: PASysékmösl; IbstbéaThe stoichi veer is made of sktcock, 1 hour; over - :; | # í * ^: # tf6 |! itet} «) initialized ants-mouse snusdhigos anrhesiate iPcikudibner AD202?) and the primary litter (SiSy-p53 nxmaxonuclease antibody Signal« §) 100 pl; DELFIA Test Buffer Bladder Eggs 1224-111 s Inkbat, The plates are then moat, and then for one hour; We have switched to 109 | (1: Ϊ3Ε1, Ρ1Α signal; humming C} ^ 8 »c« me «r ;: oid_control_cracket f 1244-105), The DEUdA test results are given by Vican Plate Reader (PerkinEitner) , I get the data 3¾ ersksMtikas..activities also poteacsáis inMbfetrak á'ltaU canyon smallKkakásans abdomen:;: - sentenced. In Tables 2, have the results of:?: Review of PI3K-, PBK-y, and mTOR-test.

At Table 3 is a mM: hSMOA kina ?: vtsagali ersdméfiyëlî mtítaiía.

Table 4 shows the results of MDA-MB'3ftl * P € 3 - our «2 § LMCap all-gels». 4, what branch

Claims (4)

I. (1} imagine 'take * where IV means RJ | çj * rik'se ado «case« nouns Slmsl-NH-COE *; R 'jaie'? <De NHR '; SkiingOse V -Q Your group ISSUtLmlk '«« (scribbled where Y jeie «f: (k; e {.' <* 4 vS" Q dirt '· ·' # subtitleWtLMo member «O ^ bg'N ^ ifeMiKifeöteS · · · 40 ag (· ((ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids ids,,,,,, ^ n ^ öp ^ Mj ^^ ipMFshldK ^ if ^ plsm. isan, itsn, pipmÄ, oxaz.m. S, oh- <bbidro-41 b 1, 3-c? c &amp; dn'2- 1, 2, 5-dicyclo [2,2,3] jophtane, 2, Sd îasb, k -M? 24 | kí: ye 3,6-dkizabk.'skio | 3. 1. ihe heptane, InSKhazabid kí.S.IJokáru 3: phthalic anhydride, β-cyclohexyl-β-imidazo [α] -2,2,2 | oxane, α-oxa-α-bicyclo [Delta] -heptate-1, 2-oxa-S-azabicyclo [2.2.21] (? 3 # ~ 0Oxa - S &amp; x8 Biol? J:, 1 µl of max. 1-b-azabicyclolls 1. illNgtdsp 3 »osavg-azabicyclo [2] oclalo-K-5. o / absdkkd:.! JfoUan, 0.8 dtoxs4 ~ aaab (C5kíoP 1 ïjok-country # Häxs ^ * Äb.k ktoPid1] bbpMbj k 'xa-'3'-a3 «bicycle [Y2ij0kMn4 - ik 2-mgbÍ-2, $ * diassbkíik-fd.í.ljhcptán-> 41, ß3 * hidmxi« S-> 82 »*. Wcfkío (3.2. I] octane ~ 8-ü ·,? · Mel 110-0 3-75> - <{5a? AbtdkI0psf; IlomáP S th. 9 - part - 3-a «Sh - nkiol3.3, I] no« 3il, 5 -oxa-9- &amp; «} fei <'? KlP.34] nop ^ f if ,. M x M IM IM IM IM Ή Ή M M Ή M Ή! 4 M'i'Osa / n? i, x '' '' '' sa sa jfôkïnîcsc or salicylic acid. 2 A; ·: í. claim series? "where Q.joi # jti | s8 34¾ iagfoCrCö hetmooikliiosopork which is a 3 horse wide Cj-C ?, beta-pentagonal glmdidium and glipipac coat vaccine or drug%: ce; »Il jkarbátn kl or healing agent soy; soja; .. 4, I φ. {µ <îiïím <RTI ID = 0.0> α1-dIlbis-y-ylfluoride-3-yl] -4,4-dimethoxy-1, 3, 3-trifluorobenzamide. 5. Oj ^ e «.:» Wipwi | m. M:, ii0 »fp ^ Ätoe ^ k« vsmtei yqytitottmM-Kftfr sagiSiRiGiA sdjpdbd «: hsgysgerbsSitem sltbpdbaii &amp; .% burning 'Ms # lake * ·: PWÍ ^ g>' Mf. ip ^ Afe Mn »« iy &amp; * I am a man or a medicine - mxëmëm .eifögadhaíé $ oh $ M is the second mix of a kfivetthatfiHiHiHiMiMiMiMi: iopotssmsífe lééité iéifité: MEK i: / 2 inElbitog kapsdiabm * throttle, fcaxöi, taxoier, .meikaptopurig boau iiidnndkarbtnmii oiambiai, etchotrophamy losfamycinmodels. campstones, bleotmcin, ifoxoroChick kianíbfem, Änbroibcln, dakíSsotmcin · ,; phkamíeln .. -mkexeak ^ L-astparagindz, döxtmibieáp «pirabüm, SbAsontsaeik döveíaxnk ptkiílaxnE tnukovorirn levantisel, inontnka» ,. ospxaBnsKtso. etoposic: Fifth »* mas% ok, BOW:>. cadaver, ionsosab ». vinyllasPitp vinctin vinot'elbi, e xxpMo, carboglycine, α> xab |> iabx> xadBib media in hexamethane, t-hm α:%% topotecin, judrozin-hoáis mbibkoídk, bribsxtinok, teieme A. ^ y »á, «Ik ik ik ik ww ww ww ww x x x mat mat mat mat mat mat et et et ható ható ható ható ható ható ható« ö ö ö ö ható ható ható The composition according to claim 6, wherein the second embodiment of the invention is selected from the group consisting of: a. lsg eifegabhaS: b: si &.FîaK; -v &amp;!: kapsölafos svndèilenessêg or mlkslThe encapsulated madslletsity, t &amp; fenftslktoaxtes, alfctf : abnormalities, arthritis, dysthythmic vetmopstim psoriasis, juvenile dysthytic prostate ftipertfl &amp; ß, aivraskfeíb i ijj. , attgiopnezis, IfnmanGfógiat tendencies, pancreatic gland, kidney disease cancer, $. The chemical or cadmium sputtering salt is the Igxayat sxaklski aliirr bl bl bl bl33333333333333333 K K ml ml ml ml ml ml ml ml vagy vagy vagy vagy vagy vagy vagy vagy vagy vagy vagy vagy®®®® «« «d d dlOROR, 10. A compound or pharmacologically active compound of claim 9 wherein said teak is selected from the group consisting of: skin cancer, bladder cancer, breast cancer, petitbillet, prostate cancer, lung cancer. ** se§ $ jf '· kaPStWm ^ ..: # t «iANIBlOnS; lonkdinia5 actit rossxiätddiatikmdlsitönta and crochet or crushed mms, ΪΨ. It is a combination of an X * 4i orthodontic or a cure for salting and a second active ingredient for use in the treatment of anomalies.