HUE049207T2 - Normál és tumorsejtek kismolekulás TRAIL-génindukciója rákellenes terápiaként - Google Patents

Normál és tumorsejtek kismolekulás TRAIL-génindukciója rákellenes terápiaként

Info

Publication number: HUE049207T2
Authority: HU; Hungary
Prior art keywords: normal; small; tumor cells; anticancer therapy; gene induction
Prior art date: 2011-04-29

Application number

HUE12776073A

Other languages

English (en)

Hungarian (hu)

Inventor

Wafik El-Deiry

Joshua Allen

Gen Wu

Original Assignee

Penn State Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-04-29

Filing date

2012-04-30

Publication date

2020-09-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47068061&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE049207(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-04-30 Application filed by Penn State Res Found filed Critical Penn State Res Found

2020-09-28 Publication of HUE049207T2 publication Critical patent/HUE049207T2/hu

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Mycology (AREA)
Cell Biology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Physics & Mathematics (AREA)
Food Science & Technology (AREA)
Dermatology (AREA)
Physiology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

HUE12776073A 2011-04-29 2012-04-30 Normál és tumorsejtek kismolekulás TRAIL-génindukciója rákellenes terápiaként HUE049207T2 (hu)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201161480743P	2011-04-29	2011-04-29

Publications (1)

Publication Number	Publication Date
HUE049207T2 true HUE049207T2 (hu)	2020-09-28

Family

ID=47068061

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HUE12776073A HUE049207T2 (hu)	2011-04-29	2012-04-30	Normál és tumorsejtek kismolekulás TRAIL-génindukciója rákellenes terápiaként
HUE20152317A HUE068623T2 (hu)	2011-04-29	2012-04-30	Normál és tumorsejtek kismolekulás TRAIL-génindukclója rákellenes terápiaként

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
HUE20152317A HUE068623T2 (hu)	2011-04-29	2012-04-30	Normál és tumorsejtek kismolekulás TRAIL-génindukclója rákellenes terápiaként

Country Status (18)

Country	Link
US (9)	US8673923B2 (fr)
EP (4)	EP3679934B1 (fr)
JP (7)	JP6132833B2 (fr)
CA (1)	CA2832342C (fr)
CY (1)	CY1123010T1 (fr)
DK (3)	DK3679934T3 (fr)
ES (3)	ES3063552T3 (fr)
FI (2)	FI3679934T3 (fr)
HR (3)	HRP20200636T1 (fr)
HU (2)	HUE049207T2 (fr)
LT (3)	LT4335511T (fr)
MX (2)	MX365365B (fr)
PL (3)	PL2701708T3 (fr)
PT (3)	PT3679934T (fr)
RS (3)	RS67757B1 (fr)
SI (3)	SI4335511T1 (fr)
SM (3)	SMT202400421T1 (fr)
WO (1)	WO2012149546A2 (fr)

