HUE033310T2 - Anti-shock agents containing a diamin trifluoromethylpyridine derivative - Google Patents

Anti-shock agents containing a diamin trifluoromethylpyridine derivative Download PDF

Info

Publication number: HUE033310T2
Authority: HU; Hungary
Prior art keywords: shock; pyridyl; agent; agents; salt
Prior art date: 2009-05-28

Application number

HUE10780439A

Other languages

English (en)

Hungarian (hu)

Inventor

Shuichi Yotsuya

Hiroshi Shikama

Original Assignee

Ishihara Sangyo Kaisha

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-05-28

Filing date

2010-05-17

Publication date

2017-11-28

2010-05-17 Application filed by Ishihara Sangyo Kaisha filed Critical Ishihara Sangyo Kaisha

2017-11-28 Publication of HUE033310T2 publication Critical patent/HUE033310T2/en

Links

UVPXDGMMAFWHMJ-UHFFFAOYSA-N 2-(trifluoromethyl)pyridine-3,4-diamine Chemical class NC1=CC=NC(C(F)(F)F)=C1N UVPXDGMMAFWHMJ-UHFFFAOYSA-N 0.000 title description 17
230000000703 anti-shock Effects 0.000 title description 7
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-1 N-ethyl-amino-5-trifluoroethyl-3-pyridyl Chemical group 0.000 claims description 5
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229920001223 polyethylene glycol Polymers 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000008213 purified water Substances 0.000 description 1
150000003222 pyridines Chemical class 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
201000003068 rheumatic fever Diseases 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
NASFKTWZWDYFER-UHFFFAOYSA-N sodium;hydrate Chemical compound O.[Na] NASFKTWZWDYFER-UHFFFAOYSA-N 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
230000009897 systematic effect Effects 0.000 description 1
239000008399 tap water Substances 0.000 description 1
235000020679 tap water Nutrition 0.000 description 1
201000004415 tendinitis Diseases 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
210000003606 umbilical vein Anatomy 0.000 description 1
ODVKSTFPQDVPJZ-UHFFFAOYSA-N urinastatin Chemical compound C1C=CCCC11COC(C=2OC=CC=2)OC1 ODVKSTFPQDVPJZ-UHFFFAOYSA-N 0.000 description 1
108010088854 urinastatin Proteins 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
239000008215 water for injection Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)

HUE10780439A 2009-05-28 2010-05-17 Anti-shock agents containing a diamin trifluoromethylpyridine derivative HUE033310T2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2009129578		2009-05-28

Publications (1)

Publication Number	Publication Date
HUE033310T2 true HUE033310T2 (en)	2017-11-28

Family

ID=43222595

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HUE10780439A HUE033310T2 (en)	2009-05-28	2010-05-17	Anti-shock agents containing a diamin trifluoromethylpyridine derivative

Country Status (9)

Country	Link
US (1)	US8604212B2 (pl)
EP (1)	EP2436672B1 (pl)
JP (1)	JP5584518B2 (pl)
CA (1)	CA2761597C (pl)
ES (1)	ES2629428T3 (pl)
HU (1)	HUE033310T2 (pl)
PL (1)	PL2436672T3 (pl)
PT (1)	PT2436672T (pl)
WO (1)	WO2010137484A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX2020004250A (es) *	2017-11-02	2020-10-22	Ishihara Sangyo Kaisha	Composicion farmaceutica de liberacion sostenida.
EP3760200A4 (en) *	2018-03-01	2021-12-15	Ishihara Sangyo Kaisha, Ltd.	PHARMACEUTICAL COMPOSITION WITH EXCELLENT STORAGE STABILITY
US12473259B2 (en)	2019-05-15	2025-11-18	Ishihara Sangyo Kaisha, Ltd.	Anhydrous crystal of monosodium n-(2-ethylsulfonylamino-5-trifluoromethyl-3-pyridyl)cyclohexane carboxamide
AU2021354445A1 (en) *	2020-09-29	2023-05-18	Ishihara Sangyo Kaisha, Ltd.	Liquid pharmaceutical composition demonstrating excellent preservation efficacy

