HUE035331T2 - Mikrorészecskék és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Mikrorészecskék és az ezeket tartalmazó gyógyszerkészítmények Download PDFInfo
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- HUE035331T2 HUE035331T2 HUE09713553A HUE09713553A HUE035331T2 HU E035331 T2 HUE035331 T2 HU E035331T2 HU E09713553 A HUE09713553 A HU E09713553A HU E09713553 A HUE09713553 A HU E09713553A HU E035331 T2 HUE035331 T2 HU E035331T2
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- microparticle
- microparticles
- polymer
- acid
- hydrophilic
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Claims (7)
- Sztthaáafori igénypontok1. Mikrorészecske. amely hidrofil hatóanyagot tartalmazó részecskék agglomerátumát tartalmazza, amely részecske tartalmaz egy amfifil pofonért, amely egy poithifoosssav hldrotób szegmenséből és egy pofiszacharid vagy poliettlértgliko! hidrofil szegmenséből áll, tartalmaz továbbá egy hidrofil hatóanyagot, és ahol az etnfoott tészerskek agglometánő aratna idoől ifi a hetodm hatramoa értékig tenedo htrtoman\ ban van.
- 2. Az 1, igénypont szerhhl mikrorészecske, ahol a hidrorfil hatóanyagot tartstfowo reszeeUo. az amíffir pofim«;- egy hidrofil szegmensét tartalmazza a belsejében, továbbá van egy amSSpolimer hkirotoh szegmensét tartalmazó kttlsö rétege,
- 3. Az 1. vágy 2, igénypont szerinti tnikrorészécske, ahoi az amfiífi pofimer égy políszácharid íbiáocböt és pölihidroxissv oitott lánctökjböl álló öjtett típusé amíifiii pofonét, 4. A 3. igénypont szerinti mikrorészecske, ahol a políszácharid ioiáne déztrán. .5, Az: 1, vagy 2. igénypont szerinti mikrorészecske, ahol az astfiSI polimer egy polish Iérígiikoiból és pofihídrosísavböl álló hiokkpofoner, ő. Az 5. igénypont szerinti mikrorészecske, ahoi a pofiefiléogiikol közepes molskokitfonege 2ÖÖÖ-i sÖOö.
- 7, Az S, vagy 0 igénypont szerinti mikrorészecske, áltól a pofihidroxisav közepes ntólekttiatömegének a pofieoiénghkos közepes molekulalőmegóre vonatkoztatott aránya 4 vagy ennél nagyobb.5. Az 1-7, igénypontok bármelyike szerinti mikrorészecske, ahol a polihiároxtsav poliCtejsav-glikolsav}.
- 9 , A z. 1-S; igénypontok bármelyike szerinti mikrorészecske, ahol a közepes részecske átmérő i-SO ttm. IQ, Az 1 -S. igénypontok bármelyike szerinti mikrorészecske, ahöí a hidrofil hatóanyag egy peptid vagy egy·' protein, ki, Eljárás az 1, igénypont szerinti mikrorészecske előállítására, amely tartalmaz:. (a) egy reverz fázisú emulzió· előállítására vonatkozó lépést, amelynek során összekeverünk egy vizes oldószert, -amely tartalmazza a hidrofil hatóanyagot, és egy vízzel sem elegyedd szerves oldószert, amely oldja az amfifil polisncrt, fh) egy hidrofil hatóanyagot tartalmazó szilárd anyag előállítására vonatkozó lépési, amelynek során a teverz fázisú emobriőból eltávolítjuk az oldószert, és V 'χ kj\ -ÏIÎX - os χηη a vihn \Uri'W\k t> tartalmazó folyadék toisba.
- 12, A fi. Igéstypooi szerlMl eljárás, ahol az oldószert a rover« toäsö emulzióból fogyasztoé» szktosi eljárással távolítjok el.
- 13, A II, vagy 12. igénypont szerint; eljárás;, ahol a szilárd anyagot tartalmazó diszpergáió folyadék diszpergálöszere egy poíihiároxisav oldására ttlkaimas oldószer, és azamfiftl polimert alkotó hidrofil szegmens oldhatósága 10 mg/ml vagy ennél kevesebb, 14, A 1 M3, igénypontok bármelyike szerinti eljárás, ahol a folyadékíázis egy vizes oldószer vagy egy vízzel elegyedő szerves oldószer. 15, ogs szerkészbmény, amely tartalmazza az l 10. igénypontok bármelyike szerint? mikrorészecskét
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008041298 | 2008-02-22 | ||
| JP2008041299 | 2008-02-22 | ||
| JP2008167027 | 2008-06-26 | ||
| JP2008167026 | 2008-06-26 | ||
| JP2008243931 | 2008-09-24 | ||
| JP2008243932 | 2008-09-24 |
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| HUE035331T2 true HUE035331T2 (hu) | 2018-05-02 |
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| HUE09713553A HUE035331T2 (hu) | 2008-02-22 | 2009-02-20 | Mikrorészecskék és az ezeket tartalmazó gyógyszerkészítmények |
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| EP (1) | EP2251006B1 (hu) |
| JP (1) | JP5712485B2 (hu) |
| KR (1) | KR101542433B1 (hu) |
| CN (1) | CN101932311B (hu) |
| AU (1) | AU2009216216B2 (hu) |