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US10813630B2 (en)	2011-08-09	2020-10-27	Corquest Medical, Inc.	Closure system for atrial wall
US10307167B2 (en)	2012-12-14	2019-06-04	Corquest Medical, Inc.	Assembly and method for left atrial appendage occlusion
US10314594B2 (en)	2012-12-14	2019-06-11	Corquest Medical, Inc.	Assembly and method for left atrial appendage occlusion
US20140142689A1 (en)	2012-11-21	2014-05-22	Didier De Canniere	Device and method of treating heart valve malfunction
PL2968294T3 (pl) *	2013-03-13	2019-10-31	Oncoceutics Inc	7-Benzylo-10-(2-metylobenzylo)-2,6,7,8,9,10-heksahydroimidazo[1,2-a]pirydo[4,3-d]pirymidyn-5(3H)-on do zastosowania w leczeniu nowotworu
US9688679B2 (en)	2013-03-13	2017-06-27	Oncoceutics, Inc.	7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy
WO2015073072A1 (fr) *	2013-11-15	2015-05-21	Oncoceutics, Inc.	7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one
US9376437B2 (en)	2013-03-13	2016-06-28	Oncoceutics, Inc	7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
SMT201900291T1 (it) *	2013-11-15	2019-07-11	Oncoceutics Inc	7-benzil-4-(2-metilbenzil)-2,4,6,7,8,9-esaidriomidazo[1,2-a]pirido[3,4-e]pirimidin-5(1h)-one, suoi sali e metodi d'uso
US9566443B2 (en)	2013-11-26	2017-02-14	Corquest Medical, Inc.	System for treating heart valve malfunction including mitral regurgitation
WO2015138638A1 (fr)	2014-03-11	2015-09-17	Theraly Pharmaceuticals, Inc.	Agonistes de récepteur de protéine trail à action prolongée pour le traitement de maladies auto-immunes
HUE069651T2 (hu)	2014-03-31	2025-03-28	Scripps Research Inst	Farmakofór TRAIL indukcióra
US10842626B2 (en)	2014-12-09	2020-11-24	Didier De Canniere	Intracardiac device to correct mitral regurgitation
SMT202500087T1 (it)	2015-01-30	2025-03-12	Oncoceutics Inc	Derivati di 7-benzil-4-(2-metilbenzil)-2,4,6,7,8,9-esaidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1h)-one, loro sali e loro uso in terapia
WO2016160918A1 (fr)	2015-03-31	2016-10-06	The University Of North Carolina At Chapel Hill	Véhicules d'apport pour cellules souches et leurs utilisations
CN104860948B (zh) *	2015-05-15	2017-09-26	南京盖特医药技术有限公司	咪唑并嘧啶酮类化合物及其制备方法和应用
US11007251B2 (en)	2015-12-17	2021-05-18	The Johns Hopkins University	Ameliorating systemic sclerosis with death receptor agonists
WO2017132661A2 (fr)	2016-01-29	2017-08-03	Oncoceutics, Inc.	Modulation des récepteurs couplés aux protéines g (rcpg) par les imipridones
CN109195620B (zh)	2016-04-07	2022-06-28	约翰霍普金斯大学	用死亡受体激动剂治疗胰腺炎和疼痛的组合物和方法
US10172862B2 (en)	2017-01-30	2019-01-08	Oncoceutics, Inc.	Imipridones for gliomas
US11767353B2 (en)	2020-06-05	2023-09-26	Theraly Fibrosis, Inc.	Trail compositions with reduced immunogenicity
CN119997956A (zh)	2022-08-05	2025-05-13	奇默里克斯公司	药物组合物及其用于治疗胶质瘤的用途
US20260191864A1 (en) *	2022-11-10	2026-07-09	Emory University	Uses of Hydroimidazopyridopyrimidinone Derivatives for Managing Aneurysms or Other Vascular Conditions or Diseases

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CN101074261A (zh) *	2006-04-30	2007-11-21	北京同为时代生物技术有限公司	Trail受体1和/或trail受体2特异性抗体及其应用
CA2656393A1 (fr) *	2006-06-30	2008-01-10	Schering Corporation	Procede d'utilisation de piperidines substituees qui augmentent l'activite de p53
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RS67757B1 (sr)	2011-04-29	2026-03-31	Penn State Res Found	Indukcija malim molekulom trail gena u normalnim i tumorskim ćelijama kao antikancerska terapija
PL2968294T3 (pl)	2013-03-13	2019-10-31	Oncoceutics Inc	7-Benzylo-10-(2-metylobenzylo)-2,6,7,8,9,10-heksahydroimidazo[1,2-a]pirydo[4,3-d]pirymidyn-5(3H)-on do zastosowania w leczeniu nowotworu