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH05170742A (ja) *	1991-05-24	1993-07-09	Ishihara Sangyo Kaisha Ltd	ジアミノトリフルオロメチルピリジン誘導体、それらの製造方法及びそれらを含有するホスホリパーゼ▲ａ２▼阻害剤
US5260320A (en)	1990-07-10	1993-11-09	Ishihara Sangyo Kaisha Ltd.	Diaminotrifluoromethylpyridine compounds and phospholipase A2 inhibitor containing them
ZA915023B (en)	1990-07-10	1992-05-27	Ishihara Sangyo Kaisha	Diaminotrifluoromethylpyridine derivatives,process for their production and phospholipase a2 inhibitor containing them
EP0465913B1 (en)	1990-07-10	1997-09-10	Ishihara Sangyo Kaisha, Ltd.	Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them
JPH06135934A (ja) *	1991-12-27	1994-05-17	Ishihara Sangyo Kaisha Ltd	ピリジン誘導体又はその塩を含有するホスホリパーゼ▲ａ２▼阻害剤、抗炎症剤又は抗膵炎剤
MX9800704A (es) *	1995-07-24	1998-04-30	Fujisawa Pharmaceutical Co	Esteres y amidas como inhibidores de fosfolipasa a2.
TW415843B (en)	1997-02-28	2000-12-21	Ishihara Sangyo Kaisha	Anti-cancer pharmaceutical compositions comprising a diaminotrifluoromethylpyridine derivatives or the pharmaceutically acceptable salts thereof
US6653333B2 (en)	2000-01-31	2003-11-25	Ishihara Sangyo Kaisha, Ltd.	Remedies or preventives for digestive diseases containing diaminotrifluoromethylpyridine derivatives
JP4848092B2 (ja)	2000-02-01	2011-12-28	石原産業株式会社	ジアミノトリフルオロメチルピリジン誘導体を含有する肺不全の治療剤又は予防剤
EP1252891B1 (en)	2000-02-01	2005-10-05	Ishihara Sangyo Kaisha, Ltd.	Use of DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVES FOR the prevention and treatment of LIVER DISEASES
EP1303262A2 (en) *	2000-07-14	2003-04-23	Eli Lilly And Company	Use of a spla2 inhibitor for the treatment of sepsis
US20040110825A1 (en)	2001-06-29	2004-06-10	Andrew Loh	Method for treating sepsis
CN101351707B (zh)	2005-12-28	2014-03-26	积水医疗株式会社	凝集测量用试剂以及凝集测量方法
JP2009129578A (ja)	2007-11-20	2009-06-11	K-One Create Corp	棚板用の照明構造

2010
- 2010-05-13 JP JP2010110765A patent/JP5584518B2/ja active Active
- 2010-05-17 CA CA2761597A patent/CA2761597C/en active Active
- 2010-05-17 PT PT107804395T patent/PT2436672T/pt unknown
- 2010-05-17 PL PL10780439T patent/PL2436672T3/pl unknown
- 2010-05-17 US US13/320,570 patent/US8604212B2/en active Active
- 2010-05-17 WO PCT/JP2010/058310 patent/WO2010137484A1/ja not_active Ceased
- 2010-05-17 HU HUE10780439A patent/HUE033310T2/en unknown
- 2010-05-17 EP EP10780439.5A patent/EP2436672B1/en active Active
- 2010-05-17 ES ES10780439.5T patent/ES2629428T3/es active Active

Also Published As

Publication number	Publication date
EP2436672B1 (en)	2017-04-12
PL2436672T3 (pl)	2017-09-29
US8604212B2 (en)	2013-12-10
JP2011006384A (ja)	2011-01-13
PT2436672T (pt)	2017-05-30
EP2436672A1 (en)	2012-04-04
WO2010137484A1 (ja)	2010-12-02
EP2436672A4 (en)	2012-11-28
CA2761597C (en)	2016-12-20
ES2629428T3 (es)	2017-08-09
CA2761597A1 (en)	2010-12-02
US20120059039A1 (en)	2012-03-08
JP5584518B2 (ja)	2014-09-03

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