| CA (1) | CA2715665C (hu) |
| DK (1) | DK2251006T3 (hu) |
| ES (1) | ES2635515T3 (hu) |
| HU (1) | HUE035331T2 (hu) |
| PL (1) | PL2251006T3 (hu) |
| PT (1) | PT2251006T (hu) |
| RU (1) | RU2490009C2 (hu) |
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| JP5804453B2 (ja) * | 2009-05-14 | 2015-11-04 | 国立大学法人 東京大学 | 結晶性ポリオール微粒子及びその調製方法 |
| JP5560719B2 (ja) * | 2010-01-08 | 2014-07-30 | 東レ株式会社 | 親水性生理活性物質含有微粒子の製造方法 |
| AU2011294244B2 (en) | 2010-08-26 | 2014-06-12 | Toray Industries, Inc. | Immunogenic composition |
| EP3778696A1 (en) * | 2012-04-23 | 2021-02-17 | NanoProteagen Ltd. | Polymeric nanoparticles and a process of preparation thereof |
| CN102657843A (zh) * | 2012-06-05 | 2012-09-12 | 云南民族大学 | 抗菌肽组合物及其制备方法 |
| TWI476019B (en) * | 2013-04-08 | 2015-03-11 | Graft copolymer hydrogel and preparation method thereof | |
| KR102343005B1 (ko) * | 2013-10-09 | 2021-12-24 | 도레이 카부시키가이샤 | 면역 부활화제 |
| JP2017500182A (ja) * | 2013-10-10 | 2017-01-05 | ニューヨーク ユニヴァーシティＮｅｗ Ｙｏｒｋ Ｕｎｉｖｅｒｓｉｔｙ | ナノ粒子の効率的捕集 |
| RU2672861C2 (ru) * | 2014-10-31 | 2018-11-20 | Общество с ограниченной ответственностью "Эксифарм" (ООО "Эксифарм") | Композиция на основе интерферона I или III типа и гамма-D-глутаминил-L-триптофана для профилактики и лечения инфекционных заболеваний и иммунодефицитных состояний (варианты) |
| CN113350489A (zh) * | 2015-04-21 | 2021-09-07 | 北卡罗来纳州立大学 | 使用缺氧敏感性纳米复合材料的葡萄糖响应性胰岛素递送系统 |
| JP6740550B2 (ja) * | 2015-10-13 | 2020-08-19 | 地方独立行政法人青森県産業技術センター | 食用マイクロカプセル，食用マイクロカプセルの製造方法及び調味料 |
| WO2018085407A1 (en) | 2016-11-02 | 2018-05-11 | Nanoproteagen | Polymeric nanoparticles |
| MX2022006824A (es) | 2019-12-05 | 2022-09-19 | Univ West Virginia | Nanoesferas de plga cargadas con proteinas. |
| EP4501320A1 (en) * | 2023-08-02 | 2025-02-05 | IQ medical GmbH | A method of preparing an aqueous dispersion of nanoparticles |
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| IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| CH656884A5 (de) | 1983-08-26 | 1986-07-31 | Sandoz Ag | Polyolester, deren herstellung und verwendung. |
| JPH0819226A (ja) | 1994-04-28 | 1996-01-19 | Sankyo Seiki Mfg Co Ltd | 回転電機 |
| ATE252894T1 (de) | 1995-01-05 | 2003-11-15 | Univ Michigan | Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung |
| DE19513659A1 (de) * | 1995-03-10 | 1996-09-12 | Boehringer Mannheim Gmbh | Polypeptid-enthaltende pharmazeutische Darreichungsformen in Form von Mikropartikeln und Verfahren zu deren Herstellung |
| DE19545257A1 (de) | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
| KR100274842B1 (ko) * | 1998-10-01 | 2001-03-02 | 김효근 | 미립구를 이용한 레티노익산의 서방형 약물방출 시스템 |
| FR2809112B1 (fr) | 2000-05-16 | 2004-05-07 | Centre Nat Rech Scient | Materiaux a base de polymeres biodegradables et son procede de preparation |
| DE60129838T2 (de) | 2000-11-09 | 2008-04-30 | Astrazeneca Ab | Orale pharmazeutische zusammensetzung mit einem blockcopolymer |
| KR100446101B1 (ko) | 2000-12-07 | 2004-08-30 | 주식회사 삼양사 | 수난용성 약물의 서방성 제형 조성물 |
| CA2600085A1 (en) * | 2005-03-09 | 2006-09-14 | Toray Industries, Inc. | Microparticle and pharmaceutical preparation |
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- 2009-02-20 RU RU2010138925/15A patent/RU2490009C2/ru active
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- 2009-02-20 JP JP2009508034A patent/JP5712485B2/ja active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| US8431161B2 (en) | 2013-04-30 |
| EP2251006A4 (en) | 2013-07-10 |
| ES2635515T3 (es) | 2017-10-04 |
| CA2715665A1 (en) | 2009-08-27 |
| US20110003007A1 (en) | 2011-01-06 |
| JPWO2009104706A1 (ja) | 2011-06-23 |
| AU2009216216B2 (en) | 2013-11-07 |
| KR20100120119A (ko) | 2010-11-12 |
| RU2490009C2 (ru) | 2013-08-20 |
| RU2010138925A (ru) | 2012-03-27 |
| KR101542433B1 (ko) | 2015-08-06 |
| AU2009216216A1 (en) | 2009-08-27 |
| PT2251006T (pt) | 2017-10-13 |
| PL2251006T3 (pl) | 2017-12-29 |
| BRPI0905790A2 (pt) | 2015-07-14 |
| EP2251006B1 (en) | 2017-07-19 |
| CN101932311A (zh) | 2010-12-29 |
| CA2715665C (en) | 2016-04-19 |
| CN101932311B (zh) | 2014-07-16 |
| EP2251006A1 (en) | 2010-11-17 |
| WO2009104706A1 (ja) | 2009-08-27 |
| DK2251006T3 (en) | 2017-10-16 |
| JP5712485B2 (ja) | 2015-05-07 |
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