2012
- 2012-04-30 RS RS20260186A patent/RS67757B1/sr unknown
- 2012-04-30 HU HUE12776073A patent/HUE049207T2/hu unknown
- 2012-04-30 SI SI201232104T patent/SI4335511T1/sl unknown
- 2012-04-30 SM SM20240421T patent/SMT202400421T1/it unknown
- 2012-04-30 HR HRP20200636TT patent/HRP20200636T1/hr unknown
- 2012-04-30 JP JP2014508181A patent/JP6132833B2/ja active Active
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- 2012-04-30 DK DK20152317.2T patent/DK3679934T3/da active
- 2012-04-30 EP EP20152317.2A patent/EP3679934B1/fr active Active
- 2012-04-30 LT LTEP23206770.2T patent/LT4335511T/lt unknown
- 2012-04-30 WO PCT/US2012/035831 patent/WO2012149546A2/fr not_active Ceased
- 2012-04-30 PT PT201523172T patent/PT3679934T/pt unknown
- 2012-04-30 HR HRP20241214TT patent/HRP20241214T1/hr unknown
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- 2012-04-30 MX MX2013012346A patent/MX365365B/es active IP Right Grant
- 2012-04-30 SI SI201231766T patent/SI2701708T1/sl unknown
- 2012-04-30 MX MX2019006379A patent/MX379539B/es unknown
- 2012-04-30 PL PL12776073T patent/PL2701708T3/pl unknown
- 2012-04-30 LT LTEP12776073.4T patent/LT2701708T/lt unknown
- 2012-04-30 DK DK23206770.2T patent/DK4335511T3/da active
- 2012-04-30 EP EP23206770.2A patent/EP4335511B1/fr active Active
- 2012-04-30 EP EP12776073.4A patent/EP2701708B1/fr active Active
- 2012-04-30 PT PT232067702T patent/PT4335511T/pt unknown
- 2012-04-30 ES ES12776073T patent/ES2786033T3/es active Active
- 2012-04-30 PT PT127760734T patent/PT2701708T/pt unknown
- 2012-04-30 HU HUE20152317A patent/HUE068623T2/hu unknown
- 2012-04-30 SM SM20200272T patent/SMT202000272T1/it unknown
- 2012-04-30 FI FIEP20152317.2T patent/FI3679934T3/fi active
- 2012-04-30 SM SM20260075T patent/SMT202600075T1/it unknown
- 2012-04-30 PL PL23206770.2T patent/PL4335511T3/pl unknown
- 2012-04-30 RS RS20240842A patent/RS65813B1/sr unknown
- 2012-04-30 PL PL20152317.2T patent/PL3679934T3/pl unknown
- 2012-04-30 RS RS20200454A patent/RS60186B1/sr unknown
- 2012-04-30 US US13/459,775 patent/US8673923B2/en not_active Ceased
- 2012-04-30 LT LTEP20152317.2T patent/LT3679934T/lt unknown
- 2012-04-30 DK DK12776073.4T patent/DK2701708T3/da active
- 2012-04-30 EP EP25217415.6A patent/EP4706682A3/fr active Pending
- 2012-04-30 CA CA2832342A patent/CA2832342C/fr active Active
- 2012-04-30 FI FIEP23206770.2T patent/FI4335511T3/fi active
2014
- 2014-02-27 US US14/192,329 patent/US9061032B2/en active Active
- 2014-07-22 US US14/338,055 patent/US9072744B1/en active Active
2015
- 2015-06-08 US US14/733,740 patent/US9452165B2/en active Active
- 2015-09-17 US US14/857,418 patent/USRE46290E1/en active Active
2016
- 2016-07-20 JP JP2016142086A patent/JP2016199580A/ja not_active Withdrawn
- 2016-09-19 US US15/269,114 patent/US9629842B2/en active Active
2017
- 2017-04-23 US US15/494,515 patent/US20170224690A1/en not_active Abandoned
2018
- 2018-11-08 JP JP2018210558A patent/JP2019019145A/ja not_active Withdrawn
2020
- 2020-04-14 CY CY20201100350T patent/CY1123010T1/el unknown
2021
- 2021-09-16 JP JP2021151110A patent/JP2021185210A/ja not_active Withdrawn
2022
- 2022-03-21 US US17/655,646 patent/US12036223B2/en active Active
2023
- 2023-03-06 JP JP2023033777A patent/JP7600286B2/ja active Active
2024
- 2024-02-27 JP JP2024027432A patent/JP2024051080A/ja active Pending
- 2024-06-12 US US18/740,833 patent/US20240415841A1/en active Pending
2025
- 2025-08-08 JP JP2025133453A patent/JP2025159099A/ja active Pending

Also Published As

Publication number	Publication date
DK2701708T3 (da)	2020-04-27
RS67757B1 (sr)	2026-03-31
MX365365B (es)	2019-05-30
EP2701708A2 (fr)	2014-03-05
MX2019006379A (es)	2019-09-04
US20150202206A1 (en)	2015-07-23
SI2701708T1 (sl)	2020-07-31
HRP20200636T1 (hr)	2020-07-10
JP6132833B2 (ja)	2017-05-24
JP2016199580A (ja)	2016-12-01
LT3679934T (lt)	2024-11-11
PT4335511T (pt)	2026-02-20
MX379539B (es)	2025-03-11
HRP20260228T1 (hr)	2026-03-27
EP3679934B1 (fr)	2024-06-05
JP2024051080A (ja)	2024-04-10
US20120276088A1 (en)	2012-11-01
US20140248264A1 (en)	2014-09-04
PL4335511T3 (pl)	2026-03-30
FI3679934T3 (fi)	2024-07-08
JP2014514326A (ja)	2014-06-19
EP2701708B1 (fr)	2020-01-22
FI4335511T3 (fi)	2026-01-29
JP2021185210A (ja)	2021-12-09
US20150265619A1 (en)	2015-09-24
WO2012149546A2 (fr)	2012-11-01
PL3679934T3 (pl)	2025-01-07
US9452165B2 (en)	2016-09-27
SI4335511T1 (sl)	2026-03-31
LT4335511T (lt)	2026-02-25
WO2012149546A3 (fr)	2013-01-03
US20240415841A1 (en)	2024-12-19
JP2025159099A (ja)	2025-10-17
PL2701708T3 (pl)	2020-11-02
DK3679934T3 (en)	2024-07-22
EP2701708A4 (fr)	2015-01-07
US9061032B2 (en)	2015-06-23
SI3679934T1 (sl)	2025-04-30
CY1123010T1 (el)	2021-10-29
EP4335511B1 (fr)	2025-11-26
EP4706682A2 (fr)	2026-03-11
US8673923B2 (en)	2014-03-18
MX2013012346A (es)	2014-08-22
JP2019019145A (ja)	2019-02-07
CA2832342A1 (fr)	2012-11-01
LT2701708T (lt)	2020-05-25
EP4706682A3 (fr)	2026-05-20
ES3063552T3 (en)	2026-04-17
SMT202400421T1 (it)	2024-11-15
JP2023060196A (ja)	2023-04-27
US20170000790A1 (en)	2017-01-05
SMT202600075T1 (it)	2026-03-09
HUE068623T2 (hu)	2025-01-28
EP3679934A1 (fr)	2020-07-15
HRP20241214T1 (hr)	2024-11-22
DK4335511T3 (da)	2026-02-02
US20170224690A1 (en)	2017-08-10
PT3679934T (pt)	2024-09-05
EP4335511A2 (fr)	2024-03-13
US9629842B2 (en)	2017-04-25
ES2786033T3 (es)	2020-10-08
RS65813B1 (sr)	2024-08-30
US12036223B2 (en)	2024-07-16
ES2992934T3 (en)	2024-12-19
JP7600286B2 (ja)	2024-12-16
SMT202000272T1 (it)	2020-07-08
US9072744B1 (en)	2015-07-07
PT2701708T (pt)	2020-05-08
USRE46290E1 (en)	2017-01-31
US20220288079A1 (en)	2022-09-15
CA2832342C (fr)	2019-12-31
RS60186B1 (sr)	2020-06-30
EP4335511A3 (fr)	2024-05-15

Publication	Publication Date	Title
DK3679934T3 (en)	2024-07-22	Small molecule trail gene induction by normal and tumor cells as an anticancer therapy
IL261569B (en)	2021-09-30	Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
IL228031A0 (en)	2013-09-30	Adno vectors for gene therapy in choroideremia
IL236182A0 (en)	2015-01-29	Methods for detecting diseases or conditions using circulating diseased cells
PL2831110T3 (pl)	2018-11-30	Terapia anty-EMP2 zmniejsza ilość rakowych komórek macierzystych
IL229242A0 (en)	2014-01-30	Allogeneic cell vaccine for cancer
GB201201397D0 (en)	2012-03-14	Gene targeting in animals
GB201102213D0 (en)	2011-03-23	Inventions and therapy
GB201102227D0 (en)	2011-03-23	Inventions and therapy
GB201102234D0 (en)	2011-03-23	Inventions and therapy
GB201102221D0 (en)	2011-03-23	Inventions and therapy
GB201102236D0 (en)	2011-03-23	Inventions and therapy
GB201102232D0 (en)	2011-03-23	Inventions and therapy
GB201102239D0 (en)	2011-03-23	Inventions and therapy
GB201102208D0 (en)	2011-03-23	Inventions and therapy
GB201102228D0 (en)	2011-03-23	Inventions and therapy
GB201102231D0 (en)	2011-03-23	Inventions and therapy
GB201102210D0 (en)	2011-03-23	Inventions and therapy
GB201102215D0 (en)	2011-03-23	Inventions and therapy
GB201102226D0 (en)	2011-03-23	Inventions and therapy
GB201102238D0 (en)	2011-03-23	Inventions and therapy
GB201102216D0 (en)	2011-03-23	Inventions and therapy
GB201102212D0 (en)	2011-03-23	Inventions and therapy